公开(公告)号：US20090156427A1

公开(公告)日：2009-06-18

申请号：US12183916

申请日：2008-07-31

Applicant: Shuguang Zhang ,  Andreas Mershin ,  Liselotte Kaiser ,  Brian Cook ,  Johanna F. Graveland-Bikker ,  Manu Prakash ,  David Kong ,  Yael Maguire

Inventor： Shuguang Zhang ,  Andreas Mershin ,  Liselotte Kaiser ,  Brian Cook ,  Johanna F. Graveland-Bikker ,  Manu Prakash ,  David Kong ,  Yael Maguire

IPC: C40B30/10 ,  B01J19/00 ,  C40B40/10 ,  C40B60/12 ,  C40B30/00 ,  C12P21/00

CPC classification number: G01N33/54366 ,  G01N2333/726

Abstract: The invention provides a bio-sensing nanodevice comprising: a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—on a support, a real time receptor-ligand binding detection method, an odorant delivery system and an odorant recognition program. The biologically-derived G-protein coupled receptor can be stabilized on nanotechnology using surfactant peptide. The said nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

Abstract translation: 本发明提供一种生物感测纳米装置，其包括：稳定的生物衍生的G蛋白偶联受体 - 支持物上的嗅觉受体，实时受体 - 配体结合检测方法，加味剂递送系统和气味识别程序。 生物衍生的G蛋白偶联受体可以使用表面活性剂肽在纳米技术上稳定。 所述纳米器件提供更大的表面积，以提高气味检测的精度和灵敏度。 本发明进一步提供了一种微流控芯片，其包含稳定的生物衍生的G蛋白偶联受体 - 嗅觉受体 - 固定在载体上，并且布置在至少二维微阵列系统中。 本发明还提供了一种递送加臭剂的方法，其包括在复杂微流体网络中操作气泡的步骤，其中气泡在携带各种气体样品的微流体通道中移动到芯片上的精确位置。 本发明还提供了制备hOR17-4嗅觉受体的方法。

公开(公告)号：US20060071391A1

公开(公告)日：2006-04-06

申请号：US10930446

申请日：2004-08-31

Applicant: Mahesan Chelvayohan ,  Brian Cook ,  Timothy Howard ,  Kevin Johnson ,  William Klein ,  Michael Lawrence

Inventor： Mahesan Chelvayohan ,  Brian Cook ,  Timothy Howard ,  Kevin Johnson ,  William Klein ,  Michael Lawrence

IPC: B65H5/00 ,  B65H7/02

CPC classification number: B65H7/02 ,  B65H2402/54 ,  B65H2403/72 ,  B65H2511/51 ,  B65H2553/81

Abstract: An imaging apparatus includes a printing mechanism having a media path. A print media source is provided for supplying a sheet of print media to the printing mechanism. A drive unit is provided, with a drive shaft coupled to the drive unit. A media sensor device is mounted to the drive shaft, wherein as the drive shaft is rotated in a first direction the media sensor device is moved from a first position that is out of the media path to a second position that is in the media path for sensing the sheet of print media. As the drive shaft is rotated in a second direction opposite to the first direction the media sensor device is moved from the second position that is in the media path for sensing the sheet of print media to the first position that is out of the media path.

Abstract translation: 成像装置包括具有媒体路径的打印机构。 提供了一种打印介质源，用于将一张打印介质供给到打印机构。 提供了一个驱动单元，其中驱动轴联接到驱动单元。 介质传感器装置安装到驱动轴上，其中当驱动轴沿第一方向旋转时，介质传感器装置从介质路径外的第一位置移动到位于介质路径中的第二位置 感测印张介质。 当驱动轴沿与第一方向相反的第二方向旋转时，介质传感器装置从用于感测印张介质的介质路径的第二位置移动到介质路径外的第一位置。

公开(公告)号：US20050203158A1

公开(公告)日：2005-09-15

申请号：US10632888

申请日：2003-08-01

Applicant: Joerg Bentzien ,  Brian Cook ,  Charles Cywin ,  Roman Fleck ,  Ho Lo ,  Peter Nemoto ,  Steven Pullen ,  Gregory Roth ,  Roger Snow ,  Hidenori Takahashi ,  Ji Wang ,  Kevin Moriarty ,  Lei Qiao ,  Michael Winters

Inventor： Joerg Bentzien ,  Brian Cook ,  Charles Cywin ,  Roman Fleck ,  Ho Lo ,  Peter Nemoto ,  Steven Pullen ,  Gregory Roth ,  Roger Snow ,  Hidenori Takahashi ,  Ji Wang ,  Kevin Moriarty ,  Lei Qiao ,  Michael Winters

