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    Cardioactive anhydrotalomethylosides and process for preparing them
    11.
    发明授权
    Cardioactive anhydrotalomethylosides and process for preparing them 失效
    心脏活性脱水甲基氯化物及其制备方法

    公开(公告)号：US3910882A

    公开(公告)日：1975-10-07

    申请号：US38266273

    申请日：1973-07-26

    Applicant: HOECHST AG

    Inventor： HAEDE WERNER ,  FRITSCH WERNER ,  STACHE ULRICH ,  LINDNER ERNST

    IPC: C07J19/00 ,  A61K20060101 ,  A61K31/585 ,  A61K31/704 ,  A61P7/10 ,  A61P9/04 ,  C07C20060101 ,  C07D20060101

    CPC classification number: C07J19/00

    Abstract: The invention relates to 3'', 4''-anhydro- Beta , Ltalomethylosides of the general formula I

    wherein R1 is methyl or formyl and R2 stands for Beta -H or Beta -OH, if there is no double bond in 4,5-position, and R3 is a butenolide or cumalin ring, a process for preparing them and their use in the treatment of cardiac and circulatory disturbances. The compounds are especially suitable for treating cardiac insufficiency, tachycardia and conduction defects.

    Abstract translation: 本发明涉及通式Ⅰ的3'，4'-脱氢-β，L-天门冬氨酸盐，其中R1是甲基或甲酰基，R2代表β-H或β--OH，如果4,5中没有双键 - 位，R3是丁烯内酯或坎加林环，其制备方法及其在治疗心脏和循环障碍中的应用。 该化合物特别适用于治疗心功能不全，心动过速和传导缺陷。

    Process for the manufacture of delta 14-20-keto-21-dialkoxy steroids
    12.
    发明授权
    Process for the manufacture of delta 14-20-keto-21-dialkoxy steroids 失效
    制造DELTA 14-20-酮二十二烷氧基甾体的方法

    公开(公告)号：US3900502A

    公开(公告)日：1975-08-19

    申请号：US15856671

    申请日：1971-06-30

    Applicant: HOECHST AG

    Inventor： RADSCHEIT KURT ,  STACHE ULRICH ,  FRITSCH WERNER ,  HAEDE WERNER

    IPC: A61K31/573 ,  A61K31/58 ,  C07C169/32

    CPC classification number: A61K31/573 ,  A61K31/58

    Abstract: Delta 14-20-KETO-21-DIALKOXY STEROIDS ARE PREPARED BY OXIDIZING 20-KETO-15 Alpha ,21-DIHYDROXY STEROIDS OF THE GENERAL FORMULA

    IN WHICH Y is an oxo group which may be ketalized, a

    GROUP WHICH MAY BE ETHERIFIED OR ESTERIFIED, A Delta 3-, Delta 2-, OR Delta 3,5-ENOL ETHER GROUP OR A Delta 3-, Delta 2-, OR Delta 3,5-ENAMINO GROUP, WHICH GROUPS MAY HAVE A DOUBLE BOND IN THE 4-POSITION, AND

    IS A LOWER ACYCLIC OR CYCLIC ACETAL GROUPING, ACETALIZING THE 15 Alpha -HYDROXY-20-KETO-21-OXO STEROIDS OBTAINED, REACTING THE 15 Alpha -HYDROXY-20-KETO-21-DIALKOXY STEROIDS THUS OBTAINED WITH SULFONIC ACID HALIDES AND TREATING THE 15-SULFONIC ACID ESTERS THUS OBTAINED WITH AGENTS SPLITTING OFF ACIDS. The products are valuable intermediates for the manufacture of medicaments.

    Steroid glycosides and process for preparing them
    19.
    发明授权
    Steroid glycosides and process for preparing them 失效
    STEROID GLYCOSIDES及其制备方法

    公开(公告)号：US3642770A

    公开(公告)日：1972-02-15

    申请号：US3642770D

    申请日：1969-03-25

    Applicant: HOECHST AG

    Inventor： HAEDE WERNER ,  STACHE ULRICH ,  FRITSCH WERNER ,  RADSCHEIT KURT

    IPC: C07J19/00 ,  C07C173/00

    CPC classification number: C07J19/00

    Abstract: 2-R2,3,4-DI(R1-O-)-3,4-DIHYDRO-2H-PYRAN

    AND METHODS OF MAKING THE SAME BY REACTING A STEROID ALCOHOL ROH, WITH A GLYCAL OF THE FORMULA

    -CH2-O-R1 OR -CH(-O-R1)-CH2-O-R2

    USEFUL FOR THE TREATMENT OF CARDIAC AND RENAL DISEASES, WHEREIN R IS A STEROID GROUP OF THE 3-HYDROXY-CARDENOLIDE OR 3-HYDROXYBUFADIENOLIDE SERIES, R1 IS ALIPHATIC OR AROMATIC ACYL, AND R2 IS HYDROGEN, METHYL, ETHYL, OR

    2-(R-O-),5-(R''-O-),6-R2-5,6-DIHYDRO-2H-PYRAN

    STEROID GLYCOSIDES OF THE FORMULA

    3beta 14beta-dihydroxy-carda-4 20(22)-dienolides and process for preparing them
    20.
    发明授权
    3beta 14beta-dihydroxy-carda-4 20(22)-dienolides and process for preparing them 失效
    3BETA 14BETA-DIHYDROXY-CARDA-4 20（22） - 二异氰酸酯及其制备方法

    公开(公告)号：US3639393A

    公开(公告)日：1972-02-01

    申请号：US3639393D

    申请日：1969-04-15

    Applicant: HOECHST AG

    Inventor： FRITSCH WERNER ,  STACHE ULRICH ,  HAEDE WERNER ,  RADSCHEIT KURT

    IPC: C07C173/02

    CPC classification number: C07J19/00

    Abstract: A PROCESS FOR PREPARING 3B,14B-DIHYDROXY-CARA-4,20(22)-DIENOLIDES WHICH COMPRISES REDUCING 3-OXO-CARDA4,14,20(22)-TRIENOLIDES BY MEANS OF COMLEX METAL HYDRIDES TO THE CORRESPONDING 3B-HYDROXY-CARDA-4,14,20(22)-TRIENOLIDES; TREATING THESE COMPOUNDS WITH ACYLATING AGENTS; REACTING THE RESULTING 3B-ACYLOXY-CARDA-4,14, 20(22)-TRIENOLDIES WITH N-BROMO-ACYL AMIDES, AND CATALYTICALLY HYDROGENATING THE 4B-ACYLOXY-3B,14B-DIHYDROXY5A,15A-DIBROMO-CARD-20(22)-ENOLIDES SO OBTAINED IN THE PRESENCE OF A PRECIOUS METAL CATALYST AT A PH IN THE RANGE FROM 4.5 TO 7.5. THE PRODUCTS OF THE INVENTION ARE VALUABLE THERAPEUTICS FOR ORAL ADMINISTRATION IN DISEASES OF THE HEART AND CIRCULATION.

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