公开(公告)号：US08518258B2

公开(公告)日：2013-08-27

申请号：US12312040

申请日：2007-10-22

Applicant: Klaus Balschat ,  Reiner Spickermann ,  Josef Winter

Inventor： Klaus Balschat ,  Reiner Spickermann ,  Josef Winter

IPC: C02F1/44 ,  A61M37/00

CPC classification number: A61M1/16 ,  A61M1/1605 ,  A61M1/1619 ,  A61M1/165 ,  A61M1/342 ,  A61M1/3441 ,  A61M1/3465 ,  A61M2205/50 ,  A61M2205/70

Abstract: A hemodialysis machine or hemodiafiltration machine is provided that may be used directly for sampling for the connection to a hemodialyzer or for providing replacement fluid, as is required for regular microbiological testing. The machine does not require any additional components or any complex hygiene measures to prevent secondary contamination. By connecting an inventive sterile sampling set, samples can easily be taken. Closing elements and pumping mechanisms are controlled by a control unit as part of a sampling control program.

Abstract translation: 提供血液透析机或血液透析滤过机，其可以直接用于取样以连接血液透析器或提供替代液体，如常规微生物测试所要求的。 机器不需要任何额外的部件或任何复杂的卫生措施来防止二次污染。 通过连接本发明的无菌取样装置，可以容易地取样。 关闭元件和泵送机构由控制单元控制，作为采样控制程序的一部分。

公开(公告)号：US08439857B2

公开(公告)日：2013-05-14

申请号：US13130116

申请日：2009-11-14

Applicant: Pascal Kopperschmidt ,  Malte Gross ,  Reiner Spickermann

Inventor： Pascal Kopperschmidt ,  Malte Gross ,  Reiner Spickermann

IPC: A61M37/00 ,  A61B5/02

CPC classification number: A61B5/02042 ,  A61M1/3639 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  A61M2205/18 ,  A61M2205/3331

Abstract: A method and a device for recognition of paravasal bleeding upon a supplying of blood to a vascular access via a line and/or upon the removal of blood from a vascular access via a line is provided. A device for extracorporeal blood treatment comprising a device for recognition of paravasal bleeding is also provided. The method and the device are based on the change of arterial pressure in the arterial branch or the venous pressure in the venous branch of the extra-corporeal circuit being registered during the extracorporeal blood treatment. One aspect of the method and the device is that pressure changes that come from a pressure level exhibiting a large difference from a reference value are more strongly considered than those that come from a pressure level that exhibits only a minor difference from the reference value.

Abstract translation: 提供了一种方法和装置，用于在通过管线向血管通路供血时和/或通过管线从血管通路中取出血液来供应血液，以识别旁路出血。 还提供了一种用于体外血液处理的装置，其包括用于识别paravasal出血的装置。 该方法和装置基于在体外血液处理期间记录的动脉分支中的动脉压的变化或在体外循环的静脉分支中的静脉压。 该方法和装置的一个方面是，从与参考值相比仅显示较小差异的压力水平的压力水平的压力变化更强烈地考虑来自与参考值的差异较大的压力水平的压力变化。

公开(公告)号：US20110180480A1

公开(公告)日：2011-07-28

申请号：US12737755

申请日：2009-08-12

Applicant: Peter Kloeffel ,  Olaf Nicholas ,  Reiner Spickermann

Inventor： Peter Kloeffel ,  Olaf Nicholas ,  Reiner Spickermann

IPC: B01D61/10 ,  C02F1/44 ,  B01D61/30

CPC classification number: B01D61/025 ,  B01D61/10 ,  C02F1/441

Abstract: The present invention relates to a reverse osmosis system having an apparatus for noise cancellation of the reverse osmosis system, wherein the apparatus has at least one sensor for the detection of at least one noise emitted by the reverse osmosis system; at least one controller connected to the sensor for the evaluation of the signal or signals obtained from the sensor; and at least one actuator connected to the controller, with the actuator being designed such that it generates an acoustic signal or a vibration by means of which the noise emitted by the reverse osmosis system is damped or cancelled out.

