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公开(公告)号：US20160376290A1
公开(公告)日：2016-12-29
申请号：US15038986
申请日：2014-12-08
Applicant: UCB BIOPHARMA SPRL
Inventor： Rikki Peter Alexander , Mezher Hussein Ali , Julien Alistair Brown , Victoria Elizabeth Jackson
IPC: C07D513/04 , A61K31/429
CPC classification number: C07D513/04 , A61K31/429 , A61K45/06 , A61K2300/00
Abstract: A series of substituted imidazo[2,1-b]thiazole derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
Abstract translation: 因此，一系列取代的咪唑并[2,1-b]噻唑衍生物及其类似物是人TNFα活性的有效调节剂，因此有益于治疗和/或预防各种人类疾病，包括自身免疫性和炎症性疾病; 神经和神经退行性疾病; 疼痛和伤害性疾病; 心血管疾病; 代谢紊乱 眼部疾病; 和肿瘤疾病。
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公开(公告)号：US10273247B2
公开(公告)日：2019-04-30
申请号：US15038986
申请日：2014-12-08
Applicant: UCB BIOPHARMA SPRL
Inventor： Rikki Peter Alexander , Mezher Hussein Ali , Julien Alistair Brown , Victoria Elizabeth Jackson
IPC: C07D513/04 , A61K31/429 , A61K45/06
Abstract: A series of substituted imidazo[2,1-b]thiazole derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号：US09969729B2
公开(公告)日：2018-05-15
申请号：US15100915
申请日：2014-12-08
Applicant: UCB BIOPHARMA SPRL
IPC: C07D471/04 , A61K31/437
CPC classification number: C07D471/04 , A61K31/437
Abstract: A series of substituted 1H imidazo[4,5-b]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号：US09850240B2
公开(公告)日：2017-12-26
申请号：US15101044
申请日：2014-12-08
Applicant: UCB BIOPHARMA SPRL
IPC: C07D471/04 , A61K31/506 , A61K31/437 , A61K31/5377
CPC classification number: C07D471/04 , A61K31/437 , A61K31/506 , A61K31/5377
Abstract: A series of substituted [1,2,4]triazolo[4,3-a]pyridine derivatives, being potent modulators of human TNF activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号：US09815797B2
公开(公告)日：2017-11-14
申请号：US15101283
申请日：2014-12-08
Applicant: UCB BIOPHARMA SPRL
Inventor： Rikki Peter Alexander , Gregory Foulkes , Martin Clive Hutchings , Victoria Elizabeth Jackson , Boris Kroeplien , James Thomas Reuberson , Sarah Margaret Rook , Zhaoning Zhu
IPC: C07D239/74 , A61K31/47 , A61K31/472 , A61K31/498 , A61K31/506 , A61K31/517 , C07D215/14 , C07D237/28 , A61K31/502 , C07D215/06 , C07D237/32 , C07D241/44 , A61K45/06 , C07D217/16 , C07D241/42 , C07D403/04
CPC classification number: C07D239/74 , A61K31/47 , A61K31/472 , A61K31/498 , A61K31/502 , A61K31/506 , A61K31/517 , A61K45/06 , C07D215/06 , C07D215/14 , C07D217/16 , C07D237/28 , C07D237/32 , C07D241/42 , C07D241/44 , C07D403/04 , A61K2300/00
Abstract: A series of substituted heteroaromatic compounds containing two fused six-membered rings, tivity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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Patent Agency Ranking
公开(公告)号：US20160355509A1
公开(公告)日：2016-12-08
申请号：US15038555
申请日：2014-12-08
Applicant: UCB BIOPHARMA SPRL
Inventor： Victoria Elizabeth Jackson , Boris Kroeplien , John Robert Porter
IPC: C07D471/04 , A61K31/444 , A61K31/437
CPC classification number: C07D471/04 , A61K31/437 , A61K31/444
Abstract: A series of substituted 3H-imidazo[4,5-c]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
