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11.发明公开公开(公告)号：US20240226329A1
公开(公告)日：2024-07-11
申请号：US18022051
申请日：2020-08-20
Inventor： Chenli Liu , Yuxuan Dong , Xuan Guo , Qian Chen , Yong Hu , Liangxia Ai , Hao Zhang
CPC classification number: A61K48/0058 , A61K35/74 , A61K38/204 , A61K38/2066 , A61K45/06
Abstract: A bacterial targeting vector and use thereof in tumor treatment, in particular, a bacterial targeting vector carrying a cytokine such as interleukin 6 and interleukin 10 or carrying a polynucleotide such as mRNA of the cytokine and use thereof in tumor treatment. An attenuated chassis bacterium capable of targeting solid tumors can be used as a delivery carrier of a tumor therapy molecule, and achieve expression and controllable release of a human/murine cytokine, thereby achieving anti-tumor effects.
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公开(公告)号：US11970391B2
公开(公告)日：2024-04-30
申请号：US17618198
申请日：2019-12-13
Applicant: Shenzhen Institutes of Advanced Technology
Inventor： Tianzhun Wu , Zhaoling Huang , Qi Zeng
CPC classification number: B81C1/00166 , B81B3/0072 , B81B2201/06 , B81B2203/0172 , B81B2203/04 , B81C2201/0114 , B81C2201/0185 , B81C2201/0187 , B81C2201/0194
Abstract: A method for preparing a flexible electrode is provided. The method comprises sequentially forming a flexible base layer and an intermediate conductive layer on a carrier plate; treating an elastomeric template having an electrode pattern with an acid, followed by transferring and printing the electrode pattern onto the intermediate conductive layer to form an electrode inducing layer; forming a titanium dioxide-polydopamine composite layer in a gap of the electrode inducing layer; forming a platinum electrode layer on the titanium dioxide-polydopamine composite layer; removing the carrier plate. The invention solves the problems of slow formation of a polydopamine film and slow formation of a platinum electrode layer. A flexible electrode is further provided.
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公开(公告)号：US20240091167A1
公开(公告)日：2024-03-21
申请号：US18267783
申请日：2021-12-22
Inventor： Yang LI , Liming WANG , Guofang ZHANG
IPC: A61K9/70 , A01N25/34 , A01N59/00 , A01N59/16 , A01N59/26 , A01P1/00 , A61K33/24 , A61K33/42 , A61K33/44 , A61K45/06 , A61P31/14 , B82Y5/00
CPC classification number: A61K9/7007 , A01N25/34 , A01N59/00 , A01N59/16 , A01N59/26 , A01P1/00 , A61K33/24 , A61K33/42 , A61K33/44 , A61K45/06 , A61P31/14 , B82Y5/00
Abstract: Provided is the use of two-dimensional nanomaterials in the inhibition of a coronavirus, and specifically disclosed is the use of the two-dimensional nanomaterials in the preparation of a medicament for treating or preventing diseases caused by a coronavirus or of a material for adhering to or inhibiting the coronavirus. The two-dimensional nanomaterial is selected from the group consisting of copper indium thiophosphate (CIPS) nanosheet, graphene oxide nanosheet, molybdenum disulfide nanosheet, black phosphorus nanosheet and mixtures thereof. The coronavirus is selected from one of HCoV-229E, HCoV-OC43, HCoV-NL63, HCoV-HKU1, SARS-CoV, SARS-CoV2 or MERS-CoV. The diseases caused by the coronavirus are diseases caused by coronavirus infection. The material has the advantages of being simple to prepare, having a high biological safety and an excellent effect.
