公开(公告)号：US20240092043A1

公开(公告)日：2024-03-21

申请号：US18450451

申请日：2023-08-16

Applicant: Alcon Inc.

Inventor： Frank Chang ,  Troy Vernon Holland ,  Thomas M. Moy

IPC: B29D11/00 ,  C08F20/06 ,  C08F30/02 ,  C08J7/056 ,  G02B1/04

CPC classification number: B29D11/00134 ,  C08F20/06 ,  C08F30/02 ,  C08J7/056 ,  G02B1/043

Abstract: The invention is related to a cost-effective method for making a coated contact lens having a hydrogel coating thereon. A method of the invention involves heating a contact lens precursor having carboxylic acid groups on and/or near its surface in an aqueous solution in the presence of a hydrophilic copolymer that comprises monomeric units of (a) at least one epoxy-containing vinylic monomer, (b) at least one amino-containing vinylic monomer having a primary or secondary amino group, (c) at least one polyethyleneglycol-containing vinylic monomer, and (d) at least one phosphorylcholine-containing vinylic monomer, at a temperature from about 100° C. to about 140° C. for at least 30 minutes, thereby forming a hydrogel coating on the contact lens precursor. Such a method can be advantageously implemented directly in a sealed lens package during autoclave.

公开(公告)号：US20230374225A1

公开(公告)日：2023-11-23

申请号：US18321416

申请日：2023-05-22

Applicant: Alcon Inc.

Inventor： Houliang Tang ,  Adam K. Sniady ,  Frank Chang ,  Troy Vernon Holland

IPC: C08G77/452

CPC classification number: C08G77/452

Abstract: Described herein is a method for producing HEVL-filtering contact lenses in a relatively efficient and consistent manner from a polymerizable composition under a controlled thermal curing scheme. The polymerizable composition comprises at least one N-vinyl amide monomer and at least one Cu(II)-meso-aryl-substituted porphyrin free of any ethylenically unsaturated group. The resultant HEVL-filtering contact lenses each comprise a polymer matrix to which the Cu(II)-meso-aryl-substituted porphyrin is grafted or covalently attached.

公开(公告)号：US20200158913A1

公开(公告)日：2020-05-21

申请号：US16683886

申请日：2019-11-14

Applicant: Alcon Inc.

Inventor： Frank Chang ,  Houliang Tang ,  Troy Vernon Holland ,  Adam K. Sniady

IPC: G02B1/04 ,  G02C7/04 ,  C08F218/08 ,  C08F216/06 ,  C08F230/02 ,  C08F216/38 ,  G02B1/10

Abstract: The invention is generally related to a soft contact lens which comprises a hydrogel lens body and a coating thereon and to a method for producing the same. The hydrogel lens body is composed of a crosslinked polymeric material comprising repeating units of at least one arylborono-containing vinylic monomer having a boronic acid group, and the coating comprises a layer of a phosphorylcholine-containing polymer which comprises (a) repeating units of vinyl alcohol, and (b) repeating units of 6-membered acetal ring substituted with a phosphorylcholine-containing group. The coating is covalently-attached to the hydrogel lens body through cyclic boronic ester linkages each formed between one of the boronic acid groups of the crosslinked polymeric material and one of the 1,2-diol and 1,3-diol moieties of the phosphorylcholine-containing polymer.