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    System and method for assessing cardiac performance through transcardiac impedance monitoring
    11.
    发明授权
    System and method for assessing cardiac performance through transcardiac impedance monitoring 有权
    通过心跳阻抗监测评估心脏性能的系统和方法

    公开(公告)号：US07488290B1

    公开(公告)日：2009-02-10

    申请号：US10782642

    申请日：2004-02-19

    Applicant: Jeffrey E. Stahmann ,  Donald L. Hopper ,  Veerichetty Kadhiresan ,  John D. Hatlestad

    Inventor： Jeffrey E. Stahmann ,  Donald L. Hopper ,  Veerichetty Kadhiresan ,  John D. Hatlestad

    IPC: A61B5/00

    CPC classification number: A61B7/00 ,  A61B5/021

    Abstract: A system and method for assessing cardiac performance through transcardiac impedance monitoring is described. Intracardiac impedance measures are directly collected through an implantable medical device. The intracardiac impedance measures are correlated to cardiac dimensional measures relative to performance of an intrathoracic pressure maneuver. The cardiac dimensional measures are grouped into at least one measures set corresponding to a temporal phase of the intrathoracic pressure maneuver. The at least one cardiac dimensional measures set is evaluated against a cardiac dimensional trend for the corresponding intrathoracic pressure maneuver temporal phase to represent cardiac performance.

    Abstract translation: 描述了通过心跳阻抗监测来评估心脏性能的系统和方法。 通过植入式医疗设备直接收集心内阻塞措施。 心内阻抗测量与胸腔内压力操作性能相关的心脏尺寸测量值相关。 心脏尺寸测量被分组为对应于胸内压力操纵的时间相位的至少一个测量组。 针对相应的胸内压力机动时间阶段的心脏尺寸趋势来评估至少一个心脏尺寸测量集合以表示心脏性能。

    CHRONICALLY IMPLANTED ABDOMINAL PRESSURE SENSOR FOR CONTINUOUS AMBULATORY ASSESSMENT OF RENAL FUNCTIONS
    14.
    发明申请
    CHRONICALLY IMPLANTED ABDOMINAL PRESSURE SENSOR FOR CONTINUOUS AMBULATORY ASSESSMENT OF RENAL FUNCTIONS 审中-公开
    用于连续评估肾功能的CHRONICALLAL IMPADAL ABDOMINAL PRESSURE传感器

    公开(公告)号：US20130144174A1

    公开(公告)日：2013-06-06

    申请号：US13674639

    申请日：2012-11-12

    Applicant: John D. Hatlestad ,  Binh C Tran ,  Bin Mi ,  Ronald W. Heil, Jr.

    Inventor： John D. Hatlestad ,  Binh C Tran ,  Bin Mi ,  Ronald W. Heil, Jr.

    IPC: A61B5/0205 ,  A61B5/03 ,  A61B5/20

    CPC classification number: A61B5/0205 ,  A61B5/0028 ,  A61B5/0031 ,  A61B5/03 ,  A61B5/036 ,  A61B5/201 ,  A61B5/416 ,  A61B5/6846

    Abstract: An implantable system for ambulatory monitoring of a high-risk heart failure patient includes a first pressure sensor implantable within an abdomen of the patient for sensing and generating an output representative of a baseline intra-abdominal pressure value of the patient and for chronically sensing and generating an output representative of an intra-abdominal pressure value of the patient at periodic intervals. At least one second implantable sensor is provided for sensing and generating an output representative of a second physiological parameter of the patient. Additionally, the system includes a processor for correlating the output of the first pressure sensor and the second physiologic sensor, and for comparing differences between the baseline intra-abdominal pressure value and subsequent intra-abdominal pressure values. The processor can reside in another implantable device or in an external device/system.

    Abstract translation: 用于高风险心力衰竭患者的动态监测的可植入系统包括可植入患者腹部的第一压力传感器，用于感测和产生代表患者的基线腹内压力值的输出，并且用于长期感测和产生 以周期性间隔代表患者的腹内压力值的输出。 提供至少一个第二可植入传感器用于感测和产生代表患者的第二生理参数的输出。 另外，该系统包括用于将第一压力传感器和第二生理传感器的输出相关联并且用于比较基线腹内压力值和随后的腹内压力值之间的差异的处理器。 处理器可以驻留在另一个可植入设备中或外部设备/系统中。

    Medical event logbook system and method
    15.
    发明授权
    Medical event logbook system and method 有权
    医疗事件日志系统和方法

