公开(公告)号：US08080590B1

公开(公告)日：2011-12-20

申请号：US12157301

申请日：2008-06-09

Applicant: LinShu Liu ,  Marshall L. Fishman ,  Kevin B. Hicks

Inventor： LinShu Liu ,  Marshall L. Fishman ,  Kevin B. Hicks

IPC: C08B37/00

CPC classification number: C08B37/0045 ,  A61L27/26 ,  A61L27/56 ,  C08J9/0061 ,  C08J9/26 ,  C08J9/28 ,  C08J2201/0444 ,  C08J2201/05 ,  C08J2367/04 ,  C08J2405/00 ,  C08L5/06 ,  C08L67/04 ,  C08L5/04 ,  C08L2666/18 ,  C08L2666/26

Abstract: A porous polymeric matrix containing at least one natural polymer and at least one synthetic polymer and optionally at least one cation. Furthermore, a method of making a porous polymeric matrix involving mixing at least one natural polymer and inorganic salts with a solution comprising at least one solvent and at least one synthetic polymer to form a slurry, casting the slurry in a mold and removing the solvent to form solid matrices, immersing the solid matrices in deionized water to allow natural polymer cross-linking and pore creation to occur simultaneously, and drying the matrices to create a porous polymeric matrix; wherein the matrix contains a cation. Also, a method of making a porous polymeric matrix, involving mixing at least one natural polymer in an aqueous solvent and mixing at least one synthetic polymer in an organic solvent, combining the mixtures and casting in a mold, and separately removing said aqueous solvent and said organic solvent to form a porous polymeric matrix; wherein the porous polymeric matrix does not contain a cation.

Abstract translation: 含有至少一种天然聚合物和至少一种合成聚合物和任选的至少一种阳离子的多孔聚合物基质。 此外，制备多孔聚合物基质的方法包括将至少一种天然聚合物和无机盐与包含至少一种溶剂和至少一种合成聚合物的溶液混合以形成浆料，将浆料浇铸到模具中并除去溶剂 形成固体基质，将固体基质浸入去离子水中以允许天然聚合物交联和孔产生同时发生，并干燥基质以产生多孔聚合物基质; 其中所述基质含有阳离子。 而且，制备多孔聚合物基质的方法，包括在水性溶剂中混合至少一种天然聚合物并在有机溶剂中混合至少一种合成聚合物，将该混合物和铸件混合在模具中，并分别除去所述水性溶剂和 所述有机溶剂形成多孔聚合物基质; 其中所述多孔聚合物基质不含阳离子。

公开(公告)号：US07635755B2

公开(公告)日：2009-12-22

申请号：US11247358

申请日：2005-10-11

Applicant: David L. Kaplan ,  Ung-Jin Kim ,  Jaehyung Park ,  Hyoung-Joon Jin

Inventor： David L. Kaplan ,  Ung-Jin Kim ,  Jaehyung Park ,  Hyoung-Joon Jin

IPC: A61K38/17 ,  C07K14/00

CPC classification number: A61L27/227 ,  A61L27/3604 ,  A61L27/38 ,  A61L27/52 ,  A61L27/56 ,  A61L2430/02 ,  B29C39/003 ,  B29C39/203 ,  B29C55/005 ,  B29D7/01 ,  B29K2089/00 ,  B29L2007/00 ,  B29L2009/00 ,  C07K14/43536 ,  C07K14/43586 ,  C08J3/07 ,  C08J3/075 ,  C08J5/18 ,  C08J9/0061 ,  C08J9/26 ,  C08J9/28 ,  C08J2201/0444 ,  C08J2201/0504 ,  C08J2205/022 ,  C08J2389/00 ,  C08L89/00 ,  D01D5/0007 ,  D01F4/02 ,  Y10T428/249921 ,  Y10T442/10 ,  Y10T442/60

Abstract: The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels.

Abstract translation: 本发明提供浓缩的水性丝素蛋白溶液和用于制备浓缩的丝心蛋白溶液的全水模式，避免使用有机溶剂，直接添加剂或刺激性化学品。 本发明进一步提供了这些溶液在生产例如纤维，薄膜，泡沫，网眼，支架和水凝胶的材料中的用途。

公开(公告)号：US20090234026A1

公开(公告)日：2009-09-17

申请号：US12425541

申请日：2009-04-17

Applicant: David L. Kaplan ,  Ung-Jin Kim ,  Jaehyung Park ,  Hyoung-Joon Jin

Inventor： David L. Kaplan ,  Ung-Jin Kim ,  Jaehyung Park ,  Hyoung-Joon Jin

IPC: A61K47/42

CPC classification number: A61L27/227 ,  A61L27/3604 ,  A61L27/38 ,  A61L27/52 ,  A61L27/56 ,  A61L2430/02 ,  B29C39/003 ,  B29C39/203 ,  B29C55/005 ,  B29D7/01 ,  B29K2089/00 ,  B29L2007/00 ,  B29L2009/00 ,  C07K14/43536 ,  C07K14/43586 ,  C08J3/07 ,  C08J3/075 ,  C08J5/18 ,  C08J9/0061 ,  C08J9/26 ,  C08J9/28 ,  C08J2201/0444 ,  C08J2201/0504 ,  C08J2205/022 ,  C08J2389/00 ,  C08L89/00 ,  D01D5/0007 ,  D01F4/02 ,  Y10T428/249921 ,  Y10T442/10 ,  Y10T442/60

Abstract: The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels.

