公开(公告)号：US09708467B2

公开(公告)日：2017-07-18

申请号：US15026153

申请日：2014-09-30

Applicant: Zimmer, Inc.

Inventor： Dirk Pletcher

IPC: C08F2/46 ,  C08G61/04 ,  C08K5/52 ,  C08K5/529 ,  A61L27/16

CPC classification number: C08K5/52 ,  A61L27/16 ,  A61L2430/24 ,  C08K5/529 ,  C08L23/06

Abstract: Certain embodiments described herein are directed to polymer compositions including a protected antioxidant. In some examples, the compositions can also include a deprotected antioxidant, an unprotected antioxidant or both. Methods of producing compositions including a protected antioxidant and articles including a protected antioxidant are also described.

公开(公告)号：US20160108184A1

公开(公告)日：2016-04-21

申请号：US14978598

申请日：2015-12-22

Applicant: Zimmer, Inc.

Inventor： Alicia Rufner ,  John Knight ,  Toni Rowe ,  Dirk Pletcher ,  Ray Gsell ,  Werner Schneider ,  Hallie E. Brinkerhuff

IPC: C08J3/24 ,  A61L27/16 ,  A61L27/50 ,  C08J3/28

CPC classification number: C08J3/247 ,  A61B17/8085 ,  A61L27/16 ,  A61L27/505 ,  C08J3/28 ,  C08J2323/26 ,  C08K5/005 ,  C08K5/1545 ,  C08K9/10 ,  C08L23/06 ,  C08L2312/06 ,  Y10T428/31 ,  Y10T428/315

Abstract: An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation, In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.

Abstract translation: 在超高分子量聚乙烯（UHMWPE）交联照射之前，与UHMWPE结合使用的抗氧化剂。 在一个示例性实施方案中，抗氧化剂是生育酚。 在将抗氧化剂与UHMWPE组合之后，所得到的共混物可以形成为板坯，棒料，和/或结合到例如金属等基材中。 然后将所得产物进行交联照射。在一个示例性实施方案中，将UHMWPE共混物在进行交联照射之前进行预热。 一旦照射，UHMWPE共混产品可以根据常规技术被加工，包装和灭菌。

公开(公告)号：US20140131925A1

公开(公告)日：2014-05-15

申请号：US14156726

申请日：2014-01-16

Applicant: Zimmer, Inc.

Inventor： Kirt Case ,  Oludele O. Popoola ,  Robby Kissling ,  Brion R. Mimnaugh ,  Archie Newsome ,  Clarence M. Panchison ,  Dirk Pletcher ,  Randy Schlemmer ,  Zhibin Fang ,  Juan Vivanco ,  Alicia Rufner

IPC: B29C70/68 ,  B29C45/14 ,  B29C43/18

CPC classification number: B29C70/682 ,  A61B17/86 ,  A61F2/30942 ,  A61F2/34 ,  A61F2002/30329 ,  A61F2002/305 ,  A61F2002/3092 ,  A61F2002/3096 ,  A61F2002/30981 ,  A61F2002/3291 ,  A61F2002/3401 ,  A61F2002/3411 ,  A61F2220/0025 ,  A61F2310/00131 ,  A61L27/18 ,  A61L27/50 ,  A61L27/56 ,  B29C43/18 ,  B29C45/14 ,  C08L71/00

Abstract: An orthopedic component having multiple layers that are selected to provide an overall modulus that is substantially lower than the modulus of known orthopedic components to more closely approximate the modulus of the bone into which the orthopedic component is implanted. In one exemplary embodiment, the orthopedic component is an acetabular shell. For example, the acetabular shell may include an outer layer configured for securement to the natural acetabulum of a patient and an inner layer configured to receive an acetabular liner. The head of a femoral prosthesis articulates against the acetabular liner to replicate the function of a natural hip joint. Alternatively, the inner layer of the acetabular shell may act as an integral acetabular liner against which the head of the femoral prosthesis articulates.

Abstract translation: 具有多个层的整形外科组件被选择以提供基本上低于已知矫形部件的模量的总模量，以更接近地将骨骼部件植入其中的骨的模数近似近似。 在一个示例性实施例中，矫形部件是髋臼壳。 例如，髋臼壳可以包括被配置用于固定到患者的天然髋臼的外层和构造成接收髋臼衬垫的内层。 股骨假体的头部与髋臼衬垫铰接以复制天然髋关节的功能。 或者，髋臼壳的内层可以作为整体的髋臼衬垫，股骨假体的头与该髋臼衬垫铰接。

公开(公告)号：US10556998B2

公开(公告)日：2020-02-11

申请号：US15783649

申请日：2017-10-13

Applicant: Zimmer, Inc.

Inventor： Alicia Rufner ,  John Knight ,  Toni Rowe ,  Dirk Pletcher ,  Ray Gsell ,  Werner Schneider ,  Hallie E Brinkerhuff

IPC: C08J3/28 ,  C08J3/24 ,  A61L27/16 ,  A61L27/50 ,  C08L23/06 ,  A61B17/80 ,  C08K5/00 ,  C08K5/1545 ,  C08K9/10

Abstract: An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.

公开(公告)号：US09926432B2

公开(公告)日：2018-03-27

申请号：US14983006

申请日：2015-12-29

Applicant: Zimmer, Inc.

