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    Epoxy resin compositions
    11.
    发明授权
    Epoxy resin compositions 有权

    公开(公告)号：US10023685B2

    公开(公告)日：2018-07-17

    申请号：US15125372

    申请日：2015-02-26

    Applicant: Dow Global Technologies LLC

    Inventor： Michael L. Tulchinsky ,  William J. Kruper, Jr. ,  Tzu-Chi Kuo ,  David C. Molzahn ,  Mark F. Sonnenschein

    IPC: C08G59/00 ,  C08G59/22 ,  C07D303/04 ,  C07D303/22 ,  C08G59/68 ,  C09D163/00

    Abstract: A novel byproduct compound having the following chemical formula B: wherein R is hydrogen or CH3; a composition including an admixture of: (A) a product having the following chemical formula A: wherein R is hydrogen or CH3; and (B) the above novel byproduct compound having the chemical formula B; and a composition including a reaction product of: (a) an aromatic epoxy resin; (b) hydrogen; (c) a catalyst; and (d) a solvent; wherein the reaction product produced is a cycloaliphatic epoxy resin admixture of the combination of (i) the above product having the chemical formula A and (ii) the novel byproduct compound having the chemical formula B; wherein the above product having the chemical formula A includes at least a cis-cis isomer, a cis-trans isomer, and a trans-trans isomer; and the novel byproduct compound having the chemical formula B includes at least a cis isomer and a trans isomer.

    Polyalkoxylated alcohols as excipients for pharmaceutical compositions
    12.
    发明授权
    Polyalkoxylated alcohols as excipients for pharmaceutical compositions 有权
    聚烷氧基化醇作为药物组合物的赋形剂

    公开(公告)号：US09592294B2

    公开(公告)日：2017-03-14

    申请号：US14649721

    申请日：2014-01-13

    Applicant: Dow Global Technologies LLC

    Inventor： Mladen Ladika ,  Jin Zhao ,  Michael L. Tulchinsky ,  Thomas H. Kalantar ,  J. Keith Harris

    IPC: A61K47/10 ,  A61K31/095 ,  A61K31/10 ,  A61K9/48 ,  A61K31/192 ,  A61K31/58 ,  C08G65/20 ,  A61K31/343 ,  C08L71/02

    CPC classification number: A61K47/10 ,  A61K9/4866 ,  A61K31/095 ,  A61K31/10 ,  A61K31/192 ,  A61K31/343 ,  A61K31/58 ,  C08G65/20 ,  C08L71/02

    Abstract: The present invention relates to the use of polyalkoxylated alcohols of the formula R—O-(AO)—H, wherein R is a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl or heterocyclic group having 7 to 25 carbon atoms, (AO) is a polyoxyalkylene moiety of the composition (BO)m(EO)n(DO)r with random or blockwise arrangement of the constituting oxyalkylene units, wherein m, n and r represent the average number of oxybutylene (BO) units, oxyethylene (EO) units and oxyalkylene units derived from at least one epoxide selected from styrene oxide and alkylene oxides having from 5 to 10 carbon atoms (DO) per molecule of the polyalkoxylated alcohol, respectively, m being a number greater than or equal to 1, n being a number greater than or equal to 1 and r being a number in the range from 0 to 50 under the proviso that (m+n+r) is less than or equal to 200 and the ratio n/(m+r) is in the range of 1 to 20, as excipients in pharmaceutical compositions. Said polyalkoxylated alcohols enable very effective solubilization of poorly soluble active pharmaceutical ingredients in aqueous media. Solid or semi-solid pharmaceutical compositions comprising one or more such polyalkoxylated alcohol combined with at least one active pharmaceutical ingredient are further long term stable under typical storage conditions and can be readily provided in various dosage forms such as tablets and filled capsules.

    Abstract translation: 本发明涉及式R-O-（AO）-H的聚烷氧基化醇的用途，其中R是具有7至25个碳原子的取代或未取代的烷基，烯基，炔基，芳基，芳烷基或杂环基，（ AO）是组成（BO）m（EO）n（DO）r的聚氧化烯部分，其具有构成的氧化烯单元的无规或块状排列，其中m，n和r表示氧化丁烯（BO）单元的平均数，氧化乙烯 （EO）单元和衍生自至少一种选自氧化苯乙烯和每分子聚烷氧基化醇具有5至10个碳原子的氧化烯（DO）的环氧化物的氧化烯单元，m分别大于或等于1， n是大于或等于1的数，r是0至50的数，条件是（m + n + r）小于或等于200，并且比率n /（m + r） 在1至20的范围内，作为药物组合物中的赋形剂。 所述聚烷氧基化的醇使得难溶性活性药物成分非常有效地溶解在水性介质中。 包含一种或多种这样的多烷氧基化醇与至少一种活性药物成分组合的固体或半固体药物组合物在典型的储存条件下进一步长期稳定，并且可以容易地以各种剂型例如片剂和填充的胶囊提供。

