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公开(公告)号:US11453736B2
公开(公告)日:2022-09-27
申请号:US17038349
申请日:2020-09-30
Applicant: Alcon Inc.
Inventor: Jinyu Huang , Frank Chang , Steve Yun Zhang , Feng Jing
IPC: C08L101/14 , C08L83/04 , C08F290/06 , G02B1/04 , C08G77/20 , C08G77/16 , C08G77/392 , C08G77/12
Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.
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公开(公告)号:US20220299796A1
公开(公告)日:2022-09-22
申请号:US17834191
申请日:2022-06-07
Applicant: Alcon Inc.
Inventor: Yongxing Qiu , John Dallas Pruitt , Kelly Kayi Tallau , Angela Driver-Scott , Chung-Yuan Chiang
IPC: G02C7/04 , B29D11/00 , G02B1/14 , C09D133/02 , C09D177/06 , G02B1/04
Abstract: The invention is related to a method for producing soft contact lenses comprises a silicone hydrogel lens body and a composite coating thereon. The composite coating comprises: a plasma base coating which is chemically-attached directly onto the surface of the silicone hydrogel contact lens and functions as a fail-proof measure for ensuring the hydrophobic silicone hydrogel lens material to be shielded from any exposure to ocular environments even after at least 30 days of daily uses including daily waring and daily cleaning/disinfecting; and a relatively-durable lubricious hydrogel top coating for ensuring wearing comfort. A method of the invention comprises forming a plasma-reactive hydrophilic polymer hybrid base coating having reactive functional groups on a silicone hydrogel contact lens and heating the silicone hydrogel contact lens with the hybrid base coating in an aqueous solution of a water-soluble and thermally crosslinkable hydrophilic polymeric material to form a stable lubricious hydrogel coating thereon. This method has a minimized adverse impact on the mechanical properties of silicone hydrogel lens body.
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公开(公告)号:US11448854B2
公开(公告)日:2022-09-20
申请号:US16790970
申请日:2020-02-14
Applicant: Alcon Inc.
Inventor: Babak Honaryar , Mauricio Jochinsen
Abstract: Certain aspects of the present disclosure provide to angle adjustment systems using one or more spring arrangements. In certain aspects, an angle adjustment system comprises a component and a first spring arrangement coupled to the component, wherein the first spring arrangement comprises at least three spring elements. Further, the first spring arrangement is configured to allow the component to rotate around a first axis of rotation and prevent a first translational movement of the component with respect to the first axis of rotation.
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公开(公告)号:US11439661B2
公开(公告)日:2022-09-13
申请号:US16911833
申请日:2020-06-25
Applicant: ALCON INC.
Inventor: Steve Yun Zhang , Richard Charles Breitkopf , Daqing Wu , Junhao Ge , Maria F. Gubitosi Raspino , Augustine Twum Kumi , Wei Liang
IPC: A61K31/80 , A61P27/04 , A61K31/015 , A61K31/07 , A61K31/122 , A61K31/202 , A61K31/355 , A61K31/593 , A61K31/736 , A61K45/06 , A61K47/10 , A61K47/26 , A61K47/34
Abstract: The invention is generally related to topical ophthalmic compositions comprising: from about 0.05 w/v % to about 5 w/v % of galactomannan polymer; a cis-diol and about 0.5 w/v % to about 10 w/v % of a hydrophilic copolymer which comprises (a) arylborono-containing repeating units each having a boronic acid, (b) repeating units of at least one phosphorylcholine-containing vinylic monomer, and (c) acrylic monomeric units of at least one acrylic monomer having 3 to 16 carbon atoms, the ophthalmic composition is substantially free of a borate for improving lubrication, hydration and drug delivery property.
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公开(公告)号:US11439499B2
公开(公告)日:2022-09-13
申请号:US16507393
申请日:2019-07-10
Applicant: Alcon Inc.
Inventor: Douglas Brent Wensrich , Todd Taber , Len Takudzwa Magara , Jian Liu
IPC: A61F2/16
Abstract: An intraocular lens (IOL) injectors and associated methods are described. The IOL injectors may include a collapsible portion configured to reduce the length of the IOL injector when the collapsible portion is altered from an uncollapsed configuration to a collapsed configuration. In some instances, an IOL may be advanced from a storage location to a dwell location when the collapsible portion is altered from the uncollapsed configuration to the collapsed configuration. The IOL injectors may also include a combination push and screw drive.
