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公开(公告)号：US20160186113A1
公开(公告)日：2016-06-30
申请号：US15063040
申请日：2016-03-07
Applicant: Corning Incorporated
Inventor： Allison Jean Tanner , Gregory Roger Martin
Abstract: A multilayered cell culture apparatus for the co-culturing of at least two cell types is disclosed. The cell co-culture apparatus is defined as an integral structure having a plurality of cell culture chambers in combination with tracheal space(s). The body of the apparatus has imparted therein gas permeable membranes in combination with tracheal spaces that will allow the free flow of gases between some cell culture chambers and the external environment. In addition, some cell culture chambers may have limited access to air creating relatively lower oxygen content cell culture chambers. The size of the apparatus, and location of an optional neck section, allows for its manipulation by standard automated assay equipment, further making the apparatus amenable to high throughput applications.
Abstract translation: 公开了用于共培养至少两种细胞类型的多层细胞培养装置。 细胞共培养装置被定义为具有与气管空间组合的多个细胞培养室的整体结构。 该装置的主体在其中赋予气体可渗透的膜与气管空间的组合，这将允许气体在一些细胞培养室和外部环境之间自由流动。 此外，一些细胞培养室可能有限制地进入空气，产生相对较低的含氧细胞培养室。 设备的尺寸和可选的颈部的位置允许其通过标准自动化测定设备的操作，进一步使得该设备适合于高通量应用。
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公开(公告)号：US20150048085A1
公开(公告)日：2015-02-19
申请号：US14081326
申请日：2013-11-15
Applicant: CORNING INCORPORATED
Inventor： Jessica Monique Brown , Nicholas Michael Illsley , Gregory Roger Martin , Ana Maria del Pilar Pardo , Allison Jean Tanner
IPC: A01N1/02
CPC classification number: A01N1/0284 , A01N1/0242 , A01N1/0263 , A01N1/0268 , A01N1/0273 , A61J1/05 , A61J1/1412 , A61J1/16 , A61M5/145 , A61M5/2425 , C12M23/48 , C12M33/04 , C12M45/22
Abstract: An article including, either: a frame having an interior cavity, and a flexible liner situated within the interior cavity; or a deformable frame having an interior cavity, as defined herein. Either frame can receive a sample, such as liquid having suspended live cells, and cooling freezes the sample to a solid sample. The solid sample can be readily ejected from the article having either a frame with the flexible liner, or the deformable frame, without extensive thawing. The solid sample can be rapidly displaced from the article by the methods and apparatus disclosed herein.
Abstract translation: 一种制品，包括：具有内部空腔的框架和位于所述内部空腔内的柔性衬里; 或具有如本文所定义的内腔的可变形框架。 任一框架可以接收样品，例如具有悬浮活细胞的液体，并且冷却将样品冻结成固体样品。 固体样品可以容易地从具有柔性衬垫的框架或可变形框架的制品中排出，而无需大量解冻。 通过本文公开的方法和装置，固体样品可以快速地从制品中移位。
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公开(公告)号：US20250145921A1
公开(公告)日：2025-05-08
申请号：US19017078
申请日：2025-01-10
Applicant: CORNING INCORPORATED
Inventor： William Joseph Lacey , Gregory Roger Martin , Allison Jean Tanner
Abstract: A cell culture vessel includes a vessel body, support columns, and a stabilizer device. The vessel body defines a cell culture chamber enclosed between a bottom wall and a top wall. The support column is within the cell culture chamber and extends between the top wall and the bottom wall. The stabilizer device covers a width and length of the cell culture chamber and has a column engaging structure that is sized to slidingly engage the support column such that the stabilizer device is movable along the support column as a liquid culture medium is received in the cell culture chamber. The support column guides the stabilizer device along a length of the support column as the stabilizer device rises with rising liquid level in the cell culture chamber during a liquid culture medium filling operation.
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公开(公告)号：US20240110141A1
公开(公告)日：2024-04-04
申请号：US18540090
申请日：2023-12-14
Applicant: CORNING INCORPORATED
Inventor： Gregory Roger Martin , Allison Jean Tanner
Abstract: A cell culture apparatus includes a cell culture module including multiple cell culture chambers. A manifold connects the multiple cell culture chambers together along a side of the cell culture module. The manifold includes a side wall base structure connected to the side of the cell culture module and a column structure that is formed as a monolithic part of the side wall base structure. The column structure defines a fluid flow pathway through the manifold and to inlets to the cell culture chambers to allow filling and emptying of the cell culture chambers of liquid medium.
