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    Ligand-accelerated catalytic asymmetric dihydroxylation
    12.
    发明授权
    Ligand-accelerated catalytic asymmetric dihydroxylation 失效
    配体加速催化不对称二羟基化

    公开(公告)号：US4965364A

    公开(公告)日：1990-10-23

    申请号：US250378

    申请日：1988-09-28

    Applicant: Istvan E. Marko ,  K. Barry Sharpless

    Inventor： Istvan E. Marko ,  K. Barry Sharpless

    IPC: C07C29/48

    CPC classification number: C07C29/48 ,  C07B2200/07 ,  C07C2101/14 ,  C07C2101/18

    Abstract: An osmium-catalyzed method of addition to an olefin. In the method of asymmetric dihydroxylation of the present invention, an olefin, a chiral ligand, an organic solvent, water, an amine oxide an osmium-containing compound and, optionally a tetraalkyl ammonium compound are combined. In the method of asymmetric oxyamination of the present invention, an olefin, a chiral ligand, an organic solvent, water, an amine derivative, an osmium-containing compound and, optionally, a tetraalkyl ammonium compound are combined. In the method of asymmetric diamination of the present invention, an olefin, a chiral ligand, an organic solvent, a metallo-chloramine derivative or an amine derivative and an osmium-containing compound are combined. In one embodiment, an olefin, a chiral ligand which is a dihydroquinidine derivative or a dihydroquinine derivative, acetone, water, N-methyl morpholine N-oxide and osmium tetroxide are combined to effect asymmetric dihydroxylation of the olefin.

    Abstract translation: 一种加入烯烃的锇催化方法。 在本发明的不对称二羟基化方法中，合并烯烃，手性配体，有机溶剂，水，氧化胺，含锇化合物和任选的四烷基铵化合物。 在本发明的不对称氧化法的方法中，合并烯烃，手性配体，有机溶剂，水，胺衍生物，含锇化合物和任选的四烷基铵化合物。 在本发明的不对称二氨基化方法中，合并烯烃，手性配体，有机溶剂，金属氯胺衍生物或胺衍生物和含锇化合物。 在一个实施方案中，将烯烃，二氢奎尼丁衍生物或二氢喹啉衍生物的手性配体，丙酮，水，N-甲基吗啉N-氧化物和四氧化锇组合以实现烯烃的不对称二羟基化。

    Copper-catalysed ligation of azides and acetylenes
    14.
    发明授权
    Copper-catalysed ligation of azides and acetylenes 有权
    铜催化的叠氮化物和乙炔的连接

    公开(公告)号：US08129542B2

    公开(公告)日：2012-03-06

    申请号：US12804644

    申请日：2010-07-26

    Applicant: K. Barry Sharpless ,  Valery Fokin ,  Vsevold V. Rostovtsev ,  Luke Green ,  Fahmi Himo

    Inventor： K. Barry Sharpless ,  Valery Fokin ,  Vsevold V. Rostovtsev ,  Luke Green ,  Fahmi Himo

    IPC: C07D249/04

    CPC classification number: C07D249/04 ,  B01J31/1805 ,  B01J2231/327 ,  B01J2531/16 ,  B01J2531/96 ,  C07D249/06 ,  C07D403/06

    Abstract: A copper catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to provide 1,4-disubstituted 1,2,3-triazole triazoles. The process comprises contacting an organic azide and a terminal alkyne with a source of reactive Cu(I) ion for a time sufficient to form by cycloaddition a 1,4-disubstituted 1,2,3-triazole. The source of reactive Cu(I) ion can be, for example, a Cu(I) salt or copper metal. The process is preferably carried out in a solvent, such as an aqueous alcohol. Optionally, the process can be performed in a solvent that comprises a ligand for Cu(I) and an amine.

    Abstract translation: 使用铜催化的点击化学连接方法结合叠氮化物和末端炔烃以提供1,4-二取代的1,2,3-三唑三唑。 该方法包括使有机叠氮化物和末端炔与活性Cu（I）离子源接触一段时间，足以通过环加成1,4-二取代的1,2,3-三唑形成。 反应性Cu（I）离子的来源可以是例如Cu（I）盐或铜金属。 该方法优选在溶剂如乙醇中进行。 任选地，该方法可以在包含Cu（I）和胺的配体的溶剂中进行。

    Method of using click chemistry to functionalize dendrimers
    15.
    发明申请
    Method of using click chemistry to functionalize dendrimers 审中-公开
    使用点击化学功能化树枝状大分子的方法

    公开(公告)号：US20090306310A1

    公开(公告)日：2009-12-10

    申请号：US11989073

    申请日：2006-07-18

    Applicant: Peng Wu ,  Valery Fokin ,  K. Barry Sharpless

    Inventor： Peng Wu ,  Valery Fokin ,  K. Barry Sharpless

    IPC: C08F291/06 ,  C08G65/00

    CPC classification number: C07D249/04 ,  Y02P20/55

    Abstract: A library of functionalized dendritic macromolecules was prepared in extremely high yields using no protecting group strategies and with only minimal purification steps through the use of copper(I)-catalyzed 1,3-dipolar cycloaddition of azides and terminal acetylenes.

