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公开(公告)号：US08063057B2
公开(公告)日：2011-11-22
申请号：US12750278
申请日：2010-03-30
Applicant: Arokiasamy Devasagayaraj , Haihong Jin , Brett Marinelli , Lakshama Samala , Zhi Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
Inventor： Arokiasamy Devasagayaraj , Haihong Jin , Brett Marinelli , Lakshama Samala , Zhi Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC: A61K31/505 , C07D239/47 , A61P1/00
CPC classification number: C07D251/18 , C07B2200/07 , C07C229/36 , C07C229/42 , C07C229/44 , C07C275/42 , C07C311/29 , C07C2601/08 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/24 , C07D249/06 , C07D251/16 , C07D251/22 , C07D251/52 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D413/12
Abstract: Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
Abstract translation: 公开了式I和II的化合物，以及包含它们的组合物及其用于治疗，预防和控制5-羟色胺介导的疾病和障碍的方法：
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12.发明申请4-Phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-Based Compounds and Methods of Their Use 有权4-苯基-6-（2,2,2-三氟-1-苯基乙氧基）嘧啶类化合物及其使用方法公开(公告)号：US20090286817A1
公开(公告)日：2009-11-19
申请号：US12468974
申请日：2009-05-20
Applicant: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
Inventor： Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC: C07D239/47 , A61K31/506 , A61P35/00
CPC classification number: A61K31/506 , A61K31/4152 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
Abstract translation: 公开了式I化合物，以及包含它们的组合物及其用于治疗，预防和/或控制疾病和病症的方法：
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13.发明申请4-PHENYL-6-(2,2,2-TRIFLUORO-1-PHENYLETHOXY)PYRIMIDINE-BASED COMPOUNDS AND METHODS OF THEIR USE 有权4-苯基-6-（2,2,2-三氟-1-苯基乙基）吡啶基化合物及其使用方法公开(公告)号：US20080153852A1
公开(公告)日：2008-06-26
申请号：US11954000
申请日：2007-12-11
Applicant: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
Inventor： Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC: A61K31/506 , C07D239/42 , A61P43/00
CPC classification number: A61K31/506 , A61K31/4152 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
Abstract translation: 公开了式I化合物，以及包含它们的组合物及其用于治疗，预防和/或控制疾病和病症的方法：
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公开(公告)号：US06278022B1
公开(公告)日：2001-08-21
申请号：US09431197
申请日：1999-11-01
Applicant: Haihong Jin
Inventor： Haihong Jin
IPC: C07C20900
CPC classification number: C07C201/08 , C07C201/12 , C07C213/02 , C07C241/02 , C07C245/22 , C07C281/02 , C07C217/84 , C07C243/22 , C07C205/22 , C07C205/37
Abstract: Disclosed herein is an improvement in a method for making compounds having the structural formulae (I) or (II): wherein: X is a) phenyl; lower phenylalkoxy; phenoxy; or benzyl; or b) one substituent from group a) and one or more substituents selected from C1-C4 alkoxy; hydroxyl; halogen; lower alkyl; and lower alkylthio; or c) along with the phenyl to which it is attached, forms a multiple fused ring heterocycle such as dibenzofuranyl; Y is H, C1-C4 alkanoyl, C1-C4 haloalkenoyl, dialkoxyphosphoryl, alkylaminocarbonyl, haloalkylsulfonyl, or C1-C4 alkoxy carbonyl; and R is H, C1-C6 alkyl, C1-C6 alkoxy, C3-C6 cycloalkoxy, haloalkyl, alkoxyalkyl, arylalkoxy, alkenyl, alkylthio, alkoxycarbonyl, alkylamino, heteroaryl, arylalkyl, haloalkoxy, aryloxy, or C3-C6 cycloalkyl; and Z is O or S, wherein the improvement comprises the steps of: A) selecting as a starting material a compound of the structural formula B) dissolving compound III in an organic solvent selected from the group consisting of methyl t-butyl ether, ethylene glycol dimethyl ether, 2-methoxyethyl ether, acetonitrile, and acetic acid, and C) nitrating with nitric acid to form a compound of the structural formula
Abstract translation: 本文公开了具有结构式（I）或（II）的化合物的制备方法的改进：其中：X为a）苯基; 低级苯基烷氧基; 苯氧基 或苄基; 或b）a）中的一个取代基和一个或多个选自C 1 -C 4烷氧基的取代基; 羟; 卤素; 低级烷基 和低级烷硫基; 或c）与其连接的苯基一起形成多重稠环杂环，例如二苯并呋喃基; Y是H，C 1 -C 4烷酰基，C 1 -C 4卤代烯酰基，二烷氧基磷酰基，烷基氨基羰基，卤代烷基磺酰基或C 1 -C 4烷氧基羰基; C 1 -C 6烷基，C 1 -C 6烷氧基，C 3 -C 6环烷氧基，卤代烷基，烷氧基烷基，芳基烷氧基，烯基，烷硫基，烷氧基羰基，烷基氨基，杂芳基，芳烷基，卤代烷氧基，芳氧基或C 3 -C 6环烷基; 并且Z为O或S，其中改进包括以下步骤：A）将化合物III溶于选自甲基叔丁基醚，乙二醇的有机溶剂中的结构式B）化合物作为起始原料 二甲醚，2-甲氧基乙醚，乙腈和乙酸，和C）用硝酸硝化形成结构式的化合物
