公开(公告)号：US20050171438A1

公开(公告)日：2005-08-04

申请号：US11009717

申请日：2004-12-09

Applicant: Zhongping Chen ,  Jun Zhang ,  J. Nelson

Inventor： Zhongping Chen ,  Jun Zhang ,  J. Nelson

IPC: A61B5/026 ,  A61B5/00 ,  A61B5/05 ,  A61B6/00 ,  A61B8/00

CPC classification number: A61B5/0066 ,  A61B5/0261 ,  A61B5/7203 ,  A61B5/7257 ,  A61B5/726 ,  G01B9/02004 ,  G01B9/0201 ,  G01B9/02078 ,  G01B9/02091

Abstract: A method for tomographic imaging comprises the steps of providing a source of at least partially coherent radiation and a frequency-swept laser source through an interferometer; phase modulating the radiation in the interferometer at a modulation frequency for elimination of DC and autocorrelation noises as well as the mirror image; detecting interference fringes of the radiation backscattered from the sample into the interferometer to obtain a spectral signal; transforming the spectral signal of the detected backscattered interference fringes to obtain a time and location dependent signal, including the Doppler shift and variance, at each pixel location in a data window; and generating a tomographic image of the fluid flow in the data window and of the structure of the scanned fluid flow sample in the data window from the time and location dependent signal. The apparatus comprises a system for tomographic imaging operating according to the above method.

Abstract translation: 一种用于层析成像的方法包括以下步骤：通过干涉仪提供至少部分相干辐射源和频率扫描激光源; 以调制频率对干涉仪中的辐射进行相位调制，以消除DC和自相关噪声以及镜像; 检测从样品反向散射到干涉仪中的辐射的干涉条纹以获得光谱信号; 变换所检测的反向散射干涉条纹的频谱信号，以在数据窗口中的每个像素位置处获得包括多普勒频移和方差的时间和位置相关信号; 以及从时间和位置相关信号在数据窗口中产生流体流的断层图像和在数据窗口中扫描的流体流动样本的结构。 该装置包括根据上述方法操作的用于层析成像的系统。

公开(公告)号：US06868347B2

公开(公告)日：2005-03-15

申请号：US10393109

申请日：2003-03-19

Applicant: Guann-Pyng Li ,  Mark Bachman ,  Zhongping Chen

Inventor： Guann-Pyng Li ,  Mark Bachman ,  Zhongping Chen

IPC: G01B9/02 ,  G01N11/00

CPC classification number: G06F19/00 ,  G01B9/0201 ,  G01B9/02027 ,  G01B9/02045 ,  G01B9/02072 ,  G01B9/02091 ,  G01B2290/35 ,  G01B2290/45 ,  G01B2290/70

Abstract: A system integration of multicomponent technologies includes an automated microfluidic probe station and the use of that station for the systematic study of nonideal, nonhomogeneous biological fluids such as blood in microfluidic chips. The probe station provides for real-time, non-invasive metrology of microfluidic chips employing optical coherence tomography and optical Doppler tomography to allow for collection of flow data at any location or depth within a microfluidics chip. Also included is a programmable fluidic loader and actuator platform as part of the probe station, and a semi-automated rapid prototyping tool used to fabricate the microfluidic chips measured on the probe station. The resulting data library produced by measurements on the probe station contains all the necessary information needed to develop mature, accurate microfluidic modeling and simulation CAD tools.

Abstract translation: 多组分技术的系统集成包括自动化微流体探针站和该站的用途，用于系统研究非流体，非均质生物流体，如微流控芯片中的血液。 探针台提供使用光学相干断层扫描和光学多普勒层析成像的微流控芯片的实时非侵入式计量，以允许在微流体芯片内的任何位置或深度收集流量数据。 还包括作为探测台的一部分的可编程流体装载器和致动器平台，以及用于制造在探针台上测量的微流体芯片的半自动化快速成型工具。 通过探针台上的测量产生的结果数据库包含开发成熟，精确的微流体建模和仿真CAD工具所需的全部必要信息。

