公开(公告)号：US6335331B2

公开(公告)日：2002-01-01

申请号：US80066501

申请日：2001-03-08

Applicant: UCB SA

Inventor： BERWAER MONIQUE ,  BODSON GUY ,  DELEERS MICHEL ,  DOGIMONT CHARLES ,  FANARA DOMENICO ,  TIMMERMANS JACQUES

IPC: C07D295/08 ,  A61K31/495 ,  A61P11/08 ,  A61P17/00 ,  A61P25/08 ,  A61P37/08 ,  A61P43/00 ,  C07D295/084 ,  C07D295/088 ,  C07D295/14

CPC classification number: C07D295/088

Abstract: The present invention relates to new pseudopolymorphic forms of 2-[2-[4-[bis (4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride, namely, anhydrous 2-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride and 2-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride monohydrate. It also relates to processes for the preparation of these pseudopolymorphic forms and to pharmaceutical compositions containing them.

Abstract translation: 本发明涉及2- [2- [4- [双（4-氟苯基）甲基] -1-哌嗪基]乙氧基]乙酸二盐酸盐的新的假多晶型形式，即无水2- [2- [4- [双 （4-氟苯基）甲基] -1-哌嗪基]乙氧基]乙酸二盐酸盐和2- [2- [4- [二（4-氟苯基）甲基] -1-哌嗪基]乙氧基]乙酸二盐酸盐一水合物。 它还涉及制备这些假多晶形式的方法和含有它们的药物组合物。

公开(公告)号：US3686269A

公开(公告)日：1972-08-22

申请号：US3686269D

申请日：1970-08-27

Applicant: UCB SA

Inventor： ARAD YAEL ,  LEVY MOSHE ,  VOFSI DAVID

IPC: C07B20060101 ,  C07C20060101 ,  C07C55/14 ,  C07C57/04 ,  C07F20060101 ,  C07C121/26

Abstract: IN THE HYDRODIMERIZATION OF ACRLONITRILE AND LOWER ALKYL-SUBSTITUTED ACRYLONITRILES BY CONTACTING THE NITRILES WITH AN ALKALI METAL AMALGAM FOR OBTAINING THE RESPECTIVE ADIPONITRILES, THE IMPROVEMENT OF USING IN THE REACTION A SOLVENT MEDIUM WHICH IS AT LEAST PARTLY WATER-MISCIBLE AND DISSOLVE BOTH THE STARTING COMPOUNDS AND THE HYDRODIMERS, THE AMOUNTS OF THE REACTANTS BEING OF THE ACYLIC ACID DERIVATIVES 5-20% BY WEIGHT, OF WATER 5-30% BY WEIGHT, AND OF A FREE QUATERNARY AMMONIUM BAS 0.0015% BY WEIGHT, THE DEGREE OF ALKALINITY BEING THAT GENERATED BY THE REACTION. TOGETHER WITH THE METNTIONED ADIPONITRILES, ALKALI METAL HYDROXIDE IS RECOVERED AS BYPRODUCT-.

公开(公告)号：US3661927A

公开(公告)日：1972-05-09

申请号：US3661927D

申请日：1969-02-05

Applicant: UCB SA

Inventor： ZIVKOVIC DUSAN

IPC: C07C51/09 ,  C07C51/38 ,  C07D223/16 ,  C07D281/18 ,  C07D49/34 ,  C07D51/36

CPC classification number: C07D223/16 ,  C07C51/09 ,  C07C51/38 ,  C07D281/18 ,  C07C57/58

Abstract: HETEROCYCLIC COMPOUNDS WITH ANTI-ARRHYTHMIC, PSYCHOSTIMULANT, ANTISPASMODIC, CARDIOVASCULAR, ANTIDEPRESSIVE AND ANTHISTAMINIC PROPERTIES HAVING THE FORMULA

