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11.发明授权公开(公告)号：US07270705B2
公开(公告)日：2007-09-18
申请号：US10940922
申请日：2004-09-14
Applicant: Jiin-Huey Chern Lin , Chien-Ping Ju , Wen-Cheng Chen , Kuan-Liang Lin , I-Chang Wang
Inventor： Jiin-Huey Chern Lin , Chien-Ping Ju , Wen-Cheng Chen , Kuan-Liang Lin , I-Chang Wang
IPC: C04B12/02
CPC classification number: C04B28/344 , A61K6/0643 , A61L24/001 , A61L24/02 , A61L27/12 , A61L27/50 , C04B12/02 , C04B28/346 , C04B2111/00086 , C04B2111/00836 , C04B12/025 , C04B20/008 , C04B22/064 , C04B40/0082 , C04B40/0259 , C04B14/383
Abstract: A method for increasing working time/setting time of monolithic tetracalcium phosphate (TTCP) cement paste formed by mixing a TTCP powder with an aqueous solution, which includes heating the TTCP powder, prior to the mixing, so that the TTCP powder is maintained at a temperature of 50-350° C. for a period of time which is greater than one minute, and that a TTCP cement paste formed by mixing the resulting heated TTCP powder with the aqueous solution has a prolonged working time in comparison with that formed by mixing TTCP powder that has not been subjected to such heating with the aqueous solution.
Abstract translation: 一种通过在混合之前将TTCP粉末与水溶液混合形成的整体式四磷酸钙（TTCP）水泥浆料的工作时间/凝固时间的方法，其包括加热该TTCP粉末，使得TTCP粉末保持在 温度为50-350℃，时间大于1分钟，通过将所得加热的TTCP粉末与水溶液混合形成的TTCP水泥浆与通过混合形成的相比具有延长的工作时间 未经水溶液加热的TTCP粉末。
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12.发明授权Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface and process for preparing the same 失效表面具有磷酸钙晶须的磷酸四钙（TTCP）及其制备方法公开(公告)号：US07169373B2
公开(公告)日：2007-01-30
申请号：US10773701
申请日：2004-02-06
Applicant: Jiin-Huey Chern Lin , Chien-Ping Ju , Wen-Cheng Chen , Kuan-Liang Lin , I-Chang Wang
Inventor： Jiin-Huey Chern Lin , Chien-Ping Ju , Wen-Cheng Chen , Kuan-Liang Lin , I-Chang Wang
CPC classification number: A61L27/12 , A61L24/001 , A61L24/02 , A61L27/50 , C04B12/02 , C04B12/025 , C04B28/344 , C04B28/346 , C04B2111/00836 , Y10T428/2991 , Y10T428/2993 , C04B40/0082
Abstract: A tetracalcium phosphate (TTCP) particle for use in preparing a fast-setting, bioresorbable calcium phosphate cement is disclosed. The TTCP particle has a basic calcium phosphate whiskers on a surface thereof; the basic calcium phosphate whiskers having a Ca/P molar ratio greater than 1.33, and having a length up to about 5000 nm and a width up to about 500 nm. The basic calcium phosphate whiskers are substantially free of a hydroxyapatite phase and mainly composed of TTCP phase.
Abstract translation: 公开了一种用于制备快速凝固的生物可再吸收的磷酸钙水泥的四磷酸钙（TTCP）颗粒。 TTCP颗粒在其表面上具有碱性磷酸钙晶须; 碱性磷酸钙晶须的Ca / P摩尔比大于1.33，长度可达约5000nm，宽度可达500nm左右。 碱性磷酸钙晶须基本上不含羟基磷灰石相，主要由TTCP相组成。
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13.发明申请Process for affecting the setting and working time of bioresorbable calcium phosphate cements 失效影响生物可吸收性磷酸钙粘结剂的设定和工作时间的方法公开(公告)号：US20050279256A1
公开(公告)日：2005-12-22
申请号：US11137113
申请日：2005-05-25
Applicant: Jiin-Huey Lin , Chien-Ping Ju , Wen-Cheng Chen
Inventor： Jiin-Huey Lin , Chien-Ping Ju , Wen-Cheng Chen
CPC classification number: C04B28/346 , A61K6/0643 , A61L24/0063 , A61L24/02 , C04B12/025 , C04B28/34 , C04B2103/10 , C04B2111/00836 , C04B2111/70 , C04B40/0082 , C04B22/064 , C04B2103/0099 , C04B22/062 , C04B22/16 , C04B22/143 , C04B22/165
Abstract: A fast-setting, bioresorbable calcium phosphate cement is prepared by a process which can be carried out with a heat treatment up to 1000° C. on a mixture of a wetting solution and a calcium phosphate powder having a Ca to P molar ratio of 0.5-2.5. The wetting solution suitable for use in the process of the present invention includes water, an organic solvent, an acidic and basic solution. A setting solution for mixing with the heated powder to form the fast-setting, bioresorbable calcium phosphate cement may be water, an acidic or basic solution according to the process of the present invention.