    Abstract translation: 通过使用铜（I）催化的叠氮化物和末端炔烃的1,3-偶极环加成，仅使用最小的纯化步骤，以非常高的产率制备了官能化的树枝状大分子的文库。

    Aminohydroxylation of olefins with tert-alkyl sulfonamides
    16.
    发明授权
    Aminohydroxylation of olefins with tert-alkyl sulfonamides 有权
    烯烃与叔烷基磺酰胺的氨基羟基化反应

    公开(公告)号：US06008376A

    公开(公告)日：1999-12-28

    申请号：US138303

    申请日：1998-08-21

    Applicant: K. Barry Sharpless ,  Alexander V. Gontcharov ,  Hong Liu

    Inventor： K. Barry Sharpless ,  Alexander V. Gontcharov ,  Hong Liu

    IPC: C07D203/24 ,  C07D203/26

    CPC classification number: C07D203/24 ,  C07D203/26

    Abstract: Tert-alkyl sulfonamides chloramine salts are used as nitrogen sources in the catalytic aminohydroxylation and/or aziridination of olefins. The tert-alkyl sulfonamides chloramine salts are close to Chloramine T with respect to their reactivity as nitrogen sources with olefins. However, unlike the tosyl sulfonyl amine group of Chloramine T, the resulting t-alkyl sulfonylamino functionalities can be easily converted to an unprotected amine under mild acidic conditions making the method a simple and cost efficient approach for producing unsubstituted hydroxy amine and/or aziridine products.

    Abstract translation: 叔烷基磺酰胺氯胺盐在烯烃的催化氨基羟基化和/或氮丙啶化中用作氮源。 叔烷基磺酰胺氯胺盐相对于作为氮源与烯烃的反应性接近氯胺。 然而，与氯胺T的甲苯磺酰基磺酰胺不同，所得的叔烷基磺酰基氨基官能团可以在温和的酸性条件下容易地转化为未保护的胺，使得该方法成为制备未取代的羟基胺和/或氮丙啶产物的简单和成本有效的方法 。

    Aziridination of olefins
    17.
    发明授权
    Aziridination of olefins 失效
    烯烃的氮丙啶化

    公开(公告)号：US5929252A

    公开(公告)日：1999-07-27

    申请号：US97845

    申请日：1998-06-15

    Applicant: K. Barry Sharpless ,  Jae Uk Jeong

    Inventor： K. Barry Sharpless ,  Jae Uk Jeong

    IPC: C07D203/02 ,  C07D203/24 ,  C07D203/08

    CPC classification number: C07D203/02 ,  C07D203/24

    Abstract: A method for the direct aziridination of olefins as well as a wide range of allylic alcohols employs phenyltrimethylammonium tribromide (PTAB) as a general and effective catalyst and N-sodio-N-chloro sulfonamides, chloramine salts, as the nitrogen source.

    Abstract translation: 烯烃的直接氮丙烯化方法以及宽范围的烯丙基醇的方法使用苯基三甲基三溴化铵（PTAB）作为一般和有效的催化剂和N-苏氨基-N-氯磺酰胺，氯胺盐作为氮源。

    Methods for catalytic asymmetric dihydroxylation of olefins
    19.
    发明授权
    Methods for catalytic asymmetric dihydroxylation of olefins 失效
    烯烃催化不对称二羟基化的方法

    公开(公告)号：US5126494A

    公开(公告)日：1992-06-30

    申请号：US512934

    申请日：1990-04-23

    Applicant: Declan Gilheany ,  Byeong M. Kim ,  Hoi-Lun Kwong ,  K. Barry Sharpless ,  Tomoyuki Shibata

    Inventor： Declan Gilheany ,  Byeong M. Kim ,  Hoi-Lun Kwong ,  K. Barry Sharpless ,  Tomoyuki Shibata

    IPC: C07D453/04 ,  C07B61/00 ,  C07C29/03 ,  C07C29/04 ,  C07C29/48 ,  C07C31/20 ,  C07C31/27 ,  C07C31/42 ,  C07C33/46 ,  C07C35/14 ,  C07C35/21 ,  C07C67/29 ,  C07C69/157 ,  C07C69/675 ,  C07D453/02

    CPC classification number: C07C29/48 ,  C07D453/02 ,  C07B2200/07 ,  C07C2101/18

    Abstract: Osmium-catalyzed methods of addition to an olefin are discussed. In the method of asymmetric dihydroxylation of the present invention, an olefin, a chiral ligand, an organic solvent, water, an oxidant and an osmium-containing compound are combined. In the method of asymmetric oxyamination of the present invention, an olefin, a chiral ligand, an organic solvent, water, a metallo-chloramine derivative, an osmium-containing compound and, optionally, a tetraalkyl ammonium compound are combined. In the method of asymmetric diamination of the present invention, an olefin, a chiral ligand, an organic solvent, a metallo-chloramine derivative, an amine and an osmium-containing compound are combined. In one embodiment, an olefin, a chiral ligand which is a polymeric dihydroquinidine derivative or a dihydroquinine derivative, acetone, water, a base, an oxidant and osmium tetroxide are combined to effect asymmetric dihydroxylation of the olefin.

    Abstract translation: 讨论了添加到烯烃中的锇催化方法。 在本发明的不对称二羟基化方法中，合并烯烃，手性配体，有机溶剂，水，氧化剂和含锇化合物。 在本发明的不对称氧化法的方法中，合并烯烃，手性配体，有机溶剂，水，金属氯胺衍生物，含锇化合物和任选的四烷基铵化合物。 在本发明的不对称二氨基化方法中，合并烯烃，手性配体，有机溶剂，金属氯胺衍生物，胺和含锇化合物。 在一个实施方案中，将烯烃，作为聚合二氢奎尼丁衍生物或二氢喹啉衍生物的手性配体，丙酮，水，碱，氧化剂和四氧化锇组合以实现烯烃的不对称二羟基化。

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