公开(公告)号：US11511283B2

公开(公告)日：2022-11-29

申请号：US16811772

申请日：2020-03-06

Applicant: Gen-Probe Incorporated

Inventor： David H. Combs ,  David A. Buse ,  Norbert D. Hagen ,  David Opalsky ,  Jin Chen

IPC: B66F9/07 ,  B01L9/00

Abstract: A system and method provides a supply of consumables to a processing instrument that uses one or more of the consumables for each of a plurality of processes performed by the instrument. The system includes a loading drawer holding a carrier for receiving a plurality of consumables and an input module for holding a carrier supporting a plurality of consumables thereon and presenting the consumables for access by the instrument. A transporter includes a vertical elevator and a lateral actuator for moving a lift platform vertically and laterally and for transporting carriers on the lift platform with or without consumables supported thereon between the loading drawer and the input module, between the loading drawer and one or more holding shelves, or between the input module and one or more holding shelves. A carrier includes parallel support rails for holding multiple receptacle units and retainer tabs for retaining the units on the support rails.

公开(公告)号：US20220364154A1

公开(公告)日：2022-11-17

申请号：US17878491

申请日：2022-08-01

Applicant: Gen-Probe Incorporated

Inventor： David A. Buse ,  Norbert D. Hagen ,  David Opalsky

IPC: C12Q1/6806 ,  G01N35/04 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686

Abstract: A reagent pack changer includes a reagent pack input device, a reagent pack storage compartment, a reagent pack storage carousel disposed within the storage compartment, and a rotary distributor. The input device includes a reagent pack input carousel rotatable about an axis of rotation, with reagent pack stations for holding reagent packs disposed around the axis of rotation of the carousel. The reagent pack storage carousel is rotatable about an axis of rotation with reagent pack stations for holding reagent packs disposed around the axis of rotation. The rotary distributor is configured to move a reagent pack between the reagent pack input carousel and the reagent pack storage carousel.

公开(公告)号：US11434521B2

公开(公告)日：2022-09-06

申请号：US17668775

申请日：2022-02-10

Applicant: Gen-Probe Incorporated

Inventor： David A. Buse ,  David Howard Combs ,  Byron J. Knight ,  Norbert D. Hagen ,  David Opalsky ,  Jason F. Rhubottom ,  Keith Moravick ,  Tyler Moore ,  Anita Prasad ,  Bruce Richardson

IPC: C12Q1/6806 ,  G01N35/04 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686

Abstract: A method for performing a nucleic acid amplification assay employs a thermally-conductive receptacle holder with one or more receptacle wells, each conforming to an outer surface of a lower portion of a vial. A through-hole extends from an inner surface of each well to an outer surface of the holder. A thermal element is positioned proximal to the holder for altering a temperature of the holder. A signal detection module is configured to generate an excitation signal directed through the through-hole of the well and detect an optical emission from a fluid contained in the vial supported by the well. At least one well supports a capped vial containing a reagent for a nucleic acid amplification assay and including an opaque cap sealing an open end of the vial. The lower portion of the vial is contained within a well, and the cap is situated above a top surface of the holder.

公开(公告)号：US11279967B2

公开(公告)日：2022-03-22

申请号：US17036730

申请日：2020-09-29

Applicant: Gen-Probe Incorporated

Inventor： David A. Buse ,  David Howard Combs ,  Byron J. Knight ,  Norbert D. Hagen ,  David Opalsky ,  Jason F. Rhubottom ,  Keith Moravick ,  Tyler Moore ,  Anita Prasad ,  Bruce Richardson

IPC: C12Q1/6806 ,  G01N35/04 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686

Abstract: A system for performing a nucleic acid amplification assay that includes a receptacle holder formed from a thermally conductive material and having a receptacle well for receiving a lower portion of a vial; a thermal element for cycling the temperature of the receptacle holder; a signal detection module in optical communication with the receptacle well; and a robotic pipettor. The receptacle holder supports a capped vial having a plastic, opaque cap in a snap-fit with a single plastic vial containing a nucleic acid amplification reagent. An upper portion of the cap includes a probe recess that is configured to be removably engaged by an end of a probe of the robotic pipettor. A lower portion of the vial is contained within the receptacle well, and the cap is situated above a top surface of the receptacle holder.

公开(公告)号：US11098343B2

公开(公告)日：2021-08-24

申请号：US16011229

申请日：2018-06-18

Applicant: GEN-PROBE INCORPORATED

Inventor： David A. Buse ,  David Opalsky ,  Jason F. Rhubottom ,  Norbert D. Hagen ,  Jennifer L. Tidd

IPC: C12Q1/6806 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686 ,  G01N35/04

Abstract: A processing module is configured to extend the capabilities of an analyzer configured to process substances within each of a plurality of receptacles. The module includes a container transport configured to transport a container from a location within the processing module to a location within the analyzer that is accessible to a substance transfer device of the analyzer. A receptacle distribution system is configured to receive a receptacle from the analyzer, transfer the receptacle into the processing module, and to move the receptacle between different locations within the analyzer. A substance transfer device of the module is configured to dispense substances into or remove substances from the receptacle within the processing module. A reagent card exchanger provides an input device for inserting reagent cards into and removing reagent cards from the module, stores reagent cards within the module, and transfers reagent cards to different location within the module.

