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    REAGENT TO LABEL PROTEINS VIA LYSINE ISOPEPTIDE BONDS
    122.
    发明申请
    REAGENT TO LABEL PROTEINS VIA LYSINE ISOPEPTIDE BONDS 有权

    公开(公告)号：US20210115424A1

    公开(公告)日：2021-04-22

    申请号：US17052116

    申请日：2019-05-01

    Applicant: The Regents of the University of California ,  The Board of Regents of The University of Texas System

    Inventor： Robert T. Clubb ,  Brendan Rayhan Amer ,  Janine Y. Fu ,  Scott McConnell ,  Hung Ton-That ,  Chungyu Chang

    IPC: C12N9/52 ,  C12P21/00 ,  C07K1/13

    Abstract: Covalently cross-linked pilus polymers displayed on the cell surface of Gram-positive bacteria are assembled by class C sortase enzymes. These pilus-specific transpeptidases located on the bacterial membrane catalyze a two-step protein ligation reaction—first, cleaving the LPXTG motif of one pilin protomer to form an acyl-enzyme intermediate, and second, joining the terminal threonine to the nucleophilic lysine residue residing within the pilin motif of another pilin protomer. Informed by the high-resolution crystal structures of corynebacterial pilus-specific sortase (SrtA) and by developing structural variants of the sortase enzyme whose catalytic pocket has been unmasked by activating mutations, we have developed new reagents capable of forming isopeptide bonds in vitro. The reagents disclosed herein can catalyze ligation of isolated SpaA domains in vitro provide a facile and versatile new platform for protein engineering and bio-conjugation that has major implications for biotechnology.

    PRESSURE MODULATING SOFT ACTUATOR ARRAY DEVICES AND RELATED SYSTEMS AND METHODS
    123.
    发明申请
    PRESSURE MODULATING SOFT ACTUATOR ARRAY DEVICES AND RELATED SYSTEMS AND METHODS 有权

    公开(公告)号：US20210113402A1

    公开(公告)日：2021-04-22

    申请号：US16606627

    申请日：2018-04-20

    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

    Inventor： Muthu WIJESUNDARA ,  Wei Carrigan

    IPC: A61G7/057 ,  A47C27/10

    Abstract: Pressure modulating soft actuator array devices and related systems and methods. One example of the present systems comprises: a device having a body that defines a plurality of cavities; a pressure source configured to be in fluid communication with the plurality of cavities; a plurality of sensors configured to capture data indicative of pressure within the plurality of cavities; and one or more controllers configured to actuate the pressure source to move fluid toward and/or away from one or more of the plurality of cavities in response to data captured by the plurality of sensors; wherein the device is configured to be disposed between a user and a surface on which the user is seated upon.

    METHODS AND SYSTEMS FOR ANALYZING BRAIN LESIONS WITH LONGITUDINAL 3D MRI DATA
    124.
    发明申请
    METHODS AND SYSTEMS FOR ANALYZING BRAIN LESIONS WITH LONGITUDINAL 3D MRI DATA 有权

    公开(公告)号：US20210090259A1

    公开(公告)日：2021-03-25

    申请号：US17031010

    申请日：2020-09-24

    Applicant: The Board of Regents of the University of Texas System

    Inventor： Darin T Okuda

    IPC: G06T7/00 ,  A61B5/00 ,  A61B5/055

    Abstract: Some methods of analyzing one or more brain lesions of a patient comprise, for each of the lesion(s), calculating one or more lesion characteristics from a first 3-dimensional (3D) representation of the lesion obtained from data taken at a first time and a second 3D representation of the lesion obtained from data taken at a second time that is after the first time. The characteristic(s) can include a change, form the first time to the second time, in the lesion's volume and/or surface area, the lesion's displacement from the first time to the second time, and/or the lesion's theoretical radius ratio at each of the first and second times. Some methods comprise characterizing whether the patient has multiple sclerosis and/or the progression of multiple sclerosis in the patient based at least in part on the calculation of the lesion characteristic(s) of each of the lesion(s).

    TISSUE-SPECIFIC DIFFERENTIATION MATRICES AND USES THEREOF
    126.
    发明申请
    TISSUE-SPECIFIC DIFFERENTIATION MATRICES AND USES THEREOF 有权

    公开(公告)号：US20210079351A1

    公开(公告)日：2021-03-18

    申请号：US16875142

    申请日：2020-05-15

    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

    Inventor： Xiao-Dong Chen

    IPC: C12N5/077 ,  C12N5/0775 ,  C12N5/073 ,  A61K35/28 ,  A61K35/34

    Abstract: In some aspects, this invention provides a method of making a bone marrow-derived tissue-specific stem cell proliferation, expansion, isolation and rejuvenation extracellular matrix. In other aspects, this invention provides a method of making a tissue-specific fibroblast-derived stem cell differentiation extracellular matrix. Also provided are methods of using such a cell-derived preservation or differentiation matrices to induce tissue-specific differentiation of pluripotent cells, repair damaged tissue, and treat a subject having a physiologic deficiency using the same.

    HICCUP RELIEVING APPARATUS
    128.
    发明申请
    HICCUP RELIEVING APPARATUS 有权

    公开(公告)号：US20210045556A1

    公开(公告)日：2021-02-18

    申请号：US16963240

    申请日：2019-01-16

    Applicant: The Board of Regents of the University of Texas System

    Inventor： Ali Seifi

    IPC: A47G21/18

    Abstract: The hiccup relieving apparatus includes a tube with a first end having a mouthpiece, a second end for immersion in water or other potable liquid in a container, and an obstruction in the tube between the first end and the second end. The obstruction requires an adult user, using the mouthpiece, to produce a threshold suction of at least 20 cm of water before water can flow from the water in the water container, through the tube, through the mouthpiece, and to the user. The obstruction can take the form of a threshold valve in the tube, a sized orifice in the immersed end of the tube, or a wad of cellulosic material in the tube.

    3-DIMENSIONAL REPRESENTATIONS OF POST-CONTRAST ENHANCED BRAIN LESIONS
    129.
    发明申请
    3-DIMENSIONAL REPRESENTATIONS OF POST-CONTRAST ENHANCED BRAIN LESIONS 有权

    公开(公告)号：US20210041518A1

    公开(公告)日：2021-02-11

    申请号：US16976028

    申请日：2019-02-26

    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

    Inventor： Darin OKUDA

    IPC: G01R33/56 ,  G01R33/48 ,  G06T7/11 ,  G06N20/00

    Abstract: Methods, apparatuses, systems, and implementations for creating 3-dimensional (3D) representations exhibiting geometric and surface characteristics of post-contrast brain lesions are disclosed. 3D MRI images of the brain may be created and acquired. After administration of a contrast substance, brain lesions and other abnormalities may be identified and isolated from the 3D MRI images, with each lesion serving as a region of interest (ROI). 3D region of contrast enhancement images may be created from segmented 3D MRI images and different regions of contrast enhancement of the brain lesion may be depicted. Saved regions of contrast enhancement may be converted into stereolithography format, maximum intensity projection (MIP) images, and/or orthographic projection images. Data corresponding to these resulting 3D region of contrast enhancement images may be used to create 3D printed models of the isolated region of contrast enhancement using 3D printing technology. Analysis of the 3D brain region of contrast enhancement images and the 3D printed region of contrast enhancement models may enable a more efficient an accurate way of determining brain lesion risk factors and effective treatment regimes.

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