公开(公告)号：US4523030A

公开(公告)日：1985-06-11

申请号：US618152

申请日：1984-06-07

Applicant: Georges Haas ,  Andreas von Sprecher ,  Pier G. Ferrini

Inventor： Georges Haas ,  Andreas von Sprecher ,  Pier G. Ferrini

IPC: C07C69/035 ,  A61K31/165 ,  A61K31/19 ,  A61K31/195 ,  A61K31/215 ,  A61P29/00 ,  C07C33/34 ,  C07C45/67 ,  C07C51/00 ,  C07C59/90 ,  C07C62/38 ,  C07C65/40 ,  C07C67/00 ,  C07C69/753 ,  C07C69/757 ,  C07C69/76 ,  C07C69/94 ,  C07C201/00 ,  C07C205/55 ,  C07C231/00 ,  C07C231/12 ,  C07C231/14 ,  C07C233/00 ,  C07C235/82 ,  C07C253/00 ,  C07C255/40 ,  C07C255/57 ,  C07C313/00 ,  C07C323/62 ,  C07C65/32

CPC classification number: C07C255/00 ,  C07C323/00 ,  C07C33/34 ,  C07C45/673 ,  C07C62/38 ,  Y02P20/55

Abstract: Substituted benzophenones of the formula ##STR1## in which Ph represents unsubstituted or substituted phenyl and R represents free, esterified or amidated carboxy, have anti-inflammatory and/or analgesic properties and can be used as active ingredients in medicaments. They are manufactured, for example, as follows:a compound or a mixture of compounds of the formula ##STR2## in which X.sub.1 and X.sub.2 together represent a group of the formula --C(.dbd.O)--O that is bonded via the carbonyl group to the radical Ph and X.sub.3 represents hydrogen, or one of the radicals X.sub.1 and X.sub.3 represents a group of the formula --C(.dbd.O)--Z, the other represents hydrogen and X.sub.2 represents a group R'O-- in which R' represents hydrogen or a hydroxy-protecting group, is subjected to acid treatment and the primary product is decomposed solvolytically.

Abstract translation: Ph取代的二苯甲酮，其中Ph代表未取代或取代的苯基，R代表游离的，酯化的或酰胺化的羧基，具有抗炎和/或止痛特性，可用作药物中的活性成分。 它们例如如下制备：式（II）的化合物或化合物的混合物，其中X 1和X 2一起表示式-C（= O）-O的基团，其通过 对于基团Ph和X 3的羰基表示氢，或者基团X 1和X 3中的一个表示式-C（= O）-Z的基团，另一个表示氢，X 2表示基团R 10 - ，其中 R'表示氢或羟基保护基，进行酸处理，初级产物在溶剂中分解。

公开(公告)号：US4517394A

公开(公告)日：1985-05-14

申请号：US563216

申请日：1983-12-19

Applicant: Shu-Chieh P. Wang ,  Martin B. Sherwin

Inventor： Shu-Chieh P. Wang ,  Martin B. Sherwin

IPC: C07C201/10 ,  C07C67/00 ,  C07C201/00 ,  C07C201/14 ,  C07C205/02 ,  C07C205/06 ,  C07C79/02

CPC classification number: C07C201/06

Abstract: A process for selectively forming nitroalkanes and nitroaromatics by contacting, at elevated temperature and pressure and in a homogeneous gas phase, an organic carboxylic acid having from two to ten carbon atoms with NO.sub.2 alone or in the presence of oxygen and/or water.

Abstract translation: 在升高的温度和压力下，在均相气相中，将具有2至10个碳原子的有机羧酸与NO 2单独或在氧气和/或水存在下接触来选择性地形成硝基烷烃和硝基芳族化合物的方法。

公开(公告)号：US4487958A

公开(公告)日：1984-12-11

申请号：US428816

申请日：1982-09-30

Applicant: Bernard C. Ream ,  Joseph P. Henry ,  Louis A. Kapicak

Inventor： Bernard C. Ream ,  Joseph P. Henry ,  Louis A. Kapicak

IPC: B01J23/00 ,  B01J23/44 ,  C07B61/00 ,  C07C67/00 ,  C07C67/36 ,  C07C69/36 ,  C07C201/00 ,  C07C201/04

CPC classification number: C07C69/36

Abstract: A process is disclosed for preparing a diester of oxalic acid by contacting carbon monoxide and an ester of nitrous acid in the vapor state under a pressure in the presence of a supported palladium monolith catalyst.