Abstract translation: 快速凝固的生物可再吸收的磷酸钙水泥通过一种方法制备，该方法可以在加氢溶液和Ca与P摩尔比为0.5的磷酸钙粉末的混合物中进行高达1000℃的热处理 -2.5。 适用于本发明方法的润湿溶液包括水，有机溶剂，酸性和碱性溶液。 与加热的粉末混合以形成快速凝固的生物可再吸收的磷酸钙水泥的凝固溶液可以是水，根据本发明的方法的酸性或碱性溶液。
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公开(公告)号：US20050271742A1
公开(公告)日：2005-12-08
申请号：US11129066
申请日：2005-05-13
Applicant: Jiin-Huey Chern Lin , Chien-Ping Ju , Wen-Cheng Chen
Inventor： Jiin-Huey Chern Lin , Chien-Ping Ju , Wen-Cheng Chen
IPC: A61C5/00 , A61C5/06 , A61K6/033 , A61K33/42 , A61L24/00 , A61L24/02 , A61L27/12 , A61L27/50 , C04B12/02 , C04B14/36 , C04B28/34
CPC classification number: A61L24/02 , A61C5/62 , A61K6/0008 , A61K6/0067 , A61K6/033 , A61K6/0643 , A61K33/42 , A61L24/001 , A61L27/12 , A61L27/50 , C04B12/02 , C04B12/025 , C04B14/366 , C04B28/34 , C04B28/344 , C04B28/346 , C04B2111/00836 , Y10T428/2991 , Y10T428/2993 , C04B20/008 , C04B40/0272 , C04B40/0218 , C04B40/0263 , C04B20/1014 , C04B22/064 , C04B22/126 , C04B20/023 , C04B20/107 , A61K6/087 , C08L89/00
Abstract: A calcium phosphate cement suitable for use in dental and bone prosthesis is disclosed, which include calcium phosphate particles having a diameter of 0.05 to 100 microns, wherein said calcium phosphate particles on their surfaces have whiskers or fine crystals having a width ranging from 1 to 100 nm and a length ranging from 1 to 1000 nm.
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公开(公告)号：US20050271740A1
公开(公告)日：2005-12-08
申请号：US11129029
申请日：2005-05-13
Applicant: Jiin-Huey Lin , Chien-Ping Ju , Wen-Cheng Chen
Inventor： Jiin-Huey Lin , Chien-Ping Ju , Wen-Cheng Chen
IPC: A61C5/00 , A61C5/06 , A61K6/033 , A61K33/42 , A61L24/00 , A61L24/02 , A61L27/12 , A61L27/50 , C04B12/02 , C04B14/36 , C04B28/34
CPC classification number: A61L24/02 , A61C5/62 , A61K6/0008 , A61K6/0067 , A61K6/033 , A61K6/0643 , A61K33/42 , A61L24/001 , A61L27/12 , A61L27/50 , C04B12/02 , C04B12/025 , C04B14/366 , C04B28/34 , C04B28/344 , C04B28/346 , C04B2111/00836 , Y10T428/2991 , Y10T428/2993 , C04B20/008 , C04B40/0272 , C04B40/0218 , C04B40/0263 , C04B20/1014 , C04B22/064 , C04B22/126 , C04B20/023 , C04B20/107 , A61K6/087 , C08L89/00
Abstract: A calcium phosphate cement suitable for use in dental and bone prosthesis is disclosed, which include calcium phosphate particles having a diameter of 0.05 to 100 microns, wherein said calcium phosphate particles on their surfaces have whiskers or fine crystals having a width ranging from 1 to 100 nm and a length ranging from 1 to 1000 nm.
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Patent Agency Ranking
16.发明授权公开(公告)号：US06960249B2
公开(公告)日：2005-11-01
申请号：US10607023
申请日：2003-06-27
Applicant: Jiin-Huey Chern Lin , Chien-Ping Ju , Wen-Cheng Chen , Kuan-Liang Lin , I-Chang Wang
Inventor： Jiin-Huey Chern Lin , Chien-Ping Ju , Wen-Cheng Chen , Kuan-Liang Lin , I-Chang Wang
IPC: A61C5/00 , A61K33/42 , A61L24/00 , A61L24/02 , A61L27/12 , A61L27/50 , C04B12/02 , C04B28/34 , C04B35/00 , C30B7/00 , C30B29/14 , C30B29/62
CPC classification number: A61L24/001 , A61L24/02 , A61L27/12 , A61L27/50 , C04B12/02 , C04B12/025 , C04B28/344 , C04B28/346 , C04B2111/00086 , C04B2111/00206 , C04B2111/0025 , C04B2111/00836 , C30B7/00 , C30B29/14 , C30B29/62 , Y10T428/2991 , Y10T428/2993 , C04B22/126 , C04B22/064 , C04B20/008 , C04B40/0082 , C04B40/0259 , C04B14/383
Abstract: A tetracalcium phosphate (TTCP) particle for use in preparing a fast-setting, bioresorbable calcium phosphate cement is disclosed. The TTCP particle has a basic calcium phosphate whiskers or fine crystals on a surface thereof; the basic calcium phosphate whiskers or fine crystals having a Ca/P molar ratio greater than 1.33, and having a length up to about 5000 nm and a width up to about 500 nm.