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公开(公告)号:US20220281193A1
公开(公告)日:2022-09-08
申请号:US17688022
申请日:2022-03-07
Applicant: Alcon Inc.
Inventor: Houliang Tang , Frank Chang
Abstract: Described herein is a method for producing a contact lens comprising a central zone that has a diameter of about 13 mm or less, is concentric with the central axis of the contact lens, and possesses at least one photo functionality. The method comprises: applying a first polymerizable fluid composition containing at least one photochemically functional compound on a central portion of the molding surface of a female mold half to form a circular layer; partially curing, in situ, the circular layer in the female mold half; dispensing a second polymerizable fluid composition over the partially-cured circular layer on the molding surface of the female mold half; and a step of curing the second polymerizable fluid composition and the partially-cured circular layer immersed therein in the mold cavity formed between the the molding surfaces of the female mold half and a male mold half.
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公开(公告)号:US20220281190A1
公开(公告)日:2022-09-08
申请号:US17750518
申请日:2022-05-23
Applicant: Alcon Inc.
Inventor: Yongxing Qiu , John Dallas Pruitt , Sibichen J. Thekveli , Robert Carey Tucker , Jared Nelson
IPC: B29D11/00 , G02B1/04 , G02C7/04 , G02B1/10 , G02B1/18 , C08J7/04 , C08L83/04 , C08G77/388 , C08J5/00 , C09D5/16 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , C09D177/06
Abstract: The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.
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公开(公告)号:US11432963B2
公开(公告)日:2022-09-06
申请号:US16884262
申请日:2020-05-27
Applicant: Alcon Inc.
Inventor: Bruno Lassalas , Mark Harrison Farley , Alireza Mirsepassi , Ronald T. Smith
Abstract: Particular embodiments disclosed herein provide a surgical laser system comprising first laser source configured to emit a first laser beam with a first wavelength and a second laser source configured to emit a second laser beam with a second wavelength. The surgical laser system further comprises a first diffraction optical element (DOE) tuned to the first wavelength and a second DOE tuned to the second wavelength, wherein the first DOE is configured to diffract the first laser beam into one or more first diffracted beams at a diffraction angle and the second DOE is configured to diffract the second laser beam into one or more second diffracted beams at the same diffraction angle. The surgical laser system further comprises one or more beam splitters configured to reflect the one or more first diffracted beams and the one or more second diffracted beams onto a lens.
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公开(公告)号:US20220275154A1
公开(公告)日:2022-09-01
申请号:US17742559
申请日:2022-05-12
Applicant: Alcon Inc.
Inventor: Steve Yun Zhang , Daqing Wu , Junhao Ge , Richard Charles Breitkopf , Xinming Qian , Zach Munoz , Matthew D. Nelson , Augustine Twum Kumi , Weihong Lang , Ying Zheng , Feng Jing , Frank Chang
IPC: C08G77/442 , C08G77/20 , C08G77/388 , C08G77/392 , C08G77/14 , C08L83/10 , G02B1/04 , C08G77/12 , B29D11/00 , G02C7/04
Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.
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公开(公告)号:US20220274307A1
公开(公告)日:2022-09-01
申请号:US17652729
申请日:2022-02-28
Applicant: ALCON INC.
Inventor: Jan Bernard , Michael Stutz , Thomas Tonn
Abstract: A method for verifying whether a molding insert (1a, 1b) is accurately mounted to a tooling plate (2a, 2b) comprises the steps of: a) providing a confocal sensor (3a, 3b); b) arranging the confocal sensor (3a, 3b) such that a confocal sensor reference plane (32a, 32b) as well as a tooling plate reference plane (22a, 22b) are normal to a mounting axis (21a, 21b) of the tooling plate and spaced from each other by a predetermined first distance (d1, e1); c) measuring a second distance (d2, e2) between the confocal sensor reference plane (32a, 32b) and a central impingement location (11a, 11b) on a molding surface (12a, 12b) of the molding insert (1a, 1b); d) based on the measured second distance (d2, e2) as well as based on the predetermined first distance (d1, e1), determining a third distance (d3, e3) of the central impingement location (11a, 11b) relative to the tooling plate reference plane (22a, 22b); e) comparing the third distance (d3, e3) with a predetermined target distance, and f) determining that the molding insert (1a, 1b) is accurately mounted to the tooling plate (2a, 2b) if the difference between the third distance (d3, e3) and the predetermined target distance is less than a threshold difference.
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