Abstract translation: 本发明提供浓缩的水性丝素蛋白溶液和用于制备浓缩的丝心蛋白溶液的全水模式，避免使用有机溶剂，直接添加剂或刺激性化学品。 本发明进一步提供了这些溶液在生产例如纤维，薄膜，泡沫，网眼，支架和水凝胶的材料中的用途。

公开(公告)号：US07553923B2

公开(公告)日：2009-06-30

申请号：US11925635

申请日：2007-10-26

Applicant: Simon F. Williams ,  David P. Martin ,  Frank A. Skraly

Inventor： Simon F. Williams ,  David P. Martin ,  Frank A. Skraly

IPC: C08G63/08

CPC classification number: A61L27/58 ,  A61F2/07 ,  A61F2210/0004 ,  A61K31/715 ,  A61L17/12 ,  A61L27/18 ,  A61L31/06 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  C08G63/06 ,  C08J9/26 ,  C08J2201/0444 ,  C08J2201/0482 ,  C08J2367/04 ,  C08K5/0033 ,  C08L67/04 ,  C12P7/625 ,  Y10S606/911

Abstract: Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

公开(公告)号：US20080051490A1

公开(公告)日：2008-02-28

申请号：US11836615

申请日：2007-08-09

Applicant: Simon Williams ,  David Martin ,  Frank Skraly

Inventor： Simon Williams ,  David Martin ,  Frank Skraly

IPC: C08G63/00 ,  A61K31/715 ,  A61K38/18 ,  A61K9/00

CPC classification number: A61L27/58 ,  A61F2/07 ,  A61F2210/0004 ,  A61K31/715 ,  A61L17/12 ,  A61L27/18 ,  A61L31/06 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  C08G63/06 ,  C08J9/26 ,  C08J2201/0444 ,  C08J2201/0482 ,  C08J2367/04 ,  C08K5/0033 ,  C08L67/04 ,  C12P7/625 ,  Y10S606/911

Abstract: Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

公开(公告)号：US20050100639A1

公开(公告)日：2005-05-12

申请号：US10934339

申请日：2004-09-02

Applicant: Tony Pearce

Inventor： Tony Pearce

IPC: A23G3/00 ,  A23G3/36 ,  A23G3/50 ,  A23G3/54 ,  A23L1/00 ,  A23L1/22 ,  A61K9/00 ,  A63B37/08 ,  A63B43/00 ,  B32B27/36 ,  B43K23/008 ,  B65D65/46 ,  A01K1/00

CPC classification number: B65D65/463 ,  A23G3/36 ,  A23G3/368 ,  A23G3/50 ,  A23G3/54 ,  A23L27/79 ,  A23P10/30 ,  A23P20/20 ,  A23V2002/00 ,  A61K9/0056 ,  A63B37/08 ,  A63B43/008 ,  A63B2037/085 ,  A63B2208/12 ,  B32B27/36 ,  B43K5/005 ,  B43K23/008 ,  C08J2201/0444 ,  A23V2250/056 ,  A23V2250/5076 ,  A23V2200/222 ,  A23V2250/264 ,  A23V2250/2482 ,  A23V2250/242 ,  A23V2200/16 ,  A23V2250/5118 ,  A23V2250/5432 ,  A23V2250/54246 ,  A23V2250/5036 ,  A23V2250/6406 ,  A23V2250/642

Abstract: Methods and substances for a consumer to create his own tasty beverage using a beverage base and flavorful drops.

Abstract translation: 消费者使用饮料基料和香味滴制造自己的美味饮料的方法和物质。

公开(公告)号：US20050008735A1

公开(公告)日：2005-01-13

申请号：US10884863

申请日：2004-07-02

Applicant: Tony Pearce

Inventor： Tony Pearce

IPC: A23G3/00 ,  A23G3/36 ,  A23G3/50 ,  A23G3/54 ,  A23L1/00 ,  A23L1/22 ,  A61K9/00 ,  A63B37/08 ,  A63B43/00 ,  B32B27/36 ,  B43K23/008 ,  B65D65/46 ,  F16L1/00

