公开(公告)号：US20070299186A1

公开(公告)日：2007-12-27

申请号：US11766227

申请日：2007-06-21

Applicant: Kwok Chan ,  Joshua Croll ,  Balakrishnan Ganesan ,  Marcus Harrigan ,  Farid Khouri ,  Gurram Kishan ,  Ritesh Mathur ,  Rachel Suffield ,  Wenhui Wang ,  James White

Inventor： Kwok Chan ,  Joshua Croll ,  Balakrishnan Ganesan ,  Marcus Harrigan ,  Farid Khouri ,  Gurram Kishan ,  Ritesh Mathur ,  Rachel Suffield ,  Wenhui Wang ,  James White

IPC: C08K5/50 ,  C08K9/04

CPC classification number: C08K5/50

Abstract: This invention relates to organic salt compositions useful in the preparation of organoclay compositions, polymer-organoclay composite compositions, and methods for the preparation of polymer nanocomposites. In one embodiment, the present invention provides an organoclay composition comprising alternating inorganic silicate layers and organic layers, said organic layers comprising a quaternary phosphonium cation having structure X wherein Ar1, Ar2, and Ar3 are independently C2-C50 aromatic radicals; Ar4 is a bond or a C2-C50 aromatic radical; “a” is a number from 1 to about 200; “c” is a number from 0 to 3; R1 is independently at each occurrence a halogen atom, a C1-C20 aliphatic radical, a C5-C20 cycloaliphatic radical, or a C2-C20 aromatic radical; and R2 is a halogen atom, a C1-C20 aliphatic radical, a C5-C20 cycloaliphatic radical, a C2-C50 aromatic radical, or a polymer chain.

Abstract translation: 本发明涉及可用于制备有机粘土组合物，聚合物 - 有机粘土复合材料组合物和制备聚合物纳米复合材料的方法的有机盐组合物。 在一个实施方案中，本发明提供了一种有机粘土组合物，其包含交替的无机硅酸盐层和有机层，所述有机层包含具有结构X的季鏻阳离子，其中Ar 1，Ar 2， >和Ar 3独立地为C 2 -C 50芳族基团; Ar 4是一个键或一个C 2 -C 50芳族基团; “a”是从1到大约200的数字; “c”是从0到3的数字; R 1在每次出现时独立地为卤素原子，C 1 -C 20脂族基团，C 5 H 12 -C 20脂环族基团或C 2 -C 20芳族基团; 和R 2是卤素原子，C 1 -C 20脂族基团，C 5 -C 20个脂环族基团，C 2 -C 20 - 50芳族基团或聚合物链。

公开(公告)号：US20060018923A1

公开(公告)日：2006-01-26

申请号：US10895064

申请日：2004-07-21

Applicant: Kwok Yuen ,  Chiu Woo ,  Kar Lau ,  Kwok Chan ,  Lit Poon ,  Joseph Peiris ,  Yi Guan

Inventor： Kwok Yuen ,  Chiu Woo ,  Kar Lau ,  Kwok Chan ,  Lit Poon ,  Joseph Peiris ,  Yi Guan

IPC: A61K39/12 ,  C07H21/04 ,  C12N15/86 ,  C07K14/01

CPC classification number: G01N33/56983 ,  A61K39/00 ,  C07K14/005 ,  C12N7/00 ,  C12N2770/20021 ,  C12N2770/20022

Abstract: The present invention provides the complete genomic sequence of a novel human coronavirus, coined as coronavirus-HKU1 (“CoV-HKU1”), isolated in Hong Kong from a patient who had a recent history of visit to Schenzhen, China. The virus belongs to the order Nidovirales of the family Coronaviridae, being a single-stranded RNA virus of positive polarity. The invention also provides the deduced amino acid sequences of the complete genome of the CoV-HKU1. The nucleotide sequences and deduced amino acid sequences of the CoV-HKU1 are useful in preventing, diagnosing and/or treating the infection by CoV-HKU1. Furthermore, the invention provides immunogenic and vaccine preparations using recombinant and chimeric forms as well as subunits of the CoV-HKU1 based on the nucleotide sequences and deduced amino acid sequences of the CoV-HKU1.

