公开(公告)号：US07202371B2

公开(公告)日：2007-04-10

申请号：US10762028

申请日：2004-01-20

Applicant: Hisashi Yamamoto ,  Arindrajit Basak ,  Wei Zhang

Inventor： Hisashi Yamamoto ,  Arindrajit Basak ,  Wei Zhang

IPC: C07D301/19 ,  C07D301/12

CPC classification number: C07D303/14 ,  B01J31/006 ,  B01J31/0201 ,  B01J31/2213 ,  B01J31/2226 ,  B01J31/2234 ,  B01J2231/70 ,  B01J2231/72 ,  B01J2531/0266 ,  B01J2531/56 ,  B01J2531/64 ,  B01J2540/34 ,  C07D301/14

Abstract: The present invention relates to the synthesis of chiral epoxides via a catalytic asymmetric oxidation of olefins. Additionally, the methodology provides a method of asymmetrically oxidizing sulfides and phosphines. This asymmetric oxidation employs a catalyst system composed of a metal and a chiral bishydroxamic acid ligand, which, in the presence of a stoichiometric oxidation reagent, serves to asymmetrically oxidize a variety of substrates.

Abstract translation: 本发明涉及通过烯烃的催化不对称氧化合成手性环氧化物。 另外，该方法提供了一种不对称氧化硫化物和膦的方法。 这种不对称氧化采用由金属和手性双硅氧酸配体组成的催化剂体系，其在化学计量氧化试剂的存在下用于不对称地氧化各种底物。