公开(公告)号：US5799649A

公开(公告)日：1998-09-01

申请号：US715736

申请日：1996-09-19

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61K49/18 ,  G01R33/28 ,  G01R33/561 ,  G01R33/563 ,  A61B5/055

CPC classification number: A61K49/18 ,  A61B5/02007 ,  A61B5/055 ,  G01R33/563 ,  A61B5/201 ,  A61B5/416 ,  A61B5/7285 ,  G01R33/281 ,  G01R33/5619 ,  G01R33/56308

Abstract: The present invention is a technique and apparatus for acquiring anatomic information used in diagnosing and characterizing abdominal aortic aneurismal disease and the like. This technique provides anatomic information, in the form of images, using a combination of a plurality of magnetic resonance angiography sequences, including a spin-echo and four contrast enhanced (e.g., gadolinium) magnetic resonance angiography sequences. The anatomic images may be used in, for example, pre-operative, operative and post-operative evaluation of aortic pathology, including aneurysms, atherosclerosis, and occlusive disease of branch vessels such as the renal arteries. The gadolinium-enhanced magnetic resonance angiography provides sufficient anatomic detail to detect aneurysms and all relevant major branch vessel abnormalities seen at angiography operation. This technique and apparatus allows for imaging the aorta at a fraction of the cost of conventional aortography and without the risks of arterial catheterization or iodinated contrast.

公开(公告)号：US5746208A

公开(公告)日：1998-05-05

申请号：US689270

申请日：1996-08-06

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61K49/18 ,  G01R33/28 ,  G01R33/561 ,  G01R33/563 ,  A61B5/055

CPC classification number: A61B5/416 ,  A61B5/411 ,  A61K49/18 ,  G01R33/5601 ,  G01R33/563 ,  A61B5/201 ,  A61B5/7285 ,  G01R33/281 ,  G01R33/5619 ,  G01R33/56308

Abstract: The present invention is a method and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue. The method and apparatus adapts the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space. The technique and apparatus temporally correlates the timing of a maximum or substantially elevated rate of infusion and the mapping of k-space according to the location of the artery of interest, the size of the artery of interest, the physical condition of the patient, the time delay due to the configuration of the contrast agent delivery system, and/or the type of pulse sequence employed by the imaging apparatus. Adapting the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space provides a period of a maximum or substantially elevated contrast concentration in the artery of interest relative to adjacent veins during collection of at least a portion of the image data corresponding to the center of k-space.

公开(公告)号：US5192278A

公开(公告)日：1993-03-09

申请号：US537925

申请日：1990-06-13

Applicant: Gary B. Hayes ,  Carter Kittrell ,  Martin R. Prince ,  Jill M. Tobin ,  Michael S. Feld

Inventor： Gary B. Hayes ,  Carter Kittrell ,  Martin R. Prince ,  Jill M. Tobin ,  Michael S. Feld

IPC: A61B17/00 ,  A61B17/22 ,  A61B18/00 ,  A61B18/22 ,  A61B18/24 ,  G02B6/42

CPC classification number: G02B6/4296 ,  A61B18/245 ,  A61B2017/00061 ,  A61B2017/22061 ,  A61B2018/1861 ,  A61B2018/2238 ,  G02B6/3504 ,  G02B6/3508 ,  G02B6/3512 ,  G02B6/3516 ,  G02B6/3548 ,  G02B6/3598

Abstract: A molded fiber-optic plug for retaining optical fibers in a fixed position within a laser catheter is disclosed in which an optically polished tubular moldable plug body is used to secure a plurality of optical fibers within a laser catheter.