Abstract translation: 本发明提供了一种新型人冠状病毒的完整基因组序列，其创造为冠状病毒HKU1（“CoV-HKU1”），在香港从最近访问中国的深圳的病人中分离出来。 该病毒属于冠状病毒科家族的Nidovirales，是正极性的单链RNA病毒。 本发明还提供了CoV-HKU1的完整基因组的推导的氨基酸序列。 CoV-HKU1的核苷酸序列和推导的氨基酸序列可用于预防，诊断和/或治疗CoV-HKU1感染。 此外，本发明基于CoV-HKU1的核苷酸序列和推定的氨基酸序列，提供使用重组和嵌合形式以及CoV-HKU1的亚基的免疫原性和疫苗制剂。

公开(公告)号：US20050215494A1

公开(公告)日：2005-09-29

申请号：US10983985

申请日：2004-11-08

Applicant: Kwok Yuen ,  Feng Chen ,  Kwok Chan ,  Yi Kao ,  Yi Guan ,  Leo Poon ,  Jsm Peiris

Inventor： Kwok Yuen ,  Feng Chen ,  Kwok Chan ,  Yi Kao ,  Yi Guan ,  Leo Poon ,  Jsm Peiris

IPC: A61K31/382 ,  A61K31/7048

CPC classification number: A61K31/382 ,  A61K31/7048

Abstract: The present invention relates to a pharmaceutical composition useful for the treatment of diseases associated with viruses of the order Nidovirales of the family Coronaviradae, such as Severe Acute Respiratory Syndrome (SARS) viruses in humans and other animals. In particular, this invention relates to a naturally occurring compound, namely, baicalin, extracted and purified from the Chinese medicinal plant Scutellaria baicalensis Georgi (Chinese name: Huang Qin), that exhibits potent antiviral activity against members of the order Nidovirales of the family Coronaviradae that infects humans and other animals; in particular, SARS viruses in humans (“hSARS virus”). The invention also relates to a therapeutic method, using pharmaceutical compositions comprising baicalin compounds, for the treatment, amelioration, management or prevention of diseases associated with members of the order Nidovirales of the family Coronaviradae, such as hSARS.

Abstract translation: 本发明涉及可用于治疗与冠状病毒家族的病毒相关的疾病的药物组合物，例如人和其他动物中的严重急性呼吸综合征（SARS）病毒。 特别地，本发明涉及一种天然存在的化合物，即黄芩苷，从中药材黄芩（中文名：黄秦）中提取和纯化，对抗冠状病毒家族的Nidovirales成员表现出强烈的抗病毒活性 感染人类和其他动物; 特别是人类中的SARS病毒（“hSARS病毒”）。 本发明还涉及使用包含黄芩苷化合物的药物组合物用于治疗，改善，管理或预防与冠状病毒家族（Norovirales）家族成员有关的疾病如hSARS的治疗方法。

公开(公告)号：US20050009009A1

公开(公告)日：2005-01-13

申请号：US10808187

申请日：2004-03-24

Applicant: Joseph Peiris ,  Kwok Yuen ,  Lit Poon ,  Yi Guan ,  Kwok Chan ,  John Nicholls

Inventor： Joseph Peiris ,  Kwok Yuen ,  Lit Poon ,  Yi Guan ,  Kwok Chan ,  John Nicholls

IPC: C07H21/04 ,  C07K16/08 ,  C12Q1/68 ,  C12Q1/70

CPC classification number: C12Q1/701 ,  C07H21/04 ,  C12Q1/6844

Abstract: The present invention relates to a diagnostic assay for the virus causing Severe Acute Respiratory Syndrome (SARS) in humans (“hSARS virus”). In particular, the invention relates to a real-time quantitative PCR assay for the detection of hSARS virus using reverse transcription and polymerase chain reaction. Specifically, the quantitative assay is a TaqMan® assay using the primers and probes constructed based on the genome of the hSARS virus. The invention further relates to a diagnostic kit that comprises nucleic acid molecules for the detection of the hSARS virus.

Abstract translation: 本发明涉及在人类中引起严重急性呼吸综合征（SARS）的病毒的诊断测定法（“hSARS病毒”）。 特别地，本发明涉及使用逆转录和聚合酶链反应检测hSARS病毒的实时定量PCR测定。 具体地，定量测定是使用基于hSARS病毒基因组构建的引物和探针的TaqMan测定法。 本发明还涉及包含用于检测hSARS病毒的核酸分子的诊断试剂盒。

公开(公告)号：US20080021175A1

公开(公告)日：2008-01-24

申请号：US11766249

申请日：2007-06-21

Applicant: Kwok Chan ,  James White

Inventor： Kwok Chan ,  James White

IPC: C08G73/16 ,  C07D213/20 ,  C07D401/02 ,  C07D401/14 ,  C08G12/08

CPC classification number: C07D213/20 ,  C07D401/14 ,  C08G65/46 ,  C08G73/1053 ,  C08L79/08

Abstract: This invention relates to organic salt compositions useful in the preparation of organoclay compositions, polymer-organoclay composite compositions, and methods for the preparation of polymer nanocomposites. In one embodiment, the present invention provides a pyridinium salt having structure XV wherein Ar6, Ar7, and Ar8 are independently C2-C50 aromatic radicals; “b” is a number from 0 to 2; “d” is a number from 0 to 4; R3 and R4 are independently at each occurrence a halogen atom, a C1-C20 aliphatic radical, a C5-C20 cycloaliphatic radical, or a C2-C20 aromatic radical; Z is a bond, a divalent C1-C20 aliphatic radical, a divalent C5-C20 cycloaliphatic radical, a divalent C2-C20 aromatic radical, an oxygen linking group, a sulfur linking group, a SO2 linking group, or a Se linking group; Ar9 is a C10-C200 aromatic radical, or a polymer chain comprising at least one aromatic group; and X− is a charge balancing counterion.

