公开(公告)号：US06894205B2

公开(公告)日：2005-05-17

申请号：US09888233

申请日：2001-06-22

Applicant: Randy D. Blakely ,  Richard Nass ,  David Miller

Inventor： Randy D. Blakely ,  Richard Nass ,  David Miller

IPC: A01K67/033 ,  C12N5/02 ,  G01N33/50 ,  G01N33/00 ,  A01K67/00

CPC classification number: G01N33/5014 ,  A01K67/0336 ,  A01K2217/05 ,  A01K2227/703 ,  A01K2267/035 ,  A01K2267/0393 ,  C12N2830/008 ,  G01N33/5008 ,  G01N33/5058 ,  G01N2500/00

Abstract: Provided are in vivo screening methods to detect and identify substances that affect neuronal viability, and/or prevent neurodegeneration, and/or confer neuroprotective effects. The screening methods utilize recombinant C. elegans expressing a detectable marker in neuronal sub-groups and the use of neurotoxins specific to specific neuronal cells. Also provided are methods for identifying modulators of neurotransmitter transporters such as the dopamine transporter. Therefore, the invention provides methods for identifying substances that can be used in the prevention and therapy of neurodegenerative diseases.

Abstract translation: 提供了体内筛选方法来检测和鉴定影响神经元活力，和/或预防神经变性和/或赋予神经保护作用的物质。 筛选方法利用在神经元亚组中表达可检测标记的重组秀丽隐杆线虫和使用特异性神经元细胞的神经毒素。 还提供了用于鉴定神经递质转运蛋白如多巴胺转运蛋白的调节剂的方法。 因此，本发明提供了用于鉴定可用于预防和治疗神经变性疾病的物质的方法。

公开(公告)号：US20050087677A1

公开(公告)日：2005-04-28

申请号：US10917272

申请日：2004-08-11

Applicant: Ray Chen ,  David Miller

Inventor： Ray Chen ,  David Miller

IPC: H01J40/14 ,  H01L31/00

CPC classification number: G01J3/32 ,  G01J3/453 ,  H01L31/1085

Abstract: An electronically tuned, wavelength-dependent optical detector is provided. The electronically tuned, wavelength-dependent optical detector is a modified metal-semiconductor-metal photodetector including a comb-like metal electrode at a common voltage and metal electrodes each supplied with a control voltage by a voltage means. The wavelength to be detected in an optical input illuminating the detector is selected based on the set of control voltages applied to the metal electrodes. In another embodiment of the invention, the wavelength to be detected with the electronically tuned, wavelength-dependent optical detector is also selected using a standing wave generator, such as an interferometer, to produce a spatially varying light intensity on the surface of the electronically tuned, wavelength-dependent optical detector. Electronic wavelength demultiplexing is also provided. Design flexibility can be obtained by providing two or more optical patterns at a detector surface, each pattern having a different wavelength dependence.

Abstract translation: 提供电子调谐的，依赖于波长的光学检测器。 电子调谐的，依赖于波长的光学检测器是一种改进的金属 - 半导体 - 金属光电探测器，其包括在公共电压下的梳状金属电极和各自由电压装置提供控制电压的金属电极。 基于施加到金属电极的控制电压的集合来选择在照射检测器的光学输入中要检测的波长。 在本发明的另一个实施例中，使用诸如干涉仪之类的驻波发生器也可以使用电子调谐的，依赖于波长的光学检测器来检测波长，以在电子调谐的表面上产生空间变化的光强度 ，依赖于波长的光检测器。 还提供电子波长解复用。 通过在检测器表面提供两个或更多个光学图案可以获得设计灵活性，每个图案具有不同的波长依赖性。

公开(公告)号：US20050087673A1

公开(公告)日：2005-04-28

申请号：US10693652

申请日：2003-10-23

Applicant: Ray Chen ,  David Miller

Inventor： Ray Chen ,  David Miller

IPC: H01J40/14 ,  H01L31/00

CPC classification number: H01L31/1085 ,  G01J3/32 ,  G01J3/453

Abstract: An apparatus and method for an electronically tuned, wavelength-dependent optical detector are disclosed. The electronically tuned, wavelength-dependent optical detector is a modified metal-semiconductor-metal photodetector comprising a comb-like metal electrode at a common voltage and metal electrodes each supplied with a control voltage by a voltage means. The wavelength to be detected in a stream of light illuminating the electronically tuned, wavelength-dependent optical detector is selected based on the set of control voltages applied to the metal electrodes using the voltage means and the relative position of the electronically tuned, wavelength-dependent optical detector. In another embodiment of the invention, the wavelength to be detected with the electronically tuned, wavelength-dependent optical detector is also selected using a standing wave generator, such as an interferometer, to produce a spatially varying light intensity on the surface of the electronically tuned, wavelength-dependent optical detector.