(R''-)(-(A-1,2-PHENYLENE)-X-(CH2)M-)>N-R"''-C
N(-R)-)(-R")

WHEREIN A IS HYDROGEN, HALOGEN, CYANO, ALKYL, ALKOXY, ACYL OR HALOALKYL, X IS METHYLENE OR SULFUR, R,R'',R" ARE EACH HYDROGEN OR ALKYL, R''" IS A STRAIGHT OR BRANCHED CHAIN ALKYLENE RADICAL HAVING 1 TO 4 CARBON ATOMS, M IS A WHOLE NUMBER FROM 2 TO 4, AND P IS A WHOLE NUMBER FROM 2 TO 5, THE PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF, AND METHODS FOR PREPARING THE SAME.

公开(公告)号：US3519674A

公开(公告)日：1970-07-07

申请号：US3519674D

申请日：1967-07-21

Applicant: UCB SA

Inventor： ARAD YAEL ,  ROSEN HAIM ,  VOFSI DAVID

IPC: C07C20060101 ,  C07C55/14 ,  C07C57/04 ,  C07C69/44 ,  C08J20060101

公开(公告)号：US3466321A

公开(公告)日：1969-09-09

申请号：US3466321D

申请日：1966-05-12

Applicant: UCB SA

Inventor： MORREN HENRI

IPC: C07D295/145 ,  C07C101/00 ,  A61K25/00 ,  C07C101/18

CPC classification number: C07D295/145

公开(公告)号：US3459738A

公开(公告)日：1969-08-05

申请号：US3459738D

申请日：1965-08-03

Applicant: UCB SA

Inventor： MORREN HENRI

IPC: C07D207/26 ,  C07D207/263 ,  C07D207/27 ,  C07D29/22 ,  A61K25/00 ,  C07D27/08

CPC classification number: C07D207/27 ,  Y10S514/872

公开(公告)号：US3438112A

公开(公告)日：1969-04-15

申请号：US3438112D

申请日：1966-10-19

Applicant: UCB SA

Inventor： LABRUYERE ROBERT MAXIMILIEN

IPC: E06B3/56 ,  B23P7/00

CPC classification number: E06B3/56 ,  Y10T29/49888

公开(公告)号：US3429947A

公开(公告)日：1969-02-25

申请号：US3429947D

申请日：1966-02-02

Applicant: UCB SA

Inventor： EYGEN CYRILLE VAN ,  WEERENS ARTHUR

IPC: C08F8/00 ,  C08F20/52 ,  C08F22/36 ,  C08F291/00 ,  C08G59/40 ,  C09D157/04 ,  C08F19/00 ,  C08F33/08

CPC classification number: C08F291/00 ,  C08F8/14 ,  C08F8/34 ,  C08F20/52 ,  C08F22/36 ,  C08F2800/20 ,  C08F2810/20 ,  C08G59/4042 ,  C09D157/04 ,  Y10T428/31511 ,  C08F228/02 ,  C08L2666/28 ,  C08F2220/1825

公开(公告)号：US3366448A

公开(公告)日：1968-01-30

申请号：US52007066

申请日：1966-01-12

Applicant: PECHINEY SAINT GOBAIN ,  UCB SA

Inventor： MICHEL MARTIN ,  LOUIS WINAND

IPC: C01B25/234

CPC classification number: C01B25/2343 ,  C01B25/234

公开(公告)号：US3358020A

公开(公告)日：1967-12-12

申请号：US33567464

申请日：1964-01-03

Applicant: UCB SA

Inventor： ANTONIN HENDRICKX

IPC: B01J21/00 ,  B01J23/887 ,  C07C51/25 ,  C07C57/055

CPC classification number: B01J21/00 ,  B01J23/8877 ,  B01J2523/00 ,  C07C51/25 ,  C07C51/252 ,  C07C57/04 ,  C07C53/08 ,  B01J2523/53 ,  B01J2523/68 ,  B01J2523/842 ,  B01J2523/55