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15.发明授权4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use 有权4-苯基-6-（2,2,2-三氟-1-苯基乙氧基）嘧啶类化合物及其使用方法公开(公告)号：US08772482B2
公开(公告)日：2014-07-08
申请号：US13162989
申请日：2011-06-17
Applicant: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
Inventor： Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC: C07D403/12 , A61K31/506 , A61P1/04 , A61P1/06 , A61K31/4152
CPC classification number: A61K31/506 , A61K31/4152 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
Abstract translation: 公开了式I化合物，以及包含它们的组合物及其用于治疗，预防和/或控制疾病和病症的方法：
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Patent Agency Ranking
16.发明授权Methods of using 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds 有权使用4-苯基-6-（2,2,2-三氟-1-苯基乙氧基）嘧啶类化合物的方法公开(公告)号：US07968559B2
公开(公告)日：2011-06-28
申请号：US12754341
申请日：2010-04-05
Applicant: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
Inventor： Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC: A61K31/506 , A61P35/00 , A61P1/00 , C07D403/12
CPC classification number: A61K31/506 , A61K31/4152 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
Abstract translation: 公开了式I化合物，以及包含它们的组合物及其用于治疗，预防和/或控制疾病和病症的方法：
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17.发明申请Methods of using 4-Phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-Based Compounds 有权使用4-苯基-6-（2,2,2-三氟-1-苯基乙氧基）嘧啶类化合物的方法公开(公告)号：US20100311764A1
公开(公告)日：2010-12-09
申请号：US12754341
申请日：2010-04-05
Applicant: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
Inventor： Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC: A61K31/506 , A61P1/00 , A61P35/00
CPC classification number: A61K31/506 , A61K31/4152 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
Abstract translation: 公开了式I化合物，以及包含它们的组合物及其用于治疗，预防和/或控制疾病和病症的方法：
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18.发明授权4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use 有权4-苯基-6-（2,2,2-三氟-1-苯基乙氧基）嘧啶类化合物及其使用方法公开(公告)号：US07709493B2
公开(公告)日：2010-05-04
申请号：US12468974
申请日：2009-05-20
Applicant: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
Inventor： Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC: C07D403/12 , A61K31/506 , A61P35/00
CPC classification number: A61K31/506 , A61K31/4152 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
Abstract translation: 公开了式I化合物，以及包含它们的组合物及其用于治疗，预防和/或控制疾病和病症的方法：
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19.发明授权4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use 有权4-苯基-6-（2,2,2-三氟-1-苯基乙氧基）嘧啶类化合物及其使用方法公开(公告)号：US07553840B2
公开(公告)日：2009-06-30
申请号：US11954000
申请日：2007-12-11
Applicant: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
Inventor： Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC: C07D239/34 , C07D403/12 , A61K31/506 , A61P9/02
CPC classification number: A61K31/506 , A61K31/4152 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
Abstract translation: 公开了式I化合物，以及包含它们的组合物及其用于治疗，预防和/或控制疾病和病症的方法：
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公开(公告)号：US08629156B2
公开(公告)日：2014-01-14
申请号：US13290261
申请日：2011-11-07
Applicant: Arokiasamy Devasagayaraj , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
Inventor： Arokiasamy Devasagayaraj , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
IPC: C07C229/36 , C07C229/42 , C07C229/44 , C07C275/42 , C07C311/29 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/24 , C07D249/06 , C07D251/16 , C07D251/18 , C07D251/22 , C07D251/52 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D413/12 , A61K31/505 , A61P1/00
CPC classification number: C07D251/18 , C07B2200/07 , C07C229/36 , C07C229/42 , C07C229/44 , C07C275/42 , C07C311/29 , C07C2601/08 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/24 , C07D249/06 , C07D251/16 , C07D251/22 , C07D251/52 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D413/12
Abstract: Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
Abstract translation: 公开了式I和II的化合物，以及包含它们的组合物及其用于治疗，预防和控制5-羟色胺介导的疾病和障碍的方法：
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