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公开(公告)号：US20240029866A1
公开(公告)日：2024-01-25
申请号：US17764755
申请日：2021-02-07
Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY
Inventor： Shuqiang WANG , Junren PAN , Yanyan SHEN
CPC classification number: G16H30/40 , G16H50/20 , G06T7/0012 , G06T2207/20081 , G06T2207/20084 , G06T2207/30016
Abstract: The present application provides an image-driven brain atlas construction method and apparatus, a device and a storage medium, and involves in the field of medical imaging technologies. The method includes: acquiring a node feature matrix, where the node feature matrix includes time sequences of multiple nodes of a brain; performing hypergraph data structure transformation on the node feature matrix to acquire a first hypergraph incidence matrix; inputting the first hypergraph incidence matrix and the node feature matrix into a trained hypergraph transition matrix generator for processing to output and acquire a first hypergraph transition matrix, where the first hypergraph transition matrix characterizes a constructed multi-modal brain atlas. The technical solution provided by the present application can construct the multi-modal brain atlas, and this multi-modal brain connection structure can express more feature information. When it is applied to the brain disease diagnosis process, the accuracy of disease diagnosis can be improved.
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15.发明授权公开(公告)号：US11816840B2
公开(公告)日：2023-11-14
申请号：US16632579
申请日：2017-07-26
Applicant: Shenzhen Institutes of Advanced Technology
Inventor： Shoujun Zhou , Baochang Zhang , Baolin Li , Cheng Wang , Pei Lu
CPC classification number: G06T7/11 , G06T5/30 , G06T7/0012 , G06T7/262 , G06V10/34 , G06T2207/20024 , G06T2207/30104 , G06T2211/404
Abstract: A method, an apparatus, a device, and a storage medium for extracting a cardiovascular vessel from a CTA image, the method including the steps of: performing erosion operation and dilation operation on image data successively via a preset structural element to obtain a structure mask; performing a slice-by-slice transformation on the plane of section images of the structural mask to acquire the first ascending aortic structure in the structural mask, and acquiring an aortic center position and an aortic radius in the last slice of the plane of section image of the said structural mask; establishing a binarized sphere structure according to the aortic center position and the aortic radius, and synthesizing a second ascending aorta structure by combining the first ascending aorta structure with the structure mask and the binarized sphere structure.
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Patent Agency Ranking
公开(公告)号：US11707635B2
公开(公告)日：2023-07-25
申请号：US16492405
申请日：2017-04-21
Inventor： Hairong Zheng , Hui Zhou , Lili Niu , Ruibiao Guo , Long Meng , Yongchuan Li , Min Su , Jiqing Huang , Ming Qian
CPC classification number: A61N7/00 , B06B1/0215 , B06B1/067 , A01K29/005 , A61N2007/0026 , B06B2201/76
Abstract: Provided is a conscious animal ultrasonic neural regulation device, including a pulse signal generation module, a transducer module and a fixing module. The pulse signal generation module is configured to generate a pulse signal with high energy. The ultrasonic transducer module is configured to convert the pulse signal into an ultrasound. The fixing module includes an upper fixing module and a lower fixing module. The upper fixing module is configured to fix the ultrasonic transducer module, and the lower fixing module is configured to be fixed on an animal neural regulation target point. The upper fixing module and the lower fixing module are connected by a connecting component. The conscious animal neural regulation device of the present disclosure can perform accurate ultrasonic stimulation on a cerebral cortex and subcortex of the animal, thereby exploring and verifying the stimulation effect of the ultrasound on the animal, which is easy in operation and convenient in use.
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公开(公告)号：US11668777B2
公开(公告)日：2023-06-06
申请号：US16760956
申请日：2017-12-01
Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY
Inventor： Shanshan Wang , Dong Liang , Sha Tan , Xin Liu , Hairong Zheng
IPC: G01R33/561 , G01R33/56 , G06T11/00
CPC classification number: G01R33/5611 , G01R33/5608 , G06T11/008 , G06T2207/10088 , G06T2207/20056 , G06T2207/20081
Abstract: Provided are a parallel magnetic resonance imaging method and apparatus based on adaptive joint sparse codes and a computer-readable medium. The method includes solving an l2−lF−l2,1 minimization objective, where the l2 norm is a data fitting term, the lF norm is a sparse representation error, and the l2,1 mixed norm is the joint sparsity constraining across multiple channels; separately updating each of a sparse matrix, a dictionary and K-space data with a corresponding algorithm, and obtaining a reconstructed image by a sum of root mean squares of all the channels. The joint sparsity of the channels is developed using the norm l2,1. In this manner, calibration is not required while information sparsity is developed. Moreover, the method is robust.