Abstract translation: 本发明涉及可用于制备有机粘土组合物，聚合物 - 有机粘土复合材料组合物和制备聚合物纳米复合材料的方法的有机盐组合物。 在一个实施方案中，本发明提供具有结构XV的吡啶鎓盐，其中Ar 6，Ar 7和Ar 8独立地为C _{2 -C 50芳族基团; “b”是从0到2的数字; “d”是从0到4的数字; R 3和R 4在每次出现时独立地为卤原子，C 1 -C 20脂族基团 ，C 5 -C 20脂环族基团或C 2 -C 20 -C 20芳族基团; Z是键，二价C 1 -C 20脂肪族基团，二价C 5 -C 20脂族基团， 脂环族基团，二价C 2 -C 20芳族基团，氧连接基团，硫连接基团，SO 2连接基团， 或Se连接组; Ar 9是C 10 -C 20芳族基团，或包含至少一个芳族基团的聚合物链; 而X - SUP是电荷平衡抗衡离子。}

公开(公告)号：US20070299189A1

公开(公告)日：2007-12-27

申请号：US11766850

申请日：2007-06-22

Applicant: Feng Cao ,  Kwok Chan ,  Erik Hagberg ,  Farid Khouri ,  Tara Mullen ,  Roy Odle ,  James White ,  Norimitsu Yamaguchi

Inventor： Feng Cao ,  Kwok Chan ,  Erik Hagberg ,  Farid Khouri ,  Tara Mullen ,  Roy Odle ,  James White ,  Norimitsu Yamaguchi

IPC: C08K9/04

CPC classification number: C08F2/44

Abstract: In one embodiment, the present invention provides a method of making a polymer-organoclay composite composition comprising (a) contacting under condensation polymerization conditions a first monomer, a second monomer, a solvent, and an organoclay composition, said organoclay composition comprising alternating inorganic silicate layers and organic layers, to provide a first polymerization reaction mixture, wherein one of said first monomer and second monomers is a diamine and the other is an dianhydride; (b) carrying out a stoichiometry verification step on the first polymerization reaction mixture; (c) optionally adding additional reactant (monomer 1, monomer 2, or chainstopper) to the first polymerization reaction mixture to provide a second polymerization reaction mixture; and (d) removing solvent from the first polymerization reaction mixture or the second polymerization reaction mixture to provide a first polymer-organoclay composite composition comprising a polymer component and an organoclay component wherein the organoclay component is at least 10% exfoliated.

Abstract translation: 在一个实施方案中，本发明提供制备聚合物 - 有机粘土复合组合物的方法，其包含（a）在缩聚条件下使第一单体，第二单体，溶剂和有机粘土组合物接触，所述有机粘土组合物包含交替的无机硅酸盐 层和有机层，以提供第一聚合反应混合物，其中所述第一单体和第二单体之一是二胺，另一个是二酐; （b）在第一聚合反应混合物上进行化学计量验证步骤; （c）任选地向第一聚合反应混合物中加入另外的反应物（单体1，单体2或链截止剂）以提供第二聚合反应混合物; 和（d）从第一聚合反应混合物或第二聚合反应混合物中除去溶剂以提供包含聚合物组分和有机粘土组分的第一聚合物 - 有机粘土复合组合物，其中有机粘土组分至少10％剥离。

公开(公告)号：US20070299187A1

公开(公告)日：2007-12-27

申请号：US11766382

申请日：2007-06-21

Applicant: Kwok Chan ,  Erik Hagberg ,  John Maxam ,  Tara Mullen ,  Roy Odle ,  James White

Inventor： Kwok Chan ,  Erik Hagberg ,  John Maxam ,  Tara Mullen ,  Roy Odle ,  James White

IPC: C08K9/04 ,  C08K5/50

CPC classification number: C08F2/44 ,  C01P2002/72 ,  C01P2004/04 ,  C08K9/04 ,  C08L79/08 ,  C09C1/42

Abstract: This invention relates to organic salt compositions useful in the preparation of organoclay compositions, polymer-organoclay composite compositions, and methods for the preparation of polymer nanocomposites. In one embodiment, the present invention provides a polymer-organoclay composite composition comprising (a) a polymeric resin; and (b) an organoclay composition comprising alternating inorganic silicate layers and organic layers, said organic layers comprising a quaternary phosphonium cation having structure XXXIII wherein Ar12, Ar13, Ar14 and Ar15 are independently C2-C50 aromatic radicals; and Ar16 is a C2-C200 aromatic radical, or a polymer chain comprising at least one aromatic group.