Abstract translation: 本发明涉及一种具有反渗透系统噪声消除装置的反渗透系统，其中该装置具有至少一个用于检测由反渗透系统发出的至少一种噪声的传感器; 连接到传感器的至少一个控制器用于评估从传感器获得的信号或信号; 以及连接到控制器的至少一个致动器，其中致动器被设计成使得其产生声信号或振动，由此反渗透系统发出的噪声被阻尼或抵消。

公开(公告)号：US07780620B2

公开(公告)日：2010-08-24

申请号：US11717812

申请日：2007-03-13

Applicant: Wei Zhang ,  Helge Brauer ,  Reiner Spickermann ,  Carsten Müller

Inventor： Wei Zhang ,  Helge Brauer ,  Reiner Spickermann ,  Carsten Müller

IPC: A31M37/00 ,  C02F1/44

CPC classification number: A61M1/3639 ,  A61M1/16 ,  A61M1/1613 ,  A61M1/3659 ,  A61M2230/207

Abstract: A method for determining the hematocrit and/or blood volume during an extracorporeal blood treatment with an extracorporeal blood circuit, in which blood is taken with a blood pump via an arterial cannula and an arterial flexible-tube line and blood is fed back via a venous flexible-tube line and a venous cannula. Pressure is measured in the extracorporeal blood circuit and a change in the hematocrit is determined from a change in the pressure. The respective relationship between hematocrit HKT or blood volume RBV and pressure P in the extracorporeal circuit is stored for various cannula diameters and various blood-flow values. The respective relationship for a given cannula diameter and blood flow is selected. The hematocrit and/or blood volume is determined taking account of the selected relationship.

Abstract translation: 一种用体外血液回路确定体外血液处理过程中的血细胞比容和/或血液体积的方法，其中通过动脉插管和血液通过血泵将动脉血管与血液一起通过静脉 柔性管线和静脉插管。 在体外血液回路中测量压力，并且根据压力的变化确定血细胞比容的变化。 针对各种插管直径和各种血流值，存储血细胞比容HKT或体积RBV与体外循环中的压力P之间的各自关系。 选择给定套管直径和血流量的相应关系。 考虑所选择的关系来确定血细胞比容和/或血容量。

公开(公告)号：US20050202397A1

公开(公告)日：2005-09-15

申请号：US10507033

申请日：2003-01-09

Applicant: Wei Zhang ,  Helge Brauer ,  Reiner Spickermann ,  Carsten Muller

Inventor： Wei Zhang ,  Helge Brauer ,  Reiner Spickermann ,  Carsten Muller

IPC: A61M1/14 ,  A61M1/36 ,  C12Q1/00 ,  C12M1/34 ,  G01N33/86

CPC classification number: A61M1/3639 ,  A61M1/16 ,  A61M1/1613 ,  A61M1/3659 ,  A61M2230/207

Abstract: A method for determining the hemocrit and/or blood volume during an extracorporeal blood treatment with an extracorporeal blood circuit, in which blood is taken with a blood pump via an arterial cannula and an arterial flexible-tube line and blood is fed back via a venous flexible-tube line and a venous cannula. Pressure is measured in the extracorporeal blood circuit and a change in the hematocrit is determined from a change in the pressure. The respective relationship between hematocrit HKT or blood volume RBV and pressure P in the extracorporeal circuit is stored for various cannula diameters and various blood-flow values. The respective relationship for a given cannula diameter and blood flow is selected. The hematocrit and/or blood volume is determined taking account of the selected relationship.

Abstract translation: 一种用体外血液回路确定体外血液处理期间的血细胞比容和/或血液体积的方法，其中通过动脉插管和血管通过血液泵取血液，并通过静脉回送血液 柔性管线和静脉插管。 在体外血液回路中测量压力，并且根据压力的变化确定血细胞比容的变化。 针对各种插管直径和各种血流值，存储血细胞比容HKT或体积RBV与体外循环中的压力P之间的各自关系。 选择给定插管直径和血流量的相应关系。 考虑所选择的关系来确定血细胞比容和/或血容量。