Abstract translation: 因此，作为人类TNFα活性的有效调节剂的一系列取代的式（I）的3H-咪唑并[4,5-c]吡啶衍生物因此有益于治疗和/或预防各种人类疾病，包括自身免疫和炎症 疾病; 神经和神经退行性疾病; 疼痛和伤害性疾病; 心血管疾病; 代谢紊乱 眼部疾病; 和肿瘤疾病。
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公开(公告)号：US20160304513A1
公开(公告)日：2016-10-20
申请号：US15101089
申请日：2014-12-08
Applicant: UCB BIOPHARMA SPRL
Inventor： Michael Louis Robert Deligny , Jag Paul Heer , Victoria Elizabeth Jackson , Boris Kroeplien , Fabien Claude Lecomte , John Robert Porter
IPC: C07D471/04 , A61K31/506 , A61K31/437
CPC classification number: C07D471/04 , A61K31/437 , A61K31/506
Abstract: A series of substituted 3H imidazo[4,5-b]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号：US20160304512A1
公开(公告)日：2016-10-20
申请号：US15101044
申请日：2014-12-08
Applicant: UCB BIOPHARMA SPRL
IPC: C07D471/04 , A61K31/506 , A61K31/437 , A61K31/5377
CPC classification number: C07D471/04 , A61K31/437 , A61K31/506 , A61K31/5377
Abstract: A series of substituted [1,2,4]triazolo[4,3-a]pyridine derivatives, being potent modulators of human TNF activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
Abstract translation: 因此，作为人类TNF活性的有效调节剂的一系列取代的[1,2,4]三唑并[4,3-a]吡啶衍生物在治疗和/或预防各种人类疾病中是有益的，包括自身免疫和炎症 疾病; 神经和神经退行性疾病; 疼痛和伤害性疾病; 心血管疾病; 代谢紊乱 眼部疾病; 和肿瘤疾病。
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公开(公告)号：US20160297827A1
公开(公告)日：2016-10-13
申请号：US15100690
申请日：2014-12-08
Applicant: UCB BIOPHARMA SPRL
Inventor： Mezher Hussein Ali , Daniel Christopher Brookings , Julien Alistair Brown , Victoria Elizabeth Jackson , Boris Kroeplien , John Robert Porter
IPC: C07D487/04 , A61K31/5377 , A61K31/519
CPC classification number: C07D487/04 , A61K31/519 , A61K31/5377
Abstract: A series of substituted imidazo[1,2-a]pyrimidine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号：US20150203486A1
公开(公告)日：2015-07-23
申请号：US14414287
申请日：2013-07-05
Applicant: UCB Biopharma SPRL
Inventor： Jonathan Mark Bentley , Daniel Christopher Brookings , Julien Alistair Brown , Thomas Paul Cain , Praful Tulshi Chovatia , Anne Marie Foley , Ellen Olivia Gallimore , Laura Jane Gleave , Alexander Heifetz , Helen Tracey Horsley , Martin Clive Hutchings , Victoria Elizabeth Jackson , James Andrew Johnson , Craig Johnstone , Boris Kroeplien , Fabien Claude Lecomte , Deborah Leigh , Martin Alexander Lowe , James Madden , John Robert Porter , Joanna Rachel Quincey , Laura Claire Reed , James Thomas Reuberson , Anthony John Richardson , Sarah Emily Richardson , Matthew Duncan Selby , Michael Alan Shaw , Zhaoning Zhu
IPC: C07D471/04 , A61K31/496 , A61K31/506 , C07D491/107 , A61K31/5377 , A61K31/5513 , A61K31/554 , A61K31/437 , A61K31/541
CPC classification number: C07D471/04 , A61K31/437 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/5513 , A61K31/554 , C07D491/107 , C07D519/00
Abstract: A series of imidazo[1,2-a]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
Abstract translation: 因此，作为人类TNFα活性的有效调节剂的一系列式（I）的咪唑并[1,2-a]吡啶衍生物因此有益于治疗和/或预防各种人类疾病，包括自身免疫和炎性疾病; 神经和神经退行性疾病; 疼痛和伤害性疾病; 心血管疾病; 代谢紊乱 眼部疾病; 和肿瘤疾病。
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