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    Separation method for dinitrotoluene and mixed acid in a toluene to dinitrotoluene process
    162.
    发明授权
    Separation method for dinitrotoluene and mixed acid in a toluene to dinitrotoluene process 有权

    公开(公告)号：US09284257B2

    公开(公告)日：2016-03-15

    申请号：US14653687

    申请日：2013-12-10

    Applicant: BASF SE ,  SHANGHAI BASF POLYURETHANE COMPANY LIMITED

    Inventor： Yuanshen Dai ,  Da Peng Li ,  Pei Shi Jia ,  Zhan Cai ,  Samuel Neto

    IPC: C07C205/00 ,  C07C201/08

    CPC classification number: C07C201/08 ,  B01D17/0217 ,  C07C201/16 ,  C07C205/06

    Abstract: Proposed is a separation method in a toluene to dinitrotoluene process, wherein said method with a first process step comprising feeding a toluene comprising first stream (1) and a nitric acid comprising second stream (2) into a first reactor (R1), reacting of the toluene comprising first stream (1) and the nitric acid comprising second stream (2) within the first reactor (R1) to a first reaction mixture (3), said first reaction mixture (3) comprising a first liquid/liquid mixed phase of an acid phase and an organic phase comprising mononitrotoluene, feeding the first reaction mixture (3) into a first separation device (S1), separating the first reaction mixture (3) within the first separation device (S1) into a first forward stream (4) having a flow direction to a second process step and a first backward stream (5) having a flow direction back to the first reactor (R1), said method having a second process step comprising feeding the first forward stream (4) into a second reactor (R2), feeding a nitric acid comprising third stream (6) and a sulfuric acid comprising fourth stream (7) into the second reactor (R2), reacting of the first forward stream (4), the nitric acid comprising third stream (6) and the sulfuric acid comprising fourth stream (7) within the second reactor (R2) to a second reaction mixture (8), said second reaction mixture (8) comprising a second liquid/liquid mixed acid phase and an organic phase comprising mononitrotoluene and dinitrotoluene, feeding the second reaction mixture (8) into a second separation device (S2), separating the second reaction mixture (8) within the second separation device (S2) into a second forward stream (9) having a flow direction to a process output and a second backward stream (10) having a flow direction back to the first reactor (R1), wherein fine separating of at least one of the streams (4, 5, 9, 10) after the first separation step (S1) and/or the second separation step (S2) in a coalescer is carried out.

    Pharmaceutical compositions comprising monoterpenes
    164.
    发明授权
    Pharmaceutical compositions comprising monoterpenes 有权
    包含单萜的药物组合物

    公开(公告)号：US09133085B2

    公开(公告)日：2015-09-15

    申请号：US13939834

    申请日：2013-07-11

    Applicant: Neonc Technologies, Inc.

    Inventor： Thomas Chen ,  Daniel Levin ,  Satish Puppali

    IPC: C07C35/18 ,  C07C29/78 ,  A61K31/045 ,  C07C29/92 ,  C07C67/14 ,  C07C201/12

    CPC classification number: C07C29/92 ,  A61K31/045 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07B2200/07 ,  C07C29/78 ,  C07C29/86 ,  C07C29/88 ,  C07C67/14 ,  C07C201/12 ,  C07C201/16 ,  C07C2601/16 ,  C07C33/14 ,  C07C205/57 ,  C07C69/76 ,  C07C69/92

    Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

    Abstract translation: 本发明提供纯化大于约98.5％（w / w）的单萜或倍半萜的方法。 该方法包括衍生单萜（或倍半萜烯）以产生单萜（或倍半萜烯）衍生物，分离单萜（或倍半萜烯）衍生物和从衍生物中释放单萜（或倍半萜烯）的步骤。 包括本发明范围的药物组合物是包含纯度大于约98.5％（w / w）的单萜（或倍半萜烯）的药物组合物。 纯化的单萜可用于治疗癌症等疾病。 本单萜（或倍半萜烯）可以单独施用，或者可以与辐射或其它治疗剂如化学治疗剂共同施用。

    Method for continuous production of nitrobenzene
    165.
    发明授权
    Method for continuous production of nitrobenzene 有权
    连续生产硝基苯的方法

