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    Biosynthetic antibody binding sites
    15.
    发明授权
    Biosynthetic antibody binding sites 失效
    生物合成抗体结合位点

    公开(公告)号：US5091513A

    公开(公告)日：1992-02-25

    申请号：US636765

    申请日：1991-01-02

    Applicant: James S. Huston ,  Hermann Oppermann

    Inventor： James S. Huston ,  Hermann Oppermann

    IPC: C07K16/00 ,  C07K16/46 ,  C12N15/62

    CPC classification number: C12N15/62 ,  C07K16/00 ,  C07K16/464 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/705 ,  Y10S530/867

    Abstract: Disclosed are a family of synthetic proteins having affinity for a preselected antigen. The proteins are characterized by one or more sequences of amino acids constituting a region which behaves as a biosynthetic antibody binding site (BABS). The sites comprise 1) non-covalently associated or disulfide bonded synthetic V.sub.H and V.sub.L dimers, 2) V.sub.H -V.sub.L or V.sub.L -V.sub.H single chains wherein the V.sub.H and V.sub.L are attached by a polypeptide linker, or 3) individuals V.sub.H or V.sub.L domains. The binding domains comprise linked CDR and FR regions, which may be derived from separate immunoglobulins. The proteins may also include other polypeptide sequences which function e.g., as an enzyme, toxin, binding site, or site of attachment to an immobilization media or radioactive atom. Methods are disclosed for producing the proteins, for designing BABS having any specificity that can be elicited by in vivo generation of antibody, and for producing analogs thereof.

    Abstract translation: 公开了对预选抗原具有亲和力的合成蛋白家族。 蛋白质的特征在于构成表现为生物合成抗体结合位点（BABS）的区域的一个或多个氨基酸序列。 所述位点包括1）非共价缔合或二硫键合的合成的VH和VL二聚体，2）VH-VL或VL-VH单链，其中VH和VL通过多肽接头连接，或3）个体VH或VL结构域。 结合域包含连接的CDR和FR区，其可以衍生自单独的免疫球蛋白。 蛋白质还可以包括其它多肽序列，其例如作为酶，毒素，结合位点或与固定化介质或放射性原子的连接位点起作用。 公开了用于生产蛋白质的方法，用于设计具有可通过体内产生抗体引发的任何特异性的BABS和用于制备其类似物的方法。

    Selective removal of immune complexes
    16.
    发明授权
    Selective removal of immune complexes 失效
    选择性去除免疫复合物

    公开(公告)号：US5084398A

    公开(公告)日：1992-01-28

    申请号：US601029

    申请日：1990-10-23

    Applicant: James S. Huston ,  Lynn Baird ,  Charles Cohen ,  Hermann Oppermann

    Inventor： James S. Huston ,  Lynn Baird ,  Charles Cohen ,  Hermann Oppermann

    IPC: A61M1/36 ,  C07K14/31 ,  C07K17/06

    CPC classification number: A61M1/3679 ,  C07K14/31 ,  C07K17/06

    Abstract: Disclosed is a method and a family of materials useful for removing immune complexes from blood preferentially to soluble antibodies. The material comprises analogs of proteins which bind to the Fc region of immunoglobulin. The analogs are produced by truncating or otherwise altering the amino acid sequence of the binding protein to reduce their affinity for Fc. An array of such analogs disposed about the surface of an insoluble matrix has the ability to form multiple points of attachment to the multiple Fc's in a complex so as to bind complex strongly, whereas only weak associations are developed between the Fc region of soluble IgG and inidivdual analogs. The preferred analogs are truncated proteins homologous to a portion of the domains of Protein A or Protein G which bind with Fc. Complex may be removed from whole blood or serum using the material and conventional plasmapheresis techniques.

    Abstract translation: 公开了一种可用于将血液中的免疫复合物优先地去除可溶性抗体的方法和一系列材料。 该材料包含与免疫球蛋白Fc区结合的蛋白质的类似物。 类似物通过截短或以其它方式改变结合蛋白的氨基酸序列来降低它们对Fc的亲和力而产生。 在不溶性基质的表面附近设置的这种类似物的阵列具有在复合物中形成与多个Fc的多个连接点的能力，以便强烈地结合复合物，而仅在可溶性IgG的Fc区和 inidivdual类似物。 优选的类似物是与蛋白A或蛋白G的结合部分与Fc结合的截短的蛋白质。 可以使用材料和常规的血浆置换技术从全血或血清中除去复合物。

    Morphogen-induced dendritic growth
    18.
    发明申请
    Morphogen-induced dendritic growth 审中-公开
    形态诱导树突生长

    公开(公告)号：US20060025571A1

    公开(公告)日：2006-02-02

    申请号：US11226555

    申请日：2005-09-13

    Applicant: David Rueger ,  Kuber Sampath ,  John Smart ,  Hermann Oppermann ,  Engin Ozkaynak ,  Charles Cohen ,  Dennis Higgins

    Inventor： David Rueger ,  Kuber Sampath ,  John Smart ,  Hermann Oppermann ,  Engin Ozkaynak ,  Charles Cohen ,  Dennis Higgins

    IPC: A61K38/18 ,  C07K14/475

    CPC classification number: C07K14/51 ,  A01N1/021 ,  A61K38/00 ,  A61K38/1841 ,  A61K38/185

    Abstract: Disclosed are methods and compositions for maintaining neural pathways in a mammal including: enhancing survival of neurons at risk of dying; inducing cellular repair of damaged neurons and neural pathways; stimulating neurons to maintain their differentiated phenotype; and promoting dendritic outgrowth, including maintaining dendritic arbors and regenerating dendritic architecture. In one embodiment, the invention provides means for stimulating CAM expression in neurons. The invention also provides means for evaluating the status of nerve tissue, including means for detecting and monitoring neuropathies in a mammal. The methods, devices and compositions include a morphogen or morphogen-stimulating agent provided to the mammal in a therapeutically effective concentration. In another embodiment, the invention provides methods and compositions which include a morphogen or morphogen-stimulating agent, and a nerve trophic factor or nerve trophic factor-stimulating agent at concentrations effective for stimulating dendrite outgrowth. The morphogen and the nerve trophic factor can be admixed in combination.

    Abstract translation: 公开了用于在哺乳动物中维持神经通路的方法和组合物，包括：增加有死亡风险的神经元的存活; 诱导损伤的神经元和神经通路的细胞修复; 刺激神经元维持其分化表型; 并促进树突生长，包括保持树枝状树枝和再生树枝状结构。 在一个实施方案中，本发明提供用于刺激神经元中的CAM表达的装置。 本发明还提供用于评估神经组织状态的手段，包括用于检测和监测哺乳动物神经病变的手段。 方法，装置和组合物包括以治疗有效浓度提供给哺乳动物的形态发生剂或形态发生剂。 在另一个实施方案中，本发明提供了包括形态发生剂或形态发生剂刺激剂以及神经营养因子或神经营养因子刺激剂的方法和组合物，其浓度有效刺激枝晶生长。 形态发生剂和神经营养因子可以组合使用。

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