公开(公告)号：US20110083540A1

公开(公告)日：2011-04-14

申请号：US12902317

申请日：2010-10-12

Applicant: Li Xing ,  Yun Huang

Inventor： Li Xing ,  Yun Huang

IPC: B27B9/04

CPC classification number: B23Q9/0014 ,  Y10T83/8878

Abstract: The present invention relates to a guide rail for a power tool with an auxiliary guide component having a locating block and a main guide component. The guide rail has a fixing device to connect the auxiliary guide component to the main guide component. The locating block has a taper-tilted edge that may be connected to a corresponding edge of the fixing device. Using the tapered fitting, the main guide component and the auxiliary guide component can be quickly connected or disconnected to adjust the positions of the auxiliary guide component and the main guide component during operation. The present invention may further include angle-indication marks. By setting the angle-indication marks on the auxiliary guide component, cutting at a certain angle can be achieved quickly to improve the convenience and efficiency of operation by the user.

Abstract translation: 本发明涉及一种具有辅助引导部件的电动工具的导轨，该导向部件具有定位块和主导向部件。 导轨具有用于将辅助引导部件连接到主引导部件的固定装置。 定位块具有可以连接到固定装置的相应边缘的锥形倾斜边缘。 使用锥形配件，可以快速地连接或断开主引导部件和辅助引导部件，以在操作期间调整辅助引导部件和主引导部件的位置。 本发明还可以包括角度指示标记。 通过设置辅助引导部件上的角度指示标记，可以快速地实现切割，以提高使用者的操作方便性和效率。

公开(公告)号：US20090215817A1

公开(公告)日：2009-08-27

申请号：US11573928

申请日：2005-08-08

Applicant: Paul V. Rucker ,  Kevin D. Jerome ,  Shaun R. Selness ,  John E. Baldus ,  Li Xing

Inventor： Paul V. Rucker ,  Kevin D. Jerome ,  Shaun R. Selness ,  John E. Baldus ,  Li Xing

IPC: A61K31/437 ,  C07D471/04 ,  A61P29/00

CPC classification number: C07D471/04

Abstract: This invention is directed generally to triazolopyridine compounds that generally inhibit p38 kinase, TNF, and/or cyclooxygenase activity. Such triazolopyridine include compounds generally corresponding in structure to the following formula: wherein R1, R2, R3, R4, and R5 are as defined in this specification. This invention also is directed to compositions of such triazolopyridines (particularly pharmaceutical compositions), intermediates for the syntheses of such triazolopyridines, methods for making such triazolopyridines, and methods for treating (including preventing) conditions (typically pathological conditions) associated with p38 kinase activity, TNF activity, and/or cyclooxygenase-2 activity.

Abstract translation: 本发明一般涉及通常抑制p38激酶，TNF和/或环氧合酶活性的三唑并吡啶化合物。 这样的三唑并吡啶包括通常在结构上对应于下式的化合物：其中R 1，R 2，R 3，R 4和R 5如本说明书中所定义。 本发明还涉及这种三唑并吡啶（特别是药物组合物）的组合物，用于合成这种三唑并吡啶的中间体，制备这种三唑并吡啶的方法，以及用于治疗（包括预防）与p38激酶活性相关的病症（通常是病理状态）的方法， TNF活性和/或环氧合酶-2活性。

公开(公告)号：US20050148777A1

公开(公告)日：2005-07-07

申请号：US10801429

申请日：2004-03-16

Applicant: Jeffery Carter ,  David Brown ,  Li Xing ,  Karl Aston ,  John Springer ,  Francis Koszyk ,  Steven Kramer ,  Renee Huff ,  Yi Yu ,  Bruce Hamper ,  Subo Laio ,  Angela Deprow ,  Theresa Fletcher ,  E. Hallinan ,  James Kiefer ,  David Limburg ,  Lijuan Wang ,  Cindy Ludwig ,  John McCall ,  John Talley

Inventor： Jeffery Carter ,  David Brown ,  Li Xing ,  Karl Aston ,  John Springer ,  Francis Koszyk ,  Steven Kramer ,  Renee Huff ,  Yi Yu ,  Bruce Hamper ,  Subo Laio ,  Angela Deprow ,  Theresa Fletcher ,  E. Hallinan ,  James Kiefer ,  David Limburg ,  Lijuan Wang ,  Cindy Ludwig ,  John McCall ,  John Talley