公开(公告)号：US20050030548A1

公开(公告)日：2005-02-10

申请号：US10637426

申请日：2003-08-09

Applicant: Chian Li

Inventor： Chian Li

IPC: A61B3/12 ,  G01B9/02 ,  G01N21/47 ,  G02B21/00 ,  G02B27/58

CPC classification number: A61B3/1225 ,  G01B9/0201 ,  G01B9/02022 ,  G01B9/02035 ,  G01B9/02091 ,  G01N21/4795 ,  G02B21/002 ,  G02B27/58

Abstract: In order to improve lateral resolution of scanning optical devices, a low-coherence sample beam is divided into beam portions by wavefront division and one of the beam portions is phase delayed relative to the other portions. The sample beam is focused on and reflected by an object. The reflected beam is coupled with a reference beam. The phase retardation is large enough that interference occurs exclusively between the phase delayed beam portion and the reference beam. The phase delayed beam portion can be used as a virtual beam within the sample beam in optical measurements. The virtual beam has a virtual beam spot that is smaller than the sample beam spot.

Abstract translation: 为了提高扫描光学器件的横向分辨率，低相干采样光束通过波前分割被划分为光束部分，并且光束部分之一相对于其它部分相位延迟。 样品束聚焦在物体上并被其反射。 反射光束与参考光束耦合。 相位延迟足够大，干扰仅在相位延迟光束部分和参考光束之间发生。 在光学测量中，相位延迟光束部分可以用作样品光束内的虚拟光束。 虚拟光束具有小于样本光束点的虚拟光束点。

公开(公告)号：US20050018201A1

公开(公告)日：2005-01-27

申请号：US10501276

申请日：2003-01-24

Applicant: Johannes de Boer ,  Guillermo Tearney ,  Brett Bouma

Inventor： Johannes de Boer ,  Guillermo Tearney ,  Brett Bouma

IPC: G01B9/02 ,  G01N21/47

CPC classification number: G01B9/02007 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/7257 ,  G01B9/02008 ,  G01B9/0201 ,  G01B9/02032 ,  G01B9/02044 ,  G01B9/02045 ,  G01B9/02079 ,  G01B9/0209 ,  G01B9/02091 ,  G01B2290/45 ,  G01N21/4795

Abstract: Apparatus, method, logic arrangement and storage medium are provided for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source can be split into N spectral bands. The N spectral bands can be individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band may be detected by a separate photo detector and amplified. For each spectral band, the signal can be band p3 filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is likely reduced by a factor equal to the number of spectral bands, while the signal amplitude can remain the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.

Abstract translation: 提供装置，方法，逻辑布置和存储介质，用于通过检测光谱带的并行组来提高光学相干断层扫描和低相干干涉测量（“LCI”）信号的检测灵敏度，每个频带是光频率的唯一组合 。 LCI宽带宽源可以分为N个光谱带。 可以单独地检测和处理N个频谱带，以使信噪比增加N倍。每个频谱带可以由单独的光检测器检测并被放大。 对于每个频谱带，信号可以通过模拟电子装置在信号频带附近进行p3滤波，并且被数字化，或者，信号可以被数字化并且在软件中进行带通滤波。 结果，对信号的散粒噪声贡献可能降低等于光谱带数的因子，而信号幅度可以保持相同。 喷射噪声的降低增加了系统的动态范围和灵敏度。

公开(公告)号：US20040257587A1

公开(公告)日：2004-12-23

申请号：US10767406

申请日：2004-01-28

Inventor： Ares J. Rosakis ,  David Owen ,  Stephen Gledden ,  Sean Olson

IPC: G01B009/02

CPC classification number: G01B9/02098 ,  G01B9/0201 ,  G01B11/2441 ,  G01B2290/35 ,  G01J9/0215

Abstract: Techniques and systems for using optical interferometers to obtain full-field optical measurements of surfaces, such as surfaces of flat panels, patterned surfaces of wafers and substrates. Applications of various shearing interferometers for measuring surfaces are described.

