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11.
公开(公告)号:US20150125948A1
公开(公告)日:2015-05-07
申请号:US14533753
申请日:2014-11-05
Applicant: FloDesign Sonics, Inc.
Inventor: Bart Lipkens , Jason Barnes , Dane Mealey , Walter M. Presz, JR. , Stanley Kowalski, III , Louis Masi , Thomas J. Kennedy, III
CPC classification number: C12M47/02 , A61M1/3678 , B01D21/0045 , B01D21/283 , B06B1/06 , C12M33/08 , C12M47/10
Abstract: An acoustophoresis device made up of modular components is disclosed. Several modules are disclosed herein, including ultrasonic transducer modules, input/output modules, collection well modules, and various connector modules. These permit different systems to be constructed that have appropriate fluid dynamics for separation of particles, such as biological cells, from a fluid.
Abstract translation: 公开了一种由模块化部件组成的消声器。 本文公开了多个模块,包括超声换能器模块,输入/输出模块,收集井模块和各种连接器模块。 这些允许构建具有用于从流体分离颗粒(例如生物细胞)的适当流体动力学的不同系统。
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公开(公告)号:US11022551B2
公开(公告)日:2021-06-01
申请号:US16889170
申请日:2020-06-01
Applicant: FloDesign Sonics, Inc.
Inventor: Jason Barnes , Dane Mealey , Jeffrey King
Abstract: Systems and methods for increasing the accuracy of a turbidity sensor are disclosed. The systems include a turbidity sensor and a flow module with a specialized flow path, with the turbidity sensor engaging with the flow module such that a measurement zone of the turbidity sensor is disposed within a flow path of the flow module and a bypass path of the flow module does not pass through the measurement zone. The methods include flowing a fluid containing bubbles into a system that separates the fluid in the flow module into a first stream of fluid containing relatively more bubbles and a second stream of fluid containing relatively fewer bubbles, the first stream flowing through a bypass path that does not pass through the measurement zone, and the second stream flowing through the measurement zone of the turbidity sensor.
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公开(公告)号:US10814253B2
公开(公告)日:2020-10-27
申请号:US15690263
申请日:2017-08-29
Applicant: FloDesign Sonics, Inc.
Inventor: Bart Lipkens , Walter M. Presz, Jr. , Jeffrey King , Jason Barnes , Dane Mealey , Brian McCarthy , Ben Ross-Johnsrud , Kedar Chitale
Abstract: Devices for separating a host fluid from a second fluid or particulate are disclosed. The devices include an acoustic chamber, a fluid outlet at a top end of the acoustic chamber, a concentrate outlet at a bottom end of the acoustic chamber, and an inlet on a first side end of the acoustic chamber. An ultrasonic transducer and reflector create a multi-dimensional acoustic standing wave in the acoustic chamber that traps and separates particulates (e.g. cells) from a host fluid. The host fluid is collected via the fluid outlet, and the particulates are collected via the concentrate outlet. The device is a large-scale device that is able to process liters/hour, and has a large interior volume.
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公开(公告)号:US10670524B2
公开(公告)日:2020-06-02
申请号:US16443817
申请日:2019-06-17
Applicant: FloDesign Sonics, Inc.
Inventor: Jason Barnes , Dane Mealey , Jeffrey King
Abstract: Systems and methods for increasing the accuracy of a turbidity sensor are disclosed. The systems include a turbidity sensor and a flow module with a specialized flow path, with the turbidity sensor engaging with the flow module such that a measurement zone of the turbidity sensor is disposed within a flow path of the flow module and a bypass path of the flow module does not pass through the measurement zone. The methods include flowing a fluid containing bubbles into a system that separates the fluid in the flow module into a first stream of fluid containing relatively more bubbles and a second stream of fluid containing relatively fewer bubbles, the first stream flowing through a bypass path that does not pass through the measurement zone, and the second stream flowing through the measurement zone of the turbidity sensor.
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公开(公告)号:US09744483B2
公开(公告)日:2017-08-29
申请号:US15249129
申请日:2016-08-26
Applicant: FloDesign Sonics, Inc.
Inventor: Bart Lipkens , Walter M. Presz, Jr. , Jeffrey King , Jason Barnes , Dane Mealey , Brian McCarthy , Ben Ross-Johnsrud , Kedar Chitale
CPC classification number: B01D21/283 , B01D21/0042 , B01D21/0045 , B01D21/0087 , B01D21/2422 , B06B1/06 , C02F1/36 , C12M47/02
Abstract: Devices for separating a host fluid from a second fluid or particulate are disclosed. The devices include an acoustic chamber, a fluid outlet at a top end of the acoustic chamber, a concentrate outlet at a bottom end of the acoustic chamber, and an inlet on a first side end of the acoustic chamber. An ultrasonic transducer and reflector create a multi-dimensional acoustic standing wave in the acoustic chamber that traps and separates particulates (e.g. cells) from a host fluid. The host fluid is collected via the fluid outlet, and the particulates are collected via the concentrate outlet. The device is a large-scale device that is able to process liters/hour, and has a large interior volume.