IPC: A61K31/4184 ,  A61K39/00 ,  A61P1/04 ,  A61P3/10 ,  A61P11/00 ,  A61P11/06 ,  A61P11/08 ,  A61P17/00 ,  A61P17/06 ,  A61P25/00 ,  A61P27/02 ,  A61P27/16 ,  A61P29/00 ,  A61P35/00 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07D235/28 ,  C07D235/30 ,  C07D409/12 ,  C07D43/02

CPC classification number: C07D409/12 ,  C07D235/30

Abstract: Disclosed are substituted benzimidazole compounds of formula (I): wherein R1, R2, R3, R4 and Xa are defined herein. The compounds of the invention inhibit Itk kinase and are therefore useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are processes for preparing these compounds and to pharmaceutical compositions comprising these compounds.

Abstract translation: 公开了式（I）的取代的苯并咪唑化合物：其中R 1，R 2，R 3，R 4， >和X > 。 本发明的化合物抑制Itk激酶，因此可用于治疗涉及炎症，免疫学障碍和过敏性疾病的疾病和病理状况。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。

公开(公告)号：US09339630B2

公开(公告)日：2016-05-17

申请号：US12389070

申请日：2009-02-19

Applicant: Brian Cook ,  James Mitchell ,  Natividad Vasquez ,  Gianfranco Pellegrini

Inventor： Brian Cook ,  James Mitchell ,  Natividad Vasquez ,  Gianfranco Pellegrini

IPC: A61F2/95 ,  A61M25/00 ,  A61F2/966 ,  A61F2/91 ,  A61M25/06

CPC classification number: A61M25/0082 ,  A61F2/91 ,  A61F2/95 ,  A61F2/966 ,  A61F2002/9665 ,  A61F2250/0068 ,  A61M25/0068 ,  A61M2025/0057 ,  A61M2025/0681

Abstract: A system for treating a vascular condition includes a catheter having an inner member and an outer member, the outer member concentrically arranged about the inner member and a retractable drug delivery device disposed at a distal end of the inner member. A coating disposed on at least a portion of an outer surface of the retractable drug delivery device includes at least one therapeutic agent.

Abstract translation: 用于治疗血管病症的系统包括具有内部构件和外部构件的导管，所述外部构件围绕内部构件同心地布置，以及设置在内部构件的远端处的可伸缩药物输送装置。 设置在可伸缩药物输送装置的外表面的至少一部分上的涂层包括至少一种治疗剂。

公开(公告)号：US20110117500A1

公开(公告)日：2011-05-19

申请号：US12620715

申请日：2009-11-18

Applicant: Jim Hennessy ,  David X. Elwell ,  Nicholas R. Pina ,  Brian Cook ,  Ryan Vest

Inventor： Jim Hennessy ,  David X. Elwell ,  Nicholas R. Pina ,  Brian Cook ,  Ryan Vest

IPC: G03F7/20 ,  B41C3/08

CPC classification number: G03F7/34 ,  B41F27/00 ,  B41N6/00 ,  B41N10/02

Abstract: An improved apparatus for thermally developing a flexographic printing element to reveal a relief image on the surface and a method of using the apparatus to develop a flexographic printing element. The apparatus typically comprises means for softening or melting a crosslinked photopolymer on the imaged and exposed surface of the flexographic printing element; at least one roll that is contactable with the imaged surface of the flexographic printing element and capable of moving over at least a portion of the imaged surface of the flexographic printing element to remove the softened or melted non-crosslinked photopolymer on the imaged and exposed surface of the flexographic printing element; and means for maintaining contact between the at least one roll and the imaged and exposed surface of the flexographic printing element. A layer of resilient compressible material is positioned between the flexographic printing element and a supporting conveying means. The means for softening or melting non-crosslinked photopolymer on the imaged and exposed surface of the flexographic printing element comprise a heater positioned adjacent to the imaged surface of the flexographic printing element and/or heating the at least one roll that contactable with the imaged surface of the flexographic printing element. The apparatus may also contain an exposure device to crosslink and cure the imaged surface of the flexographic printing element prior to thermal development.

