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公开(公告)号：US20120156160A1
公开(公告)日：2012-06-21
申请号：US13328381
申请日：2011-12-16
Applicant: Robert DiCosimo , Mark Scott Payne , John Edward Gavagan
Inventor： Robert DiCosimo , Mark Scott Payne , John Edward Gavagan
IPC: A61L9/01 , C12N9/16 , C12N1/21 , D21H21/32 , A61K31/22 , C07H21/04 , D06L3/00 , C12P7/40 , C12N15/63
CPC classification number: A61L2/186 , A61L2/22 , A61L2/23 , A61L2202/24 , C12N9/18 , C12Y301/01072
Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
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公开(公告)号：US20120156155A1
公开(公告)日：2012-06-21
申请号：US13328305
申请日：2011-12-16
Applicant: Robert Dicosimo , Mark Scott Payne , John Edward Gavagan
Inventor： Robert Dicosimo , Mark Scott Payne , John Edward Gavagan
IPC: C12N9/18 , C12N15/63 , C12N1/15 , C12N1/19 , C12N1/21 , D06L3/02 , A01N37/16 , A01P1/00 , A61L2/16 , C12M1/40 , D21C9/16 , C12N15/55 , C12P7/40
CPC classification number: C11D3/3945 , C12N9/18 , C12P7/40 , C12P7/54 , C12Y301/01072 , D21C5/005 , D21C9/166
Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
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公开(公告)号：US08188205B2
公开(公告)日：2012-05-29
申请号：US12277667
申请日：2008-11-25
Applicant: David Richard Corbin , Robert DiCosimo , Neville Everton Drysdale , Hari Babu Sunkara
Inventor： David Richard Corbin , Robert DiCosimo , Neville Everton Drysdale , Hari Babu Sunkara
IPC: C08F18/24
CPC classification number: C08G64/30 , C08G64/0208
Abstract: The present invention relates to the use of hydrotalcites as catalysts for the polymerization of unsubstituted or substituted trimethylene carbonate.
Abstract translation: 本发明涉及水滑石作为未取代或取代的三亚甲基碳酸酯聚合的催化剂的用途。
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公开(公告)号：US08168676B2
公开(公告)日：2012-05-01
申请号：US12722288
申请日：2010-03-11
Applicant: Robert Dicosimo , John Edward Gavagan , Mark Scott Payne , Frederick B. Cooling, III
Inventor： Robert Dicosimo , John Edward Gavagan , Mark Scott Payne , Frederick B. Cooling, III
CPC classification number: A01N37/02 , A01N37/16 , A01N37/36 , A01N59/00 , A61L2/186 , C12P7/40 , C12P7/62 , A01N63/02 , A01N2300/00
Abstract: A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. The present perhydrolase catalysts are classified as members of the carbohydrate esterase family 7 (CE-7) based on the conserved structural features. Further, disinfectant formulations comprising the peracids produced by the processes described herein are provided.
Abstract translation: 提供了从羧酸酯制备过氧羧酸的方法。 更具体地说，羧酸酯与无机过氧化物如过氧化氢在具有过水解活性的酶催化剂存在下反应。 基于保守的结构特征，本发明的过水解酶催化剂被分类为碳水化合物酯酶家族7（CE-7）的成员。 此外，提供包含通过本文所述方法生产的过酸的消毒剂制剂。
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15.发明授权公开(公告)号：US08110382B2
公开(公告)日：2012-02-07
申请号：US12189912
申请日：2008-08-12
Applicant: Robert DiCosimo , Anna Panova , Jeffery Scott Thompson , Robert D. Fallon , F. Glenn Gallagher , Thomas Foo , Xu Li , George C. Fox , Joseph J. Zaher , Mark S. Payne , Daniel P. O'Keefe
Inventor： Robert DiCosimo , Anna Panova , Jeffery Scott Thompson , Robert D. Fallon , F. Glenn Gallagher , Thomas Foo , Xu Li , George C. Fox , Joseph J. Zaher , Mark S. Payne , Daniel P. O'Keefe
CPC classification number: C07C51/48 , C07C51/42 , C07C51/487 , C12P7/42 , C07C59/06
Abstract: A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile having low concentrations of impurities. The glycolonitrile is subsequently converted to an aqueous solution of ammonium glycolate using an enzyme catalyst having nitrilase activity derived from Acidovorax facilis 72W (ATCC 57746). Glycolic acid is recovered in the form of the acid or salt from the aqueous ammonium glycolate solution using a variety of methods described herein.
Abstract translation: 提供从甲醛和氰化氢生产乙醇酸的方法。 更具体地，使热处理的甲醛和氰化氢反应以制备具有低浓度杂质的乙醇腈。 随后使用具有源自Acidovorax facilis 72W（ATCC 57746）的腈水解酶活性的酶催化剂将乙醇腈转化为乙醇酸铵水溶液。 使用本文所述的各种方法，从乙醇酸水溶液中以酸或盐的形式回收乙醇酸。
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Patent Agency Ranking
公开(公告)号：US08084238B2
公开(公告)日：2011-12-27
申请号：US12189902
申请日：2008-08-12
Applicant: Robert DiCosimo , Anna Panova , Jeffery Scott Thompson , Robert D. Fallon , F. Glenn Gallagher , Thomas Foo , Xu Li , George C. Fox , Joseph J. Zaher , Mark S. Payne , Daniel P. O'Keefe
Inventor： Robert DiCosimo , Anna Panova , Jeffery Scott Thompson , Robert D. Fallon , F. Glenn Gallagher , Thomas Foo , Xu Li , George C. Fox , Joseph J. Zaher , Mark S. Payne , Daniel P. O'Keefe
CPC classification number: C07C51/48 , C07C51/42 , C07C51/487 , C12P7/42 , C07C59/06
Abstract: A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile having low concentrations of impurities. The glycolonitrile is subsequently converted to an aqueous solution of ammonium glycolate using an enzyme catalyst having nitrilase activity derived from Acidovorax facilis 72W (ATCC 57746). Glycolic acid is recovered in the form of the acid or salt from the aqueous ammonium glycolate solution using a variety of methods described herein.
