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    SOLID PHASE PEPTIDES SYNTHESIS PROCESSES AND ASSOCIATED SYSTEMS
    15.
    发明申请
    SOLID PHASE PEPTIDES SYNTHESIS PROCESSES AND ASSOCIATED SYSTEMS 有权
    固相化合物合成方法及相关系统

    公开(公告)号：US20160102118A1

    公开(公告)日：2016-04-14

    申请号：US14853683

    申请日：2015-09-14

    Applicant: Massachusetts Institute of Technology

    Inventor： Mark David Simon ,  Bradley L. Pentelute ,  Andrea Adamo ,  Patrick Louis Heider ,  Klavs F. Jensen

    IPC: C07K1/04 ,  C07K1/06 ,  C07K1/08

    CPC classification number: C07K1/045 ,  C07K1/04 ,  C07K1/042 ,  C07K1/061 ,  C07K1/08

    Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.

    Abstract translation: 通常描述用于进行固相肽合成的系统和方法。 固相肽合成是将已经固定在固体支持物上的肽加入氨基酸残基的已知方法。 在某些实施方案中，本发明的系统和方法可用于快速进行固相肽合成，同时保持高产率。 某些实施方案涉及可用于以减少进行固相肽合成所需时间量的方式加热，运输和/或混合试剂的方法和系统。

    SOLID PHASE PEPTIDE SYNTHESIS PROCESSES AND ASSOCIATED SYSTEMS
    16.
    发明申请
    SOLID PHASE PEPTIDE SYNTHESIS PROCESSES AND ASSOCIATED SYSTEMS 有权
    固相化合物合成方法及相关系统

    公开(公告)号：US20160031931A1

    公开(公告)日：2016-02-04

    申请号：US14776870

    申请日：2014-02-24

    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

    Inventor： Mark David Simon ,  Bradley L. Pentelute ,  Andrea Adamo ,  Patrick Louis Heider ,  Klavs F. Jensen

    IPC: C07K1/04 ,  C07K1/08 ,  C07K1/06

    CPC classification number: C07K1/042 ,  C07K1/045 ,  C07K1/061 ,  C07K1/08

    Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.

    Abstract translation: 通常描述用于进行固相肽合成的系统和方法。 固相肽合成是将已经固定在固体支持物上的肽加入氨基酸残基的已知方法。 在某些实施方案中，本发明的系统和方法可用于快速进行固相肽合成，同时保持高产率。 某些实施方案涉及可用于以减少进行固相肽合成所需时间量的方式加热，运输和/或混合试剂的方法和系统。

    Methods and systems for solid phase peptide synthesis
    18.
    发明授权
    Methods and systems for solid phase peptide synthesis 有权

    公开(公告)号：US11584776B2

    公开(公告)日：2023-02-21

    申请号：US16874824

    申请日：2020-05-15

    Applicant: Massachusetts Institute of Technology

    Inventor： Dale Arlington Thomas, III ,  Alexander James Mijalis ,  Bradley L. Pentelute ,  Mark David Simon ,  Surin Mong

    IPC: C07K1/04 ,  C07K14/60 ,  C07K7/06 ,  C07K14/47 ,  C07K14/61 ,  C07K14/62 ,  G01N21/33 ,  G01N33/487 ,  G01N21/84 ,  G01N21/27 ,  G01N21/3577

    Abstract: Methods and systems for control of solid phase peptide synthesis are generally described. Control of solid phase peptide synthesis involves the use of feedback from one or more reactions and/or processes (e.g., reagent removal) taking place in the solid phase peptide synthesis system. In some embodiments, a detector may detect one or more fluids flowing across a detection zone of a solid phase peptide synthesis system and one or more signals may be generated corresponding to the fluid(s). For instance, an electromagnetic radiation detector positioned downstream of a reactor may detect a fluid exiting the reactor after a deprotection reactor and produce a signal(s). In some embodiments, based at least in part on information derived from the signal(s), a parameter of the system may be modulated prior to and/or during one or more subsequent reactions and/or processes taking place in the solid phase peptide synthesis system. In some embodiments, the methods and systems, described herein, can be used to conduct quality control to determine and correct problems (e.g., aggregation, truncation, deletion) in reactions (e.g., coupling reactions) taking place in the solid phase peptide synthesis system.

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