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    SERUM/PLASMA MICRONAS AND USES THEREOF
    142.
    发明申请
    SERUM/PLASMA MICRONAS AND USES THEREOF 审中-公开

    公开(公告)号：US20100173288A1

    公开(公告)日：2010-07-08

    申请号：US12302196

    申请日：2007-12-06

    Applicant: Chenyu Zhang ,  Junfeng Zhang ,  Xi Chen ,  Yi Ba ,  Jiangning Chen ,  Jin Wang ,  Ke Zeng ,  Hongjie Zhang

    Inventor： Chenyu Zhang ,  Junfeng Zhang ,  Xi Chen ,  Yi Ba ,  Jiangning Chen ,  Jin Wang ,  Ke Zeng ,  Hongjie Zhang

    IPC: C12Q1/68 ,  C12M1/34

    CPC classification number: C12Q1/6886 ,  C12Q1/6809 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/178 ,  C12Q2525/207

    Abstract: This invention provides a combination of microRNAs for evaluating the physiological and/or pathological condition of a subject, wherein the combination comprises all detectable microRNAs stably existing in the serum/plasma of a subject; and a method for evaluating the physiological and/or pathological condition of a subject, wherein the method includes determining all detectable microRNAs stably existing in the serum/plasma of a subject; and a kit for evaluating the physiological and/or pathological condition of a subject, wherein the kit contains the tools for determining all detectable microRNAs that stably existing in the serum/plasma of a subject; and a biochip for evaluating the physiological and/or pathological condition of a subject, wherein the biochip contains the components for determining all detectable microRNAs stably existing in the serum/plasma of a subject. The aforementioned combination, method, kit and biochip can be used for diagnosis as well as differentially diagnosis of diseases including various tumors; various acute/chronic infectious diseases, e.g. viral diseases such as viral influenza, viral hepatitis, AIDS, SARS, bacterial diseases such as tuberculosis, bacterial pneumonia, and other acute/chronic infectious diseases caused by various pathogenic microorganisms; other acute/chronic diseases such as diseases of respiratory system, diseases of immune system, diseases of blood and hematopoietic system, diseases of circulatory system such as cardio-cerebrovascular diseases, metabolic diseases of endocrine system, diseases of digestive system, diseases of nervous system, diseases of urinary system, diseases of reproductive system and diseases of locomotor system, prediction of complications occurrence and malignant diseases relapse, evaluation of therapeutic effects, screening of pharmaceutical active ingredients, assessment of drug efficacy as well as forensic authentication and prohibited drug inspection and the like, possessing a number of advantages such as extensive detection spectrum, high sensitivity, low cost, convenience for sampling, ease for sample preservation, etc. The said method can be widely used in work related to general survey of diseases and so on, improve the low-specificity and low-sensitivity caused by individual differences which single markers are difficult to overcome, significantly increasing the clinical detection rate of diseases, all of which make it become an effective means for diagnosing diseases in an early phase.

    EXCHANGE-ASSISTED SPIN TRANSFER TORQUE SWITCHING
    143.
    发明申请
    EXCHANGE-ASSISTED SPIN TRANSFER TORQUE SWITCHING 有权
    交换辅助转子扭矩开关

    公开(公告)号：US20100039855A1

    公开(公告)日：2010-02-18

    申请号：US12541111

    申请日：2009-08-13

    Applicant: Randall H. Victora ,  Xi Chen

    Inventor： Randall H. Victora ,  Xi Chen

    IPC: G11C11/00 ,  G11C5/00 ,  B05D5/12 ,  G11C11/15

    CPC classification number: G11C11/161

    Abstract: In general, the invention is directed to techniques for reducing the amount of switching current that is utilized within a magnetic storage (e.g., MRAM) device. An example apparatus includes a fixed magnetic layer that provides a fixed direction of magnetization, an exchange-coupled magnetic multi-layer structure, and a non-magnetic layer placed between the fixed magnetic layer and the exchange-coupled magnetic multi-layer structure. The exchange-coupled magnetic multi-layer structure includes a recording layer configured to record information and an assisting layer having a lower anisotropy than the recording layer. The exchange coupling between the recording and assisting layers is operable to switch a magnetization direction of the recording layer. In some cases, the exchange-coupled magnetic multi-layer structure may further include a spacer separating the recording and assisting layers and configured to weaken an exchange coupling between the recording and assisting layers.

    Abstract translation: 通常，本发明涉及用于减少在磁存储（例如MRAM）设备内使用的开关电流量的技术。 示例性设备包括提供固定磁化方向的固定磁性层，交换耦合磁性多层结构和置于固定磁性层和交换耦合磁性多层结构之间的非磁性层。 交换耦合磁性多层结构包括记录信息的记录层和具有比记录层低的各向异性的辅助层。 记录层和辅助层之间的交换耦合可操作以切换记录层的磁化方向。 在一些情况下，交换耦合磁性多层结构还可以包括隔离记录和辅助层并被配置为削弱记录层和辅助层之间的交换耦合的隔离物。

    Fused heterocyclic compounds
    149.
    发明申请
    Fused heterocyclic compounds 审中-公开
    稠合杂环化合物

    公开(公告)号：US20080058365A1

    公开(公告)日：2008-03-06

    申请号：US11881805

    申请日：2007-07-26

    Applicant: Xi Chen ,  Xiaoqi Chen ,  Pingchen Fan ,  Juan Jaen ,  Leping Li ,  Jeffrey Mihalic

    Inventor： Xi Chen ,  Xiaoqi Chen ,  Pingchen Fan ,  Juan Jaen ,  Leping Li ,  Jeffrey Mihalic

    IPC: A61K31/4353 ,  A61P3/04

    CPC classification number: C07D471/04

    Abstract: Compounds, compositions and methods are provided that are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. In particular, the compounds of the invention are useful in the treatment and/or prevention of eating disorders, obesity, anxiety disorders and mood disorders.

    Abstract translation: 提供了可用于治疗和/或预防由G蛋白偶联受体介导的病症或病症的化合物，组合物和方法。 特别地，本发明的化合物可用于治疗和/或预防进食障碍，肥胖，焦虑障碍和情绪障碍。

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