    公开(公告)号：US08323204B2

    公开(公告)日：2012-12-04

    申请号：US12403880

    申请日：2009-03-13

    Applicant: Jeffrey E. Stahmann ,  John D. Hatlestad ,  Jesse W. Hartley ,  Quan Ni ,  Kent Lee

    Inventor： Jeffrey E. Stahmann ,  John D. Hatlestad ,  Jesse W. Hartley ,  Quan Ni ,  Kent Lee

    IPC: A61B5/08 ,  A61B5/02

    CPC classification number: A61B5/0803 ,  A61B5/02405 ,  A61N1/3601

    Abstract: An event-based approach to collecting and organizing information associated with events affecting respiration is presented. The detection or prediction of an event affecting the respiration of a patient initiates acquisition of information associated with the event. The respiratory logbook system acquires information associated with the event during the event and during intervals proximate in time to the event. The information is organized as a respiratory log entry. The user can access the information by operating a user interface. The information may be presented in textual or graphical form.

    Abstract translation: 提出了一种基于事件的方法来收集和组织与影响呼吸的事件相关的信息。 影响患者呼吸的事件的检测或预测启动与事件相关联的信息的获取。 呼吸记录系统在事件期间以及在时间上接近事件的间隔期间获取与事件相关联的信息。 信息被组织为呼吸日志条目。 用户可以通过操作用户界面访问信息。 信息可以以文本或图形形式呈现。

    Physiological event detection systems and methods
    17.
    发明授权
    Physiological event detection systems and methods 有权
    生理事件检测系统和方法

    公开(公告)号：US08257271B2

    公开(公告)日：2012-09-04

    申请号：US12776557

    申请日：2010-05-10

    Applicant: Krzysztof Z. Siejko ,  John D. Hatlestad

    Inventor： Krzysztof Z. Siejko ,  John D. Hatlestad

    IPC: A61B5/04

    CPC classification number: A61B5/00 ,  A61B5/053 ,  A61B5/746 ,  A61B7/023 ,  A61N1/3627 ,  A61N1/36514

    Abstract: Systems and methods using constant false alarm rate techniques for event detection. One example of an event detection method includes collecting a first distribution of measurements for a first physiological parameter. In another example, the first distribution of measurements includes only non-event measurements. One or more values are determined corresponding to at least a first tail area of the first distribution from at least one measurement of the first physiological parameter toward an end point of the distribution. A threshold is established based on a specified false alarm rate. The one or more values are compared to the threshold. The method includes determining if the measurement is representative of a detected event using the comparison.

    Abstract translation: 用于事件检测的常数误报率技术的系统和方法。 事件检测方法的一个示例包括收集第一生理参数的测量的第一分布。 在另一示例中，测量的第一分布仅包括非事件测量。 从第一生理参数的至少一个测量到分布的终点，确定对应于第一分布的至少第一尾区的一个或多个值。 基于指定的虚警率建立阈值。 将一个或多个值与阈值进行比较。 该方法包括使用比较来确定测量是否表示检测到的事件。

    SYSTEMS AND METHODS FOR USING ELECTRICAL IMPEDANCE FOR NEURO CARDIAC THERAPY
    18.
    发明申请
    SYSTEMS AND METHODS FOR USING ELECTRICAL IMPEDANCE FOR NEURO CARDIAC THERAPY 有权
    用于神经心脏治疗的电阻抗系统和方法

    公开(公告)号：US20120172742A1

    公开(公告)日：2012-07-05

    申请号：US13309320

    申请日：2011-12-01

    Applicant: Shantha Arcot-Krishnamurthy ,  Yi Zhang ,  John D. Hatlestad

    Inventor： Shantha Arcot-Krishnamurthy ,  Yi Zhang ,  John D. Hatlestad

    IPC: A61N1/372 ,  A61B5/085 ,  A61N1/365

    CPC classification number: A61N1/36053 ,  A61B5/0538 ,  A61N1/36117 ,  A61N1/36135 ,  A61N1/36521

    Abstract: A device embodiment is configured to deliver vagal stimulation therapy (VST) to a vagus nerve of a patient. The device embodiment includes a neural stimulator, an implantable impedance sensor and an impedance analyzer. The neural stimulator is configured to deliver the VST to the vagus nerve in a cervical region of the patient. The implantable impedance sensor is configured to detect impedance changes in a cervical region of the patient caused by laryngeal vibrations. The impedance sensor is configured to generate sensed impedance values. The impedance analyzer is configured to analyze the sensed impedance values generated by the sensor. The analyzer is configured to detect laryngeal vibrations or cough from the sensed impedance values.

