公开(公告)号：US10039826B2

公开(公告)日：2018-08-07

申请号：US15549528

申请日：2016-02-05

Applicant: UCB Biopharma SPRL

Inventor： Michael Joseph Edouard Boonen ,  Claude Peerboom

IPC: A61K39/395 ,  C07K16/28 ,  A61K47/18 ,  A61K47/26 ,  A61K47/12

Abstract: The current invention relates to a new pharmaceutical formulation, in particular to a pharmaceutical formulation comprising a protein, more particularly an antibody as an active ingredient.

公开(公告)号：US20180194832A1

公开(公告)日：2018-07-12

申请号：US15742070

申请日：2016-07-05

Applicant: UCB BIOPHARMA SPRL

Inventor： Kerry Louise TYSON ,  Terence Seward BAKER ,  Georges MAIRET-COELLO ,  Patrick DOWNEY ,  Jean-Philippe COURADE ,  David Edward Ormonde KNIGHT

IPC: C07K16/18 ,  A61P25/28 ,  G01N33/68

CPC classification number: C07K16/18 ,  A61K2039/505 ,  A61P25/28 ,  C07K14/4711 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  G01N33/6896 ,  G01N2333/4703 ,  G01N2800/28 ,  G01N2800/2821

Abstract: The present invention relates to Tau-binding antibodies and binding fragments thereof.

公开(公告)号：US20180171008A1

公开(公告)日：2018-06-21

申请号：US15736535

申请日：2015-10-22

Applicant: UCB Biopharma SPRL

Inventor： James Philip O'CONNELL ,  John Robert PORTER ,  Alastair LAWSON ,  Daniel John LIGHTWOOD ,  Rebecca Jayne WOOTTON

IPC: C07K16/24 ,  G01N33/68

CPC classification number: G01N33/6845 ,  A61K47/6425 ,  A61P35/00 ,  A61P37/00 ,  C07D213/72 ,  C07D235/04 ,  C07D239/26 ,  C07D401/14 ,  C07D471/00 ,  C07D471/04 ,  C07K14/525 ,  C07K14/70575 ,  C07K16/241 ,  C07K2317/55 ,  C07K2317/92 ,  G01N33/6854 ,  G01N33/6863 ,  G01N2333/525 ,  G01N2500/02

Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.

公开(公告)号：USD819804S1

公开(公告)日：2018-06-05

申请号：US29602184

申请日：2017-04-28

Applicant: UCB Biopharma SPRL

Designer： Barry Alan Knight ,  Marko Plevnik ,  Norihiko Inoue ,  Jamie Buckley ,  Lisa Hornsey

公开(公告)号：US09988446B2

公开(公告)日：2018-06-05

申请号：US14690892

申请日：2015-04-20

Applicant: UCB Biopharma SPRL

Inventor： Ralph Adams ,  Terence Seward Baker ,  Alastair David Griffiths Lawson

IPC: A61K39/395 ,  C07K16/24

CPC classification number: C07K16/244 ,  C07K2317/33 ,  C07K2317/92

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

公开(公告)号：US09988383B2

公开(公告)日：2018-06-05

申请号：US15100697

申请日：2014-12-08

Applicant: UCB BIOPHARMA SPRL

Inventor： Victoria Elizabeth Jackson ,  Boris Kroeplien ,  Martin Alexander Lowe ,  John Robert Porter

IPC: C07D473/00 ,  C07D473/32 ,  A61K31/5377

CPC classification number: C07D473/00 ,  A61K31/5377 ,  C07D473/32

Abstract: A series of substituted purine derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

公开(公告)号：US20180142026A1

公开(公告)日：2018-05-24

申请号：US15577035

申请日：2016-05-25

Applicant: UCB BIOPHARMA SPRL

Inventor： PATRICE MARIE CHARLES GODARD ,  RAFAL MARIAN KAMINSKI ,  KARINE JOSEE JEANNE LECLERCQ ,  JONATHAN MARIE M VAN EYLL

IPC: C07K16/28 ,  A61P25/28 ,  A61P25/18 ,  A61P25/16

CPC classification number: C07K16/2866 ,  A61K2039/505 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  C07K2317/20 ,  C07K2317/70 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention pertain an inhibitor of CSF-1R activity for use in the treatment and/or prophylaxis of neurologic diseases and new method of treatment of neurologic diseases.

公开(公告)号：USD816834S1

公开(公告)日：2018-05-01

申请号：US29602191

申请日：2017-04-28

Applicant: UCB Biopharma SPRL

Designer： Barry Alan Knight ,  Marko Plevnik ,  Norihiko Inoue ,  Jamie Buckley ,  Lisa Hornsey

公开(公告)号：US09956274B2

公开(公告)日：2018-05-01

申请号：US14991048

申请日：2016-01-08

Applicant: UCB Biopharma SPRL

Inventor： Terence Seward Baker

IPC: C12N5/07 ,  A61K39/395 ,  A61K39/00 ,  A61K38/12 ,  C07K16/00 ,  C07K14/705 ,  C07K16/28

CPC classification number: A61K39/0005 ,  A61K2039/545 ,  A61K2039/6081 ,  A61K2039/62 ,  C07K14/705 ,  C07K16/28 ,  C07K2317/14 ,  C07K2317/20 ,  C07K2317/76

Abstract: The present invention provides a method for generating a functionally modifying antibody to an ion channel comprising immunizing a host with a cyclic peptide comprising at least part of an extracellular sequence of said ion channel.

公开(公告)号：US09932342B2

公开(公告)日：2018-04-03

申请号：US15100690

申请日：2014-12-08

Applicant: UCB BIOPHARMA SPRL

Inventor： Mezher Hussein Ali ,  Daniel Christopher Brookings ,  Julien Alistair Brown ,  Victoria Elizabeth Jackson ,  Boris Kroeplien ,  John Robert Porter

IPC: C07D487/04 ,  A61K31/519 ,  A61K31/5377

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K31/5377

Abstract: A series of substituted imidazo[1,2-a]pyrimidine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.