公开(公告)号：US10729693B2

公开(公告)日：2020-08-04

申请号：US16288820

申请日：2019-02-28

Applicant: PONCE MEDICAL SCHOOL FOUNDATION, INC. ,  The Board of Regents of the University of Texas System

Inventor： Annelyn Torres-Reveron ,  Caroline B. Appleyard ,  Idhaliz Flores

IPC: C07D487/04 ,  A61K31/519 ,  A61P15/00 ,  A61K31/505

Abstract: The present disclosure provides methods for treating a mammal that has endometriosis using a CHRH1 antagonist composition. In some embodiments, the CHRH1 antagonist is antalarmin or an equivalent.

公开(公告)号：US20200231971A1

公开(公告)日：2020-07-23

申请号：US16823904

申请日：2020-03-19

Applicant: Regulus Therapeutics Inc. ,  Board of Regents of the University of Texas System

Inventor： John R. ANDROSAVICH ,  B. Nelson CHAU ,  Vishal D. PATEL

IPC: C12N15/113 ,  A61K45/06 ,  A61K31/713 ,  A61P9/12 ,  A61P13/12

Abstract: Provided herein are methods for the treatment of polycystic kidney disease, including autosomal dominant polycystic kidney disease, using modified oligonucleotides targeted to miR-17.

公开(公告)号：US20200215100A1

公开(公告)日：2020-07-09

申请号：US16702164

申请日：2019-12-03

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Shao-Ling HUANG ,  David MCPHERSON ,  Yong-Jian GENG ,  Xing YIN ,  Hyunggun KIM ,  Melvin KLEGERMAN ,  Tao PENG

IPC: A61K33/00 ,  A61K47/02 ,  A61K47/14 ,  A61K9/00 ,  A61K47/24 ,  A61K9/107 ,  A61K47/44 ,  A23D7/005 ,  A23L33/115 ,  A23L33/16 ,  A23L33/25 ,  A61K47/69 ,  A61J1/14 ,  A61K47/28 ,  A61K47/42

Abstract: Provided herein is a novel composition for oral administration and delivery of Noble gas, such as xenon or argon. Methods of treating and preventing neuronal or cardiovascular damage with such compositions are also provided.

公开(公告)号：US20200207742A1

公开(公告)日：2020-07-02

申请号：US16303043

申请日：2017-06-29

Applicant: Bruce BEUTLER ,  Dale L. BOGER ,  The Scripps Research Institute ,  The Board of Regents of the University of Texas System

Inventor： Bruce Beutler ,  Dale L. Boger

IPC: C07D403/10 ,  A61P37/04

Abstract: A diprovocim compound that corresponds in structure to structural Formula V is disclosed, wherein A, W, Z, R1, R2, R3 and R4 (when present) are defined within. A diprovocim compound has immune-adjuvant properties on human and mouse cells in culture and on in vivo immunization of mice. A composition containing a diprovocim and a method of using a compound are also disclosed. A The immunostimulatory activity of a diprovocim compound is similar to that of LPS, to which there is no apparent structural similarity. A contemplated compound bears no structural similarity to either the TLR1/TLR2 lipoprotein agonists nor to any other synthetic TLR agonist, and is remarkably easy to prepare and synthetically modify.

公开(公告)号：US10697080B2

公开(公告)日：2020-06-30

申请号：US15572321

申请日：2016-05-06

Applicant: The Board of Regents of The University of Texas System

Inventor： Allen J. Bard ,  Huayi Yin

IPC: C25D3/66 ,  C25D9/04 ,  H01L21/02 ,  H01L31/18 ,  C25D9/08 ,  C25B1/00 ,  C25D21/12 ,  H01L21/66 ,  H01L31/0445 ,  H01L31/068

Abstract: Photoactive silicon films may be formed by electrodeposition from a molten salt electrolyte. In an embodiment, SiO2 is electrochemically reduced in a molten salt bath to deposit silicon on a carbonaceous substrate.

公开(公告)号：US20200179654A1

公开(公告)日：2020-06-11

申请号：US16792765

申请日：2020-02-17

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Daniel H. KIM ,  Dong Suk SHIN ,  Viljar PALMRE

IPC: A61M25/01 ,  A61M25/00 ,  A61M25/09 ,  A61L29/04

Abstract: The disclosure provides a flexible, narrow medical device (such as a micro-catheter or a guidewire) that is controllably moved and steered through lumens of a body. The medical device may include an electrically-actuatable bendable portion at a distal end, which may be provided by a polymer electrolyte layer, electrodes distributed about the polymer electrolyte layer, and electrical conduits coupled to the electrodes, such that the polymer electrolyte layer deforms asymmetrically in response to an electrical signal through one or more conduits. The disclosure further includes a controller for moving the device into and out of bodily lumens and for applying the electrical signal for steering the device. The device further includes methods of preparing the polymer electrolyte layer in tubular shape.

公开(公告)号：US10667754B2

公开(公告)日：2020-06-02

申请号：US16163661

申请日：2018-10-18

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Peter Starr ,  Steven Bailey ,  Mauli Agrawal

IPC: G01L9/00 ,  A61B5/00 ,  A61B5/0215 ,  A61B5/103 ,  A61M1/10 ,  A61B5/1473 ,  A61B7/02 ,  A61F2/24 ,  B29C65/48 ,  A61B5/145 ,  A61B17/00 ,  A61M1/12 ,  A61B5/03 ,  B29L31/00

Abstract: A thin-film, diaphragm based device is disclosed which can be used to perform an array of sensing and actuating operations where a very thin profile is desired, such as in millimeter, micrometer, or nanometer tight spaces.

公开(公告)号：US10660586B2

公开(公告)日：2020-05-26

申请号：US16443360

申请日：2019-06-17

Applicant: The Board of Regents of the University of Texas System

Inventor： Hak Choy ,  Steve Jiang ,  Robert Timmerman ,  Arnold Pompos

IPC: A61B6/10 ,  A61N5/10 ,  A61B6/04 ,  G21F3/00

Abstract: Radiation therapy systems and their components, including secondary radiation shields. At least some versions of the disclosed systems combine a radiation delivery device, a primary radiation shielding device, and a secondary shielding layer into an integrated, modular unit. This is accomplished by using a small direct beam shield capable of blocking a primary beam from a radiation delivery device. In turn, a thinner shielding layer can be used to surround the radiation delivery device and primary shielding device, enabling a single modular unit to be delivered to an installation site. In some embodiments, a bed may be disposed within the secondary shielding layer. In some embodiments, the system is configured to provide up to 4-pi (4π) steradians of radiation coverage to the bed from the radiation delivery device.

公开(公告)号：US20200147151A1

公开(公告)日：2020-05-14

申请号：US16481187

申请日：2018-01-30

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Herbert L. DUPONT ,  Zhi-Dong JIANG

IPC: A61K35/742 ,  A61K47/26

Abstract: The present disclosure provides human fecal microbiota compositions, including fresh, frozen, and lyophilized compositions, for the treatment of disorders associated with dysfunctional microbiota, such as recurrent Clostridium difficile infection. In particular, the fecal microbiota composition comprises a cryoprotectant sugar, such as mannitol.

公开(公告)号：US20200095206A1

公开(公告)日：2020-03-26

申请号：US16484045

申请日：2018-02-06

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  Board of Regents of The University of Texas System

Inventor： Sanford Markowitz ,  Yiyuan Yuan ,  Yongyou Zhang ,  Joseph Ready ,  Bin Hu

IPC: C07D235/18 ,  C07D239/74 ,  C07D241/42 ,  C12N9/04

Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.