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公开(公告)号：US10722713B2
公开(公告)日：2020-07-28
申请号：US15598063
申请日：2017-05-17
Applicant: Oculeve, Inc.
Inventor： Manfred Franke , James Donald Loudin
Abstract: Described herein are electrical stimulation patterns and methods of use thereof for treating dry eye disease, tired eye, or other forms of ocular discomfort. The methods generally include applying patterned stimulation to an anatomical structure located in an ocular region or a nasal region to increase tear production.
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公开(公告)号：US20190308009A1
公开(公告)日：2019-10-10
申请号：US16357033
申请日：2019-03-18
Applicant: Oculeve, Inc.
Inventor： James Donald Loudin , Daniel N. Hamilton , Manfred Franke , Douglas Michael Ackermann
Abstract: Described here are devices, systems, and methods for treating one or more conditions, such as allergic rhinitis, non-allergic rhinitis, nasal congestion, ocular allergy, and/or symptoms associated with these conditions, by providing stimulation to nasal or sinus tissue. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs, and the nasal insertion prongs may be configured to deliver an electrical stimulus to the tissue.
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公开(公告)号：US20190217095A1
公开(公告)日：2019-07-18
申请号：US16248493
申请日：2019-01-15
Applicant: Oculeve, Inc.
Inventor： Manfred Franke , James Donald Loudin , Janusz Kuzma , Paul Taehyun Yu , Douglas Michael Ackermann
CPC classification number: A61N1/36046 , A61N1/3606 , A61N1/37205 , A61N1/3756 , A61N2001/37294
Abstract: Described here are systems, devices, and methods for implanting a nasal stimulator into nasal tissue and electrically stimulating nasal tissue. In some variations, a nasal microstimulator implantation system may comprise an implantation tool and an implantable microstimulator. An implantation tool may comprise a shaft and features to releasably attach a microstimulator. A microstimulator may comprise a passive stimulation circuit and one or more electrodes. In other variations, a nasal implantation system may additionally comprise one or more additional devices, such as a controller, an electrical probe, and/or a dissection tool.
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公开(公告)号：US20190022392A1
公开(公告)日：2019-01-24
申请号：US16137464
申请日：2018-09-20
Applicant: Oculeve, Inc.
Inventor： Manfred Franke , James Donald Loudin , John Wardle , Mark Jeffrey Holdbrook
Abstract: Described herein are devices and methods of use thereof for treating dry eye, tired eye, or other forms of ocular discomfort such as from contact lenses. The methods generally include applying spatially and/or temporally patterned stimulation to one or more anatomical structures located in an ocular or nasal region. The electrical stimulation may elicit a reflex that activates the lacrimal gland or may directly activate the lacrimal gland or nerves innervating the lacrimal gland to produce tears. The devices may be implantable or handheld, and may be configured to deliver the spatially and/or temporally patterned stimulation patterns described.
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Patent Agency Ranking
公开(公告)号：US20210370051A1
公开(公告)日：2021-12-02
申请号：US17164709
申请日：2021-02-01
Applicant: Oculeve Inc.
Inventor： James Donald Loudin , Daniel N. Hamilton , Manfred Franke , Douglas Michael Ackermann
Abstract: Described here are devices, systems, and methods for treating one or more conditions, such as allergic rhinitis, non-allergic rhinitis, nasal congestion, ocular allergy, and/or symptoms associated with these conditions, by providing stimulation to nasal or sinus tissue. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs, and the nasal insertion prongs may be configured to deliver an electrical stimulus to the tissue.
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公开(公告)号：US10918864B2
公开(公告)日：2021-02-16
申请号：US15584956
申请日：2017-05-02
Applicant: Oculeve, Inc.
Inventor： Manfred Franke , Diane Michelle Senchyna , Daniel N. Hamilton
Abstract: Described here are devices, systems, and methods for treating meibomian gland disease and/or blepharitis by providing intranasal stimulation. Generally, the devices may deliver electrical stimulation to the nasal mucosa. Intranasal stimulation may unblock obstructed meibomian glands and increase the lipid content of tears, both acutely during stimulation and subsequent to intranasal stimulation. The methods may include an initial round of stimulation to unblock obstructed meibomian glands, and subsequent shorter rounds of stimulation to cause meibum secretion and maintain the open glands.
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公开(公告)号：US20200030615A1
公开(公告)日：2020-01-30
申请号：US16595846
申请日：2019-10-08
Applicant: Oculeve, Inc.
Inventor： James Donald Loudin , Manfred Franke , Daniel N. Hamilton , Anand Doraiswamy , Douglas Michael Ackermann
Abstract: Described here are devices, systems, and methods for increasing tear production by stimulating the cornea, conjunctiva, and/or subconjunctiva. In some variations, the devices may be in the form of a contact lens. The contact lens may comprise a lens body and a stimulator chip, where the stimulator chip is embedded in the lens body. An external power source wirelessly transmits energy to the stimulator chip, where the stimulator chip may convert the energy to an electric waveform to stimulate the cornea, conjunctiva, and/or subconjunctiva. Stimulation may activate the lacrimal reflex to increase tear production. The devices and systems for increasing tear production may be used in methods of treating dry eye, reducing the symptoms of tired eye, increasing comfort for contact lens wearers, and extending the number of years a contact lens user can wear contacts. Also described are methods of manufacturing a contact lens.
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公开(公告)号：US09737712B2
公开(公告)日：2017-08-22
申请号：US14920860
申请日：2015-10-22
Applicant: Oculeve, Inc.
Inventor： Manfred Franke , James Donald Loudin , John Wardle , Mark Jeffrey Holdbrook
CPC classification number: A61N1/36046 , A61N1/0526 , A61N1/0546 , A61N1/3606 , A61N1/36146 , A61N1/37205 , A61N1/37247 , A61N1/3756 , A61N1/3758
Abstract: Described herein are devices and methods of use thereof for treating dry eye, tired eye, or other forms of ocular discomfort such as from contact lenses. The methods generally include applying spatially and/or temporally patterned stimulation to one or more anatomical structures located in an ocular or nasal region. The electrical stimulation may elicit a reflex that activates the lacrimal gland or may directly activate the lacrimal gland or nerves innervating the lacrimal gland to produce tears. The devices may be implantable or handheld, and may be configured to deliver the spatially and/or temporally patterned stimulation patterns described.
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公开(公告)号：US09687652B2
公开(公告)日：2017-06-27
申请号：US14809109
申请日：2015-07-24
Applicant: Oculeve, Inc.
Inventor： Manfred Franke , James Donald Loudin , Jarren Armond Baldwin
CPC classification number: A61N1/36046 , A61N1/0526 , A61N1/0546 , A61N1/3606 , A61N1/36146 , A61N1/3756
Abstract: Described herein are electrical stimulation patterns and methods of use thereof for treating dry eye disease, tired eye, or other forms of ocular discomfort. The methods generally include applying patterned stimulation to an anatomical structure located in an ocular region or a nasal region to increase tear production.
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