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公开(公告)号：US11054423B2
公开(公告)日：2021-07-06
申请号：US16790658
申请日：2020-02-13
Inventor： James E. Crowe, Jr. , Andrew I. Flyak , Alexander Bukreyev , Philipp Ilinykh
IPC: G01N33/569 , A61K39/42 , C07K16/10 , G01N33/577 , A61K39/395 , G01N33/68 , A61K39/00
Abstract: The present disclosure is directed to antibodies binding to and neutralizing ebolavirus and methods for use thereof. The present disclosure is directed to a method of detecting an ebolavirus infection in a subject comprising (a) contacting a sample from said subject with an antibody or antibody fragment having clone-paired heavy and light chain CDR sequences from Table 2, or an antibody fragment thereof; and (b) detecting ebolavirus glycoprotein in said sample by binding of said antibody or antibody fragment to antigen in said sample. In still further embodiments, the present disclosure concerns immunodetection kits for use with the iminunodetection methods described above.
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112.发明申请公开(公告)号：US20210196676A1
公开(公告)日：2021-07-01
申请号：US17058380
申请日：2019-05-30
Inventor： Ellen S. VITETTA
IPC: A61K31/365 , A61K9/00 , A61K9/06 , A61K31/60 , A61K31/19 , A61K31/513 , A61K45/06 , A61K31/122 , A61K31/4745 , A61K31/4164 , A61K9/70 , A61P31/22 , A61F13/40 , A61M35/00 , A61B18/02 , A61B18/20 , A61B18/14 , A61B17/3205
Abstract: The present disclosure relates to the use of the sequiterpene lactones and Helenalin (H. tox) or its derivatives to treat viral infection and virally induced lesions, such as warts or wart-associated skin or mucosal lesion. A topical application, optionally using a skin covering such as gauze, a bandage, or a patch, can substantially reduce and even eliminate persistent, recurrent and/or treatment-resistant warts.
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公开(公告)号：US11040959B2
公开(公告)日：2021-06-22
申请号：US16303043
申请日：2017-06-29
Applicant: The Scripps Research Institute , The Board of Regents of the University of Texas System , Bruce Beutler , Dale L. Boger
Inventor： Bruce Beutler , Dale L. Boger
IPC: C07D403/10 , A61P37/04
Abstract: A diprovocim compound that corresponds in structure to structural Formula V is disclosed, wherein A, W, Z, R1, R2, R3 and R4 (when present) are defined within. A diprovocim compound has immune-adjuvant properties on human and mouse cells in culture and on in vivo immunization of mice. A composition containing a diprovocim and a method of using a compound are also disclosed. The immunostimulatory activity of a diprovocim compound is similar to that of LPS, to which there is no apparent structural similarity. A contemplated compound bears no structural similarity to either the TLR1/TLR2 lipoprotein agonists nor to any other synthetic TLR agonist, and is remarkably easy to prepare and synthetically modify.
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公开(公告)号：US11027273B2
公开(公告)日：2021-06-08
申请号：US15555002
申请日：2016-03-01
Inventor： Xiujun Li , Sanjay Timilsina
IPC: B01L3/00 , G01N33/543 , G01N33/558
Abstract: Certain embodiments are directed to a paper hybrid microfluidic microplate. In certain aspects, the hybrid microfluidic microplate is a low-cost, sensitive, and fast diagnostic apparatus for detecting pathogens, diagnosing disease and other bio-applications, especially for low-resource settings.
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公开(公告)号：US20210156729A1
公开(公告)日：2021-05-27
申请号：US17097889
申请日：2020-11-13
Inventor： Constantine Tarawneh , Stephen Crown
Abstract: Described herein is a load sensor for a railcar that includes one or more strain gauges and one or more temperature sensors. The load sensor has a size and configuration that allows the load sensor to be embedded in a bearing adapter under the polymer steering pad of the railcar.
