公开(公告)号：US20180271820A1

公开(公告)日：2018-09-27

申请号：US15984605

申请日：2018-05-21

Applicant: Vijaykumar Rajasekhar

Inventor： Vijaykumar Rajasekhar

IPC: A61K31/225 ,  A61K9/16 ,  A61P9/04

CPC classification number: A61K31/225 ,  A61K9/16 ,  A61K9/4808 ,  A61K9/4891 ,  A61K9/5021 ,  A61K45/06 ,  A61P9/04

Abstract: Pharmaceutical preparations and methods for treating or preventing a heart failure disease, including heart failure with preserved ejection fraction (HFPEF), with one or more dialkyl fumarates alone or in combination with one or more second agents are provided herein. In some embodiments, the pharmaceutical preparations are in the form of micro-tablets or pellets.

公开(公告)号：US20170056372A1

公开(公告)日：2017-03-02

申请号：US15249820

申请日：2016-08-29

Applicant: Vijaykumar Rajasekhar

Inventor： Vijaykumar Rajasekhar

IPC: A61K31/4015 ,  A61K45/06

CPC classification number: A61K31/4015 ,  A61K45/06

Abstract: Methods and pharmaceutical compositions comprising one or more prodrugs (e.g., aminoalkyl prodrugs) of monomethyl fumarate (MMF) thereof are provided herein for the treatment of a heart failure disease, including heart failure with preserved ejection fraction. The compounds of the present disclosure are configured to be converted in vivo, upon oral administration, to monomethyl fumarate. Upon conversion, the active moiety (i.e., monomethyl fumarate) of various embodiments is effective in treating subjects suffering from a heart failure disease, including heart failure with preserved ejection fraction.

Abstract translation: 本文提供包含一种或多种富马酸单甲酯（MMF）的前体药物（如氨基烷基前药）的药物组合物，用于治疗心力衰竭疾病，包括保留射血分数的心力衰竭。 本公开的化合物被配置为在口服给药时在体内转化为富马酸单甲酯。 转化后，各种实施方案的活性部分（即，富马酸单甲酯）可有效治疗患有心力衰竭疾病的受试者，包括具有保留的射血分数的心力衰竭。

公开(公告)号：US08663192B2

公开(公告)日：2014-03-04

申请号：US12768628

申请日：2010-04-27

Applicant: Jerome E. Hester ,  Anthony J. Abbate ,  Richard E. Kaufman ,  David C. Gale ,  Gail M. Zaler ,  Bin Huang ,  Lisa Earnhardt ,  Vijaykumar Rajasekhar

Inventor： Jerome E. Hester ,  Anthony J. Abbate ,  Richard E. Kaufman ,  David C. Gale ,  Gail M. Zaler ,  Bin Huang ,  Lisa Earnhardt ,  Vijaykumar Rajasekhar

IPC: A61M31/00

CPC classification number: A61L31/16 ,  A61B17/04 ,  A61B17/06166 ,  A61B17/064 ,  A61B17/0644 ,  A61B17/068 ,  A61B17/08 ,  A61B17/083 ,  A61B17/26 ,  A61B17/3468 ,  A61B2017/0073 ,  A61B2017/00893 ,  A61B2017/06176 ,  A61B2017/0641 ,  A61B2017/0647 ,  A61B2017/0649 ,  A61B2090/3987 ,  A61B2090/3991 ,  A61L17/10 ,  A61M31/00 ,  A61M31/002 ,  A61M37/0069

Abstract: Described here are devices and methods for treating one or more conditions or symptoms associated with a tonsil procedure. In some variations, a drug-releasing device may be at least partially delivered to one or more tonsillar tissues before, during, or after a tonsil procedure. In some variations, the drug-releasing device may be configured to be biodegradable. In other variations, the drug-releasing device may comprise one or more hemostatic materials or one or more adhesives. The drug-releasing device may be configured to release one or more drugs or agents, such as, for example, one or more analgesics, local anesthetics, vasoconstrictors, antibiotics, combinations thereof and the like.

Abstract translation: 这里描述了用于治疗与扁桃体过程相关的一种或多种病症或症状的装置和方法。 在一些变型中，药物释放装置可以在扁桃体手术之前，期间或之后至少部分递送至一个或多个扁桃体组织。 在一些变型中，药物释放装置可以被配置为可生物降解的。 在其它变型中，药物释放装置可以包括一种或多种止血材料或一种或多种粘合剂。 药物释放装置可以被配置为释放一种或多种药物或药剂，例如一种或多种止痛剂，局部麻醉剂，血管收缩剂，抗生素及其组合等。

公开(公告)号：US20100043197A1

公开(公告)日：2010-02-25

申请号：US12512855

申请日：2009-07-30

Applicant: Anthony J. ABBATE ,  Bin Huang ,  Gail M. Zaler ,  David C. Gale ,  Richard E. Kaufman ,  Vijaykumar Rajasekhar

Inventor： Anthony J. ABBATE ,  Bin Huang ,  Gail M. Zaler ,  David C. Gale ,  Richard E. Kaufman ,  Vijaykumar Rajasekhar

IPC: B23P11/00 ,  B23P19/02

CPC classification number: A61F2/95 ,  A61F2/0095 ,  A61F2/24 ,  A61F2002/9511 ,  A61F2002/9522 ,  B25B27/10 ,  Y10T29/49908 ,  Y10T29/53657 ,  Y10T29/53709 ,  Y10T29/53783 ,  Y10T29/53991

Abstract: Described here are devices and methods for crimping self-expanding devices. The crimping devices may be useful for crimping a variety of different self-expanding devices (whether such devices are biodegradable or bio-durable). The crimping devices may have crimping members to engage the self-expanding device to reduce the device from an expanding configuration to an unexpanded configuration. The crimping member may comprise or include a suture, wire, ribbon, guiding hoop, pusher, prong, holding bar, balloon, jaws, combinations thereof, or the like. The crimping devices may also include or comprise a holding structure to hold the self-expanding device in an unexpanded or expanded configuration.

Abstract translation: 这里描述了用于卷曲自扩张装置的装置和方法。 卷曲装置可用于卷曲各种不同的自扩张装置（无论这种装置是可生物降解的还是生物耐久的）。 压接装置可以具有压接构件以接合自膨胀装置，以将装置从扩张构型减小到未膨胀构型。 压接构件可以包括或包括缝合线，线，带，引导环，推动器，插脚，保持杆，气球，钳口，其组合等。 压接装置还可以包括或包括用于将自膨胀装置保持在未膨胀或膨胀构型的保持结构。