Abstract translation: 公开了一种通过在负载的钯整体催化剂的存在下在压力下使一氧化碳和亚硝酸的酯接触来制备草酸二酯的方法。

公开(公告)号：US4477556A

公开(公告)日：1984-10-16

申请号：US409096

申请日：1982-08-18

Applicant: Thomas E. Dueber ,  William J. Nebe

Inventor： Thomas E. Dueber ,  William J. Nebe

IPC: C07C67/00 ,  C07C201/00 ,  C07C205/37 ,  C07C205/44 ,  C07C205/56 ,  C07C209/00 ,  C07C211/52 ,  G03F7/027 ,  C07C79/46 ,  G03C5/00

CPC classification number: G03F7/027 ,  C07C205/37 ,  C07C205/44 ,  C07C205/56 ,  Y10S430/118

Abstract: A photopolymerizable coating composition comprising(1) a nongaseous, ethylenically unsaturated, polymerizable compound,(2) a specified acidic o-nitroaromatic compound, and(3) an organic, radiation-sensitive, free-radical generating system which is useful for making a positive or negative polymeric image on a substrate.

Abstract translation: 一种可光聚合的涂料组合物，其包含（1）非气态，烯属不饱和的可聚合化合物，（2）特定的酸性邻硝基芳族化合物和（3）有机，辐射敏感的自由基产生体系，其可用于制备 在基底上的正或负聚合物图像。

公开(公告)号：US4474989A

公开(公告)日：1984-10-02

申请号：US394261

申请日：1982-07-01

Applicant: Anatoli Onopchenko ,  Edward T. Sabourin ,  Charles M. Selwitz

Inventor： Anatoli Onopchenko ,  Edward T. Sabourin ,  Charles M. Selwitz

IPC: C07C201/08 ,  C07B61/00 ,  C07C2/68 ,  C07C45/28 ,  C07C67/00 ,  C07C201/00 ,  C07C205/45 ,  C07C45/00 ,  C07C49/786

CPC classification number: C07C201/08 ,  C07C2/68 ,  C07C45/28 ,  C07C2527/126

Abstract: A process for preparing dinitrobenzophenones which comprises reacting benzene with ethylene in the presence of an alkylation catalyst to obtain an alkylation product containing unreacted benzene, ethylbenzene, polyethylbenzenes, 1,1-diphenylethane and heavier products, separating benzene, ethylbenzene and polyethylbenzenes from said alkylation product, recovering from the remainder of said alkylation product a fraction whose boiling points fall within the temperature range of about 260.degree. to about 290.degree. C., reacting said fraction with nitric acid at a temperature within the range of about 130.degree. to about 210.degree. C., wherein the molar ratio of nitric acid to said fraction is in the range of about 3:1 to about 8:1, and thereafter reacting the total resulting reaction product with nitric acid in oleum to obtain a nitration product predominating in dinitrobenzophenones.

Abstract translation: 一种制备二硝基二苯甲酮的方法，其包括在烷基化催化剂存在下使苯与乙烯反应，得到含有未反应苯，乙苯，聚乙苯，1,1-二苯基乙烷和较重产物的烷基化产物，从所述烷基化产物中分离苯，乙苯和聚乙基苯 从所述烷基化产物的剩余部分中回收沸点落在约260℃至约290℃的温度范围内的馏分，使所述馏分与硝酸在约130至约210℃的温度范围内反应。 其中硝酸与所述馏分的摩尔比在约3:1至约8:1的范围内，然后使总产生的反应产物与硝酸在发烟硫酸中反应，得到主要在二硝基二苯甲酮中的硝化产物。

公开(公告)号：US4463195A

公开(公告)日：1984-07-31

申请号：US484842

申请日：1983-04-14

Applicant: Hans-Rudolf Marti ,  Rene Gnehm

Inventor： Hans-Rudolf Marti ,  Rene Gnehm

IPC: C07C201/12 ,  C07C67/00 ,  C07C201/00 ,  C07C205/56 ,  C07C45/27

CPC classification number: C07C201/12

Abstract: Ortho-nitrobenzaldehyde, a well known compound suitable as an indicator and as an intermediate for many organic syntheses including production of pharmaceuticals, is obtained by contacting a C.sub.1 -C.sub.4 lower alkyl ester of o-nitrophenyl pyruvic acid in the form of its enolate, i.e. the enol salt or enol ester, with hydrogen peroxide; the enol salt can be the enolate of an alkali metal, an alkaline earth metal or of aluminum, and the enol ester can be the ester formed by the enolic hydroxyl and formic, acetic, propionic or butyric acid.