Abstract translation: 用于热显影柔性版印刷元件以在表面上露出浮雕图像的改进的装置以及使用该装置来开发柔性版印刷元件的方法。 该装置通常包括用于软化或熔化柔性版印刷元件的成像和暴露表面上的交联光聚合物的装置; 至少一个辊，其能够与柔性版印刷元件的成像表面接触并且能够移动柔性版印刷元件的成像表面的至少一部分以去除成像和曝光表面上的软化或熔融的非交联光聚合物 的柔性版印刷元件; 以及用于保持柔性版印刷元件的至少一个辊与成像和暴露的表面之间的接触的装置。 弹性可压缩材料层位于柔性版印刷元件和支撑输送装置之间。 用于软化或熔化柔性版印刷元件的成像和暴露表面上的非交联光聚合物的装置包括邻近柔性版印刷元件的成像表面定位的加热器和/或加热可与成像表面接触的至少一个辊 的柔性版印刷元件。 该装置还可以包含用于在热显影之前交联和固化柔性版印刷元件的成像表面的曝光装置。

公开(公告)号：US20100092535A1

公开(公告)日：2010-04-15

申请号：US12249611

申请日：2008-10-10

Applicant: Brian Cook ,  James Mitchell ,  Feridun Ozdil ,  Natividad Vasquez

Inventor： Brian Cook ,  James Mitchell ,  Feridun Ozdil ,  Natividad Vasquez

IPC: A61K9/00 ,  A61K39/395 ,  A61F2/82

CPC classification number: A61F2/04 ,  A61F2/82 ,  A61F2250/0067 ,  A61L17/005 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/256 ,  A61L2300/258 ,  A61L2300/416 ,  A61L2300/432 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2400/12

Abstract: Disclosed herein are controlled release drug delivery systems. The systems comprise a medical device at least one nonoporous surface, at least one bioactive agent and optionally a biodegradable polymer. The nanoporous surfaces of the medical devices contain nanopores capable of acting as reservoirs for drugs that are controllably released.

Abstract translation: 本文公开了控释药物递送系统。 该系统包括至少一个非孔表面的医疗装置，至少一种生物活性剂和任选的可生物降解的聚合物。 医疗装置的纳米多孔表面含有能够作为可控制释放的药物的储存器的纳米孔。

公开(公告)号：US20100024672A1

公开(公告)日：2010-02-04

申请号：US12183461

申请日：2008-07-31

Applicant: Ryan Vest ,  Brian Cook ,  Jim Hennessy ,  David Elwell

Inventor： Ryan Vest ,  Brian Cook ,  Jim Hennessy ,  David Elwell

IPC: B41M5/00 ,  G03F7/26

CPC classification number: G03F7/40 ,  B41C1/1075 ,  B41C1/1083 ,  G03F7/36

Abstract: The present invention pertains to a process and an apparatus for treating a photosensitive element to form a relief structure suitable for flexographic printing plate. The apparatus comprises an enclosure, a conveyor, a heatable roller with absorbent material conducted over it, and a roller that can significantly smooth or uniformly roughen the relief structure of the flexographic printing plate. Previously selectively cured photosensitive elements are developed by means of the heatable roller by blotting with the absorbent material, and the resulting relief structure is made uniform by way of a smoothing or roughening roller. The flexographic plates produced by the method and apparatus are especially suited to processes that require substantially smoothed or uniformly roughened printing plate surfaces, which are capable of producing better quality printing.

Abstract translation: 本发明涉及一种用于处理感光元件以形成适于柔性版印刷版的浮雕结构的方法和设备。 该装置包括外壳，输送机，带有吸收材料的可加热辊，并且能够显着平滑或均匀地粗糙柔性版印刷版的浮雕结构。 先前选择性地固化的感光元件通过用吸收材料吸墨通过可加热辊显影，并且通过平滑或粗糙的辊使得到的浮雕结构均匀。 通过该方法和设备生产的柔版印刷板特别适用于需要基本上平滑或均匀粗糙的印版表面的工艺，其能够生产更好质量的印刷。

公开(公告)号：US20050275150A1

公开(公告)日：2005-12-15

申请号：US10865632

申请日：2004-06-10

Applicant: Brian Cook ,  William Klein

Inventor： Brian Cook ,  William Klein

IPC: B41J13/00 ,  B65H3/06 ,  B65H5/06 ,  B65H7/02 ,  F16H61/16 ,  F16H61/18

CPC classification number: B41J13/0018 ,  B65H3/0676 ,  B65H5/06 ,  B65H7/02 ,  B65H2403/40 ,  B65H2404/1441 ,  B65H2404/16 ,  B65H2511/11 ,  B65H2511/51 ,  B65H2515/32 ,  B65H2220/01 ,  B65H2220/02

Abstract: Printer (1) has a pivotally mounted autocompensating system (19) mounted at an intermediate position in paper guide (17). That system (19) is driven by a motor (40) through a slip drive (70, 72, 74). The motor also drives paper feed system (15). When the motor turns in a direction to feed by system (15), the intermediate system is moved away from the paper guide. When a sheet reaches a position to be fed by the intermediate system, the motor is reversed, and the intermediate system pivots against the paper for moving it further through the paper guide.