    Abstract translation: 设备实施例被配置为将迷走神经刺激治疗（VST）递送到患者的迷走神经。 装置实施例包括神经刺激器，可植入阻抗传感器和阻抗分析器。 神经刺激器被配置成将VST输送到患者的颈部区域中的迷走神经。 可植入阻抗传感器被配置为检测由喉部振动引起的患者的颈部区域中的阻抗变化。 阻抗传感器被配置为产生感测的阻抗值。 阻抗分析器被配置为分析由传感器产生的感测阻抗值。 分析器被配置为检测来自感测的阻抗值的喉部振动或咳嗽。

    PHYSIOLOGIC RESPONSE TO POSTURE
    19.
    发明申请
    PHYSIOLOGIC RESPONSE TO POSTURE 审中-公开
    生理反应

    公开(公告)号：US20120157798A1

    公开(公告)日：2012-06-21

    申请号：US13325354

    申请日：2011-12-14

    Applicant: Viktoria A. Averina ,  John D. Hatlestad ,  Abhilash Patangay ,  Pramodsingh Hirasingh Thakur ,  Yi Zhang ,  Kenneth C. Beck

    Inventor： Viktoria A. Averina ,  John D. Hatlestad ,  Abhilash Patangay ,  Pramodsingh Hirasingh Thakur ,  Yi Zhang ,  Kenneth C. Beck

    IPC: A61B5/11 ,  A61B5/08 ,  A61B5/053 ,  A61B5/00 ,  A61B5/0205

    CPC classification number: A61N1/36542 ,  A61B5/0205 ,  A61B5/0538 ,  A61B5/0809 ,  A61B5/1116 ,  A61B5/686 ,  A61B5/6869 ,  A61B7/04

    Abstract: An implantable or other ambulatory medical apparatus comprises a posture sensing circuit, a physiologic sensing circuit that senses a time varying physiologic signal, and a processor circuit. The processor circuit includes a posture calculation circuit and a measurement circuit. The posture calculation circuit determines a posture of the subject using posture data obtained using the posture signal and determines when the posture of the subject is steady state. The measurement circuit derives a physiologic measurement using physiologic data extracted from the physiologic signal during at least one time period when posture is determined to be steady state and provides the physiologic measurement to at least one of a user and a process in association with the determined steady state posture.

    Abstract translation: 植入式或其他动态医疗装置包括姿势感测电路，感测时变生理信号的生理感测电路和处理器电路。 处理器电路包括姿势计算电路和测量电路。 姿势计算电路使用姿势信号获得的姿势数据来确定对象的姿势，并且确定被摄体的姿势何时处于稳定状态。 测量电路使用在至少一个时间段内从生理信号中提取的生理数据进行生理测量，当姿势被确定为稳态时，并且将生理测量结果与所确定的稳定性相关联地向用户和过程中的至少一个提供生理测量 状态。

    Sleep state detection
    20.
    发明授权
    Sleep state detection 有权
    睡眠状态检测

    公开(公告)号：US08083682B2

    公开(公告)日：2011-12-27

    申请号：US11458602

    申请日：2006-07-19

    Applicant: Yousufali Dalal ,  Yachuan Pu ,  John D. Hatlestad

    Inventor： Yousufali Dalal ,  Yachuan Pu ,  John D. Hatlestad

    IPC: A61B5/08 ,  A61B5/02

    CPC classification number: A61B5/0205 ,  A61B5/0816 ,  A61B5/4809 ,  A61B5/4812 ,  A61B5/4818 ,  G06F19/00

    Abstract: This document discusses, among other things, systems and methods for determining sleep state, such as awake, sleeping, non-REM sleep, or REM sleep. Respiration and heart contractions are monitored. A cardio-respiratory ratio such as beats per breath is computed and used in the sleep state determination. Other information, such as heart rate variability (HRV), posture, and activity level can also be used in the sleep state determination. The sleep state information can be used to qualify or trigger storage of other physiological sensor data, or to permit remote sleep study monitoring of a subject, or to control or adjust one or more monitoring, diagnostic, or therapy algorithms, such as, for example a continuous positive airflow pressure (CPAP) device.

    Abstract translation: 本文件还讨论了用于确定睡眠状态的系统和方法，例如清醒，睡眠，非REM睡眠或REM睡眠。 监测呼吸和心脏收缩。 在睡眠状态确定中计算并使用诸如每次呼吸的心跳呼吸比例。 其他信息，例如心率变异性（HRV），姿势和活动水平也可用于睡眠状态确定。 休眠状态信息可用于限定或触发其他生理传感器数据的存储，或允许对对象进行远程睡眠研究监视，或者控制或调整一个或多个监视，诊断或治疗算法，例如 连续正气流压力（CPAP）装置。

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