公开(公告)号：US09506864B2

公开(公告)日：2016-11-29

申请号：US14582428

申请日：2014-12-24

Applicant: Industrial Technology Research Institute

Inventor： Cheng-Tai Chen ,  Pei-Shin Jiang ,  Ting-Shou Chen ,  Jane S-C Tsai

IPC: G01N21/64 ,  G01N21/00 ,  C09K11/06 ,  C09K11/00

CPC classification number: C09K11/06 ,  B82Y15/00 ,  B82Y20/00 ,  B82Y35/00 ,  C09K11/00 ,  C09K2211/10 ,  G01N21/6428 ,  G01N2021/6439 ,  Y10S977/774 ,  Y10S977/896 ,  Y10S977/95

Abstract: A gold nanocluster composition and method for preparing the same are provided. The method includes providing a gold ion-containing solution. Next, the method entails mixing the gold ion-containing solution and a reducing agent solution to obtain a first mixture liquid, and heating the first mixture liquid to obtain a second mixture liquid, wherein the second mixture liquid contains the gold nanoclusters, which are partially capped by reducing agent.

Abstract translation: 提供了一种金纳米簇组合物及其制备方法。 该方法包括提供含金离子的溶液。 接着，将含金离子的溶液和还原剂溶液混合，得到第一混合液，加热第一混合液，得到第二混合液，其中第二混合液含有金纳米团簇， 由还原剂加盖。

公开(公告)号：US11859176B2

公开(公告)日：2024-01-02

申请号：US16228763

申请日：2018-12-21

Applicant: Industrial Technology Research Institute ,  National Taiwan University Hospital

Inventor： Cheng-Tai Chen ,  Chien-An Chen ,  Wen-Ting Chiang ,  Su-Feng Chiu ,  Pei-Shin Jiang ,  Jih-Luh Tang ,  Chien-Ting Lin ,  Xuan-Hui Lin

IPC: C12N5/00 ,  C12N13/00 ,  G01N33/543 ,  C12N5/0783 ,  C12N5/078 ,  A61K9/14

CPC classification number: C12N13/00 ,  C12N5/0634 ,  C12N5/0636 ,  C12N5/0646 ,  G01N33/54333 ,  C12N2501/505 ,  C12N2501/515 ,  C12N2501/998 ,  C12N2529/00 ,  C12N2533/10 ,  C12N2533/30 ,  C12N2535/00 ,  C12N2535/10

Abstract: A method for in vitro activation and/or expansion of immune cells is provided, including the steps of: a) providing magnetic particles having multi-protrusive surface modified with at least one type of immuno-inducing substance, in which each magnetic particle includes a copolymer core, a polymer layer, a magnetic substance layer, and a silicon-based layer from the inside to the outside; b) providing a cell solution including at least one type of immune cell in the cell solution; and c) bringing the magnetic particles in contact with the cell solution, in which the at least one type of immuno-inducing substance on the surface of the magnetic particle activates and/or expands the at least one type of immune cell in the cell solution.

公开(公告)号：US20190206598A1

公开(公告)日：2019-07-04

申请号：US16226651

申请日：2018-12-20

Applicant: Industrial Technology Research Institute

Inventor： Chien-An Chen ,  Cheng-Tai Chen ,  Pei-Shin Jiang

IPC: H01F1/26 ,  H01F1/37

CPC classification number: H01F1/26 ,  G01N33/5434 ,  H01F1/0054 ,  H01F1/37

Abstract: Described herein is a magnetic particle, which includes a knobby copolymer core, a polymer layer, a magnetic substance layer and a silicon-based layer. The polymer layer covers the knobby copolymer core and has at least one functional group. In addition, the magnetic substance layer covers the polymer layer and the silicon-based layer covers the magnetic substance layer. Furthermore, a manufacturing method of the magnetic particle is also described.

公开(公告)号：US20190203195A1

公开(公告)日：2019-07-04

申请号：US16228763

申请日：2018-12-21

Applicant: Industrial Technology Research Institute ,  National Taiwan University Hospital

Inventor： Cheng-Tai Chen ,  Chien-An Chen ,  Wen-Ting Chiang ,  Su-Feng Chiu ,  Pei-Shin Jiang ,  Jih-Luh Tang ,  Chien-Ting Lin ,  Xuan-Hui Lin

IPC: C12N13/00 ,  C12N5/078

CPC classification number: C12N13/00 ,  C12N5/0634 ,  C12N5/0636 ,  C12N2501/505 ,  C12N2501/515 ,  C12N2501/998 ,  C12N2529/00 ,  C12N2533/10 ,  C12N2533/30 ,  C12N2535/00 ,  C12N2535/10 ,  G01N33/54333

Abstract: A method for in vitro activation and/or expansion of immune cells is provided, including the steps of: a) providing magnetic particles having multi-protrusive surface modified with at least one type of immuno-inducing substance, in which each magnetic particle includes a copolymer core, a polymer layer, a magnetic substance layer, and a silicon-based layer from the inside to the outside; b) providing a cell solution including at least one type of immune cell in the cell solution; and c) bringing the magnetic particles in contact with the cell solution, in which the at least one type of immuno-inducing substance on the surface of the magnetic particle activates and/or expands the at least one type of immune cell in the cell solution.

公开(公告)号：US09664664B2

公开(公告)日：2017-05-30

申请号：US14582844

申请日：2014-12-24

Applicant: Industrial Technology Research Institute

Inventor： Cheng-Tai Chen ,  Pei-Shin Jiang

IPC: B82Y15/00 ,  B82Y20/00 ,  G01N33/20

CPC classification number: G01N33/20 ,  G01N21/6428 ,  G01N31/22 ,  G01N33/54346 ,  G01N33/553 ,  G01N33/587 ,  G01N33/84 ,  G01N2021/7786

Abstract: A method for detecting metal ions and chemical/biochemical molecules is provided. The method includes providing a probe, wherein the probe includes: a gold nanocluster; a reducing agent and a chelating agent partially capped on a surface of the gold nanocluster, wherein the probe is formed of reducing gold ions by the reducing agent, and the gold ions and the reducing agent have a molar ratio of 1:0.7 to 1:1.9. The probe may interact with several metal ions of an aqueous solution to produce different changes of fluorescent spectra. Chemical/biochemical molecules can be detected by the fluorescent spectra difference caused by the interaction between the metal ions and the chemical/biochemical molecules.