公开(公告)号：US20160298121A1

公开(公告)日：2016-10-13

申请号：US14874420

申请日：2015-10-03

Applicant: Cold Spring Harbor Laboratory

Inventor： Adrian Krainer ,  Isabel Aznarez

IPC: C12N15/113 ,  C12Q1/68

CPC classification number: C12N15/1137 ,  C07K14/47 ,  C07K14/4702 ,  C07K14/4736 ,  C07K14/805 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/3341 ,  C12N2320/11 ,  C12N2320/33 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Y101/01205 ,  C12Y304/24087 ,  C12N2310/321 ,  C12N2310/3521

Abstract: Provided herein are methods and compositions for increasing production of a target protein or functional RNA by a cell.

Abstract translation: 本文提供了用于增加细胞产生靶蛋白或功能性RNA的方法和组合物。

公开(公告)号：US20210108208A1

公开(公告)日：2021-04-15

申请号：US16878409

申请日：2020-05-19

Applicant: Cold Spring Harbor Laboratory

Inventor： Adrian Krainer ,  Isabel Aznarez

IPC: C12N15/113 ,  C07K14/805 ,  C07K14/47 ,  C12N15/11 ,  C12Q1/6883

Abstract: Provided herein are methods and compositions for increasing production of a target protein or functional RNA by a cell.

公开(公告)号：US09976143B2

公开(公告)日：2018-05-22

申请号：US14874420

申请日：2015-10-03

Applicant: Cold Spring Harbor Laboratory

Inventor： Adrian Krainer ,  Isabel Aznarez

IPC: A61K48/00 ,  C12N15/113 ,  C07K14/805 ,  C07K14/47 ,  C12Q1/68 ,  C12N15/11

CPC classification number: C12N15/1137 ,  C07K14/47 ,  C07K14/4702 ,  C07K14/4736 ,  C07K14/805 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/3341 ,  C12N2320/11 ,  C12N2320/33 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Y101/01205 ,  C12Y304/24087 ,  C12N2310/321 ,  C12N2310/3521

Abstract: Provided herein are methods and compositions for increasing production of a target protein or functional RNA by a cell.

公开(公告)号：US20170159049A9

公开(公告)日：2017-06-08

申请号：US14916561

申请日：2014-09-04

Applicant: COLD SPRING HARBOR LABORATORY

Inventor： Adrian Krainer ,  Isabel Aznarez ,  Tomoki Nomakuchi

IPC: C12N15/11 ,  A61K31/726 ,  A61K31/4245 ,  A61K31/713

CPC classification number: C12N15/111 ,  A61K31/4245 ,  A61K31/713 ,  A61K31/726 ,  C12N2310/11 ,  C12N2320/30 ,  C12N2320/31 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156

Abstract: The present disclosure relates to compositions and methods for inhibiting nonsense-mediated mRNA decay in a gene-specific manner, for example in the treatment of diseases or disorders caused by nonsense mutations.