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18.发明授权公开(公告)号：US11579229B2
公开(公告)日：2023-02-14
申请号：US16473806
申请日：2018-07-24
Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY
Inventor： Haifeng Wang , Dong Liang , Sen Jia , Xin Liu , Hairong Zheng
IPC: G01V3/00 , G01R33/561 , G01R33/56 , G01R33/58
Abstract: There are provided a parallel rapid imaging method and device based on a complex number conjugate symmetry of multi-channel coil data and nonlinear GRAPPA image reconstruction, and a medium. The imaging method includes: obtaining virtual conjugate coil data by expanding the actual multi-channel coil data; combining actual multi-channel coil data and virtual multi-channel coil data to obtain a linear data term and a nonlinear data term; calibrating weighting factors of the linear data term and the nonlinear data term by using combined low-frequency full-sampling data (margins of the low-frequency full-sampling data includes parts of high-frequency data); reconstructing data which is under-sampled in a high-frequency region according to the calibrated weighting factors; fusing the low-frequency full-sampling data and the reconstructed data for the high-frequency region.
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公开(公告)号：US20220411667A1
公开(公告)日：2022-12-29
申请号：US17767454
申请日：2019-10-10
Inventor： Suibin LUO , Pengpeng XU , Panpan RUAN , Shuhui YU , Tao ZHAO , Rong SUN
IPC: C09J7/30 , B32B27/36 , B32B27/32 , B32B27/08 , B32B7/06 , B32B37/24 , B32B37/06 , C09J7/25 , C09J11/04 , C09J163/00
Abstract: The insulation adhesive film material is composed of a three-layer structure, its insulation polymer composite is supported by a thin film material, and a surface of the insulation polymer composite is covered with a layer of protective film. A release force of a support film is 25-60 μN/mm, and a release force of the protective film is 2-60 μN/mm. A thickness of the insulation polymer composite is 1-300 μm. The insulation adhesive film material is prepared as follows: after a high molecular polymer, an inorganic filler, a high molecular polymer curing agent, a molding auxiliary agent, and a solvent are mixed, dispersion technologies such as ball milling, sand milling, ultrasound are conducted to prepare an electronic paste of the insulation polymer composite, and the electronic paste is then applied to a surface of a support film material, and bonded with the protective film to form the insulation adhesive film material.
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20.发明授权公开(公告)号：US11514621B2
公开(公告)日：2022-11-29
申请号：US16878633
申请日：2020-05-20
Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY
Inventor： Zhan Li Hu , Dong Liang , Hai Rong Zheng , Xin Liu , Yong Feng Yang , Zhen Xing Huang
Abstract: The disclosure provides a low-dose image reconstruction method and system based on prior anatomical structure difference. The method includes: determining the weights of different parts in the low-dose image based on prior information of anatomical structure differences; constructing a generative network being taking the low-dose image as input extract features, and integrating the weights of the different parts in the feature extraction process, outputting a predicted image; constructing a determining network being taking the predicted image and standard-dose image as input, to distinguish the authenticity of the predicted image and standard-dose image as the first optimization goal, and identifying different parts of the predicted image as the second optimization goal, collaboratively training the generative network and the determining network to obtain the mapping relationship between the low-dose image and the standard-dose image; and reconstructing the low-dose image by using the obtained mapping relationship. The disclosure can obtain more accurate high-definition images.
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