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公开(公告)号：US20140335596A1
公开(公告)日：2014-11-13
申请号：US14364191
申请日：2012-12-18
Applicant: Novozymes A/S
Inventor： Werner Besenmatter , Astrid Benie , Esben Peter Friis , Pernille Ollendorf Micheelsen
IPC: C12N9/54
CPC classification number: C12N9/50 , C11D3/386 , C11D3/38609 , C11D3/38618 , C11D3/38681 , C12N9/54 , C12Y304/21 , C12Y304/21062 , C12Y304/21112
Abstract: The present invention relates to protease variants and methods for obtaining protease variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
Abstract translation: 本发明涉及蛋白酶变体和获得蛋白酶变体的方法。 本发明还涉及编码这些变体的多核苷酸; 核酸构建体，载体和包含多核苷酸的宿主细胞; 以及使用这些变体的方法。
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公开(公告)号：US20140302586A1
公开(公告)日：2014-10-09
申请号：US14193478
申请日：2014-02-28
Applicant: Novozymes A/S
Inventor： Werner Besenmatter , Esben Peter Friis , Keith Gibson , Frank Winther Rasmussen , Michael Skjoet
IPC: C12N9/26
CPC classification number: C12N9/2437 , C11D3/38636 , C12N9/2408 , C12N9/2434 , C12Y302/01151
Abstract: The present invention relates to variants of a parent xyloglucanase. The present invention also relates to polynucleotides encoding the variant xyloglucanases and to nucleic acid constructs, vectors, and host cells comprising the polynucleotide.
Abstract translation: 本发明涉及亲本木葡聚糖酶的变体。 本发明还涉及编码变体木葡聚糖酶的多核苷酸以及包含多核苷酸的核酸构建体，载体和宿主细胞。
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公开(公告)号：US20140141489A1
公开(公告)日：2014-05-22
申请号：US14129565
申请日：2012-06-29
Applicant: NOVOZYMES A/S
Inventor： Svend Kaasgaard , Jens Oebro , Signe Eskildsen Larsen , Allan Svendsen , Annette Helle Johansen , Michael Skjoet , Carsten Andersen , Lars Beier , Esben Peter Friis , Miguel Duarte Guilherme Pereira Toscano , Mads Bjoernvad , Frank Winther Rasmussen , Liv Spaanger Christiansen
IPC: C12N9/28
CPC classification number: C12N9/2417 , C12Y302/01001
Abstract: The present invention relates to variants of a parent alpha-amylase. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
Abstract translation: 本发明涉及母体α-淀粉酶的变体。 本发明还涉及编码这些变体的多核苷酸; 核酸构建体，载体和包含多核苷酸的宿主细胞; 以及使用这些变体的方法。
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公开(公告)号：US20140011259A1
公开(公告)日：2014-01-09
申请号：US13936300
申请日：2013-07-08
Applicant: Novozymes A/S
Inventor： Erwin Ludo Roggen , Steffen Ernst , Allan Svendsen , Esben Peter Friis , Claus Von Der Osten
IPC: C12N9/54
CPC classification number: C12N9/54 , A21D2/267 , A21D8/042 , A61K39/00 , C07K1/047 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1019 , C07K5/1021 , C07K14/001 , C07K16/40 , C07K16/4283 , C11D3/38627 , C11D3/38645 , C12N9/0061 , C12N9/20 , C12Y110/03002 , C12Y304/21062 , Y10S435/911
Abstract: The present invention relates to a method of selecting a protein variant having modified immunogenicity as compared to the parent protein comprising the steps obtaining antibody binding peptide sequences, using the sequences to localise epitope sequences on the 3-dimensional structure of parent protein, defining an epitope area including amino acids situated within 5 Å from the epitope amino acids constituting the epitope sequence, changing one or more of the amino acids defining the epitope area of the parent protein by genetical engineering mutations of a DNA sequence encoding the parent protein, introducing the mutated DNA sequence into a suitable host, culturing said host and expressing the protein variant, and evaluating the immunogenicity of the protein variant using the parent protein as reference. The invention further relates to the protein variant and use thereof, as well as to a method for producing said protein variant.
