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    Sequence symmetric modified IGG4 bispecific antibodies
    13.
    发明授权
    Sequence symmetric modified IGG4 bispecific antibodies 有权

    公开(公告)号：US10221251B2

    公开(公告)日：2019-03-05

    申请号：US14380309

    申请日：2013-02-22

    Applicant: UCB Biopharma SPRL

    Inventor： David Paul Humphreys ,  Shirley Jane Peters

    IPC: C07K16/00 ,  C07K16/46

    Abstract: The present disclosure relates to a symmetric bispecific antibody of the class IgG4 comprising two heavy chains which each comprise a variable domain, CH1 domain and a hinge region, wherein in each heavy chain: the cysteine in the CH1 domain which forms an inter-chain disulphide bond with a cysteine in a light chain is substituted with another amino acid; and optionally one or more of the amino acids positioned in the upper hinge region is substituted with cysteine, wherein the constant region sequence of each heavy chain is similar or identical and the variable region in each heavy chain is different, formulations comprising the same, the use of each of the above in treatment and processes for preparing said antibodies and formulations.

    ALBUMIN BINDING ANTIBODIES AND BINDING FRAGMENTS THEREOF
    15.
    发明申请
    ALBUMIN BINDING ANTIBODIES AND BINDING FRAGMENTS THEREOF 有权

    公开(公告)号：US20180134774A1

    公开(公告)日：2018-05-17

    申请号：US15795874

    申请日：2017-10-27

    Applicant: UCB Biopharma SPRL

    Inventor： Ralph ADAMS ,  Pallavi BHATTA ,  Sam Philip HEYWOOD ,  David Paul HUMPHREYS

    IPC: C07K16/18 ,  C07K16/28

    CPC classification number: C07K16/18 ,  C07K16/2878 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/624 ,  C07K2317/92

    Abstract: A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or comprising a light chain variable domain having the sequence given in SEQ ID NO:3 or SEQ ID NO:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 1 and SEQ ID NO:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 2 and SEQ ID NO:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides. The disclosure further includes pharmaceutical compositions comprising the antibodies or fragments and therapeutic used of any one of the same.

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