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公开(公告)号：US11912968B2
公开(公告)日：2024-02-27
申请号：US16629665
申请日：2018-07-13
Applicant: CORNING INCORPORATED
Inventor： Gregory Roger Martin , Allison Jean Tanner
Abstract: A microcavity dish (10) for cultivating cells includes a dish body including a sidewall (16) that encloses a cell culture chamber within the dish body. The dish body has a top and a bottom (12). The bottom includes a cell culturing substrate comprising an array of microcavities (46). The sidewall includes a transition portion (30) that divides the sidewall into an upper portion and a lower portion that is offset inward relative to the upper portion defining a liquid medium delivery surface (26) that extends at least partially along an interior surface (28) of the sidewall and slopes toward the bottom.
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Patent Agency Ranking
公开(公告)号：US20230276791A1
公开(公告)日：2023-09-07
申请号：US18196720
申请日：2023-05-12
Applicant: CORNING INCORPORATED
Inventor： William Joseph Lacey , Gregory Roger Martin , Allison Jean Tanner
CPC classification number: A01N1/0268 , B01L3/50825 , C12M45/22 , B01L3/5082 , B01L2300/042 , B01L2300/046 , B01L2300/0858 , B01L2300/0609 , B01L2300/123 , B01L2200/141 , B01L2300/043 , B01L2300/0832
Abstract: Vial assemblies comprise a tubular body and a cap, the cap including a first portion configured to abut a lip of an open end of the tubular body, a threaded portion configured to couple to threading on an internal surface of the tubular body, and a second portion protruding from the threaded portion and extending into a cavity of the tubular body. Methods for storing and removing frozen samples from such vial assemblies are also described.
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公开(公告)号：US11667874B2
公开(公告)日：2023-06-06
申请号：US16569852
申请日：2019-09-13
Applicant: Corning Incorporated
Inventor： Gregory Roger Martin , Allison Jean Tanner
CPC classification number: C12M23/12 , C12M1/14 , C12M3/04 , C12M23/16 , C12M25/14 , C12M29/10 , C12M1/00 , C12M3/00
Abstract: A cell culture apparatus includes one or more plates having a first major surface and an opposing second major surface. The first major surface comprises a structured surface defining a plurality of wells. Each well has an interior surface defining an upper aperture and a nadir, wherein the upper aperture of each well has a diametric dimension in a range from 100 micrometers to 2000 micrometers. The apparatus also includes a plurality of spacers extending from the first major surface along a length of the bottom surface. A plurality of flow channels are defined between adjacent rails.
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公开(公告)号：US11441121B2
公开(公告)日：2022-09-13
申请号：US15708473
申请日：2017-09-19
Applicant: CORNING INCORPORATED
Inventor： Scott Matthew Bennett , Brian Robb Douglass , Paul Ernest Gagnon, Jr. , Gregory Roger Martin , Paul Michael Szlosek , Allison Jean Tanner
Abstract: A spheroid cell culture article including: a frame having a chamber including: an opaque side wall surface; a top aperture; a gas-permeable, transparent bottom; and optionally a chamber annex surface and second bottom, and at least a portion of the transparent bottom includes at least one concave arcuate surface, is disclosed. Methods of making and using the article are also disclosed.
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公开(公告)号：US20220120729A1
公开(公告)日：2022-04-21
申请号：US17564465
申请日：2021-12-29
Applicant: CORNING INCORPORATED
Inventor： Joshua Monroe Cobb , Gregory Roger Martin , Robert Raymond Raczkowski , Mark Christian Sanson , Horst Schreiber , Todd Michael Upton
Abstract: A cell monitoring plate comprises a flat surface on which multiple cell culturing vessels may be stacked. The flats surface has multiple optical imaging systems embedded therein to fully image a cell culture vessels stacked on the plate. Each one of the multiple optical imaging systems provides both illumination and imaging through a single aperture in the surface of the monitoring plate.
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公开(公告)号：US11274273B2
公开(公告)日：2022-03-15
申请号：US15671485
申请日：2017-08-08
Applicant: Corning Incorporated
Inventor： Gregory Roger Martin , Allison Jean Tanner
Abstract: A multilayered cell culture apparatus for the culturing of cells is disclosed. The cell culture apparatus is defined as an integral structure having a plurality of cell culture chambers in combination with tracheal space(s). The body of the apparatus has imparted therein gas permeable membranes in combination with tracheal spaces that will allow the free flow of gases between the cell culture chambers and the external environment. The flask body also includes an aperture that will allow access to the cell growth chambers by means of a needle or cannula. The size of the apparatus, and location of an optional neck and cap section, allows for its manipulation by standard automated assay equipment, further making the apparatus ideal for high throughput applications.
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