Abstract translation: 公开了一种用于电子调谐的，依赖于波长的光学检测器的装置和方法。 电子调谐的，依赖于波长的光学检测器是一种改进的金属 - 半导体 - 金属光电探测器，其包括在公共电压下的梳状金属电极和金属电极，每个金属电极通过电压装置提供控制电压。 基于使用电压装置施加到金属电极的控制电压的集合以及电子调谐的波长依赖的光学检测器的相对位置来选择在被照亮电波调谐的波长相关光学检测器的光流中被检测的波长 光学检测器。 在本发明的另一个实施例中，使用诸如干涉仪的驻波发生器也可以使用电子调谐的，依赖于波长的光学检测器来检测波长，以在电子调谐的表面上产生空间变化的光强度 ，依赖于波长的光检测器。

公开(公告)号：US06874886B2

公开(公告)日：2005-04-05

申请号：US10384957

申请日：2003-03-10

Applicant: David Miller ,  Ernesto Blanco

Inventor： David Miller ,  Ernesto Blanco

IPC: A61F2/14 ,  G02C7/04

CPC classification number: G02C7/16 ,  A61F2/145 ,  A61F2/15 ,  A61F2/1613 ,  A61F2/1659 ,  A61F2002/1699 ,  A61F2250/0098 ,  B01D69/141 ,  B01D2323/34 ,  G02C7/04 ,  G02C7/042 ,  G02C7/044 ,  G02C7/046 ,  G02C7/12 ,  G02C7/165 ,  G02C2202/20 ,  G02C2202/22

Abstract: A method and apparatus for increasing the depth of focus of the human eye is comprised of a lens body, an optic in the lens body configured to produce light interference, and a pinhole-like optical aperture substantially in the center of the optic. The optic may be configured to produce light scattering or composed of a light reflective material. Alternatively, the optic may increase the depth of focus via a combination of light interference, light scattering, light reflection and/or light absorption. The optic may also be configured as a series of concentric circles, a weave, a pattern of particles, or a pattern of curvatures. One method involves screening a patient for an ophthalmic lens using a pinhole screening device in the lens to increase the patient's depth of focus. Another method comprises surgically implanting a mask in the patient's eye to increase the depth of focus.

公开(公告)号：US20050039002A1

公开(公告)日：2005-02-17

申请号：US10630283

申请日：2003-07-29

Applicant: Charles Kaufman ,  David Miller ,  Mary Zurko

Inventor： Charles Kaufman ,  David Miller ,  Mary Zurko

IPC: G06F21/00 ,  H04L9/00 ,  H04L29/06

CPC classification number: G06F21/554 ,  H04L63/08

Abstract: Under the present invention, a (computer) user logs into a distributed application provided on a server. After authentication, a security value (e.g., a pseudo-random number) is generated for the user. The security value is stored at the server, and then sent to the user along with session information. Thereafter, the security value is associated with a set (e.g., one or more) of commands of the distributed application. When one of the set of commands is received from the user, the URL corresponding thereto is checked for the security value. If the value is present, the command is permitted. However, if the security value is not present, the command is not permitted and an error message is returned to the user.

Abstract translation: 在本发明中，（计算机）用户登录到服务器上提供的分布式应用程序。 在认证之后，为用户生成安全值（例如伪随机数）。 安全值存储在服务器上，然后与会话信息一起发送给用户。 此后，安全值与分布式应用的一组（例如，一个或多个）命令相关联。 当从用户接收到一组命令时，检查与之对应的URL的安全值。 如果存在该值，则允许该命令。 但是，如果不存在安全值，则不允许该命令，并向用户返回错误消息。