公开(公告)号：US20210017579A1

公开(公告)日：2021-01-21

申请号：US17036730

申请日：2020-09-29

Applicant: Gen-Probe Incorporated

Inventor： David A. Buse ,  David Howard Combs ,  Byron J. Knight ,  Norbert D. Hagen ,  David Opalsky ,  Jason F. Rhubottom ,  Keith Moravick ,  Tyler Moore ,  Anita Prasad ,  Bruce Richardson

IPC: C12Q1/6806 ,  G01N35/04 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686

Abstract: A system for performing a nucleic acid amplification assay comprises a thermally-conductive receptacle holder with one or more receptacle wells, each conforming to an outer surface of a lower portion of a vial. A through-hole extends from an inner surface of each well to an outer surface of the holder. A thermal element is positioned proximal to the holder for altering a temperature of the holder. A signal detection module is configured to generate an excitation signal directed through the through-hole of the well and detect an optical emission from a fluid contained in the vial supported by the well. At least one well supports a capped vial containing a reagent for a nucleic acid amplification assay and including an opaque cap sealing an open end of the vial. The lower portion of the vial is contained within a well, and the cap is situated above a top surface of the holder.

公开(公告)号：US12173352B2

公开(公告)日：2024-12-24

申请号：US18230549

申请日：2023-08-04

Applicant: Gen-Probe Incorporated

Inventor： David A. Buse ,  Norbert D. Hagen ,  David Opalsky

IPC: C12Q1/6806 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686 ,  G01N35/04

Abstract: A system includes a reagent pack input carousel, a carousel frame supporting the carousel, and a track on which the carousel frame is supported for movement of the carousel into and out of an instrument in drawer-like fashion. The carousel is rotatable about an axis of rotation and includes a plurality of reagent pack input stations arranged about the perimeter of the carousel. Each input station is adapted to carry a reagent pack, and the input stations are oriented at an angle with respect to a radial orientation relative to the axis of rotation. Each input station includes an alignment block located at a radially inner end of the station, and the block is received within a recess formed in an end of the reagent pack placed in the station to align and position of the reagent pack within the station.

公开(公告)号：USD1051368S1

公开(公告)日：2024-11-12

申请号：US29794587

申请日：2021-06-14

Applicant: GEN-PROBE INCORPORATED

Designer： David A. Buse ,  Byron J. Knight

公开(公告)号：US20230383333A1

公开(公告)日：2023-11-30

申请号：US18230549

申请日：2023-08-04

Applicant: Gen-Probe Incorporated

Inventor： David A. Buse ,  Norbert D. Hagen ,  David Opalsky

IPC: C12Q1/6806 ,  G01N35/04 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686

CPC classification number: C12Q1/6806 ,  G01N35/04 ,  B01L3/50825 ,  B01L3/565 ,  B01L7/5255 ,  C12Q1/686 ,  G01N2035/0418 ,  G01N2035/0436 ,  B01L3/527 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2300/046

Abstract: A system includes a reagent pack input carousel, a carousel frame supporting the carousel, and a track on which the carousel frame is supported for movement of the carousel into and out of an instrument in drawer-like fashion. The carousel is rotatable about an axis of rotation and includes a plurality of reagent pack input stations arranged about the perimeter of the carousel. Each input station is adapted to carry a reagent pack, and the input stations are oriented at an angle with respect to a radial orientation relative to the axis of rotation. Each input station includes an alignment block located at a radially inner end of the station, and the block is received within a recess formed in an end of the reagent pack placed in the station to align and position of the reagent pack within the station.

公开(公告)号：US11761027B2

公开(公告)日：2023-09-19

申请号：US17877776

申请日：2022-07-29

Applicant: Gen-Probe Incorporated

Inventor： David A. Buse ,  Norbert D. Hagen ,  David Opalsky

IPC: C12Q1/6806 ,  C12Q1/686 ,  G01N35/04 ,  B01L3/00 ,  B01L7/00

CPC classification number: C12Q1/6806 ,  B01L3/50825 ,  B01L3/565 ,  B01L7/5255 ,  C12Q1/686 ,  G01N35/04 ,  B01L3/527 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2300/046 ,  G01N2035/0418 ,  G01N2035/0436

Abstract: A system includes a reagent pack input carousel, a carousel frame supporting the carousel, and a track on which the carousel frame is supported for movement of the carousel into and out of an instrument in drawer-like fashion. The carousel is rotatable about an axis of rotation and includes a plurality of reagent pack input stations arranged about the perimeter of the carousel. Each input station is adapted to carry a reagent pack, and the input stations are oriented at an angle with respect to a radial orientation relative to the axis of rotation. Each input station includes an alignment block located at a radially inner end of the station, and the block is received within a recess formed in an end of the reagent pack placed in the station to align and position of the reagent pack within the station.