Abstract translation: 使用光学干涉仪获得表面的全场光学测量的技术和系统，例如平板的表面，晶片和衬底的图案化表面。 描述了用于测量表面的各种剪切干涉仪的应用。

公开(公告)号：US20040257577A1

公开(公告)日：2004-12-23

申请号：US10765368

申请日：2004-01-27

Applicant: Zetetic Institute

Inventor： Henry Allen Hill

IPC: G01B009/02

CPC classification number: G01B9/02007 ,  A45D2008/006 ,  G01B9/02002 ,  G01B9/0201 ,  G01B9/02014 ,  G01B9/02022 ,  G01B9/02042 ,  G01B9/02079 ,  G01B9/04 ,  G01B2290/70 ,  G02B21/0056 ,  G02B21/14 ,  G02B27/017 ,  G02B27/108 ,  G02B27/126 ,  G02B27/143 ,  G02B27/144 ,  G02B27/145

Abstract: An interferometery system for making interferometric measurements of an object, the system including: a beam generation module which during operation delivers an output beam that includes a first beam at a first frequency and a second beam at a second frequency that is different from the first frequency, the first and second beams within the output beam being coextensive, the beam generation module including a beam conditioner which during operation introduces a sequence of different shifts in a selected parameter of each of the first and second beams, the selected parameter selected from a group consisting of phase and frequency; a detector assembly having a detector element; and an interferometer constructed to receive the output beam at least a part of which represents a first measurement beam at the first frequency and a second measurement beam at the second frequency, the interferometer further constructed to image both the first and second measurement beams onto a selected spot on the object to produce therefrom corresponding first and second return measurement beams, and to then simultaneously image the first and second return measurement beams onto said detector element.

Abstract translation: 一种用于对物体进行干涉测量的干涉仪系统，所述系统包括：光束产生模块，其在操作期间传送包括第一频率的第一光束和不同于第一频率的第二频率的第二光束的输出光束 输出光束内的第一和第二光束共同延伸，光束产生模块包括光束调节器，其在操作期间引入第一和第二光束中的每一个的选定参数中的不同偏移序列，所选参数选自组 由相位和频率组成; 具有检测器元件的检测器组件; 以及干涉仪，其被构造为接收输出光束，所述输出光束的至少一部分表示第一频率处的第一测量光束和在第二频率处的第二测量光束，所述干涉仪还被构造成将所述第一和第二测量光束成像到所选择的 对象上产生相应的第一和第二返回测量光束，然后同时将第一和第二返回测量光束成像到所述检测器元件上。

公开(公告)号：US06775007B2

公开(公告)日：2004-08-10

申请号：US10059723

申请日：2002-01-29

Applicant: Joseph A. Izatt ,  Andrew M. Rollins

Inventor： Joseph A. Izatt ,  Andrew M. Rollins

IPC: G01B902

CPC classification number: A61B5/0066 ,  A61B5/0073 ,  G01B9/02002 ,  G01B9/02007 ,  G01B9/0201 ,  G01B9/02028 ,  G01B9/02091 ,  G01B2290/35 ,  G01B2290/40 ,  G01N21/4795

Abstract: Rapid scan optical delay techniques are used in parallel implementation of OCT using a detector and signal processing can be carried out using algorithms. Frequency encoded parallel OCT and multi-path, frequency encoded reference delay networks are used. A large number of frequency-correlated depth channels are used to acquire multiple depth scans of a sample. A different frequency shift (Doppler shift) on each different path length, or delay, is used to obtain simultaneous respective signals and, thus, information about the sample, from different depths in the sample. Reference delay line functions are obtained using bulk optics, integrated optics and fiber optics.