Abstract translation: 公开了一种用于将光纤保持在激光导管内的固定位置的模制光纤塞，其中使用光学抛光的管状可模塑塞体将多个光纤固定在激光导管内。

公开(公告)号：US4967745A

公开(公告)日：1990-11-06

申请号：US235721

申请日：1988-08-17

Applicant: Gary B. Hayes ,  Carter Kittrell ,  Martin R. Prince ,  Jill M. Tobin ,  Michael S. Feld

Inventor： Gary B. Hayes ,  Carter Kittrell ,  Martin R. Prince ,  Jill M. Tobin ,  Michael S. Feld

IPC: A61B17/00 ,  A61B17/22 ,  A61B18/00 ,  A61B18/22 ,  A61B18/24 ,  G02B6/42

CPC classification number: A61B18/245 ,  G02B6/4296 ,  A61B2017/00061 ,  A61B2017/22061 ,  A61B2018/1861 ,  A61B2018/2238 ,  G02B6/3504 ,  G02B6/3508 ,  G02B6/3512 ,  G02B6/3516 ,  G02B6/3548 ,  G02B6/3598

Abstract: A molded fiber-optic plug for retaining optical fibers in a fixed position within a laser catheter is disclosed in which an optically polished tubular moldable plug body is used to secure a plurality of optical fibers within a laser catheter.

Abstract translation: 公开了一种用于将光纤保持在激光导管内的固定位置的模制光纤塞，其中使用光学抛光的管状可模塑塞体将多个光纤固定在激光导管内。

公开(公告)号：US20100174175A1

公开(公告)日：2010-07-08

申请号：US12725140

申请日：2010-03-16

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61B5/055

CPC classification number: A61B5/055 ,  A61B5/02007

Abstract: Technique and apparatus for acquiring anatomic information used in diagnosing and characterizing abdominal aortic aneurismal disease and the like. This technique provides anatomic information, in the form of images, using a combination of a plurality of magnetic resonance angiography sequences, including a spin-echo and four contrast enhanced (e.g., gadolinium) magnetic resonance angiography sequences. The anatomic images may be used in, for example, pre-operative, operative and post-operative evaluation of aortic pathology, including aneurysms, atherosclerosis, and occlusive disease of branch vessels such as the renal arteries. The gadolinium-enhanced magnetic resonance angiography provides sufficient anatomic detail to detect aneurysms and all relevant major branch vessel abnormalities seen at angiography operation. This technique and apparatus allows for imaging the aorta at a fraction of the cost of conventional aortography and without the risks of arterial catheterization or iodinated contrast.

Abstract translation: 用于获取用于诊断和表征腹主动脉瘤性疾病等的解剖信息的技术和装置。 该技术以图像的形式使用包括自旋回波和四个对比度增强（例如，钆）磁共振血管造影序列的多个磁共振血管造影术序列的组合来提供解剖信息。 解剖图像可以用于例如主动脉病理学的术前，手术和术后评价，包括动脉瘤，动脉粥样硬化和分支血管如肾动脉的闭塞性疾病。 钆增强磁共振血管造影提供足够的解剖学细节来检测血管造影术中所见的动脉瘤和所有相关主要分支血管异常。 该技术和装置允许以常规造影术的成本的一小部分成像主动脉，并且不存在动脉导管插入或碘化对比的风险。

公开(公告)号：US07747309B2

公开(公告)日：2010-06-29

申请号：US10808693

申请日：2004-03-25

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61B5/05

CPC classification number: A61B5/416 ,  A61B5/201 ,  A61B5/411 ,  A61B5/7285 ,  A61K49/18 ,  G01R33/281 ,  G01R33/5601 ,  G01R33/5619 ,  G01R33/563 ,  G01R33/56308

Abstract: The present invention is a method and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue. The method and apparatus adapts the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space. The technique and apparatus temporally correlates the timing of a maximum or substantially elevated rate of infusion and the mapping of k-space according to the location of the artery of interest, the size of the artery of interest, the physical condition of the patient, the time delay due to the configuration of the contrast agent delivery system, and/or the type of pulse sequence employed by the imaging apparatus. Adapting the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space provides a period of a maximum or substantially elevated contrast concentration in the artery of interest relative to adjacent veins during collection of at least a portion of the image data corresponding to the center of k-space.