公开(公告)号：US06798114B2

公开(公告)日：2004-09-28

申请号：US10719181

申请日：2003-11-20

Applicant: David Miller ,  Lilac Muller ,  Robert L. Anderson

Inventor： David Miller ,  Lilac Muller ,  Robert L. Anderson

IPC: H02N200

CPC classification number: G02B6/352 ,  B81B2201/042 ,  B81C1/00968 ,  G02B6/3512 ,  G02B6/3518 ,  G02B6/3548 ,  G02B6/356 ,  G02B6/3564 ,  G02B6/3568 ,  G02B6/357 ,  G02B6/3584 ,  G02B26/0841 ,  H02N1/002 ,  H02N1/006

Abstract: A number of methods and systems for overcoming stiction are provided. The systems include electro-mechanical systems capable of exerting a variety of forces upon areas prone to stiction. The systems can be MEMS arrays or other types of devices where stiction related forces occur. The methods include a variety of ways of causing movement in areas prone to stiction forces. Such movement can be vibrational in nature and is sufficient to overcome stiction, allowing a trapped element to be moveed to a desired location.

公开(公告)号：US06709175B1

公开(公告)日：2004-03-23

申请号：US10139014

申请日：2002-05-03

Applicant: Alexander V. Drynkin ,  David Miller

Inventor： Alexander V. Drynkin ,  David Miller

IPC: B41J2315

CPC classification number: B41J2/325 ,  B41J3/4071 ,  B41J2202/36

Abstract: A thermal transfer printer having a print head and a media support platform in the form of a removable tray that is displaced relative to the print head, the media support platform having a rigid support surface for a media item having a non-rectangular configuration such as a compact disk, the support platform having a mask with a cutout substantially in the shape of the non-rectangular disk, the mask and media item combining to form a contact surface for the print head to uniformly distribute a constant force of the print head in a uniform pressure across the mask and media item during printing, the mask providing, in addition, a holding apparatus for the media item which is contacted by a displaceable retainer urging the media item against the edge of the mask with the print head avoiding contact with the retainer on the printing area, the printer having a mechanism to displace the retainer and sense whether a media item is properly placed in the cutout and retained by the retaining apparatus, and the printer having a print head unit that can be flipped to the side of the printer for replacement of the print ribbon or access to the print head and internal components for maintenance and servicing.

Abstract translation: 一种热转印打印机，其具有打印头和相对于打印头移动的可移除托盘形式的介质支撑平台，所述介质支撑平台具有用于具有非矩形配置的介质项的刚性支撑表面，例如 所述支撑平台具有基本上为非矩形盘形状的切口的掩模，所述掩模和介质项目组合以形成用于所述打印头的接触表面，以将所述打印头的恒定力均匀地分布在 在打印期间跨过掩模和介质项目的均匀压力，掩模还提供用于介质物品的保持装置，该保持装置由可移动的保持器接触，以使打印头与打印头抵靠着面具的边缘，以避免与 打印机上的保持器，打印机具有移动保持器并感测介质物品是否被适当地放置在切口中并由保持件保持的机构 装置，并且打印机具有打印头单元，打印头单元可以翻转到打印机的侧面，以更换打印色带或访问打印头和内部组件进行维护和维修。

公开(公告)号：US06532198B1

公开(公告)日：2003-03-11

申请号：US09696376

申请日：2000-10-25

Applicant: David Miller

Inventor： David Miller

IPC: G11B1722

CPC classification number: G11B17/228 ,  G11B17/08 ,  G11B17/22

Abstract: A system for the duplication of binary data onto CD-R disks, the system including a copy unit, a host computer and computer software, the software being installed in the host computer to provide a user interface and to direct the transfer of data from the host computer to the copy unit, the copy unit including a set of multiple stacked recordable disk drives, a microprocessor electronically connected to the activating mechanism of a pivotal transport tower and to the set of multiple stacked recordable disk drives. A robotic disk pickup head on the pivotal transport tower is encompassed by a set of disk spindle members arranged in a symmetric semi-circular pattern around the central tower, the disk pickup head being connected to the pivotal transport tower with an elevator mechanism for lifting and transporting compact disks among the disk spindle members and any selected one of the stacked recordable disk drive members. The microprocessor concurrently directs the movement of the disk pickup head and the copying of data to the CD-R disks in the disk drive members. After a disk copy operation is completed, the computer software and microprocessor may direct the stacked recordable disk drive members to inspect the burned CD-R disks for copy errors and further direct the disk pickup head to remove and eject defective burned CD-R disks and place properly burned CD-R disks on a specified disk spindle member. The system allows for source data to be read from multiple master compact disks inserted in specified stacked recordable disk drive members to provide for random access copying from the multiple master compact disks.