Abstract translation: 通过使其以烯醇化合物形式的邻硝基苯基丙酮酸的C 1 -C 4低级烷基酯接触，即作为指示剂的公知化合物和作为包括药物生产在内的许多有机合成的中间体的正 - 硝基苯甲醛，即 烯醇盐或烯醇酯，与过氧化氢; 烯醇盐可以是碱金属，碱土金属或铝的烯醇化物，烯醇酯可以是由烯醇羟基和甲酸，乙酸，丙酸或丁酸形成的酯。

公开(公告)号：US4456772A

公开(公告)日：1984-06-26

申请号：US354424

申请日：1982-03-03

Applicant: Gerhard Marzolph ,  Heinz U. Blank

Inventor： Gerhard Marzolph ,  Heinz U. Blank

IPC: C07C205/44 ,  C07C45/63 ,  C07C47/55 ,  C07C67/00 ,  C07C201/00 ,  C07C201/12 ,  C07C79/36

CPC classification number: C07C201/12

Abstract: Optionally substituted fluoro-nitro-benzaldehydes are prepared from optionally substituted halogeno-nitro-benzaldehydes and an alkali metal fluoride in a substantially anhydrous inert aprotic solvent, by heating to 50.degree. to 250.degree. C.

Abstract translation: 任选取代的氟 - 硝基 - 苯甲醛由任选取代的卤代硝基 - 苯甲醛和碱金属氟化物在基本上无水的惰性非质子传递溶剂中，通过加热至50至250℃制备。

公开(公告)号：US4446075A

公开(公告)日：1984-05-01

申请号：US236546

申请日：1981-02-20

Applicant: Kurt Eiglmeier ,  Reinhard Knieps

Inventor： Kurt Eiglmeier ,  Reinhard Knieps

IPC: B01J23/00 ,  B01J27/00 ,  C07B61/00 ,  C07C17/14 ,  C07C45/00 ,  C07C45/43 ,  C07C45/63 ,  C07C47/55 ,  C07C49/807 ,  C07C51/00 ,  C07C51/363 ,  C07C63/70 ,  C07C67/00 ,  C07C201/00 ,  C07C201/12 ,  C07C205/12 ,  C07C253/00 ,  C07C255/50 ,  C07C120/00

CPC classification number: C07C17/14 ,  C07C201/12 ,  C07C45/43 ,  C07C45/63 ,  C07C47/55 ,  C07C49/807 ,  C07C63/70

Abstract: Substituted bromofluorobenzene, wherein the fluorine is in para-position and the bromine in meta-position to another substituent, is prepared by direct bromination of the corresponding fluorobenzene derivative. Bromination is advantageously carried out in the presence of a catalyst, preferably a metal or metal salt. The elementary bromine is used in an amount of 0.9 to 1.3 mols per mol of fluorobenzene derivative and the reaction temperature is between 20.degree. and 200.degree. C. The bromofluorobenzene derivatives are suitable for the synthesis of medicaments and plant protective agents.

Abstract translation: 通过直接溴化相应的氟苯衍生物制备取代的溴氟苯，其中氟位于对位并且溴位于另一取代基的间位。 溴化有利地在催化剂，优选金属或金属盐的存在下进行。 基本溴的使用量为每摩尔氟苯衍生物为0.9〜1.3摩尔，反应温度为20〜200℃。溴氟苯衍生物适用于药物和植物保护剂的合成。

公开(公告)号：US4438043A

公开(公告)日：1984-03-20

申请号：US392886

申请日：1982-06-28

Applicant: Michel Desbois

Inventor： Michel Desbois

IPC: B01J27/00 ,  C07B31/00 ,  C07B41/06 ,  C07B61/00 ,  C07C45/00 ,  C07C45/43 ,  C07C45/46 ,  C07C49/84 ,  C07C67/00 ,  C07C201/00 ,  C07C205/45 ,  C07C255/56 ,  C07C313/00 ,  C07C319/20 ,  C07C323/22 ,  C07C121/75 ,  C07C149/00