公开(公告)号：US06736789B1

公开(公告)日：2004-05-18

申请号：US09176744

申请日：1998-10-21

Applicant: Reiner Spickermann

Inventor： Reiner Spickermann

IPC: A61M3700

CPC classification number: A61B5/02125 ,  A61B5/0285 ,  A61M1/3413 ,  A61M1/3639 ,  A61M2230/30 ,  Y10S128/03 ,  A61M2230/005

Abstract: A method and a device for continuous, noninvasive monitoring of an extracorporeal blood treatment, a patient's blood pressure or a quantity that correlates with the blood pressure is measured and compared with a predetermined limit value. If the measured blood pressure or its relative change drops below the predetermined limit value, an activation or deactivation signal is generated to initiate an intervention in the treatment sequence. The blood treatment machine therefore has a control unit. The continuous, noninvasive measurement of blood pressure is based on a determination of the propagation rate or transit time of the pulse waves produced by the patient's cardiac contractions and their propagation through the arterial system. To determine the pulse wave velocity or transit time, the blood treatment machine has an electrocardiograph and a device for detecting the pulse waves at a location on the patient remote from the heart.

Abstract translation: 对体外血液处理，患者血压或与血压相关的量进行连续无创监测的方法和装置，并与预定的极限值进行比较。 如果测量的血压或其相对变化降低到预定极限值以下，则产生激活或去激活信号以启动治疗序列中的干预。 因此，血液处理机具有控制单元。 连续无创的血压测量是基于由患者心脏收缩产生的脉搏波及其通过动脉系统传播的脉搏波的传播速率或传播时间的确定。 为了确定脉搏波速度或通过时间，血液处理机具有心电图仪和用于检测远离心脏的患者位置处的脉搏波的装置。

公开(公告)号：US09005153B2

公开(公告)日：2015-04-14

申请号：US13059249

申请日：2009-08-14

Applicant: Pascal Kopperschmidt ,  Reiner Spickermann

Inventor： Pascal Kopperschmidt ,  Reiner Spickermann

IPC: A61M37/00 ,  F04B43/12 ,  A61M1/16 ,  F04B43/00 ,  A61M1/10

CPC classification number: F04B43/12 ,  A61M1/1006 ,  A61M1/1037 ,  A61M1/1039 ,  A61M1/1086 ,  A61M1/16 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3607 ,  A61M2205/3331 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/702 ,  F04B43/0081 ,  F04B2201/1203

Abstract: The invention further relates to an apparatus and method for monitoring a peristaltic hose pump, in particular a peristaltic hose pump of an extracorporeal blood treatment device. The power consumed by the pump and/or the pressure in the tubing segment upstream or downstream of the pump is/are measured during operation of the pump and test signals I1(t), I2(t) which are associated with the individual displacement members are determined. The power or pressure signals associated with the individual displacement members significantly differ from each other during abnormal operation of the hose pump, but no significant differences can be recognized during normal operation of the pump.

Abstract translation: 本发明还涉及一种用于监测蠕动软管泵，特别是体外血液处理装置的蠕动软管泵的装置和方法。 在泵的运行期间测量泵所消耗的功率和/或泵上游或下游的管段中的压力，并且与各个位移构件相关联的测试信号I1（t），I2（t） 确定。 与各个位移构件相关联的动力或压力信号在软管泵的异常操作期间彼此显着不同，但是在泵的正常操作期间不能识别出明显的差异。

公开(公告)号：US20120091048A1

公开(公告)日：2012-04-19

申请号：US13379762

申请日：2010-06-16

Applicant: Reiner Spickermann ,  Gerhard Wiesen

Inventor： Reiner Spickermann ,  Gerhard Wiesen

IPC: B01D61/26 ,  B01D61/32 ,  B01D61/30

CPC classification number: A61M1/3627 ,  A61M1/1601 ,  A61M2205/7536 ,  B01D19/0031

Abstract: The present invention relates to a chamber for a blood treatment system having a blood inlet and a blood outlet, a filter element for air separation which is arranged at the head side with respect to the position of the chamber in the operating state and which can be decoupled from the blood present in the chamber in the operating state by means of a further liquid, to a blood hose system and to a blood treatment system.

