公开(公告)号：US20200249249A1

公开(公告)日：2020-08-06

申请号：US16477221

申请日：2018-02-15

Applicant: Hitachi High-Technologies Corporation

Inventor： Hiroya UMEKI ,  Kenta IMAI ,  Yoshihiro YAMASHITA ,  Shunsuke SASAKI ,  Akihiro ENDOU

IPC: G01N35/00 ,  G01N35/10

Abstract: An automatic analysis device includes a probe that performs a dispensing operation including a suction process and a discharge process with respect to liquid; a syringe that generates a pressure change for dispensing liquid at the probe; a flow path that connects the probe and the syringe with each other; a pressure sensor that measures the pressure change in the flow path at the time of liquid dispensing; a storage portion that stores a pressure change of time-series when reference fluid is discharged as a reference discharge pressure waveform; and a determination portion that determines whether or not there is an abnormality in the suction process of the sample from a relationship between a value of difference or a ratio between the reference discharge pressure waveform and the pressure waveform of a determination target at the time of discharge of liquid and normal range.

公开(公告)号：US20200241029A1

公开(公告)日：2020-07-30

申请号：US16641349

申请日：2018-06-21

Applicant: Hitachi High-Technologies Corporation

Inventor： Kenta IMAI ,  Hiroya UMEKI ,  Shunsuke SASAKI ,  Yoshihiro YAMASHITA ,  Taku SAKAZUME

IPC: G01N35/10 ,  G01N33/49 ,  G01N33/493 ,  G01N35/04

Abstract: There is provided an automatic analysis device that can easily realize introduction and replacement of additional reagents in operation even in a small-scale configuration. The automatic analysis device includes a reagent dispensing mechanism 107 that dispenses a reagent from a reagent container 113 containing a reagent, and a normal reagent storage portion 130 that stores a reagent container and an additional reagent storage portion 111. The normal reagent storage portion 130 is positioned in a normal movable area 132, which is a portion of a movable area 131 of the reagent dispensing mechanism 107 and the additional reagent storage portion 111 is positioned in an area excluding the normal movable area 132 in the movable area 131 of the reagent dispensing mechanism 107. The reagent dispensing mechanism 107 performs an access operation in the normal movable area 132 in the normal operation and performs an access operation to the additional reagent storage portion 111 upon receiving a predetermined instruction.

公开(公告)号：US20200209273A1

公开(公告)日：2020-07-02

申请号：US16646622

申请日：2018-11-29

Applicant: Hitachi High-Technologies Corporation ,  Roche Diagnostics Operations, Inc.

Inventor： Yuichiro OTA ,  Takaaki HAGIWARA ,  Yoshihiro YAMASHITA ,  Koshin HAMASAKI ,  Michaela WINDFUHR ,  Heike GUGGEMOS ,  Johannes STOECKEL ,  Guenter ZIEGLER ,  Michael KUEHNL

IPC: G01N35/10

Abstract: The object of the invention is to provide an automatic analysis apparatus capable of setting a dispensing mechanism for measuring dispensing accuracy and a dispensing volume, and capable of performing dispensing accuracy measurement without absorbance measurement. Regarding a dispensing accuracy, a dispensing mechanism to be measured is designated. Parameters including a dispensing volume and the like are input. A dispensing operation of the input dispensing volume is automatically performed for each designated dispensing mechanism. A reaction vessel contains, for example, a reagent of the input dispensing volume which has been dispensed by the designated dispensing mechanism. By measuring a weight of the reagent in the reaction vessel, or the like, it is possible to measure the dispensing accuracy of the designated dispensing mechanism.

公开(公告)号：US20190204346A1

公开(公告)日：2019-07-04

申请号：US16329021

申请日：2017-08-04

Applicant: Hitachi High-Technologies Corporation

Inventor： Daisuke EBIHARA ,  Kenta IMAI ,  Yoshihiro YAMASHITA ,  Shigeki MATSUBARA ,  Taku SAKAZUME

IPC: G01N35/00

CPC classification number: G01N35/00623 ,  G01N35/00 ,  G01N35/00871 ,  G01N2035/00891

Abstract: In order to aspire to higher sensitivity in an automatic analysis device, it is important to prevent the mixing of dust and the like in a reaction part in which a sample and a reagent react. The present invention presents an automatic analysis device that is provided with a configuration for making the pressure inside a specific block in the device such as a reaction part, or inside the device become positive. By making the pressure become positive and forming an air flow that flows out from the inside of the reaction part or the device, it is possible to limit, to a certain amount or less, the amount of dust penetrating into the reaction part.