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    Process for making a metallic grating
    111.
    发明授权
    Process for making a metallic grating 有权

    公开(公告)号：US11733439B2

    公开(公告)日：2023-08-22

    申请号：US17972816

    申请日：2022-10-25

    Applicant: Government of the United States of America, as represented by the Secretary of Commerce

    Inventor： Daniel Josell ,  Thomas Polk Moffat

    IPC: G02B5/18

    CPC classification number: G02B5/1852 ,  G02B5/1809 ,  G02B5/1857

    Abstract: A metallic grating is formed to include a substrate; a plurality of high aspect ratio trenches disposed in the substrate such that the high aspect ratio trenches are spaced apart from one another by a field surface of the substrate; a metallic superconformal filling formed and disposed in the high aspect ratio trenches; and a grating including a spatial arrangement of the high aspect ratio trenches that are filled with the metallic superconformal filling such that the metallic superconformal filling is void-free, and the high aspect ratio trenches are bottom-up filled with the metallic superconformal filling, wherein a height of the metallic superconformal filling is less than or equal to the height of the high aspect ratio trenches.

    OPTOMECHANICAL ACCELEROMETER AND PERFORMING OPTOMECHANICAL ACCELEROMETRY
    114.
    发明申请
    OPTOMECHANICAL ACCELEROMETER AND PERFORMING OPTOMECHANICAL ACCELEROMETRY 有权

    公开(公告)号：US20230017010A1

    公开(公告)日：2023-01-19

    申请号：US17363354

    申请日：2021-06-30

    Applicant: Government of the United States of America, as represented by the Secretary of Commerce

    Inventor： Jason John Gorman ,  Thomas Warren LeBrun ,  David Alexander Long

    IPC: G01P15/093

    Abstract: An optomechanical accelerometer includes: a fiducial mass for a microscale Fabry-Perot optical cavity; a proof mass for the microscale Fabry-Perot optical cavity, such that the proof mass oscillates in a displacement motion toward and away from the fiducial mass in response to acceleration of the optomechanical accelerometer; a basal member; microscale beams that mechanically suspend the proof mass from the basal member; and the microscale Fabry-Perot optical cavity that has a cavity resonance at a cavity resonance wavelength provided by the cavity length, receives excitation radiation at an excitation wavelength that is reflected in the cavity as dynamic cavity light when the excitation wavelength is resonant with the cavity resonance wavelength, and transmits the dynamic cavity light as cavity output light when the dynamic cavity light is produced from the excitation radiation.

    Molecular scrivener for reading or writing data to a macromolecule
    115.
    发明授权
    Molecular scrivener for reading or writing data to a macromolecule 有权

    公开(公告)号：US11507135B2

    公开(公告)日：2022-11-22

    申请号：US16383707

    申请日：2019-04-15

    Applicant: Government of the United States of America, as represented by the Secretary of Commerce

    Inventor： Kin P Cheung ,  Joseph W Robertson ,  John J Kasianowicz

    IPC: G11C13/00 ,  G06F1/16 ,  B82Y35/00

    Abstract: A molecular scrivener reads data from or writes data to a macromolecule and includes: a pair of shielding electrodes; a scrivener electrode between the first and second shielding electrodes and that electrically floats at a third potential that, in an absence of a charged or dipolar moiety of the macromolecule, is intermediate between the first and second potentials and changes in a presence of the charged or dipolar moiety; a dielectric layer interposed between shielding electrodes and the scrivener electrode; and a nanopore that communicates the macromolecule through the electrodes and dielectric layers. Reading data from or writing data to a macromolecule includes: sequentially receiving, at the scrivener electrode, individual moieties of the macromolecule so that the third potential responds to individual moieties; communicating the macromolecule from the scrivener electrode to the second shielding electrode and from second shielding electrode to expel the macromolecule from the nanopore.

    Fiber-to-chip coupler
    116.
    发明授权
    Fiber-to-chip coupler 有权

    公开(公告)号：US11480736B2

    公开(公告)日：2022-10-25

    申请号：US17144980

    申请日：2021-01-08

    Applicant: The Regents of the University of Colorado, a body corporate ,  Government of the United States of America as represented by the Secretary of Commerce

    Inventor： Saeed Khan ,  Jeffrey Shainline

    IPC: G02B6/30 ,  G02B6/42 ,  G02B6/293

    Abstract: A fiber-to-chip coupler includes a substrate, a waveguide on a top surface of the substrate, an optical fiber axially aligned to the waveguide, and a cap. The waveguide has a uniform region with uniform width and a tapered-waveguide region having a width that adiabatically increases from a minimum width to the uniform width. The optical fiber has a tapered fiber tip having a minimum core diameter, a cylindrical section having a maximum core diameter, and a tapered-fiber section therebetween. The optical fiber is located at least in part above the tapered-waveguide region, and has a core diameter that adiabatically decreases within a taper length of the tapered-fiber section. The cap extends from the tapered fiber tip toward the cylindrical section, is formed of a second material having a cap refractive index that exceeds a refractive index of the optical fiber, and includes a cap-region disposed on the tapered-waveguide region.

    Gradient elution moving boundary electrophoresis for use with complex samples and detection of toxins
    117.
    发明授权
    Gradient elution moving boundary electrophoresis for use with complex samples and detection of toxins 有权

    公开(公告)号：US11479804B1

    公开(公告)日：2022-10-25

    申请号：US16236697

    申请日：2018-12-31

    Applicant: Applied Research Associates, Inc. ,  Government of the United States of America, as represented by the Secretary of Commerce, The National Institute Of Standards And Technology

    Inventor： Alyssa Catharyn Henry ,  David Judson Ross

    IPC: C12Q1/46 ,  B01L3/00 ,  G01N27/447 ,  C12Q1/527 ,  B01D57/02 ,  G01N30/28

    Abstract: Methods of detecting the presence of toxins in a sample using electrophoretic separations and of performing electrophoretic separation of complex samples are provided. The method of detecting the presence of toxins includes reacting a sample and a substrate with a signaling enzyme which converts the substrate to the product in a reaction medium, introducing a run buffer into a separation channel having an inlet end, selectively introducing at least one of the substrate and the product of the reaction medium into the inlet end of the separation channel, electrophoretically separating the substrate and the product, and determining the rate of conversion of the substrate to the product, wherein a change in the rate of conversion is indicative of the presence of toxins. The method of performing electrophoretic separations of complex samples having charged particulates and oppositely charged analytes comprising introducing a run buffer into a separation channel having an inlet end, selectively introducing the oppositely charged analytes in the complex sample into the separation channel, and electrophoretically separating the charged particulates and the oppositely charged analytes. Additionally, a device for varying with respect to time the bulk flow of a fluid in a separation channel of an electrophoretic device having a buffer reservoir in fluid contact with the separation channel is provided. The device includes a pressure sensor in fluid contact with a buffer reservoir, a high pressure reservoir in selective fluidic communication with the buffer reservoir, a low pressure reservoir in selective fluidic communication with the buffer reservoir and in fluidic communication with the high pressure reservoir, and a pumping device for pumping a gas from the low pressure reservoir to the high pressure reservoir.

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