公开(公告)号：US12060421B2

公开(公告)日：2024-08-13

申请号：US17227642

申请日：2021-04-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Mark F. Maurer ,  Tseng-hui Timothy Chen ,  Brigitte Devaux ,  Mohan Srinivasan ,  Susan H. Julien ,  Paul O. Sheppard ,  Daniel F. Ardourel ,  Indrani Chakraborty

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00

CPC classification number: C07K16/2803 ,  A61P35/00 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/30

Abstract: The present invention provides antibodies, or antigen binding fragments thereof, that bind to human TIGIT (T cell immunoreceptor with Ig and ITIM domains), as well as uses of these antibodies or fragments in therapeutic applications, such as in the treatment of cancer or chronic viral infection. Such method of treatment include combination therapy with inhibitors of other immunomodulatory receptor interactions, such as the PD-1/PD-L1 interaction. The invention further provides polynucleotides encoding the heavy and/or light chain variable region of the antibodies, expression vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies, cells comprising the vectors, and methods of making the antibodies or fragments by expressing them from the cells.

公开(公告)号：US20200071412A1

公开(公告)日：2020-03-05

申请号：US16687107

申请日：2019-11-18

Applicant: The Rockefeller University ,  BRISTOL-MYERS SQUIBB COMPANY

Inventor： Jeffrey V. Ravetch ,  Rony Dahan ,  Bryan C. Barnhart ,  Brigitte Devaux ,  Aaron P. Yamniuk ,  Shannon L. Okada ,  Brenda L. Stevens

IPC: C07K16/28

Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for FcγRIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.

公开(公告)号：US11008390B2

公开(公告)日：2021-05-18

申请号：US16228095

申请日：2018-12-20

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Mark F. Maurer ,  Tseng-hui Timothy Chen ,  Brigitte Devaux ,  Mohan Srinivasan ,  Susan H. Julien ,  Paul O. Sheppard ,  Daniel F. Ardourel ,  Indrani Chakraborty

IPC: C07K16/28 ,  A61P35/00 ,  A61K39/00

Abstract: The present invention provides antibodies, or antigen binding fragments thereof, that bind to human TIGIT (T cell immunoreceptor with Ig and ITIM domains), as well as uses of these antibodies or fragments in therapeutic applications, such as in the treatment of cancer or chronic viral infection. Such method of treatment include combination therapy with inhibitors of other immunomodulatory receptor interactions, such as the PD-1/PD-L1 interaction. The invention further provides polynucleotides encoding the heavy and/or light chain variable region of the antibodies, expression vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies, cells comprising the vectors, and methods of making the antibodies or fragments by expressing them from the cells.

公开(公告)号：US20190248911A1

公开(公告)日：2019-08-15

申请号：US16399379

申请日：2019-04-30

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Bryan C. Barnhart ,  Brigitte Devaux ,  Aaron P. Yamniuk ,  Shannon L. Okada ,  Brenda L. Stevens

IPC: C07K16/28 ,  A61P35/04 ,  A61P35/00 ,  A61P35/02 ,  A61P31/12

CPC classification number: C07K16/2878 ,  A61K2039/505 ,  A61P31/12 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/72 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/75 ,  C07K2317/92 ,  C07K2317/94

Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for FcγRIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.

公开(公告)号：US20180298097A1

公开(公告)日：2018-10-18

申请号：US16017489

申请日：2018-06-25

Applicant: Bristol-Myers Squibb Company

Inventor： Xiao Min Schebye ,  Mark J. Selby ,  Michelle Minhua Han ,  Christine Bee ,  Andy X. Deng ,  Anan Chuntharapai ,  Brigitte Devaux ,  Huiming Li ,  Paul O. Sheppard ,  Alan J. Korman ,  Daniel F,. Ardourel ,  Ekaterina Deyanova ,  Richard Huang ,  Guodong Chen ,  Michelle Kuhne ,  Hong-An Troung

IPC: C07K16/28 ,  C07K16/30 ,  A61K39/00

Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.

公开(公告)号：US10077306B2

公开(公告)日：2018-09-18

申请号：US15649380

申请日：2017-07-13

Applicant: Bristol-Myers Squibb Company

Inventor： Xiao Min Schebye ,  Mark J. Selby ,  Michelle Minhua Han ,  Christine Bee ,  Andy X. Deng ,  Anan Chuntharapai ,  Brigitte Devaux ,  Huiming Li ,  Paul O. Sheppard ,  Alan J. Korman ,  Daniel F. Ardourel ,  Ekaterina Deyanova ,  Richard Huang ,  Guodong Chen ,  Michelle Kuhne ,  Hong-An Troung

IPC: C07K16/00 ,  C07K16/28 ,  C07K16/30 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A61K47/6849 ,  A61K2039/505 ,  A61K2039/507 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/2878 ,  C07K16/30 ,  C07K16/3046 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/74 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/57492

Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.

公开(公告)号：US11952427B2

公开(公告)日：2024-04-09

申请号：US17694890

申请日：2022-03-15

Applicant: Bristol-Myers Squibb Company ,  CytomX Therapeutics, Inc.

Inventor： Bryan C. Barnhart ,  Brigitte Devaux ,  Aaron P. Yamniuk ,  Shannon L. Okada ,  Brenda L. Stevens ,  James William West

IPC: C07K16/28 ,  C12N15/63

CPC classification number: C07K16/2878 ,  C12N15/63 ,  C07K2317/56

Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40 and comprise improved heavy and light chain variable regions that impart improved yield and reduced aggregation. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.

公开(公告)号：US11306149B2

公开(公告)日：2022-04-19

申请号：US16958563

申请日：2018-12-27

Applicant: Bristol-Myers Squibb Company ,  CytomX Therapeutics, Inc.

Inventor： Bryan C. Barnhart ,  Brigitte Devaux ,  Aaron P. Yamniuk ,  Shannon L. Okada ,  Brenda L. Stevens ,  James William West

IPC: C07K16/28 ,  C12N15/63

Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40 and comprise improved heavy and light chain variable regions that impart improved yield and reduced aggregation. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.

公开(公告)号：US10479838B2

公开(公告)日：2019-11-19

申请号：US15195098

申请日：2016-06-28

Applicant: The Rockefeller University ,  BRISTOL-MYERS SQUIBB COMPANY

Inventor： Jeffrey V. Ravetch ,  Rony Dahan ,  Bryan C. Barnhart ,  Brigitte Devaux ,  Aaron P. Yamniuk ,  Shannon L. Okada ,  Brenda L. Stevens

IPC: A61K39/395 ,  C07K16/28 ,  A61K39/00

Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for FcγRIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.

公开(公告)号：US12129297B2

公开(公告)日：2024-10-29

申请号：US16961545

申请日：2019-01-11

Applicant: Bristol-Myers Squibb Company

Inventor： Xiao Min Schebye ,  Mark J. Selby ,  Michelle Minhua Han ,  Christine Bee ,  Andy X. Deng ,  Anan Chuntharapai ,  Brigitte Devaux ,  Huiming Li ,  Paul O. Sheppard ,  Alan J. Korman ,  Daniel F. Ardourel ,  Ekaterina Deyanova ,  Richard Yu-Cheng Huang ,  Guodong Chen ,  Michelle Kuhne ,  Hong-An Truong

IPC: C07K16/28 ,  A61P35/00 ,  G01N33/68 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A61P35/00 ,  G01N33/6854 ,  A61K2039/507 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/74 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/70503

Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof.