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公开(公告)号:US20100032555A1
公开(公告)日:2010-02-11
申请号:US12442325
申请日:2007-09-20
Applicant: Michael MacDonald , Kishan Dholakia , Daniel Rhodes , Graham Milne
Inventor: Michael MacDonald , Kishan Dholakia , Daniel Rhodes , Graham Milne
IPC: G01N30/00
CPC classification number: G01N15/0205 , G01N1/40 , G01N2015/149 , G02B21/32
Abstract: A method for sorting particles in a fluid. The method involves generating an optical landscape using an acousto-optic device. Preferably, the optical landscape is arranged to sort particles based on size or refractive index or shape.
Abstract translation: 用于分选流体中的颗粒的方法。 该方法涉及使用声光装置产生光学景观。 优选地,光学景观布置成基于尺寸或折射率或形状对颗粒进行分类。
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公开(公告)号:US20080279558A1
公开(公告)日:2008-11-13
申请号:US12036975
申请日:2008-02-25
Applicant: Barbara A. Capron , William A. McNeely , Kishan Dholakia , Antonia Erika Carruthers
Inventor: Barbara A. Capron , William A. McNeely , Kishan Dholakia , Antonia Erika Carruthers
IPC: H04B10/00
CPC classification number: H04B10/112
Abstract: A method and apparatus for clearing an optical channel for transmitting data through free space between a first and second location includes a light beam, wherein the light beam has a spatially and/or time-dependent modulated intensity profile, and is substantially collimated so that the intensity profile is conserved over a specified distance of operation. The light beam includes a cross-sectional profile having regions of low and high intensity, portions of which are provided for the transmission of an optical data signal. A light source wavelength and intensity are selected for types of obscurant particles having optical properties whereby the radiation pressure acts on the particles, and the particles may then be either attracted into or repelled from portions of the spatially modulated optical beam, leaving certain portions of the optical channel beam absent of obscurant particles, thereby enabling transmission of optical data through the cleared optical channel with low attenuation.
Abstract translation: 用于清除用于通过第一和第二位置之间的自由空间传输数据的光信道的方法和装置包括光束,其中光束具有空间和/或时间依赖的调制强度分布,并且基本准直,使得 强度分布在指定的操作距离内保存。 光束包括具有低强度和高强度区域的横截面轮廓,其部分设置用于传输光学数据信号。 对于具有光学特性的不透明粒子的类型,选择光源波长和强度,由此辐射压力作用在颗粒上,然后可以将颗粒从空间调制的光束的部分吸引或排斥,留下某些部分的 光通道光束不存在晦暗的颗粒,从而能够以低衰减通过清除光信道传输光学数据。
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公开(公告)号:US07173711B2
公开(公告)日:2007-02-06
申请号:US10451576
申请日:2001-12-18
Applicant: Kishan Dholakia , Michael Peter Macdonald , Jochen Arlt
Inventor: Kishan Dholakia , Michael Peter Macdonald , Jochen Arlt
IPC: G01B9/02
Abstract: Apparatus for and a method of rotating microscopic objects uses a beam of electromagnetic radiation. A microscopic, non-circularly symmetric distribution of electro-magnetic radiation is projected on to a region containing an object to be rotated so as to cause photons in the beam to refract around the objects. Rotating means then rotate that distribution and so rotate the objects. The distribution may be formed on the interference pattern between a beam having a Laguerre-Gaussian wave fronts and either a plane wave or a further Laguerre-Gaussian beam of opposite helicity.
Abstract translation: 用于旋转微观物体的装置和方法使用电磁辐射束。 将电磁辐射的微观非圆对称分布投影到包含要旋转的物体的区域上,以使光束中的光子折射到物体周围。 然后,旋转装置旋转该分布并因此旋转物体。 该分布可以形成在具有拉格尔 - 高斯波阵面的波束和具有相反螺旋度的平面波或另一拉格尔 - 高斯波束之间的干涉图案上。
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公开(公告)号:US10222362B2
公开(公告)日:2019-03-05
申请号:US14861570
申请日:2015-09-22
Applicant: Praveen Cheriyan Ashok , Gajendra Pratap Singh , Kishan Dholakia
Inventor: Praveen Cheriyan Ashok , Gajendra Pratap Singh , Kishan Dholakia
Abstract: A Raman spectroscopic detection device comprising at least one microfluidic sample channel; at least one excitation waveguide for exciting a Raman signal and at least one collection waveguide for collecting a Raman signal. The output of the excitation waveguide and the input of the collection waveguide are positioned directly in the microfluidic sample channel.
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公开(公告)号:US09957476B2
公开(公告)日:2018-05-01
申请号:US13639296
申请日:2011-04-11
Applicant: Frank Gunn-Moore , Kishan Dholakia , Yoshihiko Arita
Inventor: Frank Gunn-Moore , Kishan Dholakia , Yoshihiko Arita
CPC classification number: C12N5/0006 , C12M35/02 , C12N15/87
Abstract: A method for porating one or more cells comprising positioning a particle near each cell; and causing laser-induced breakdown of the particle to create one or more cavitations, wherein the cavitation(s) causes poration of the cell.
