Abstract:
past positions of a plurality of composing elements indicated by various past arrangement examples are given to each potential function corresponding to one composing element, and parameter values of the potential functions corresponding to the composing elements are automatically set on condition that a past total potential energy obtained by solving the potential functions is minimized. Thereafter, the parameter values are given to the potential functions in which a position of any composing element is not determined, and particular positions of the composing elements are determined on condition that a total potential energy obtained by solving the potential functions is minimized. Because each potential function corresponding to one composing element has an attraction term indicating the attraction between the composing element and the other composing elements and an attraction-repulsion term indicating the setting of the composing element at a position spaced at moderate distances from the other composing elements, the particular positions of the composing elements are set in an optimum arrangement. Accordingly, the optimum arrangement of the composing elements can be automatically obtained without extracting any arrangement knowledge from a skilled person.
Abstract:
The present invention provides a medicament exhibiting excellent retinoic acid receptor agonism.A Carboxylic acid derivative having a fused ring which is represented by the following formula or a pharmacologically acceptable salt thereof: ##STR1## {wherein the symbol ----- represents a single bond or a double bond; X, Y, Z, P, Q, U, V and W are each a group represented by the formula: --O-- or --S--, or a group represented by the formula: ##STR2## [wherein R.sup.k (k:1 to 8) is hydrogen, halogeno, optionally substituted lower alkyl or the like, with either of R.sup.7 and R.sup.8 being a group represented by the formula: ##STR3## (wherein A and B are each independently an optionally substituted aromatic hydrocarbon ring or an optionally substituted unsaturated heterocycle; and D is optionally protected carboxyl)]}.
Abstract:
A vibration type measuring instrument measures at least one of a mass flow rate and a density of a fluid flowing through a straight measurement pipe by vibrating the measurement pipe, obtains a frequency ratio of a resonant frequency of a first vibration mode to a resonant frequency of a second vibration mode of the measurement pipe, and corrects a measured value of at least one of the mass flow rate and the density according to the frequency ratio. The instrument includes a first vibration detector for detecting at least one of a vibration generated in the measurement pipe depending on the mass flow rate and the resonant frequency of the first vibration mode of the measurement pipe; and a second vibration detector for detecting the resonant frequency of the second vibration mode of the measurement pipe. The second vibration detector is provided around an antinode of the second vibration mode of the measurement pipe to improve the detection sensitivity in the second vibration mode.
Abstract:
A heterocycle-containing carbonic acid derivative represented by the following general formula (I): ##STR1## or a physiologically acceptable salt thereof which exhibits an excellent preventive and therapeutic effect against various diseases, and an intermediate which is useful for the production of the heterocycle-containing carbonic acid derivative.
Abstract:
A glycerin derivative having the following formula (I) or (I') and a pharmacologically acceptable salt thereof are useful to treat diseases caused by the platelet activating factor. ##STR1##
Abstract:
A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to treat allergic diseases: ##STR1## in which R1 and R2 are hydrogen or an alkyl, R3 is hydrogen or a halogen, R4 is hydrogen or an alkyl, X is --OCO--, --NHCO--, --CO-- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.
Abstract:
An aminobenzoic acid derivative represented by the following general formulas (I), (I-2) or (I-3), or a pharmacologically acceptable salt thereof, which exhibits a serotonin antagonism and an acetylcholine release accelerating activity at a well-balanced activity ratio and which is efficacious as a drug for patients with gastrointestinal unindentified complaints: ##STR1## wherein R.sup.1 represents a group such as an alkynyl or cyanoalkyl group; R.sup.2 represents a group such as an amino or acylamino group;R.sup.3 represents a halogen atom;X represents --O-- or --NH--; andA represents an oxygen or sulfur atom.
Abstract:
In the continuously hot rolling of plural sheet bars, in order to simply and surely join the sheet bars to the back end portion of the preceding sheet bar and the front end portion of the succeeding sheet bar are prejoined by butting to each other at an entrance side of a finish rolling mill and then bitten into the finish rolling mill, during which the joining of the sheet bars are promoted to conduct the continuous rolling.
Abstract:
A glycerin derivative having the following formula (I) or (I') and a pharmacologically acceptable salt thereof are useful to treat diseases caused by the platelet activating factor. ##STR1##
Abstract:
A process for producing a high resilience polyurethane foam by reacting a polyol with a polyisocyanate in the presence of a catalyst, a blowing agent, and a foam stabilizer; said polyisocyanate containing at least diphenylmethane diisocyanate and/or a mixture of diphenylmethane diisocyanate with a derivative thereof, the blowing agent being water, or water and a halogenated hydrocarbon in amounts of not less than 2 parts by weight of water and not more than 20 parts by weight of the halogenated hydrocarbon based on 100 parts by weight of the polyol, and the catalyst being at least one selected from the compounds represented by the formula (I) below: ##STR1## where R.sup.1 is alkyl having 1 to 4 carbons, dimethylaminopropyl, benzyl, vinyl, or hydroxyalkyl having 1 to 3 carbons; R.sup.2 is hydrogen, alkyl having 1 to 4 carbons, alkyl, benzyl or phenyl; and R.sup.3 and R.sup.4 are independently hydrogen, alkyl having 1 to 4 carbons, or hydroxymethyl.