    公开(公告)号：US09012700B2

    公开(公告)日：2015-04-21

    申请号：US14240058

    申请日：2012-08-29

    Applicant: Thomas Knauf ,  Michael Merkel

    Inventor： Thomas Knauf ,  Michael Merkel

    IPC: C07C205/00 ,  C07C209/00 ,  C07C201/06 ,  C07C205/06

    CPC classification number: C07C201/06 ,  C07C201/08 ,  C07C201/16 ,  C07C205/06 ,  C07C209/36 ,  C07C211/46

    Abstract: The invention relates to a method for producing nitrobenzene, in which crude nitrobenzene is first produced by nitrating benzene and said crude nitrobenzene is then washed in succession in at least one acid wash, in at least one alkaline wash and in at least one neutral wash, at least one additional wash with an aqueous solution of a potassium salt being interposed between the last alkaline wash and the first neutral wash.

    Abstract translation: 本发明涉及生产硝基苯的方法，其中首先通过硝化苯生产粗硝基苯，然后将所述粗硝基苯在至少一种酸洗涤液，至少一种碱性洗涤液和至少一种中性洗涤液中连续洗涤， 在最后的碱性洗涤和第一中性洗涤之间插入钾盐水溶液至少一次另外的洗涤。

    METHOD AND APPARATUS FOR PURIFYING NITRATION PRODUCTS
    166.
    发明申请
    METHOD AND APPARATUS FOR PURIFYING NITRATION PRODUCTS 有权
    用于净化硝化产品的方法和装置

    公开(公告)号：US20140221703A1

    公开(公告)日：2014-08-07

    申请号：US14118737

    申请日：2012-05-18

    Applicant: Jürgen Pöhlmann ,  Heinrich Hermann ,  Mirko Handel ,  Jürgen Gebauer

    Inventor： Jürgen Pöhlmann ,  Heinrich Hermann ,  Mirko Handel ,  Jürgen Gebauer

    IPC: C07C201/16

    CPC classification number: C07C201/16 ,  B01J19/24 ,  B01J2219/24 ,  C07C205/06

    Abstract: The present invention relates to a method for removing impurities from nitrated crude products obtained during the nitration of nitratable aromatic compounds, after removal of the final nitrating acid, by treatment with a washing medium, and also to a plant or apparatus suitable for implementing this method. Further provided by the invention is a production plant for the nitration of nitratable aromatic compounds with subsequent purification of the nitrated products.

    Abstract translation: 本发明涉及一种从硝化硝化硝酸中除去硝化酸后，通过用洗涤介质处理而得到的硝化粗产物中除去杂质的方法，以及适用于实施该方法的设备或装置 。 本发明进一步提供了一种用于硝化硝化的芳族化合物的生产设备，随后硝化产物的纯化。

    WASHING SYSTEM FOR NITROAROMATIC COMPOUNDS
    169.
    发明申请
    WASHING SYSTEM FOR NITROAROMATIC COMPOUNDS 有权
    硝基化合物洗涤系统

    公开(公告)号：US20120136181A1

    公开(公告)日：2012-05-31

    申请号：US13388836

    申请日：2009-08-18

    Applicant: Sergio Berretia

    Inventor： Sergio Berretia

    IPC: C07C201/16 ,  B01J19/00

    CPC classification number: C07C201/16 ,  C02F1/04 ,  C02F1/20 ,  C02F2101/38 ,  C02F2209/06 ,  C07C205/06

    Abstract: A method of removing alkalinity and salt from a nitroaromatic product downstream of water washing to remove mineral acids and alkaline washing to remove salts of organic acids, comprises washing the product stream with an acidic aqueous solution, prior to the step of removing excess organic reactant, by steam stripping or distillation. Acid removed from the stripper or column is recycled back for use in the acidic washing. The acidic washing is done instead of the neutral washing step of the prior art. It removes residual salt and decreases the level of entrained colloidal water in the nitroaromatic product.

    Abstract translation: 一种从水洗下游的硝基芳族化合物产物中去除碱度和盐的方法，以除去无机酸和碱洗涤以除去有机酸的盐，包括在除去过量有机反应物的步骤之前用酸性水溶液洗涤产物流， 通过汽提或蒸馏。 从汽提塔或塔中除去的酸被循环使用，用于酸洗。 进行酸性洗涤代替现有技术的中性洗涤步骤。 它去除残留的盐并降低硝基芳族产物中夹带的胶体水的含量。

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