Abstract translation: 本发明是一种用于相对于相邻静脉和背景组织提供感兴趣的动脉的优先增强的方法和装置。 所述方法和装置使最大或基本上提高的输注速率的时间适应与对应于k空间中心的图像数据的收集相关。 技术和设备根据感兴趣的动脉的位置，感兴趣的动脉的大小，患者的身体状况，时间上相关联的最大或基本上升高的输注速率的时间和k空间的映射 由于造影剂传送系统的配置引起的时间延迟和/或成像装置采用的脉冲序列的类型。 适应最大或基本上提高的输注速率的时间与对应于k空间中心的图像数据的收集相关联，提供在收集期间相对于相邻静脉的感兴趣动脉中的最大或基本上升高的对比浓度的周期 的图像数据的至少一部分对应于k空间的中心。

公开(公告)号：US07729741B2

公开(公告)日：2010-06-01

申请号：US11964037

申请日：2007-12-25

Applicant: James F. M. Meaney ,  Martin R. Prince

Inventor： James F. M. Meaney ,  Martin R. Prince

IPC: A61B5/055

CPC classification number: A61B5/055 ,  G01R33/5601 ,  G01R33/5635 ,  G01R33/56383 ,  G06F19/00

Abstract: The present invention is a technique of, and system for, imaging vascular anatomy over distance considerably greater than the maximum practical field of view of a magnetic resonance imaging system while using substantially one contrast agent injection. The technique and system of the present invention acquires image data of a plurality of image volumes which are representative of different portions of the patient's body. The image data of each image volume includes image data which is representative of the center of k-space. The acquisition of image data which is representative of the center of k-space is correlated with a concentration of contrast agent in the artery(ies) residing in the image volume being substantially greater than the concentration of contrast agent in veins and background tissue adjacent to the artery(ies). This provides preferential enhancement of arteries relative to adjacent veins and background tissue for each acquisition, wherein each acquisition is representative of a different portion of the arterial system (e.g., abdominal aorta, femoral, popliteal, and tibial arteries).

Abstract translation: 本发明是一种技术，并且用于在使用基本上一个造影剂注射的情况下远远超过磁共振成像系统的最大实际视野来对血管解剖结构进行成像的技术和系统。 本发明的技术和系统获取代表患者身体的不同部分的多个图像体积的图像数据。 每个图像体积的图像数据包括表示k空间中心的图像数据。 代表k空间中心的图像数据的获取与静止在图像体积中的动脉中的造影剂的浓度基本上大于静脉和邻近的静脉和背景组织中造影剂的浓度相关 动脉。 这提供了相对于每个采集的相邻静脉和背景组织的动脉的优先增强，其中每个采集代表动脉系统的不同部分（例如，腹主动脉，股骨，po骨和胫骨动脉）。

公开(公告)号：US07003343B2

公开(公告)日：2006-02-21

申请号：US10109888

申请日：2002-04-01

Applicant: Richard Watts ,  Yi Wang ,  Martin R. Prince

Inventor： Richard Watts ,  Yi Wang ,  Martin R. Prince

IPC: A61B5/05 ,  G01V3/00

CPC classification number: G01R33/5601 ,  A61B5/055

Abstract: Current bolus chase magnetic resonance angiography is limited by the imaging time for each station. Tailoring the density of k-space sampling along the anterior-posterior direction of the coronal station allows a substantial decrease in scan time that leads to greater contrast bolus sharing among stations and consequently a significant improvement in image quality. Fast arterial-venous transit in the carotid arteries requires accurate, reliable timing of the acquisition to the bolus transit to maximize arterial signal and minimize venous artifacts. The rising edge of the bolus is not utilized in conventional elliptical-centric view ordering because the critical k-space center must be acquired with full arterial enhancement. The invention provides a recessed elliptical-centric view ordering scheme is introduced in which the k-space center is acquired a few seconds following scan initiation. The recessed view ordering is shown to be more robust to timing errors in a patient studies.