CPC classification number: A23L27/79 ,  A23G3/36 ,  A23G3/368 ,  A23G3/50 ,  A23G3/54 ,  A23P10/30 ,  A23P20/20 ,  A23V2002/00 ,  A61K9/0056 ,  A63B37/08 ,  A63B43/008 ,  A63B2037/085 ,  A63B2208/12 ,  B32B27/36 ,  B43K5/005 ,  B43K23/008 ,  B65D65/463 ,  C08J2201/0444 ,  A23V2250/056 ,  A23V2250/5076 ,  A23V2200/222 ,  A23V2250/264 ,  A23V2250/2482 ,  A23V2250/242 ,  A23V2250/5118 ,  A23V2250/5432 ,  A23V2250/54246 ,  A23V2250/5036 ,  A23V2200/16 ,  A23V2250/6406 ,  A23V2250/642

Abstract: Edible chocolate snacks including polymer, chocolate and other ingredients.

Abstract translation: 食用巧克力小吃，包括聚合物，巧克力等成分。

公开(公告)号：US20040009875A1

公开(公告)日：2004-01-15

申请号：US10364902

申请日：2003-02-11

Applicant: EdiZONE, LC

Inventor： Tony M. Pearce

IPC: B41M005/035 ,  B41M005/38

CPC classification number: A23G3/54 ,  A23G3/36 ,  A23G3/368 ,  A23G3/50 ,  A23L27/79 ,  A23P10/30 ,  A23P20/20 ,  A23V2002/00 ,  A61K9/0056 ,  A63B43/008 ,  A63B2037/085 ,  A63B2208/12 ,  A63H33/04 ,  A63H33/28 ,  B32B27/36 ,  B41M5/0355 ,  B43K23/008 ,  B43M99/006 ,  B65D65/463 ,  C08J9/26 ,  C08J2201/0444 ,  Y10S428/91 ,  Y10T428/1352 ,  Y10T428/24744 ,  Y10T428/2861 ,  Y10T428/31786 ,  A23V2250/056 ,  A23V2250/5076 ,  A23V2200/222 ,  A23V2250/264 ,  A23V2250/2482 ,  A23V2250/242 ,  A23V2250/5118 ,  A23V2250/5432 ,  A23V2250/54246 ,  A23V2250/5036 ,  A23V2200/16 ,  A23V2250/6406 ,  A23V2250/642

Abstract: Methods for using biaxially stretched polyester as a photo-receptive layer for dye sublimation printing are disclosed. Two-sided sublimation printing on polyester is achieved.

Abstract translation: 公开了使用双轴拉伸聚酯作为感光层用于染料升华印刷的方法。 实现了在聚酯上的双面升华印刷。

公开(公告)号：US20030234462A1

公开(公告)日：2003-12-25

申请号：US10364921

申请日：2003-02-11

Applicant: EdiZONE, LC

Inventor： Tony M. Pearce

IPC: B29C044/02

CPC classification number: A23G3/54 ,  A23G3/36 ,  A23G3/368 ,  A23G3/50 ,  A23L27/79 ,  A23P10/30 ,  A23P20/20 ,  A23V2002/00 ,  A61K9/0056 ,  A63B43/008 ,  A63B2037/085 ,  A63B2208/12 ,  A63H33/04 ,  A63H33/28 ,  B32B27/36 ,  B41M5/0355 ,  B43K23/008 ,  B43M99/006 ,  B65D65/463 ,  C08J9/26 ,  C08J2201/0444 ,  Y10S428/91 ,  Y10T428/1352 ,  Y10T428/24744 ,  Y10T428/2861 ,  Y10T428/31786 ,  A23V2250/056 ,  A23V2250/5076 ,  A23V2200/222 ,  A23V2250/264 ,  A23V2250/2482 ,  A23V2250/242 ,  A23V2250/5118 ,  A23V2250/5432 ,  A23V2250/54246 ,  A23V2250/5036 ,  A23V2200/16 ,  A23V2250/6406 ,  A23V2250/642

Abstract: Methods for making formable polymers including elastomeric gels resulting in a formable polymer having air voids or pockets are disclosed. The methods can include forming a formable polymer around salt particles or other dissolvable particles, permitting the formable polymer to solidify, then reducing the salt or other dissolvable particles by use of water or a solvent or melting, leaving air pockets or voids in the formable polymer.

Abstract translation: 公开了制备可成形聚合物的方法，包括弹性体凝胶，得到具有空隙或凹穴的可成形聚合物。 所述方法可以包括在盐颗粒或其它可溶性颗粒周围形成可成形聚合物，允许可成型聚合物固化，然后通过使用水或溶剂来还原盐或其它可溶性颗粒或熔融，从而在可成型聚合物中留下气泡或空隙 。

公开(公告)号：US2432221A

公开(公告)日：1947-12-09

申请号：US56602944

申请日：1944-11-30

Applicant: NCR CO

Inventor： WILSON GALEN J

IPC: C08J9/26

CPC classification number: C08J9/26 ,  C08J2201/0444 ,  C08J2321/00