IPC: A61K31/352 ,  A61K31/382 ,  A61K31/395 ,  A61K31/47 ,  A61K31/4709 ,  A61P29/00 ,  C07D20060101 ,  C07D215/38 ,  C07D215/54 ,  C07D311/58 ,  C07D311/64 ,  C07D311/92 ,  C07D335/06 ,  C07D401/02 ,  C07D405/02 ,  C07D407/02 ,  C07D409/02 ,  C07D493/04

CPC classification number: C07D311/58 ,  C07D311/64 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D407/04 ,  C07D407/12 ,  C07D409/04 ,  C07D409/06 ,  C07D409/12 ,  C07D417/04 ,  C07D417/06 ,  C07D493/04

Abstract: The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula 1 Wherein Z, X, R1, R 2, R3, and R4 are as described in the specification.

Abstract translation: 本发明涉及可用于治疗与环氧合酶-2介导的病症有关的病症的方法和化合物。 特别感兴趣的化合物是苯并吡喃及其由式1定义的类似物，其中Z，X，R 1，R 2，R 3和R 4 >如说明书中所述。

公开(公告)号：US08906863B2

公开(公告)日：2014-12-09

申请号：US13224151

申请日：2011-09-01

Applicant: R. Holland Cheng ,  Li Xing

Inventor： R. Holland Cheng ,  Li Xing

IPC: A61K38/16 ,  A61K39/21 ,  C07K16/10 ,  C07K14/005 ,  A61K39/29 ,  A61K39/00

CPC classification number: C07K14/005 ,  A61K9/5184 ,  A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  A61K39/29 ,  A61K2039/5258 ,  A61K2039/53 ,  A61K2039/541 ,  A61K2039/542 ,  C07K16/10 ,  C07K16/1063 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/40 ,  C12N7/00 ,  C12N2710/14143 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16234 ,  C12N2770/28123 ,  C12N2770/28134 ,  C12N2770/28142

Abstract: This invention provides a peptide/nucleic acid composition for oral/mucosal, dual-modal activation of immune protection systems.

Abstract translation: 本发明提供了用于免疫保护系统的口腔/粘膜，双重模态激活的肽/核酸组合物。

公开(公告)号：US08800416B2

公开(公告)日：2014-08-12

申请号：US13218016

申请日：2011-08-25

Applicant: Li Xing ,  Wei Dai ,  Shaojun Wang

Inventor： Li Xing ,  Wei Dai ,  Shaojun Wang

IPC: B27B11/02

CPC classification number: B23D59/00 ,  B25H1/0078 ,  Y10T83/8763 ,  Y10T83/8878

Abstract: A guiding mechanism for an electric tool includes at least two guiding elements at least one of which has a first end portion having at least one protruding portion extending outwards therefrom and the other of which has a second end portion having at least one groove therein which may be engaged with the protruding portion. The groove has a cut-out and the protruding portion has an elastic clamping portion which may be engaged with the cut-out.

Abstract translation: 电动工具的引导机构包括至少两个引导元件，其中至少一个引导元件具有第一端部部分，该第一端部部分具有从其向外延伸的至少一个突出部分，另一个引导元件具有第二端部，其中至少一个凹槽 与突出部分接合。 凹槽具有切口，并且突出部分具有可与切口接合的弹性夹持部分。

公开(公告)号：US20110028757A1

公开(公告)日：2011-02-03

申请号：US12742217

申请日：2008-10-30

Applicant: Byoung Joo Gwag ,  Jae Young Cho ,  Young Ae Lee ,  Cheng Qiling ,  Yulian Wu ,  Li Xing

Inventor： Byoung Joo Gwag ,  Jae Young Cho ,  Young Ae Lee ,  Cheng Qiling ,  Yulian Wu ,  Li Xing

IPC: C07C227/18

CPC classification number: C07C227/18 ,  C07C229/64

Abstract: The present invention provides an efficient method for mass-producing 2-hydroxy-5-(substituted)phenylalkylaminobenzoic acid derivative represented by the specific Chemical formula or its salt, particularly 2-hydroxy-5-[2-(4-trifluoromethylphenyl)ethylamino] benzoic acid or its salt.