Abstract translation: 打印机（1）具有安装在纸张引导件（17）中的中间位置的可枢转地安装的自动补偿系统（19）。 该系统（19）由马达（40）通过滑动驱动（70,72,74）驱动。 电机还驱动送纸系统（15）。 当电机沿着由系统（15）馈送的方向转动时，中间系统从导纸器移开。 当纸张到达要由中间系统供给的位置时，电动机反转，并且中间系统抵靠纸张枢转，以使其进一步移动通过纸张引导件。

公开(公告)号：US20050209284A1

公开(公告)日：2005-09-22

申请号：US11055798

申请日：2005-02-09

Applicant: Joerg Bentzien ,  Brian Cook ,  Xiang Li ,  Ho Lo ,  Chuk Man ,  Ingo Mugge ,  Peter Nemoto ,  Steven Pullen ,  Doris Riether ,  Gregory Roth ,  Fariba Soleymanzadeh ,  Hidenori Takahashi ,  Ji Wang ,  Andre White ,  Renee Zindell

Inventor： Joerg Bentzien ,  Brian Cook ,  Xiang Li ,  Ho Lo ,  Chuk Man ,  Ingo Mugge ,  Peter Nemoto ,  Steven Pullen ,  Doris Riether ,  Gregory Roth ,  Fariba Soleymanzadeh ,  Hidenori Takahashi ,  Ji Wang ,  Andre White ,  Renee Zindell

IPC: A61K31/4184 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  C07D235/30 ,  C07D401/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/02 ,  C07D413/12 ,  C07D413/14 ,  C07D417/02 ,  C07D417/14 ,  C07D491/10 ,  C07D43/02

CPC classification number: C07D235/30 ,  C07D401/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D491/10

Abstract: Disclosed are compounds of formula(I): wherein Ar1, Ar2, R1, R2, R3, R4 and Xa are defined herein. The compounds of the invention inhibit Itk kinase and are therefore useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are processes for preparing these compounds and to pharmaceutical compositions comprising these compounds.

Abstract translation: 公开了式（I）的化合物：其中Ar 1，Ar 2，R 1，R 2， R 3，R 4和X a a在本文中定义。 本发明的化合物抑制Itk激酶，因此可用于治疗涉及炎症，免疫学障碍和过敏性疾病的疾病和病理状况。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。

公开(公告)号：US20050185037A1

公开(公告)日：2005-08-25

申请号：US11063796

申请日：2005-02-23

Applicant: Thomas Bailey ,  Jeffery Buchanan ,  Johnnie Coffey ,  Brian Cook ,  David Greer ,  Ganesh Phatak

Inventor： Thomas Bailey ,  Jeffery Buchanan ,  Johnnie Coffey ,  Brian Cook ,  David Greer ,  Ganesh Phatak

IPC: B41J2/175

CPC classification number: B41J2/17513 ,  B41J2/17553

Abstract: Multi-compartmentalized ink cartridges for ink jet printers and improved methods for making the ink cartridges. The multi-compartmentalized ink cartridge includes a molded, open-topped body having an interior cavity and a printhead surface area opposite the interior cavity. A divider wall is integrally molded with the molded body structure and disposed in the interior cavity to provide at least three segregated ink chambers. The divider wall includes a first wall section and a second wall section attached substantially perpendicular to the first wall section. At least first, second, third molded ink flow paths connect each of the at least three segregated ink chambers with the printhead surface area. The second and third ink flow paths are oriented relative to their corresponding ink chambers for molding with a mold insert tool so that the cartridge body does not require a separately attached member to close mold insert tool insertion areas in the body.

Abstract translation: 用于喷墨打印机的多间隔墨盒和用于制造墨盒的改进方法。 多间隔墨盒包括具有内腔和与内腔相对的打印头表面区域的模制的开顶本体。 分隔壁与成型体结构整体模制并且设置在内腔中以提供至少三个分离的墨室。 分隔壁包括基本上垂直于第一壁部分附接的第一壁部分和第二壁部分。 至少第一，第二，第三模制油墨流动路径将至少三个分离的油墨室中的每一个连接到打印头表面区域。 第二和第三墨水流动路径相对于其相应的墨水腔定向，以便用模具插入工具进行模制，使得墨盒主体不需要单独附接的构件来封闭体内的模具插入工具插入区域。