公开(公告)号：US20060127463A1

公开(公告)日：2006-06-15

申请号：US11013131

申请日：2004-12-15

Applicant: Peter Nugara ,  Bruce Begnoche ,  Stephen Franzyshen ,  Fenghua Deng ,  Daniel Sanders ,  Christine Creegan ,  Steven Cosentino

Inventor： Peter Nugara ,  Bruce Begnoche ,  Stephen Franzyshen ,  Fenghua Deng ,  Daniel Sanders ,  Christine Creegan ,  Steven Cosentino

IPC: A61F13/02 ,  A61L15/16

CPC classification number: A61K9/703 ,  A61K9/7084

Abstract: A composite structure suitable for making transdermal delivery devices includes in sequence: (a) a liner film layer; (b) a containment layer having from zero to 15 wt % content of vinyl acetate repeating units, the layer including either a thermal bonding copolyester resin or a combination of an ethylene-vinyl acetate component and a nonpolar polymer; and (c) a polyester film layer less than 20 μm in thickness. A drug layer lies either between the liner film layer and the containment layer or within a concave depression in the containment layer. A composition including an ethylene-vinyl acetate component and an ABA block copolymer, wherein the A segments of the block copolymer are styrenic segments, is also provided. The composition includes between 1 and 15 wt % of vinyl acetate repeating units, based on the total weight of composition exclusive of any solvents.

Abstract translation: 适于制备透皮递送装置的复合结构包括：（a）衬垫膜层; （b）包含乙酸乙烯酯重复单元含量为零至15重量％的容纳层，所述层包括热粘合共聚酯树脂或乙烯 - 乙酸乙烯酯组分与非极性聚合物的组合; 和（c）厚度小于20μm的聚酯薄膜层。 药物层位于衬垫膜层和容纳层之间或位于容纳层中的凹陷凹陷内。 还提供了包含乙烯 - 乙酸乙烯酯组分和ABA嵌段共聚物的组合物，其中嵌段共聚物的A链段是苯乙烯链段。 基于不包括任何溶剂的组合物的总重量，该组合物包含1至15重量％的乙酸乙烯酯重复单元。

公开(公告)号：US20110052789A1

公开(公告)日：2011-03-03

申请号：US12890291

申请日：2010-09-24

Applicant: Peter N. Nugara ,  Bruce C. Begnoche ,  Stephen K. Franzyshen ,  Fenghua Deng ,  Daniel C. Sanders ,  Christine A. Creegan ,  Steven R. Cosentino

Inventor： Peter N. Nugara ,  Bruce C. Begnoche ,  Stephen K. Franzyshen ,  Fenghua Deng ,  Daniel C. Sanders ,  Christine A. Creegan ,  Steven R. Cosentino

IPC: B05D3/00

CPC classification number: A61K9/703 ,  A61K9/7084

Abstract: A composite structure suitable for making transdermal delivery devices includes in sequence: (a) a liner film layer; (b) a containment layer having from zero to 15 wt % content of vinyl acetate repeating units, the layer including either a thermal bonding copolyester resin or a combination of an ethylene-vinyl acetate component and a nonpolar polymer; and (c) a polyester film layer less than 20 μm in thickness. A drug layer lies either between the liner film layer and the containment layer or within a concave depression in the containment layer.A composition including an ethylene-vinyl acetate component and an ABA block copolymer, wherein the A segments of the block copolymer are styrenic segments, is also provided. The composition includes between 1 and 15 wt % of vinyl acetate repeating units, based on the total weight of composition exclusive of any solvents.

Abstract translation: 适于制备透皮递送装置的复合结构包括：（a）衬垫膜层; （b）包含乙酸乙烯酯重复单元含量为零至15重量％的容纳层，所述层包括热粘合共聚酯树脂或乙烯 - 乙酸乙烯酯组分与非极性聚合物的组合; 和（c）厚度小于20μm的聚酯薄膜层。 药物层位于衬垫膜层和容纳层之间或位于容纳层中的凹陷凹陷内。 还提供了包含乙烯 - 乙酸乙烯酯组分和ABA嵌段共聚物的组合物，其中嵌段共聚物的A链段是苯乙烯链段。 基于不包括任何溶剂的组合物的总重量，该组合物包含1至15重量％的乙酸乙烯酯重复单元。