Abstract translation: 一种用于将二进制数据复制到CD-R磁盘上的系统，该系统包括复制单元，主计算机和计算机软件，该软件被安装在主计算机中以提供用户接口并且指导从 主机到复制单元，复印单元包括一组多个堆叠的可记录磁盘驱动器，电子连接到枢转运输塔的启动机构的微处理器和多个堆叠的可记录磁盘驱动器的集合。 枢转运输塔上的机器人磁盘拾取头由围绕中心塔布置成对称半圆形图案的一组盘心轴构件包围，盘拾取头通过用于提升的电梯机构连接到枢转运输塔， 在盘主轴构件和任何所选择的一个可堆叠的可记录盘驱动构件之间传送压缩盘。 微处理器同时将磁盘拾取头的移动和将数据复制到磁盘驱动器构件中的CD-R盘。 磁盘复制操作完成后，计算机软件和微处理器可以指示堆叠的可记录磁盘驱动器成员检查刻录的CD-R磁盘是否有复印错误，并进一步引导磁盘拾取头，以去除和弹出有损坏的刻录的CD-R磁盘; 在指定的磁盘主轴成员上放置正确烧录的CD-R磁盘。 系统允许从插入指定的堆叠可记录磁盘驱动器成员的多个主光盘读取源数据，以提供从多个主光盘的随机存取复制。

公开(公告)号：US06379357B1

公开(公告)日：2002-04-30

申请号：US09718915

申请日：2000-11-22

Applicant: Avi Bernstein ,  Stewart Young ,  Andrew Simonton ,  David Miller ,  David L. Brumfield

Inventor： Avi Bernstein ,  Stewart Young ,  Andrew Simonton ,  David Miller ,  David L. Brumfield

IPC: A61B1770

CPC classification number: A61B17/7041 ,  A61B17/7007 ,  A61B17/701 ,  A61B17/7035 ,  A61B17/7044 ,  A61F2002/30171 ,  A61F2002/30347 ,  A61F2220/0033 ,  A61F2230/005

Abstract: A modular bone fastener system for use with a longitudinal member, such as a plate, having a fastener with a threaded lower potion for engaging a spinal element and an upper portion adapted to receive a headpiece. The headpiece is adapted to mate with the upper portion of the fastener and to engage a longitudinal member. A plurality of headpieces having angulated projections, lateral sections, and angulated lateral sections, all of which are adapted to engage a longitudinal member and overcome angular and translational misalignment of the fastener, may also be provided. The headpieces of some connectors are configured to permit angulation of a bore fastener relative to the connector.

Abstract translation: 一种用于与纵向构件（例如板）一起使用的模块化骨骼紧固件系统，其具有用于接合脊椎元件的螺纹下部药剂和适于接收头盔的上部的紧固件。 头盔适于与紧固件的上部配合并与纵向构件接合。 还可以提供具有角度突起，侧向部分和角度侧向部分的多个头盔，所有这些头部都适于接合纵向构件并克服紧固件的角度和平移不对准。 一些连接器的头盔被配置成允许孔扣相对于连接器成角度。

公开(公告)号：US06360642B1

公开(公告)日：2002-03-26

申请号：US09136809

申请日：1998-08-19

Applicant: David Miller ,  Kim Dewayne Stanford

Inventor： David Miller ,  Kim Dewayne Stanford

IPC: B26D702

CPC classification number: B27B27/10 ,  B27B27/02 ,  Y10T83/727 ,  Y10T83/7647 ,  Y10T83/773

Abstract: A workpiece guide includes a fence receiving member having first and second sides, a first mounting member disposed adjacent the first side, and a second mounting member disposed adjacent the second side. A first linking member is connected to the first mounting member, and a second linking member is connected to the second mounting member. A link receiving member is connected to both linking members and may be manipulated to selectively simultaneously bias the first and second mounting members toward or away from the link receiving member.

Abstract translation: 工件引导件包括具有第一和第二侧面的栅栏接收构件，邻近第一侧设置的第一安装构件和邻近第二侧设置的第二安装构件。 第一连接构件连接到第一安装构件，第二连接构件连接到第二安装构件。 连杆接收构件连接到两个连接构件，并且可以被操纵以选择性地同时将第一和第二安装构件朝向或远离连杆接收构件偏置。