    FOAM CONTROL
    18.
    发明申请
    FOAM CONTROL 有权

    公开(公告)号：US20210244060A1

    公开(公告)日：2021-08-12

    申请号：US16636005

    申请日：2019-02-12

    Applicant: Dow Global Technologies LLC

    Inventor： Clark H. Cummins ,  Stephen W. King ,  Xue Chen ,  Michael L. Tulchinsky

    IPC: A23L29/00 ,  A23L19/12

    Abstract: A method for controlling foam comprising providing a food composition comprising a foam control agent and a food-stuff, and processing the food composition, wherein the foodstuff comprises potato derivatives or beet derivatives. A food composition comprising a foodstuff and a foam control agent, and wherein the foodstuff comprises potato derivatives or beet derivatives.

    POLYALKOXYLATED ALCOHOLS AS EXCIPIENTS FOR PHARMACEUTICAL COMPOSITIONS
    19.
    发明申请
    POLYALKOXYLATED ALCOHOLS AS EXCIPIENTS FOR PHARMACEUTICAL COMPOSITIONS 有权
    聚烷氧基醇作为药物组合物的成分

    公开(公告)号：US20150374823A1

    公开(公告)日：2015-12-31

    申请号：US14649721

    申请日：2014-01-13

    Applicant: DOW GLOBAL TECHNOLOGIES LLC

    Inventor： Mladen Ladika ,  Jin Zhao ,  Michael L. Tulchinsky ,  Thomas H. Kalantar ,  J. Keith Harris

    IPC: A61K47/10 ,  A61K31/095 ,  A61K31/343 ,  A61K31/192 ,  A61K31/58

    CPC classification number: A61K47/10 ,  A61K9/4866 ,  A61K31/095 ,  A61K31/10 ,  A61K31/192 ,  A61K31/343 ,  A61K31/58 ,  C08G65/20 ,  C08L71/02

    Abstract: The present invention relates to the use of polyalkoxylated alcohols of the formula R—O-(AO)—H, wherein R is a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl or heterocyclic group having 7 to 25 carbon atoms, (AO) is a polyoxyalkylene moiety of the composition (BO)m(EO)n(DO)r with random or blockwise arrangement of the constituting oxyalkylene units, wherein m, n and r represent the average number of oxybutylene (BO) units, oxyethylene (EO) units and oxyalkylene units derived from at least one epoxide selected from styrene oxide and alkylene oxides having from 5 to 10 carbon atoms (DO) per molecule of the polyalkoxylated alcohol, respectively, m being a number greater than or equal to 1, n being a number greater than or equal to 1 and r being a number in the range from 0 to 50 under the proviso that (m+n+r) is less than or equal to 200 and the ratio n/(m+r) is in the range of 1 to 20, as excipients in pharmaceutical compositions. Said polyalkoxylated alcohols enable very effective solubilisation of poorly soluble active pharmaceutical ingredients in aqueous media. Solid or semi-solid pharmaceutical compositions comprising one or more such polyalkoxylated alcohol combined with at least one active pharmaceutical ingredient are further long term stable under typical storage conditions and can be readily provided in various dosage forms such as tablets and filled capsules.

    Abstract translation: 本发明涉及式R-O-（AO）-H的聚烷氧基化醇的用途，其中R是具有7至25个碳原子的取代或未取代的烷基，烯基，炔基，芳基，芳烷基或杂环基，（ AO）是组成（BO）m（EO）n（DO）r的聚氧化烯部分，其具有构成的氧化烯单元的无规或阻塞排列，其中m，n和r表示氧丁烯（BO）单元的平均数，氧化乙烯 （EO）单元和衍生自至少一种选自氧化苯乙烯和每分子聚烷氧基化醇具有5至10个碳原子的氧化烯（DO）的环氧化物的氧化烯单元，m分别大于或等于1， n是大于或等于1的数，r是0至50的数，条件是（m + n + r）小于或等于200，并且比率n /（m + r） 在1至20的范围内，作为药物组合物中的赋形剂。 所述聚烷氧基化的醇使得难溶性活性药物成分在水性介质中非常有效地溶解。 包含一种或多种这样的多烷氧基化醇与至少一种活性药物成分组合的固体或半固体药物组合物在典型的储存条件下进一步长期稳定，并且可以容易地以各种剂型例如片剂和填充的胶囊提供。

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