公开(公告)号：US20090098375A1

公开(公告)日：2009-04-16

申请号：US11989341

申请日：2006-07-13

Applicant: David Voisin ,  Fenghua Deng

Inventor： David Voisin ,  Fenghua Deng

IPC: B32B27/30 ,  B29C47/00

CPC classification number: B32B27/08 ,  B32B27/30 ,  B32B27/304 ,  B32B27/306 ,  B32B27/308 ,  B32B27/32 ,  B32B27/34 ,  B32B27/36 ,  B32B2255/10 ,  B32B2307/31 ,  B32B2307/748 ,  B32B2323/04 ,  B32B2323/10 ,  B32B2327/00 ,  B32B2331/04 ,  B32B2333/08 ,  B32B2333/12 ,  B32B2367/00 ,  B32B2377/00 ,  B32B2435/02 ,  Y10T428/266 ,  Y10T428/269 ,  Y10T428/31797 ,  Y10T428/31928

Abstract: A heat-sealable, composite film comprising a polymeric substrate layer having a first and second surface, a primer layer disposed on the first surface of the substrate layer, and a heat-sealable polymeric layer disposed on the primer layer, wherein (i) the polymeric material of the primer layer comprises poly(vinylidene chloride)(PVdC); (ii) the thickness of the primer layer is in the range 0.01 to 6 μm; (iii) the heat-sealable polymeric layer comprises a copolymer comprising repeating monomeric units of ethylene [—CH2CH2—] and one or more types of repeating monomeric units derived from acrylic acid, methacrylic acid and vinyl acetate having the formula [—CH2C(R1)(X)—] wherein: X is selected from —COOR2 and —OC(O)CH3; R1=H or methyl; and R2 is selected from H, C1-10 alkyl and a counterion M; and (iv) the thickness of the heat-sealable layer is 25 μm or less, methods of manufacture of the same, use of said film as a packaging material for sealing a container and use of a PVdC primer layer in a heat-sealable, peelable composite polymeric film.

Abstract translation: 一种可热封的复合膜，其包括具有第一和第二表面的聚合物基底层，设置在基底层的第一表面上的底漆层和设置在底漆层上的可热封聚合物层，其中（i） 底漆层的聚合物材料包括聚（偏二氯乙烯）（PVdC）; （ii）底漆层的厚度在0.01〜6μm的范围内; （iii）可热封聚合物层包含共聚物，其包含乙烯[-CH 2 CH 2 - ]的重复单体单元和衍生自具有式[-CH 2 C（R 1）的丙烯酸，甲基丙烯酸和乙酸乙烯酯的一种或多种类型的重复单体单元 ）（X） - ]其中：X选自-COOR 2和-OC（O）CH 3; R1 = H或甲基; 并且R 2选自H，C 1-10烷基和抗衡离子M; 和（iv）可热封层的厚度为25μm或更小，其制造方法，使用所述膜作为用于密封容器的包装材料，以及在可热封的层中使用PVdC底漆层， 可剥离复合聚合物膜。

公开(公告)号：US06432486B1

公开(公告)日：2002-08-13

申请号：US09554590

申请日：2000-08-15

Applicant: Henry G. Paris ,  Fenghua Deng ,  Charles L. Liotta ,  Charles A. Eckert ,  Zhengui Liu

Inventor： Henry G. Paris ,  Fenghua Deng ,  Charles L. Liotta ,  Charles A. Eckert ,  Zhengui Liu

IPC: B05D108

CPC classification number: C09D169/00 ,  B05D1/10 ,  B05D3/0254 ,  B05D7/00 ,  C08G63/6828 ,  C08G71/04 ,  C09D167/06

Abstract: A method treats an article and more specifically an aircraft surface in order to prevent icing and to provide a coating that emits very low volatile organic compounds (VOC) during application and setting. Icing on critical aircraft surfaces creates dangerous conditions that impair the stability of the aircraft. The specific areas are referred to as “cold-soak” conditions and some areas on the “leading edges” of the wings. The invention eliminates icing on these surfaces. Ice will not form on the surface of certain polymer coatings with low surface energy such as Teflon. This is a consequence of the high contact angle between the water droplet and the surface that establishes a non-wetting surface. The invention implements such coatings and a deposition process. The coating may be used for other objects such as automobiles, consumer products, such as refrigerators, stoves, etc.

Abstract translation: 一种方法处理制品，更具体地说是飞机表面，以防止结冰并提供在施用和固化期间发射非常低挥发性有机化合物（VOC）的涂层。 在关键飞机表面上结冰会造成危害飞机稳定性的危险状况。 具体地区被称为“冷浸”条件，翼翼“前缘”的某些区域。 本发明消除了这些表面上的结冰。 在表面能较差的某些聚合物涂层（例如特氟纶）的表面上不会形成冰。 这是水滴和表面之间的高接触角的结果，其建立了不润湿的表面。 本发明实现了这种涂层和沉积工艺。 该涂层可用于其他物体，例如汽车，消费品如冰箱，炉子等。