Abstract translation: 快速扫描光延迟技术用于使用检测器并行执行OCT，并且可以使用算法执行信号处理。 使用频率编码的并行OCT和多路径，频率编码的参考延迟网络。 使用大量频率相关深度通道来采集样本的多个深度扫描。 使用每个不同路径长度或延迟上的不同频移（多普勒频移）来从样本中的不同深度获得相应的信号，从而获得关于样本的信息。 参考延迟线功能使用体光学，集成光学和光纤获得。

公开(公告)号：US20040126048A1

公开(公告)日：2004-07-01

申请号：US10679952

申请日：2003-10-06

Inventor： Digant P. Dave ,  Thomas E. Milner ,  Taner Akkin

IPC: G02B006/00

CPC classification number: G01P5/26 ,  A61B5/0066 ,  A61B5/0261 ,  G01B9/0201 ,  G01B9/02027 ,  G01B9/02045 ,  G01B9/02091 ,  G01B2290/45 ,  G01B2290/70 ,  G01N21/4795 ,  G01P5/001

Abstract: Generally, and in one form of the present invention, is a polarization-maintaining fiber-based polarization sensitive optical low coherence reflectometer for depth resolved birefringence measurement. With the present invention, linear birefringence of a sample may be measured from data recorded in a single A-Scan. In addition, the present invention provides for the simultaneous measurement of retardation and orientation of birefringent axes, wherein measured retardation is insensitive to sample rotation in the plane perpendicular to ranging.

Abstract translation: 通常，在本发明的一种形式中，是用于深度分辨双折射测量的基于偏振保持光纤的偏振敏感光学低相干反射计。 利用本发明，可以从记录在单个A-Scan中的数据测量样品的线性双折射。 此外，本发明提供了同时测量双折射轴的延迟和取向，其中测量的延迟对垂直于测距的平面中的样品旋转不敏感。

公开(公告)号：US06687010B1

公开(公告)日：2004-02-03

申请号：US09656799

申请日：2000-09-07

Applicant: Akihiro Horii ,  Mamoru Kaneko ,  Tadashi Hirata ,  Hitoshi Mizuno

Inventor： Akihiro Horii ,  Mamoru Kaneko ,  Tadashi Hirata ,  Hitoshi Mizuno

IPC: G01B902

CPC classification number: G01B9/02007 ,  G01B9/02003 ,  G01B9/0201 ,  G01B9/0205 ,  G01B9/02091 ,  G01B2290/20 ,  G01B2290/35 ,  G01B2290/40 ,  G01B2290/65 ,  G01B2290/70

Abstract: An optical imaging device includes a reference scanning unit offering a high signal-to-noise ratio and capable of scanning an object rapidly. An interference optical system can be realized inexpensively. In the optical imaging device, low coherent light passed through an optical coupler and another optical coupler, irradiated from an optical scanner probe, reflected from an observed point in a living tissue, returned to the optical coupler, propagated over a fourth SM optical fiber, and routed to another optical coupler shall be referred to as sample light. Light passed through an optical length variation optical system via the optical coupler and routed to the optical coupler shall be referred to as reference light. At this time, a difference between a delay time undergone by the sample light and a delay time undergone by the reference light is proportional to a difference between an optical length for the sample light and an optical length for the reference light. When the optical length difference falls within a coherence length, the sample light and reference light interfere with each other. An interfering signal is acquired into a computer through detectors, a differential amplifier, a demodulator, and an A/D converter.

公开(公告)号：US06643024B2

公开(公告)日：2003-11-04

申请号：US09848055

申请日：2001-05-03

Applicant: Leslie L. Deck ,  David Stephenson ,  Edward J. Gratix ,  Carl A. Zanoni

Inventor： Leslie L. Deck ,  David Stephenson ,  Edward J. Gratix ,  Carl A. Zanoni

IPC: G01B902

CPC classification number: G02B27/48 ,  G01B9/0201 ,  G01B9/02022 ,  G01B9/02034 ,  G01B9/02057 ,  G01B9/02069 ,  G01B9/02082

Abstract: Interferometric apparatus and methods for reducing the effects of coherent artifacts in interferometers. Fringe contrast in interferograms is preserved while coherent artifacts that would otherwise be present in the interferogram because of coherent superposition of unwanted radiation generated in the interferometer are suppressed. Use is made of illumination and interferogrammetric imaging architectures that generate individual interferograms of the selected characteristics of a test surface from the perspective of different off-axis locations of illumination in an interferometer and then combine them to preserve fringe contrast while at the same time arranging for artifacts to exist at different field locations so that their contribution in the combined interferogram is diluted.