Abstract translation: 本发明提供了用于大规模生产由特定化学式表示的2-羟基-5-（取代的）苯基烷基氨基苯甲酸衍生物或其盐，特别是2-羟基-5- [2-（4-三氟甲基苯基）乙基氨基] 苯甲酸或其盐。

公开(公告)号：US07629363B2

公开(公告)日：2009-12-08

申请号：US11226556

申请日：2005-09-14

Applicant: Balekudru Devadas ,  John Walker ,  Shaun R. Selness ,  Terri L. Boehm ,  Richard C. Durley ,  Rajesh Devraj ,  Brian S. Hickory ,  Paul V. Rucker ,  Kevin D. Jerome ,  Heather M. Madsen ,  Edgardo Alvira ,  Michele A. Promo ,  Radhika M. Blevis-Bal ,  Laura D. Marruto ,  Jeff Hitchcock ,  Thomas Owen ,  Win Naing ,  Li Xing ,  Huey S. Shieh ,  Aruna Sambandam ,  Shuang Liu ,  Ian L. Scott ,  Kevin F. McGee

Inventor： Balekudru Devadas ,  John Walker ,  Shaun R. Selness ,  Terri L. Boehm ,  Richard C. Durley ,  Rajesh Devraj ,  Brian S. Hickory ,  Paul V. Rucker ,  Kevin D. Jerome ,  Heather M. Madsen ,  Edgardo Alvira ,  Michele A. Promo ,  Radhika M. Blevis-Bal ,  Laura D. Marruto ,  Jeff Hitchcock ,  Thomas Owen ,  Win Naing ,  Li Xing ,  Huey S. Shieh ,  Aruna Sambandam ,  Shuang Liu ,  Ian L. Scott ,  Kevin F. McGee

IPC: A61K31/44 ,  C07D211/02

CPC classification number: C07D213/64 ,  C07D213/69 ,  C07D213/70 ,  C07D213/74 ,  C07D213/75 ,  C07D213/79 ,  C07D213/84 ,  C07D213/85 ,  C07D215/22 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D409/14 ,  C07D413/10

Abstract: Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3/R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

Abstract translation: 公开了式I化合物及其药学上可接受的盐，其中R 1，R 2，R 3 / R 4和R 5在本文中定义。 这些化合物可用于治疗由不受调节的p38 MAP激酶和/或TNF活性引起或加重的疾病和病症。 还公开了含有化合物的药物组合物，制备化合物的方法和使用该化合物的治疗方法。

公开(公告)号：US20090209577A1

公开(公告)日：2009-08-20

申请号：US11573764

申请日：2005-08-08

Applicant: Paul V. Rucker ,  Kevin D. Jerome ,  Shaun R. Selness ,  John E. Baldus ,  Li Xing

Inventor： Paul V. Rucker ,  Kevin D. Jerome ,  Shaun R. Selness ,  John E. Baldus ,  Li Xing

IPC: A61K31/437 ,  C07D471/04 ,  A61P19/02

CPC classification number: C07D471/04

Abstract: This invention is directed generally to triazolopyridine compounds that generally inhibit p38 kinase, TNF, and/or cyclooxygenase activity. Such triazolopyridine include compounds generally corresponding in structure to the following formula: wherein R1, R2 and R3, are as defined in this specification. This invention also is directed to compositions of such triazolopyridines (particularly pharmaceutical compositions), intermediates for the syntheses of such triazolopyridines, methods for making such triazolopyridines, and methods for treating (including preventing) conditions (typically pathological conditions) associated with p38 kinase activity, TNF activity, and/or cyclooxygenase-2 activity.