公开(公告)号：US06463318B2

公开(公告)日：2002-10-08

申请号：US09828429

申请日：2001-04-07

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61B5055

CPC classification number: A61K49/18 ,  A61B5/201 ,  A61B5/411 ,  A61B5/416 ,  A61M5/007 ,  A61M5/1456 ,  A61M5/16827 ,  G01R33/281 ,  G01R33/5601 ,  G01R33/5619 ,  G01R33/563 ,  G01R33/56308 ,  G01R33/5635

Abstract: The present invention is a technique and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue by correlating the collection of a predetermined portion of data of a magnetic resonance contrast image during the arterial phase of the magnetic resonance contrast enhancement. The arterial phase of the contrast enhancement may be described as a period of a maximum, substantially elevated, or elevated contrast concentration in the artery of interest relative to adjacent veins. The present invention includes a detection system for monitoring and detecting the arrival of the contrast agent in the artery and tissues of interest. When the concentration of contrast agent in the artery of the region of interest is maximum, substantially elevated or elevated (e.g., about 20-50% greater than the response of the region of interest to a series of magnetic resonance pulses before administration of a magnetic resonance contrast agent), a predetermined portion of the magnetic resonance image data (e.g., data which is representative of the center of k-space) may be acquired. Thus, the present invention facilitates synchronization between collecting the central portion of k-space image data with the arterial phase of contrast enhancement. The center of k-space corresponds to the lowest spatial frequency data which dominates image contrast.

Abstract translation: 本发明是一种通过将磁共振对比度增强的动脉期期间的磁共振对比度图像的预定部分数据的收集相关联来提供相对于相邻静脉和背景组织的感兴趣的动脉的优先增强的技术和装置 。 对比度增强的动脉期可以描述为相对于相邻静脉的感兴趣动脉中的最大，基本升高或升高的对比浓度的周期。本发明包括用于监测和检测对比度的到达的检测系统 在动脉和组织中的药剂。 当感兴趣区域的动脉中的造影剂的浓度最大时，基本升高或升高（例如，在给予磁性之前一系列磁共振脉冲的感兴趣区域的响应大约20-50％ 共振造影剂），可以获取磁共振图像数据的预定部分（例如，表示k空间的中心的数据）。 因此，本发明有助于将k空间图像数据的中心部分与对比度增强的动脉相位之间的同步。 k空间的中心对应于支配图像对比度的最低空间频率数据。

公开(公告)号：US06230041B1

公开(公告)日：2001-05-08

申请号：US09124262

申请日：1998-07-29

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61B5055

CPC classification number: A61K49/18 ,  A61B5/02007 ,  A61B5/055 ,  A61B5/201 ,  A61B5/416 ,  A61B5/7285 ,  G01R33/281 ,  G01R33/5619 ,  G01R33/563 ,  G01R33/56308

Abstract: The present invention is a technique and apparatus for acquiring anatomic information used in diagnosing and characterizing abdominal aortic aneurismal disease and the like. This technique provides anatomic information, in the form of images, using a combination of a plurality of magnetic resonance angiography sequences, including a spin-echo and four contrast enhanced (e.g., gadolinium) magnetic resonance angiography sequences. The anatomic images may be used in, for example, pre-operative, operative and post-operative evaluation of aortic pathology, including aneurysms, atherosclerosis, and occlusive disease of branch vessels such as the renal arteries. The gadolinium-enhanced magnetic resonance angiography provides sufficient anatomic detail to detect aneurysms and all relevant major branch vessel abnormalities seen at angiography operation. This technique and apparatus allows for imaging the aorta at a fraction of the cost of conventional aortography and without the risks of arterial catheterization or iodinated contrast.

Abstract translation: 本发明是用于获取用于诊断和表征腹主动脉瘤性疾病等的解剖信息的技术和装置。 该技术以图像的形式使用包括自旋回波和四个对比度增强（例如，钆）磁共振血管造影序列的多个磁共振血管造影术序列的组合来提供解剖信息。 解剖图像可以用于例如主动脉病理学的术前，手术和术后评价，包括动脉瘤，动脉粥样硬化和分支血管如肾动脉的闭塞性疾病。 钆增强磁共振血管造影提供足够的解剖学细节来检测血管造影术中所见的动脉瘤和所有相关主要分支血管异常。 该技术和装置允许以常规造影术的成本的一小部分成像主动脉，并且不存在动脉导管插入或碘化对比的风险。