公开(公告)号：US06862542B2

公开(公告)日：2005-03-01

申请号：US10053103

申请日：2002-01-17

Applicant: Peter Lockhart ,  Robert Splinter ,  Matthew J. Davis

Inventor： Peter Lockhart ,  Robert Splinter ,  Matthew J. Davis

IPC: A61B5/00 ,  G01N21/31 ,  G06F19/00

CPC classification number: A61B5/411 ,  G01N21/3151

Abstract: The present invention provides an erythema meter comprising a light guide that carries light of two specific wavelengths (probing and reference) at two distinct frequencies that are generated and modulated by a either a single or multiple source(s), a photodetector mounted in the tip of the guide that receives light reflected from the surface being examined, and circuitry electrically coupled to the guide for processing the light data, and determining the level of erythema present on the examined surface. The probing and reference wavelengths are delivered in sinusoidal or amplitude modulated fashion, thereby permitting electronic filtering of the received data. A calculating circuit determines the quotient of the two wavelengths after having been reflected off of a surface, such as mucosal or dermal surfaces, which is representative of the severity of erythema present in the surface.

Abstract translation: 本发明提供了一种红斑计，其包括导光体，该导光体以两个不同的频率携带两个特定波长的光（探测和参考），其由单个或多个源产生和调制;安装在尖端中的光电检测器 接收从被检测的表面反射的光的引导件，以及电耦合到引导件的电路，用于处理光数据，以及确定存在于被检查表面上的红斑水平。 探测和参考波长以正弦或幅度调制方式传送，从而允许接收数据的电子滤波。 计算电路确定两个波长在从表面反射之后的商，例如粘膜或皮肤表面，其代表存在于表面中的红斑的严重程度。

公开(公告)号：US09848952B2

公开(公告)日：2017-12-26

申请号：US11923488

申请日：2007-10-24

Applicant: Krishn Khanna ,  Robert Splinter

Inventor： Krishn Khanna ,  Robert Splinter

IPC: A61B18/20 ,  A61B18/24 ,  A61B18/22 ,  G02B6/032

CPC classification number: A61B18/24 ,  A61B18/20 ,  A61B18/245 ,  A61B2018/00577 ,  A61B2018/206 ,  A61B2018/2222 ,  A61B2018/2244 ,  A61B2018/2261 ,  A61L29/02 ,  G02B6/032

Abstract: A catheter system to ablate target matter within a mammalian body using light energy is described. The system may include an open-ended catheter tip through which a liquid light guide medium flows to the target matter, where at least a portion of the liquid light guide medium exiting the catheter tip creates a fluid optical channel to transmit the light energy from the catheter tip to the target matter. The system may also include a catheter lumen whose distal end includes the open-ended catheter tip, a light source to generate the light energy, and a liquid light guide medium source fluidly coupled to the catheter lumen. The liquid light guide medium source may include a reservoir of the liquid light guide medium that includes a magnesium chloride solution or a lactated Ringer's solution.

公开(公告)号：US09066742B2

公开(公告)日：2015-06-30

申请号：US11937583

申请日：2007-11-09

Applicant: Robert Splinter

Inventor： Robert Splinter

IPC: A61B6/00 ,  A61B18/24 ,  A61B19/00

CPC classification number: A61B5/1079 ,  A61B5/0084 ,  A61B5/1076 ,  A61B5/4836 ,  A61B18/24 ,  A61B18/245 ,  A61B2018/00642 ,  A61B2018/00732 ,  A61B2018/00904 ,  A61B2090/065 ,  A61B2090/0813 ,  A61B2562/0247

Abstract: A laser catheter with a pressure sensor is provided according to embodiments of the invention. The pressure sensor may be coupled with the distal end of the laser catheter and may comprise any of various piezoelectric materials, for example Polyvinylidene Difluoride (PVDF). In various embodiments of the invention the pressure sensor is configured to detect pressure longitudinally and coaxially. The pressure sensor may provide an electric potential that is proportional to the vessel pressure and may be used to monitor and/or adjust laser parameters. In other embodiments the results from the pressure sensor may be used to determine the vessel size and/or the type of material being ablated.

Abstract translation: 根据本发明的实施例提供具有压力传感器的激光导管。 压力传感器可以与激光导管的远端联接，并且可以包括各种压电材料中的任何一种，例如聚偏二氟乙烯（PVDF）。 在本发明的各种实施例中，压力传感器构造成纵向和同轴地检测压力。 压力传感器可以提供与容器压力成比例的电位，并且可以用于监测和/或调整激光参数。 在其他实施例中，来自压力传感器的结果可用于确定容器尺寸和/或被烧蚀的材料的类型。

公开(公告)号：US20090171330A1

公开(公告)日：2009-07-02

申请号：US11966214

申请日：2007-12-28

Applicant: Kevin Taylor ,  Robert Splinter

Inventor： Kevin Taylor ,  Robert Splinter

IPC: A61B18/18

CPC classification number: A61B18/24 ,  A61B5/0059 ,  A61B2017/00061 ,  A61B2018/2211

Abstract: A method of locating and ablating a target tissue is described. The method includes providing a catheter that has at least one light guide, where the light guide is adaptable to receive light from a light source. A distal portion of the catheter is advanced through vasculature of a patient towards the target tissue. A nanoparticle dye is introduced into the patient, where the nanoparticles selectively bind to the target tissue. The target tissue is mapped by detecting fluorescence light emitted from the nanoparticle dye bound to the tissue. The distal tip of the catheter is positioned adjacent to the mapped target tissue, and a light pulse is transmitted through the light guide to ablate at least a portion of the target tissue.

Abstract translation: 描述了定位和消融靶组织的方法。 该方法包括提供具有至少一个光导的导管，其中光导适合于接收来自光源的光。 导管的远端部分通过患者的脉管系统前进到目标组织。 将纳米颗粒染料引入患者体内，其中纳米颗粒选择性地结合靶组织。 通过检测从与组织结合的纳米颗粒染料发射的荧光来映射靶组织。 导管的远端位于与被映射的目标组织相邻的位置处，并且光脉冲透射通过光导以烧蚀目标组织的至少一部分。