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公开(公告)号：US20110300121A1
公开(公告)日：2011-12-08
申请号：US13213583
申请日：2011-08-19
Applicant: Robert DICOSIMO , Arie Ben-Bassat , Mark S. Payne , Raymond Richard Zolandz
Inventor： Robert DICOSIMO , Arie Ben-Bassat , Mark S. Payne , Raymond Richard Zolandz
CPC classification number: C12N9/18 , A61L2/183 , A61L2/186 , A61L2/22 , A61L2202/24 , C11D3/06 , C11D3/10 , C11D3/201 , C11D3/2017 , C11D3/2044 , C11D3/2048 , C11D3/2068 , C11D3/2079 , C11D3/2082 , C11D3/2086 , C11D3/2093 , C11D3/221 , C11D3/226 , C11D3/32 , C11D3/361 , C11D3/38636 , C11D3/3947 , C11D17/041 , C12P7/40 , C12Y301/01001 , Y02E50/16
Abstract: Disclosed herein is a method for stabilization of the perhydrolase activity of the CE-7 esterase in a formulation with a carboxylic acid ester that employs the addition of a buffering agent, substantially undissolved, to the mixture of the CE-7 esterase and the carboxylic acid ester. Further, disinfectant and laundry care formulations comprising the peracids produced by the processes described herein are provided.
Abstract translation: 本文公开了一种用于在具有羧酸酯的制剂中稳定CE-7酯酶的过水解酶活性的方法，其使用向CE-7酯酶和羧酸的混合物中添加基本上未溶解的缓冲剂 酯。 此外，提供包含通过本文所述方法生产的过酸的消毒剂和衣物护理制剂。
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公开(公告)号：US08063008B2
公开(公告)日：2011-11-22
申请号：US12471030
申请日：2009-05-22
Applicant: Robert DiCosimo , Mark Scott Payne , Eugenia Costa Hann , Vincent Brian Croud , John Edward Gavagan , Lorraine Winona Wagner
Inventor： Robert DiCosimo , Mark Scott Payne , Eugenia Costa Hann , Vincent Brian Croud , John Edward Gavagan , Lorraine Winona Wagner
CPC classification number: C11D3/3947 , A61L2/183 , A61L2/186 , A61L2202/18 , A61L2202/24 , A61L2202/26 , C11D3/2093 , C11D3/32 , C11D3/38627 , C11D3/48 , C12P7/00 , C12P7/40
Abstract: A process is provided to produce a concentrated aqueous peracid solution in situ using at least one enzyme having perhydrolase activity in the presence of hydrogen peroxide (at a concentration of at least 500 mM) under neutral to acidic reaction conditions from suitable carboxylic acid esters (including glycerides) and/or amides substrates. The concentrated peracid solution produced is sufficient for use in a variety of disinfection and/or bleaching applications.
Abstract translation: 提供了一种方法，在中性至酸性反应条件下，使用至少一种在过氧化氢（至少500mM浓度）存在下具有过水解酶活性的酶，从合适的羧酸酯（包括 甘油酯）和/或酰胺底物。 所生产的浓缩的过酸溶液足以用于各种消毒和/或漂白应用。
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19.发明申请ENZYMATIC IN SITU PREPARATION OF PERACID-BASED REMOVABLE ANTIMICROBIAL COATING COMPOSITIONS AND METHODS OF USE 审中-公开基于渗透性的可除去抗微生物涂层组合物的原位制备及其使用方法公开(公告)号：US20110177148A1
公开(公告)日：2011-07-21
申请号：US12843087
申请日：2010-07-26
Applicant: Robert Dicosimo , Carl W. Erkenbrecher, JR. , Christian Hoffmann , Lynn Leger , Mark S. Payne , Christina S. Stauffer
Inventor： Robert Dicosimo , Carl W. Erkenbrecher, JR. , Christian Hoffmann , Lynn Leger , Mark S. Payne , Christina S. Stauffer
CPC classification number: A01N59/00 , A01N37/16 , A01N63/02 , A01N25/02 , A01N25/10 , A01N33/12 , A01N2300/00
Abstract: In-situ enzymatic preparation of peracid-based removable antimicrobial coating compositions and their methods of use for controlling microorganisms at various loci are disclosed.
Abstract translation: 公开了基于过酸的可去除的抗微生物涂层组合物的原位酶制剂及其用于控制各种位点微生物的方法。
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公开(公告)号：US07960528B1
公开(公告)日：2011-06-14
申请号：US12632462
申请日：2009-12-07
Applicant: Robert DiCosimo , John Edward Gavagan , Mark S. Payne
Inventor： Robert DiCosimo , John Edward Gavagan , Mark S. Payne
Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in the ratio of peracetic acid formation to peracetic acid hydrolysis specific activities (PAAF/PAAH ratio). The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
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