公开(公告)号：US20190321495A1

公开(公告)日：2019-10-24

申请号：US16312846

申请日：2017-06-25

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Michael K. Schultz ,  Frances L. Johnson ,  Somya Kapoor ,  Dongyoul Lee ,  Mengshi Li

IPC: A61K51/04 ,  A61P35/00 ,  A61K47/54 ,  A61K47/60 ,  A61K47/64 ,  A61K31/167 ,  A61K31/4427 ,  A61K31/519 ,  A61K31/437 ,  A61K31/192 ,  A61K38/08

Abstract: The invention provides compositions, kits and methods to treat a hyperproliferative disorder with an agent that increases expression of MCR1 and an MCR1 ligand. The invention also provides a method of treating drug-resistant melanoma, comprising administering an MCR1 ligand to a patient in need thereof. The present invention also provides in certain embodiments a melanoma-targeting conjugate comprising Formula (I): T-L-X wherein T is a MCR1 ligand, L is a linker, and X an anti-cancer composition, for the therapeutic treatment of a hyperproliferative disorder. The present invention also provides methods, kits and uses of the conjugate of Formula (I).