CPC classification number: C07C45/008 ,  C07C323/00 ,  C07C45/43

Abstract: A process for the preparation of di- or trifluoromethoxyphenyl ketones or di- or trifluoromethylthiophenyl ketones, characterized in that, in a first stage, a di- or trihalomethoxybenzene or a di- or trihalomethylthiobenzene is reacted with a trihalomethylated aromatic or aliphatic compound in the presence of boron trifluoride in an amount such that the absolute pressure of boron trifluoride within the reaction vessel exceeds 1 bar, and in the presence of hydrofluoric acid as a solvent and in that, in a second stage, the product of the first stage is hydrolyzed. The resultant products are useful as intermediates in the synthesis of compounds having a pharmaceutical or phytosanitary (e.g., herbicidal) activity.

Abstract translation: 一种制备二 - 或三氟甲氧基苯基酮或二 - 或三氟甲硫基苯基酮的方法，其特征在于，在第一阶段中，二 - 或三卤甲氧基苯或二 - 或三卤代甲硫基苯与三卤甲基化芳族或脂族化合物在存在下反应 的三氟化硼的量使得反应容器内的三氟化硼的绝对压力超过1巴，在作为溶剂的氢氟酸的存在下，在第二阶段中，第一阶段的产物被水解。 所得产物可用作合成具有药物或植物检疫（例如除草）活性的化合物的中间体。

公开(公告)号：US4435208A

公开(公告)日：1984-03-06

申请号：US318899

申请日：1981-11-06

Applicant: Heinz Forster ,  Ludwig Eue ,  Robert Schmidt

Inventor： Heinz Forster ,  Ludwig Eue ,  Robert Schmidt

IPC: A01N39/02 ,  A01N35/00 ,  A01N37/34 ,  A01N37/48 ,  C07C20060101 ,  C07C45/71 ,  C07C47/575 ,  C07C67/00 ,  C07C67/02 ,  C07C201/00 ,  C07C205/38 ,  C07C205/42 ,  C07C205/56 ,  C07C235/12 ,  C07C253/00 ,  C07C255/37 ,  C07C255/38 ,  C07C255/40 ,  C07C255/50 ,  C07C255/53 ,  C07C325/00 ,  C07C327/32 ,  A01N37/10 ,  C07C69/618 ,  C07C121/75

CPC classification number: C07C205/56 ,  A01N37/48 ,  C07C205/38 ,  C07C205/42 ,  C07C205/44 ,  C07C255/00 ,  C07C45/71 ,  C07C47/575

Abstract: Herbicidally active compounds of the formula ##STR1## in which R.sup.1 represents a hydrogen or chlorine atom,R.sup.2 represents a hydrogen atom, a cyano group, an optionally substituted radical selected from alkyl, aryl, alkanoyl, benzoyl, alkoxycarbonyl, alkenoxycarbonyl, alkinoxycarbonyl, aralkoxycarbonyl and aryloxycarbonyl, or a radical of the general formula --COOM,in whichM represents a hydrogen atom, one equivalent of an alkali metal ion or alkaline earth metal ion or optionally substituted ammonium, andR.sup.3 represents a cyano group or a radical of the general formula ##STR2## wherein Y represents an oxygen or sulphur atom or an imino (NH) or alkylimino (N-alkyl) group,R.sup.4 and R.sup.5 independently of each other represent a hydrogen atom or a methyl group,n is 0 or 1 andZ represents an optionally substituted radical.

Abstract translation: 其中R 1表示氢或氯原子的式“IMAGE”的除草活性化合物，R 2表示氢原子，氰基，任选取代的选自烷基，芳基，烷酰基，苯甲酰基，烷氧基羰基，烯氧基羰基，烷氧基羰基，芳烷氧基羰基 和芳氧基羰基，或通式-COOM的基团，其中M表示氢原子，1当量的碱金属离子或碱土金属离子或任选取代的铵，R 3表示一般的氰基或基团 其中Y表示氧或硫原子或亚氨基（NH）或烷基亚氨基（N-烷基）基团，R4和R5彼此独立地表示氢原子或甲基，n为0或1，Z为 代表任选取代的基团。