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公开(公告)号:US20170369865A1
公开(公告)日:2017-12-28
申请号:US15672288
申请日:2017-08-08
Applicant: FloDesign Sonics, Inc.
Inventor: Bart Lipkens , Brian McCarthy , Ben Ross-Johnsrud , Jason Barnes , Dane Mealey , Thomas J. Kennedy, III
CPC classification number: C12N13/00 , B01D21/283
Abstract: An acoustophoresis device includes an acoustic chamber with a piezoelectric element located within its volume. The piezoelectric element vibrates and generates acoustic standing waves from both sides, so that particles can be separated from fluid passing through the acoustic chamber. This permits the element to be cooled more efficiently, reducing transient heat loads in the fluid traveling through the device.
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公开(公告)号:US09827511B2
公开(公告)日:2017-11-28
申请号:US14791115
申请日:2015-07-02
Applicant: FloDesign Sonics, Inc.
Inventor: Bart Lipkens , Brian McCarthy , Jason Barnes , Dane Mealey , Ben Ross-Johnsrud , Walter M. Presz, Jr. , Kedar Chitale
CPC classification number: B01D21/283 , B01D21/0045
Abstract: An acoustophoresis device which includes a substantially vertical flow path of the fluid mixture in order to improve separation of particles/secondary fluid from a primary fluid is disclosed. The vertical flow path reduces velocity non-uniformities in the acoustic chamber resulting from gravity forces. The device includes an acoustic chamber in which multidimensional acoustic standing waves are generated. The fluid can be introduced into the acoustic chamber using a dump diffuser in which a plurality of inlets enter near the bottom of the acoustic chamber such that flow symmetry reduces both, gravity driven flow non-uniformities, and any flow interference effects between inlet mixture flow into the acoustic chamber and the continuous gravity driven particle cluster drop out.
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公开(公告)号:US09725710B2
公开(公告)日:2017-08-08
申请号:US14592337
申请日:2015-01-08
Applicant: FloDesign Sonics, Inc.
Inventor: Bart Lipkens , Brian McCarthy , Ben Ross-Johnsrud , Jason Barnes , Dane Mealey , Thomas J. Kennedy, III
CPC classification number: C12N13/00 , B01D21/283
Abstract: An acoustophoresis device includes an acoustic chamber with a piezoelectric element located within its volume. The piezoelectric element vibrates and generates acoustic standing waves from both sides, so that particles can be separated from fluid passing through the acoustic chamber. This permits the element to be cooled more efficiently, reducing transient heat loads in the fluid traveling through the device.
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公开(公告)号:US09675906B2
公开(公告)日:2017-06-13
申请号:US14870952
申请日:2015-09-30
Applicant: FloDesign Sonics, Inc.
Inventor: Bart Lipkens , Jeff King , David Sokolowski , Anthony B. Masi , Brian T. Kennedy , Brian McCarthy , Benjamin Ross-Johnsrud , Jason Dionne , Dane Mealey , Jason Barnes
CPC classification number: B01D21/283 , B01D17/044 , B01D17/06 , B01D19/0078 , B06B1/06 , B06B1/0622 , B06B1/0644 , B06B2201/71 , C12M47/04 , C12N13/00
Abstract: Acoustophoretic devices for separating particles from a non-flowing host fluid are disclosed. The devices include a substantially acoustically transparent container and a separation unit, with the container being placed within the separation unit. An ultrasonic transducer in the separation unit creates a planar or multi-dimensional acoustic standing wave within the container, trapping particles disposed within the non-flowing fluid and causing them to coalesce or agglomerate, then separate due to buoyancy or gravity forces.
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公开(公告)号:US20170088809A1
公开(公告)日:2017-03-30
申请号:US15284529
申请日:2016-10-03
Applicant: FloDesign Sonics, Inc.
Inventor: Bart Lipkens , Thomas J. Kennedy, III , Jeffrey King , Jason Barnes , Brian McCarthy , Dane Mealey , Erik Miller , Walter M. Presz, JR. , Benjamin Ross-Johnsrud , John Rozembersky
CPC classification number: C12M33/08 , A61M1/3678 , B01D21/0045 , B01D21/283 , B06B1/0223 , B06B1/0276 , B06B1/06 , C12M47/02 , C12N13/00
Abstract: An acoustophoresis device made up of modular components is disclosed. Several modules are disclosed herein, including ultrasonic transducer modules, input/output modules, collection well modules, and various connector modules. These permit different systems to be constructed that have appropriate fluid dynamics for separation of particles, such as biological cells, from a fluid.
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