Abstract translation: 本发明涉及可用于制备有机粘土组合物，聚合物 - 有机粘土复合材料组合物和制备聚合物纳米复合材料的方法的有机盐组合物。 在一个实施方案中，本发明提供了一种聚合物 - 有机粘土复合材料组合物，其包含（a）聚合物树脂; 和（b）有机粘土组合物，其包含交替的无机硅酸盐层和有机层，所述有机层包含具有结构XXXIII的季鏻阳离子，其中Ar 12，Ar 13，Ar， SUP> 14和Ar 15独立地为C 2 -C 50芳族基团; 和Ar 16是C 2 -C 20芳族基团，或包含至少一个芳族基团的聚合物链。

公开(公告)号：US20060205958A1

公开(公告)日：2006-09-14

申请号：US11078022

申请日：2005-03-11

Applicant: Daniel Brunelle ,  James Cella ,  Qing Ye ,  Kwok Chan

Inventor： Daniel Brunelle ,  James Cella ,  Qing Ye ,  Kwok Chan

IPC: C07D407/02

CPC classification number: C07C51/367 ,  C07C65/24

Abstract: This invention is related to a method for making diether dianhydrides by the reaction of halophthalic anhydride and a metal salt of an aromatic dihydroxy compound in the presence of a solvent and a phase transfer catalyst. Typical phase transfer catalyst include guanidium salts, aminopyridinium salts, or phosphazenium salts.

Abstract translation: 本发明涉及通过卤代邻苯二甲酸酐和芳族二羟基化合物的金属盐在溶剂和相转移催化剂的存在下反应制备二醚二酸酐的方法。 典型的相转移催化剂包括胍盐，氨基吡啶鎓盐或磷氮烯基鏻盐。

公开(公告)号：US20050136333A1

公开(公告)日：2005-06-23

申请号：US10742461

申请日：2003-12-19

Applicant: Brian Lawrence ,  Eugene Boden ,  Marc Dubois ,  Kwok Chan ,  Peifang Tian ,  Kathryn Longley ,  Robert Filkins ,  Peter Lorraine

Inventor： Brian Lawrence ,  Eugene Boden ,  Marc Dubois ,  Kwok Chan ,  Peifang Tian ,  Kathryn Longley ,  Robert Filkins ,  Peter Lorraine

IPC: G03F7/00 ,  G11B7/0065 ,  G11B7/246 ,  G11B7/26 ,  G11C13/04 ,  G03H1/04

CPC classification number: G11B7/2534 ,  G03H2001/0264 ,  G03H2001/2289 ,  G03H2260/53 ,  G03H2270/53 ,  G11B7/0065 ,  G11B7/246 ,  G11B7/2467 ,  G11B7/2533 ,  G11B7/2535 ,  G11B7/26 ,  G11C13/042

Abstract: Holographic storage media including a substrate and a dye material capable of undergoing a photo-induced change are disclosed. Data may be written into the holographic storage media using light of one wavelength and read using light of a different wavelength.

Abstract translation: 公开了包括基底和能够经历光诱导变化的染料的全息存储介质。 可以使用一种波长的光将数据写入全息存储介质，并使用不同波长的光读取。

公开(公告)号：US20050053909A1

公开(公告)日：2005-03-10

申请号：US10657032

申请日：2003-09-08

Applicant: Kwok Chan

Inventor： Kwok Chan

IPC: A63H11/00 ,  A63H17/395 ,  A63H30/00 ,  A63H33/00 ,  B25J9/22 ,  G05B19/42 ,  G05B19/425 ,  G05D1/02 ,  G09B25/00

CPC classification number: A63H30/00 ,  A63H11/00 ,  A63H33/00 ,  G05B19/425 ,  G05B2219/36401 ,  G05B2219/45007

Abstract: A learn-and-play programming method, for controlling a mechanical movement of an output shaft of a motorized toy and a domestic appliance, includes the steps of: learning the mechanical movement of the output shaft by inputting a movement data into the operation system corresponding to the mechanical movement of the output shaft and storing the movement data of the output shaft in a memorizing means; and reproducing the mechanical movement of the output shaft corresponding to the movement data in the memorizing means. Therefore, the operation system is executed through the learning program to repeatedly control the mechanical movement of the output shaft.

Abstract translation: 一种用于控制电动玩具和家用电器的输出轴的机械运动的学习和播放编程方法，包括以下步骤：通过将运动数据输入到对应的操作系统中来学习输出轴的机械运动 输出轴的机械运动并将输出轴的运动数据存储在记忆装置中; 以及再现与存储装置中的运动数据对应的输出轴的机械运动。 因此，通过学习程序来执行操作系统，以重复地控制输出轴的机械运动。