Abstract translation: 公开了一种用于制备快速凝固的生物可再吸收的磷酸钙水泥的四磷酸钙（TTCP）颗粒。 TTCP颗粒在其表面上具有碱性磷酸钙晶须或细晶体; 碱性磷酸钙晶须或Ca / P摩尔比大于1.33的细晶体，其长度可达5000nm左右，宽度可达500nm左右。
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公开(公告)号：USD691087S1
公开(公告)日：2013-10-08
申请号：US29405393
申请日：2011-11-02
Applicant: Yu-Ching Lin , Chien-Yao Liao , Wen-Cheng Chen
Designer： Yu-Ching Lin , Chien-Yao Liao , Wen-Cheng Chen
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公开(公告)号：USD690650S1
公开(公告)日：2013-10-01
申请号：US29405395
申请日：2011-11-02
Applicant: Yu-Ching Lin , Chien-Yao Liao , Wen-Cheng Chen
Designer： Yu-Ching Lin , Chien-Yao Liao , Wen-Cheng Chen
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公开(公告)号：US08329464B2
公开(公告)日：2012-12-11
申请号：US12873536
申请日：2010-09-01
Applicant: Wen-Cheng Chen , Chun-Cheng Hung , Chia-Ling Ko
Inventor： Wen-Cheng Chen , Chun-Cheng Hung , Chia-Ling Ko
IPC: C12N5/00 , C12N5/07 , C12N5/071 , C22C1/00 , C23C8/36 , C21D1/54 , C21D1/70 , B32B15/01 , A61C8/00
CPC classification number: A61L27/06 , A61L27/3813 , A61L27/3821 , A61L27/50 , A61L2400/18
Abstract: The present disclosure uses different kinds of surface treatment processes on titanium-made dental implants. The growth and attachment conditions of bone cells (MC3T3-E), fibroblasts (NIH 3T3) and epidermal cells (XB-2) on the metal surface of titanium slices with different surface treatments are observed. Tetra-calcium phosphate is used to perform secondary sand-blasting process to clean up the metal surface and provide calcium ions for osteoblastoma physiology. Thus, by adjusting the cells adhesive and proliferative abilities, the success rate of the clinical applications in dental implant is improved.
Abstract translation: 本公开在钛制牙科植入物上使用不同种类的表面处理方法。 观察到不同表面处理的钛片的金属表面上的骨细胞（MC3T3-E），成纤维细胞（NIH 3T3）和表皮细胞（XB-2）的生长和附着条件。 四磷酸钙用于进行二次喷砂处理以清理金属表面，并提供钙离子用于成骨细胞瘤生理学。 因此，通过调整细胞粘附和增殖能力，提高了牙种植体临床应用的成功率。
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公开(公告)号：US20110318835A1
公开(公告)日：2011-12-29
申请号：US12873536
申请日：2010-09-01
Applicant: Wen-Cheng Chen , Chun-Cheng Hung , Chia-Ling Ko
Inventor： Wen-Cheng Chen , Chun-Cheng Hung , Chia-Ling Ko
IPC: C12N5/077
CPC classification number: A61L27/06 , A61L27/3813 , A61L27/3821 , A61L27/50 , A61L2400/18
Abstract: The present disclosure uses different kinds of surface treatment processes on titanium-made dental implants. The growth and attachment conditions of bone cells (MC3T3-E), fibroblasts(NIH 3T3) and epidermal cells (XB-2) on the metal surface of titanium slices with different surface treatments are observed. Tetra-calcium phosphate is used to perform secondary sand-blasting process to clean up the metal surface and provide calcium ions for osteoblastoma physiology. Thus, by adjusting the cells adhesive and proliferative abilities, the success rate of the clinical applications in dental implant is improved.
Abstract translation: 本公开在钛制牙科植入物上使用不同种类的表面处理方法。 观察到不同表面处理的钛片的金属表面上的骨细胞（MC3T3-E），成纤维细胞（NIH 3T3）和表皮细胞（XB-2）的生长和附着条件。 四磷酸钙用于进行二次喷砂处理以清理金属表面，并提供钙离子用于成骨细胞瘤生理学。 因此，通过调整细胞粘附和增殖能力，提高了牙种植体临床应用的成功率。
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