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Patent Agency Ranking
公开(公告)号：US11013818B2
公开(公告)日：2021-05-25
申请号：US16114187
申请日：2018-08-27
Inventor： Jinming Gao , Gang Huang , Tian Zhao , Xinpeng Ma , Yiguang Wang , Yang Li , Baran D. Sumer
IPC: A61K49/00 , C09B69/10 , G01N33/84 , G01N33/58 , G01N21/64 , C08F8/42 , C08F8/34 , C08F8/32 , C08F8/30
Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
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公开(公告)号：US20210148825A1
公开(公告)日：2021-05-20
申请号：US17135679
申请日：2020-12-28
Inventor： Reto P. Fiolka
Abstract: This disclosure includes an imaging system that is configured to image in parallel multiple focal planes in a sample uniquely onto its corresponding detector while simultaneously reducing blur on adjacent image planes. For example, the focal planes can be staggered such that fluorescence detected by a detector for one of the focal planes is not detected, or is detected with significantly reduced intensity, by a detector for another focal plane. This enables the imaging system to increase the volumetric image acquisition rate without requiring a stronger fluorescence signal. Additionally or alternatively, the imaging system may be operated at a slower volumetric image acquisition rate (e.g., that of a conventional microscope) while providing longer exposure times with lower excitation power. This may reduce or delay photo-bleaching (e.g., a photochemical alteration of the dye that causes it to no longer be able to fluoresce), thereby extending the useful life of the sample.
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公开(公告)号：US20210146969A1
公开(公告)日：2021-05-20
申请号：US17097450
申请日：2020-11-13
Inventor： Constantine Tarawneh , Robert Jones , Anthony Villarreal , Harry Siegel
Abstract: Described herein is an electrically and thermally conductive thermoplastic polyurethane. The conductive thermoplastic polyurethane is formed in an injection-molded process from vapor grown carbon nanofibers and a modified form of thermoplastic polyurethane (TPU). The polymer pad encompassing the injection-molded insert may be used to replace an existing railcar adapter pad.
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119.发明申请公开(公告)号：US20210139934A1
公开(公告)日：2021-05-13
申请号：US17092240
申请日：2020-11-07
Inventor： Steven J. GRAY , Frances C. SHAFFO
Abstract: The present disclosure provides methods and compositions for the treatment of diseases and genetic disorders linked to SLC6A1 loss and/or misfunction. The methods and compositions of the present disclosure comprise rAAV vectors and rAAV viral vectors comprising transgene nucleic acid molecules comprising nucleic acid sequences encoding for a GAT1 polypeptide.
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公开(公告)号：US10995056B2
公开(公告)日：2021-05-04
申请号：US16316692
申请日：2017-07-11
Inventor： John R. Falck , Mahesh P. Paudyal , László Kürti
IPC: C08F4/64 , C08F4/60 , C08F10/00 , C08F4/619 , C08F110/02 , C07C209/02 , C07D211/02 , C07C213/02 , C07J41/00 , C07C227/06 , C07D489/02 , C07D215/06 , C07D215/20 , C07D215/18 , C07D215/12 , C07D265/36 , C07D209/08 , C07D223/16 , C07D207/06 , C07D209/58 , C07D203/10 , C07C209/00 , C07C303/30 , C07D211/12 , C07D209/96 , C07J1/00
Abstract: In some aspects, the present disclosure provides methods of aminating an aromatic compound comprising reacting an aminating agent with an aromatic compound in the presence of a rhodium catalyst. In some embodiments, the methods may comprise aminating an aromatic compound which contains multiple different functional groups. The methods described herein may also be used to create bicyclic system comprising reacting an intramolecular aminating agent with an aromatic ring to obtain a second ring containing a nitrogen atom. In another aspect, the methods described herein may also be used to create a cyclic aliphatic cyclic/poly cyclic amine system comprising a reacting an intramolecular aminating agent by insertion into a C(sp3)-H bond.
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