Abstract translation: 本发明涉及选择与亲本蛋白相比具有改良的免疫原性的蛋白质变体的方法，其包括获得抗体结合肽序列的步骤，使用该序列来定位母体蛋白的3维结构上的表位序列，限定表位 包括位于构成表位序列的表位氨基酸5埃范围内的氨基酸，通过编码母体蛋白质的DNA序列的遗传工程突变改变限定母体蛋白表位区域的一个或多个氨基酸，引入突变的 DNA序列转化为合适的宿主，培养所述宿主并表达蛋白质变体，并使用亲本蛋白作为参考来评估蛋白质变体的免疫原性。 本发明还涉及蛋白质变体及其用途，以及生产所述蛋白质变体的方法。
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公开(公告)号：US12012623B2
公开(公告)日：2024-06-18
申请号：US17378288
申请日：2021-07-16
Applicant: Novozymes A/S
Inventor： Svend Kaasgaard , Jens Oebro , Signe Eskildsen Larsen , Allan Svendsen , Annette Helle Johansen , Michael Skjoet , Carsten Andersen , Lars Beier , Esben Peter Friis , Miguel Duarte Guilherme Pereira Toscano , Mads Bjoernvad , Frank Winther Rasmussen , Liv Spaanger Christiansen
CPC classification number: C12N9/2417 , C12N9/2414 , C12N15/63 , C12Y302/01001
Abstract: The present invention relates to variants of a parent alpha-amylase. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
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Patent Agency Ranking
公开(公告)号：US20240076579A1
公开(公告)日：2024-03-07
申请号：US18506648
申请日：2023-11-10
Applicant: Novozymes A/S
Inventor： Peter Kamp Hansen , Esben Peter Friis , Torben Vedel Borchert , Lars Lehmann Hylling Christensen , Jens Erik Nielsen , Maria Berggaard Silow
CPC classification number: C11D3/38618 , C11D3/044 , C11D3/08 , C12N9/54 , C12Y304/21062
Abstract: The present invention relates to compositions comprising protease variants suitable for use in cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions.
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公开(公告)号：US20230183669A1
公开(公告)日：2023-06-15
申请号：US18052489
申请日：2022-11-03
Applicant: Novozymes A/S
Inventor： Jens Erik Nielsen , Pernille Hede , Esben Peter Friis
CPC classification number: C12N9/54 , C12Y304/21062 , C11D3/386 , C12Y304/21
Abstract: The present invention relates to protease variants and methods for obtaining protease variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
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公开(公告)号：US20210189297A1
公开(公告)日：2021-06-24
申请号：US17252446
申请日：2019-06-24
Applicant: NOVOZYMES A/S
Inventor： Rolf Thomas Lenhard , Lars Lehmann Hylling Christensen , Carl Mikael Bauer , Esben Peter Friis , Julie Bille Rannes
Abstract: The invention relates to subtilase variants having improved stability, compositions comprising the variants, in particular detergent compositions, polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; as well as methods of producing the variants and methods for stabilizing a subtilase variant
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公开(公告)号：US20210009979A1
公开(公告)日：2021-01-14
申请号：US17040207
申请日：2019-03-21
Applicant: NOVOZYMES A/S
Inventor： Esben Peter Friis , Rolf Thomas Lenhard , Lars Lehmann Hylling Christensen , Carl Mikael Bauer
Abstract: The invention relates to subtilase variants and detergent compositions comprising the variants, as well as methods of producing the variants and methods for stabilizing a subtilase variant.
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公开(公告)号：US20200308563A1
公开(公告)日：2020-10-01
申请号：US16903487
申请日：2020-06-17
Applicant: Novozymes A/S
Inventor： Carsten Andersen , Signe E. Larsen , Esben Peter Friis , Pernille Ollendorff Micheelsen , Anders Viksoee-Nielsen , Randy Deinhammer , Xinyu Shen
Abstract: The present invention relates to alpha-amylase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
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