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公开(公告)号:US09815058B2
公开(公告)日:2017-11-14
申请号:US10554937
申请日:2004-05-07
Applicant: Michael Peter MacDonald , Kishan Dholakia , Steven Leonard Neale , Gabriel Cooper Spalding
Inventor: Michael Peter MacDonald , Kishan Dholakia , Steven Leonard Neale , Gabriel Cooper Spalding
CPC classification number: B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2300/0864 , B01L2400/0454 , G01N15/1434 , G01N15/1459 , G01N2015/145 , G01N2015/149 , G01N30/02 , B01D2015/3895
Abstract: A fractionation system comprising means for forming a three dimensional optical lattice that is operable to separate particles that have different physical characteristics. Preferably, the wells of the optical lattice are interlinked. For example, the wells may be linked in such a manner as to provide deflection greater than or equal to 15 degrees.
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公开(公告)号:US20130173194A1
公开(公告)日:2013-07-04
申请号:US13640453
申请日:2011-04-13
Applicant: Kishan Dholakia , Jorg Baumgartl , Michael Mazilu , Anna Chiara De Luca
Inventor: Kishan Dholakia , Jorg Baumgartl , Michael Mazilu , Anna Chiara De Luca
IPC: G06F17/11
CPC classification number: G02B27/58 , G02B2207/125
Abstract: A method of optimising at least one measure that is a quadratic function of a wavefunction, such as the spot size of a laser, the method comprising: superimposing a plurality of wavefunctions; determining a relationship between the superimposed wavefunctions and the quadratic measure, and using the determined relationship to identify the superimposed wavefunctions that provide a desired or optimised quadratic measure.
Abstract translation: 一种优化作为波函数的二次函数的至少一个度量的方法,例如激光器的光斑尺寸,该方法包括:叠加多个波函数; 确定叠加的波函数和二次测量之间的关系,并且使用确定的关系来识别提供期望或优化的二次方法的叠加波函数。
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公开(公告)号:US20130113140A1
公开(公告)日:2013-05-09
申请号:US13639296
申请日:2011-04-11
Applicant: Frank Gunn-Moore , Kishan Dholakia , Yoshihiko Arita
Inventor: Frank Gunn-Moore , Kishan Dholakia , Yoshihiko Arita
IPC: C12N5/00
CPC classification number: C12N5/0006 , C12M35/02 , C12N15/87
Abstract: A method for porating one or more cells comprising positioning a particle near each cell; and causing laser-induced breakdown of the particle to create one or more cavitations, wherein the cavitation(s) causes poration of the cell.
Abstract translation: 一种用于对一个或多个单元进行加工的方法,包括将颗粒定位在每个单元附近; 并引起激光诱发的颗粒破坏以产生一个或多个空化,其中空化引起细胞的扩孔。
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公开(公告)号:US08139944B2
公开(公告)日:2012-03-20
申请号:US12036975
申请日:2008-02-25
Applicant: Barbara A Capron , William A McNeely , Kishan Dholakia , Antonia Erika Carruthers
Inventor: Barbara A Capron , William A McNeely , Kishan Dholakia , Antonia Erika Carruthers
CPC classification number: H04B10/112
Abstract: A method and apparatus for clearing an optical channel for transmitting data through free space between a first and second location includes a light beam, wherein the light beam has a spatially and/or time-dependent modulated intensity profile, and is substantially collimated so that the intensity profile is conserved over a specified distance of operation. The light beam includes a cross-sectional profile having regions of low and high intensity, portions of which are provided for the transmission of an optical data signal. A light source wavelength and intensity are selected for types of obscurant particles having optical properties whereby the radiation pressure acts on the particles, and the particles may then be either attracted into or repelled from portions of the spatially modulated optical beam, leaving certain portions of the optical channel beam absent of obscurant particles, thereby enabling transmission of optical data through the cleared optical channel with low attenuation.
Abstract translation: 用于清除用于通过第一和第二位置之间的自由空间传输数据的光信道的方法和装置包括光束,其中光束具有空间和/或时间依赖的调制强度分布,并且基本准直,使得 强度分布在指定的操作距离内保存。 光束包括具有低强度和高强度区域的横截面轮廓,其部分设置用于传输光学数据信号。 对于具有光学特性的不透明粒子的类型,选择光源波长和强度,由此辐射压力作用在颗粒上,然后可以将颗粒从空间调制的光束的部分吸引或排斥,留下某些部分的 光通道光束不存在晦暗的颗粒,从而能够以低衰减通过清除光信道传输光学数据。
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公开(公告)号:US08080399B2
公开(公告)日:2011-12-20
申请号:US11720488
申请日:2005-11-29
Applicant: Kishan Dholakia , Christian Thomas Alcuin Brown , Lynn Paterson
Inventor: Kishan Dholakia , Christian Thomas Alcuin Brown , Lynn Paterson
IPC: C12N13/00
Abstract: An opening is formed in a cell using laser radiation. A Bessel beam is formed using the laser radiation and the Bessel beam is directed onto the cell to form an opening. The guiding of material towards the opening may be involved using optical trapping/manipulation. The material may change cellular function or analyse cell behaviour. Both pulsed laser radiation and continuous wave radiation may be formed using the same laser.
Abstract translation: 在使用激光辐射的电池中形成开口。 使用激光辐射形成贝塞尔光束,并且贝塞尔光束被引导到细胞上以形成开口。 材料向开口的引导可能涉及使用光学捕获/操纵。 该物质可能改变细胞功能或分析细胞行为。 可以使用相同的激光器来形成脉冲激光辐射和连续波辐射。
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