Abstract translation: 本发明涉及一种用于血液处理系统的腔室，其具有血液入口和血液出口，用于空气分离的过滤器元件，其相对于处于操作状态的腔室的位置位于头侧，并且可以是 在操作状态下通过另外的液体将存在于腔室中的血液分离到血管系统和血液处理系统。

公开(公告)号：US08104348B2

公开(公告)日：2012-01-31

申请号：US11921624

申请日：2006-04-15

Applicant: Klaus Balschat ,  Tobias Fritsche ,  Alfred Gagel ,  Steffen Kirchner ,  Hans-Joachim Muench ,  Olaf Nicholas ,  Jochen Schneider ,  Reiner Spickermann ,  Santer Zur Host-Meyer

Inventor： Klaus Balschat ,  Tobias Fritsche ,  Alfred Gagel ,  Steffen Kirchner ,  Hans-Joachim Muench ,  Olaf Nicholas ,  Jochen Schneider ,  Reiner Spickermann ,  Santer Zur Host-Meyer

IPC: G01H3/12

CPC classification number: G01N29/032 ,  A61M1/3626 ,  G01N2291/02433 ,  G01N2291/02466 ,  G01N2291/02854

Abstract: The present invention relates to a method and a device for monitoring a flowing medium, in particular the blood flowing in an extracorporeal blood circulation, for the presence of air, in particular micro-bubbles. A sequence of signal pulses or a continuous signal is injected into the flowing medium, and the signal pulses or continuous signal leaving the flowing medium are received. To detect micro-bubbles, a signal pattern that is characteristic of the variation over time of the received signal pulses or the continuous signal in a predetermined period of time is extracted from the signal received. The characteristic signal pattern is compared with one or more characteristic reference patterns, and the presence of air bubbles is determined if the characteristic signal pattern deviates from the characteristic reference pattern by a predetermined amount. Statistical characteristic variables, in particular the variance, are preferably determined from the signal patterns and compared with one another.

Abstract translation: 本发明涉及用于监测流动介质，特别是在体外血液循环中流动的血液，用于存在空气，特别是微气泡的方法和装置。 信号脉冲序列或连续信号被注入到流动介质中，并且接收离开流动介质的信号脉冲或连续信号。 为了检测微气泡，从接收到的信号中提取出在接收到的信号脉冲或连续信号随时间变化的特征的信号模式。 将特征信号图案与一个或多个特征参考图案进行比较，并且如果特征信号图案偏离特征参考图案预定量，则确定气泡的存在。 统计特征变量，特别是方差，优选地根据信号图案确定并相互比较。

公开(公告)号：US20110230814A1

公开(公告)日：2011-09-22

申请号：US13059249

申请日：2009-08-14

Applicant: Pascal Kopperschmidt ,  Reiner Spickermann

Inventor： Pascal Kopperschmidt ,  Reiner Spickermann

IPC: A61M1/14 ,  G01N27/00

CPC classification number: F04B43/12 ,  A61M1/1006 ,  A61M1/1037 ,  A61M1/1039 ,  A61M1/1086 ,  A61M1/16 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3607 ,  A61M2205/3331 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/702 ,  F04B43/0081 ,  F04B2201/1203

Abstract: The invention further relates to an apparatus and method for monitoring a peristaltic hose pump, in particular a peristaltic hose pump of an extracorporeal blood treatment device. The power consumed by the pump and/or the pressure in the tubing segment upstream or downstream of the pump is/are measured during operation of the pump and test signals I1(t), I2(t) which are associated with the individual displacement members are determined. The power or pressure signals associated with the individual displacement members significantly differ from each other during abnormal operation of the hose pump, but no significant differences can be recognized during normal operation of the pump.

Abstract translation: 本发明还涉及用于监测蠕动软管泵的装置和方法，特别是体外血液处理装置的蠕动软管泵。 在泵的运行期间测量泵所消耗的功率和/或泵上游或下游的管段中的压力，并且与各个位移构件相关联的测试信号I1（t），I2（t） 确定。 与各个位移构件相关联的动力或压力信号在软管泵的异常操作期间彼此显着不同，但是在泵的正常操作期间不能识别出明显的差异。