Abstract translation: 本发明一般涉及通常抑制p38激酶，TNF和/或环氧合酶活性的三唑并吡啶化合物。 这样的三唑并吡啶包括通常在结构上对应于下式的化合物：其中R1，R2和R3如本说明书中所定义。 本发明还涉及这种三唑并吡啶（特别是药物组合物）的组合物，用于合成这种三唑并吡啶的中间体，制备这种三唑并吡啶的方法，以及用于治疗（包括预防）与p38激酶活性相关的病症（通常是病理状态）的方法， TNF活性和/或环氧合酶-2活性。

公开(公告)号：US07264818B2

公开(公告)日：2007-09-04

申请号：US10866505

申请日：2004-06-10

Applicant: Suresh K. Tikoo ,  Li Xing

Inventor： Suresh K. Tikoo ,  Li Xing

IPC: A61K39/23 ,  C12N5/10 ,  C12N7/00

CPC classification number: C12N15/86 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/10322 ,  C12N2710/10323 ,  C12N2710/10343

Abstract: The present invention relates to the identification of bovine adenovirus sequence(s) essential for encapsidation and E1 transcriptional control regions. The present invention provides adenovirus expression systems, host cells and compositions comprising adenovirus vectors which comprise one or more BAV sequence(s) essential for encapsidation, as well as helper virus which express BAV sequences essential for encapsidation. The present invention also provides helper vectors comprising a BAV sequence essential for encapsidation which is used in a helper virus for propagating recombinant adenovirus. The present invention also provides adenovirus expression systems, host cells and compositions comprising adenovirus vectors which comprise modifications in BAV E1 transcriptional control regions. The present invention also provides methods for making adenovirus vectors comprising BAV sequence(s) essential for encapsidation as well as modifications in BAV E1 transcriptional control regions.

Abstract translation: 本发明涉及鉴定用于壳化和E1转录控制区必需的牛腺病毒序列。 本发明提供腺病毒表达系统，宿主细胞和包含腺病毒载体的组合物，所述腺病毒载体包含一个或多个用于包囊所必需的BAV序列，以及表达对于壳化所必需的BAV序列的辅助病毒。 本发明还提供了辅助载体，其包含用于辅助病毒用于繁殖重组腺病毒的壳化所必需的BAV序列。 本发明还提供腺病毒表达系统，宿主细胞和包含腺病毒载体的组合物，其包含BAV E1转录控制区域中的修饰。 本发明还提供了制备包含BAV序列的腺病毒载体的方法，所述BAV序列对于包囊是必需的，以及在BAV E1转录控制区中的修饰。

公开(公告)号：US20050129713A1

公开(公告)日：2005-06-16

申请号：US10866505

申请日：2004-06-10

Applicant: Suresh Tikoo ,  Li Xing

Inventor： Suresh Tikoo ,  Li Xing

IPC: A61K39/23 ,  A61K39/235 ,  A61K48/00 ,  C07K14/075 ,  C12N7/00 ,  C12N7/04 ,  C12N15/861 ,  C12Q1/70

CPC classification number: C12N15/86 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/10322 ,  C12N2710/10323 ,  C12N2710/10343

Abstract: The present invention relates to the identification of bovine adenovirus sequence(s) essential for encapsidation and E1 transcriptional control regions. The present invention provides adenovirus expression systems, host cells and compositions comprising adenovirus vectors which comprise one or more BAV sequence(s) essential for encapsidation, as well as helper virus which express BAV sequences essential for encapsidation. The present invention also provides helper vectors comprising a BAV sequence essential for encapsidation which is used in a helper virus for propagating recombinant adenovirus. The present invention also provides adenovirus expression systems, host cells and compositions comprising adenovirus vectors which comprise modifications in BAV E1 transcriptional control regions. The present invention also provides methods for making adenovirus vectors comprising BAV sequence(s) essential for encapsidation as well as modifications in BAV E1 transcriptional control regions.

Abstract translation: 本发明涉及鉴定对于壳化和E1转录控制区必需的牛腺病毒序列。 本发明提供腺病毒表达系统，宿主细胞和包含腺病毒载体的组合物，所述腺病毒载体包含一个或多个用于包囊所必需的BAV序列，以及表达对于壳化所必需的BAV序列的辅助病毒。 本发明还提供了辅助载体，其包含用于辅助病毒用于繁殖重组腺病毒的壳化所必需的BAV序列。 本发明还提供腺病毒表达系统，宿主细胞和包含腺病毒载体的组合物，其包含BAV E1转录控制区域中的修饰。 本发明还提供了制备包含BAV序列的腺病毒载体的方法，所述BAV序列对于包囊是必需的，以及在BAV E1转录控制区中的修饰。