Inventor： Alicia Rufner ,  John Knight ,  Toni Rowe ,  Dirk Pletcher ,  Ray Gsell ,  Hallie E Brinkerhuff ,  Werner Schneider

IPC: C08J3/24 ,  C08K5/1545 ,  A61L27/16 ,  A61L27/50 ,  A61B17/80 ,  A61L31/04 ,  A61L31/14 ,  C08J3/28 ,  C08L23/06

CPC classification number: C08K5/1545 ,  A61B17/8085 ,  A61L27/16 ,  A61L27/505 ,  A61L31/048 ,  A61L31/143 ,  C08J3/24 ,  C08J3/28 ,  C08J2323/26 ,  C08L23/06 ,  C08L2312/06 ,  Y10T428/31 ,  Y10T428/315

Abstract: An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.

公开(公告)号：US20170015794A1

公开(公告)日：2017-01-19

申请号：US15124454

申请日：2015-02-26

Applicant: ZIMMER, INC.

Inventor： Dirk Pletcher

IPC: C08J3/205 ,  B29C71/02 ,  A61L27/50 ,  C08K5/1545 ,  A61L27/16 ,  B29C43/00 ,  C08J7/06

CPC classification number: C08J3/2056 ,  A61L27/16 ,  A61L27/505 ,  A61L2430/02 ,  A61L2430/24 ,  B29C43/003 ,  B29C71/0009 ,  B29C71/02 ,  B29C2071/0018 ,  B29K2023/0683 ,  B29K2105/0044 ,  B29L2031/7532 ,  C08J7/065 ,  C08J7/08 ,  C08J7/12 ,  C08J2323/06 ,  C08K5/005 ,  C08K5/134 ,  C08K5/1545 ,  C08K2201/013 ,  C08L23/06 ,  C08L23/26 ,  C08L2207/068 ,  C08L67/02

Abstract: Various embodiments disclosed relate to melt-stabilized materials including ultra high molecular weight polyethylene (UHMWPE), methods of making the same, and medical implants including the same. In various embodiments, the present invention provides a method of melt-stabilizing a material including UHMWPE. The method includes obtaining or providing a solid material including UHMWPE including a first concentration of free-radicals. The method includes coating at least part of the solid material with a liquid composition including at least one antioxidant, to provide a coated solid material. The method includes heating the coated solid material in an environment including oxygen, the heating being sufficient to melt at least part of the UHMWPE, to provide a heated material. The method also includes solidifying the heated material, to provide a melt-stabilized material including UHMWPE including a second concentration of free-radicals, wherein the second concentration of free-radicals is less than the first concentration of free-radicals.

Abstract translation: 所公开的各种实施方案涉及包括超高分子量聚乙烯（UHMWPE）的熔融稳定材料，其制备方法和包括其的医用植入物。 在各种实施方案中，本发明提供了熔融稳定包含UHMWPE的材料的方法。 该方法包括获得或提供包括UHMWPE的固体材料，其包括第一浓度的自由基。 该方法包括用包含至少一种抗氧化剂的液体组合物涂覆至少部分固体材料，以提供涂覆的固体材料。 该方法包括在包括氧的环境中加热涂覆的固体材料，加热足以熔化至少部分UHMWPE，以提供加热的材料。 该方法还包括固化加热的材料，以提供包含UHMWPE的熔融稳定材料，其包括第二浓度的自由基，其中第二浓度的自由基小于第一浓度的自由基。

公开(公告)号：US20160222190A1

公开(公告)日：2016-08-04

申请号：US15026153

申请日：2014-09-30

Applicant: ZIMMER, INC.

Inventor： Dirk Pletcher

IPC: C08K5/52 ,  A61L27/16

CPC classification number: C08K5/52 ,  A61L27/16 ,  A61L2430/24 ,  C08K5/529 ,  C08L23/06

Abstract: Certain embodiments described herein are directed to polymer compositions including a protected antioxidant. In some examples, the compositions can also include a deprotected antioxidant, an unprotected antioxidant or both. Methods of producing compositions including a protected antioxidant and articles including a protected antioxidant are also described.

Abstract translation: 本文所述的某些实施方案涉及包含受保护的抗氧化剂的聚合物组合物。 在一些实例中，组合物还可以包括去保护的抗氧化剂，未保护的抗氧化剂或两者。 还描述了制备包含受保护的抗氧化剂的组合物和包含受保护的抗氧化剂的制品的方法。

公开(公告)号：US20140194935A1

公开(公告)日：2014-07-10

申请号：US14157708

申请日：2014-01-17

Applicant: Zimmer, Inc.

Inventor： Alicia Rufner ,  John Knight ,  Toni Rowe ,  Dirk Pletcher ,  Ray Gsell ,  Hallie E. Brinkerhuff ,  Werner Schneider

IPC: A61B17/80

CPC classification number: C08K5/1545 ,  A61B17/8085 ,  A61L27/16 ,  A61L27/505 ,  A61L31/048 ,  A61L31/143 ,  C08J3/24 ,  C08J3/28 ,  C08J2323/26 ,  C08L23/06 ,  C08L2312/06 ,  Y10T428/31 ,  Y10T428/315

Abstract: An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.

Abstract translation: 在超高分子量聚乙烯（UHMWPE）交联照射之前，与UHMWPE结合使用的抗氧化剂。 在一个示例性实施方案中，抗氧化剂是生育酚。 在将抗氧化剂与UHMWPE组合之后，所得到的共混物可以形成为板坯，棒料，和/或结合到例如金属等基材中。 然后将所得产物进行交联照射。 在一个示例性实施方案中，在对其进行交联照射之前，将UHMWPE共混物预热。 一旦照射，UHMWPE共混产品可以根据常规技术被加工，包装和灭菌。