公开(公告)号：US11911711B2

公开(公告)日：2024-02-27

申请号：US17938653

申请日：2022-10-06

Applicant: Cytiva BioProcess R&D AB

Inventor： Klaus Gebauer

IPC: B01D15/14 ,  B01D15/18 ,  B01D15/22 ,  G01N30/46 ,  G01N30/60 ,  G01N30/88

CPC classification number: B01D15/14 ,  B01D15/1864 ,  B01D15/1885 ,  B01D15/22 ,  G01N30/466 ,  G01N30/6043 ,  G01N30/6091 ,  G01N30/6039 ,  G01N2030/8881 ,  Y10T29/49826

Abstract: A parallel assembly of chromatography column modules, the assembly having one common assembly inlet and one common assembly outlet, each column module comprising a bed space filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules are adapted to connect the bed space of the column module with the assembly inlet and the assembly outlet, wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.

公开(公告)号：US20210148870A1

公开(公告)日：2021-05-20

申请号：US17156939

申请日：2021-01-25

Applicant: CYTIVA BIOPROCESS R&D AB

Inventor： Klaus Gebauer

IPC: G01N30/60 ,  B01D15/22 ,  G01N30/86 ,  G01N30/56 ,  B01D15/20 ,  B01D15/18

Abstract: The present invention relates to axial flow chromatography columns, methods for separating one or more analytes in a liquid by the use of such columns, and systems employing such columns. The column comprises a first port and a second port, the first port and said second port being at essentially the same level or elevation above the level of the bed space on the chromatography column.

公开(公告)号：US10928365B2

公开(公告)日：2021-02-23

申请号：US16459525

申请日：2019-07-01

Applicant: Cytiva BioProcess R&D AB

Inventor： Klaus Gebauer

IPC: G01N30/60 ,  B01D15/22 ,  G01N30/86 ,  G01N30/56 ,  B01D15/20 ,  B01D15/18

Abstract: The present invention relates to axial flow chromatography columns, methods for separating one or more analytes in a liquid by the use of such columns, and systems employing such columns. The column comprises a first port and a second port the first port and said second port being at essentially the same level or elevation above the level of the bed space on the chromatography column.

公开(公告)号：US20210170303A1

公开(公告)日：2021-06-10

申请号：US17169699

申请日：2021-02-08

Applicant: Cytiva BioProcess R&D AB

Inventor： Klaus Gebauer

IPC: B01D15/10 ,  B01D15/18 ,  G01N30/46 ,  B01D15/20 ,  G01N30/60 ,  G01N30/02 ,  G01N30/56

Abstract: Disclosed herein is a packing method for high efficiency chromatography columns starting from dry swellable particles, as well as columns packed by the method and the use of the columns in separation of biomolecules. In the packing method, an amount of dry swellable particles sufficient to give a swollen volume in a liquid of about 105-120% of the column chamber volume is transferred to the column, the column is closed and the liquid is provided to the column.

公开(公告)号：US20210113940A1

公开(公告)日：2021-04-22

申请号：US17125645

申请日：2020-12-17

Applicant: Cytiva BioProcess R&D AB

Inventor： Klaus Gebauer

IPC: B01D15/14 ,  B01D15/18 ,  B01D15/22 ,  G01N30/46 ,  G01N30/60

Abstract: A parallel assembly of chromatography column modules, the assembly having one common assembly inlet and one common assembly outlet, each column module comprising a bed space filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules are adapted to connect the bed space of the column module with the assembly inlet and the assembly outlet, wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.

公开(公告)号：US20210077920A1

公开(公告)日：2021-03-18

申请号：US17102801

申请日：2020-11-24

Applicant: Cytiva BioProcess R&D AB

Inventor： Klaus Gebauer ,  Manoj Kumar Ramakrishna ,  Daniel Salomonsson ,  Per Lofving

IPC: B01D15/22 ,  B01D15/18 ,  G01N30/46 ,  G01N30/60 ,  F16L55/00

Abstract: A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b) connected in a rigid housing (21; 61), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules in the rigid housing are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.