-
公开(公告)号：US20240182502A1
公开(公告)日：2024-06-06
申请号：US18284108
申请日：2022-03-30
Applicant: BASF SE
Inventor： Klaus Ditrich , Ana Escribano Cuesta
CPC classification number: C07F9/301 , C12P41/006
Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) ammonium salt are provided. The methods comprise a refined multi-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. The third step involves the enrichment of the desired enantiomer in the yield by conversion of the obtained side product to the desired final product as well. By addition of the third refinement step, the proportion of the D-glufosinate present in a mixture of L-glufosinate and D-glufosinate can substantially be converted to the desired L-glufosinate ammonium salt.
-
公开(公告)号：US09834798B2
公开(公告)日：2017-12-05
申请号：US14423448
申请日：2013-09-03
Applicant: BASF SE
Inventor： Andrea Piatesi , Kai-Uwe Baldenius , Klaus Ditrich , Alois Kindler , Marta Zajaczkowski-Fischer , Ralf Boehling , Alwin Rehfinger
IPC: C12P7/64 , C12N9/88 , C07H21/04 , C07K1/00 , C07C51/235 , C07C51/373
CPC classification number: C12P7/6427 , C07C51/235 , C07C51/373 , C12P7/6409 , C12Y402/01053 , C07C59/147 , C07C55/20
Abstract: A process for preparing sebacic acid by reacting in a first step (i) linoleic acid with water catalyzed by an oleate hydratase to form 10-hydroxy-12-octadecenoic acid, in a second step (ii) pyrolysing the 10-hydroxy-12-octadecenoic acid to 1-octene and 10-oxo-decanoic acid and in a third step (iii) oxidizing the 10-oxo-decanoic acid to sebacic acid.
-
公开(公告)号：US09828617B2
公开(公告)日：2017-11-28
申请号：US14421872
申请日：2013-08-13
Inventor： Michael Naesby , Christophe Folly , Curt Aimé Friis Nielsen , Anaelle Hatsch , Markus Schwab , Oskar Zelder , Stefan Haefner , Hartwig Schroeder , Birgit Hoff , Andrea Molt , Klaus Ditrich , Michael Breuer , Holger Hartmann , Karsten Koerber
IPC: C12N15/53 , C12P17/12 , C12N9/02 , C12N9/90 , C12N15/52 , C12P17/10 , C12P17/18 , C07D209/90 , C07D487/06 , C07K16/40 , C12N9/10
CPC classification number: C12P17/12 , C07D209/90 , C07D487/06 , C07K16/40 , C12N9/0004 , C12N9/001 , C12N9/1007 , C12N9/1085 , C12N9/90 , C12N15/52 , C12P17/10 , C12P17/182 , C12Y205/01
Abstract: Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.
-
公开(公告)号：US20170145451A1
公开(公告)日：2017-05-25
申请号：US15323515
申请日：2015-07-02
Applicant: BASF SE
Inventor： Kai-Uwe Baldenius , Michael Breuer , Klaus Ditrich , Vaidotas Navickas , Francesco Mutti , Tanja Knaus , Nicholas Turner
CPC classification number: C12P13/001 , C12N9/0006 , C12N9/0016 , C12N9/0018 , C12Y101/01001 , C12Y104/01009 , C12Y104/0102
Abstract: The present invention relates to a novel biocatalytic method for the production of primary and secondary amines, comprising coupled enzymatic oxidation and reduction processes simultaneously regenerating the required cofactor; making use of two enzymes—i.e. an alcohol dehydrogenase and an amine dehydrogenase—operating simultaneously in a one pot process (i.e. biocatalytic cascade). Furthermore, the overall process is redox neutral, since the hydride generated from the first oxidative step is internally recycled in the second reductive step. The invention also relates to recombinant expression systems and microorganisms procuring the required enzyme activities; and bioreactors for performing such methods.
-
-
-
Search Results
14
records
(took 0.019 seconds)
